Prophylactic Antibiotics and Prevention of Surgical Site Infections

Surgical Clinics of North America

Volumn 95, Issue 2, 2015, Pages 269-283

  Najjar, Peter A ^a   Smink, Douglas S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Perioperative infection control; Prophylactic antibiotics; Surgical site infection

Indexed keywords

ANTIBIOTIC AGENT; GLUCOSE; ANTIINFECTIVE AGENT;

ANTIBIOTIC PROPHYLAXIS; BLOOD GLUCOSE MONITORING; BLOOD TRANSFUSION; CHECKLIST; ESTHETIC SURGERY; HOMEOSTASIS; HUMAN; INFECTION PREVENTION; INFECTION RISK; INTESTINE PREPARATION; LAPAROSCOPY; OUTCOME ASSESSMENT; PATIENT SAFETY; PREOPERATIVE CARE; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SKIN DECONTAMINATION; SKIN INCISION; SURGICAL INFECTION; SURGICAL WOUND; WOUND CLOSURE; WOUND INFECTION; ECONOMICS; PERIOPERATIVE PERIOD; SURGICAL WOUND INFECTION;

ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; HUMANS; PERIOPERATIVE CARE; SURGICAL WOUND INFECTION;

EID: 84925588000     PISSN: 00396109     EISSN: 15583171     Source Type: Journal    
DOI: 10.1016/j.suc.2014.11.006     Document Type: Review

References (64)

1. April 2013 CDC/NHSN protocol corrections, clarification, and additions. Available at: Accessed May 28, 2014. http://www.cdc.gov/nhsn/PDFs/pscManual/9pscSSIcurrent.pdf.
2. Magill S.S., Hellinger W., Cohen J., et al. Prevalence of healthcare-associated infections in acute care hospitals in Jacksonville, Florida. Infect Control Hosp Epidemiol 2012, 33(3):283-291.
3. Meeks D.W., Lally K.P., Carrick M.M., et al. Compliance with guidelines to prevent surgical site infections: as simple as 1-2-3?. Am J Surg 2011, 201:76-83.
4. CDC. Data from the National Hospital Discharge Survey. 2010. Available at: Accessed May 28, 2014. http://www.cdc.gov/nchs/data/nhds/4procedures/2010pro_numberpercentage.pdf.
5. Mu Y., Edwards J.R., Horan T.C., et al. Improving risk-adjusted measures of surgical site infection for the national healthcare safety network. Infect Control Hosp Epidemiol 2011, 32(10):970-986.
6. Klevens R.M., Edwards J.R., Richards C.L., et al. Estimating health care-associated infections and deaths in U.S. hospitals. Public Health Rep 2007, 122(2):160-166.
7. Hawn M., Vick C.C., Richman J., et al. Surgical site infection prevention. Ann Surg 2011, 8:494-501.
8. Anthony T., Murray B., Sum-Ping W., et al. Evaluating an evidence-based bundle for preventing surgical site infection: a randomized trial. Arch Surg 2011, 146(3):263-269.
9. Astagneau P., Rioux C., Golliot F., INCISO Network Study Group, et al. Morbidity and mortality associated with surgical site infections: results from the 1997-1999 INCISO surveillance. JHosp Infect 2001, 48(4):267-274.
10. Anderson D.J., Kaye K.S., Classen D., et al. Strategies to prevent surgical site infections in acute care hospitals. Infect Control Hosp Epidemiol 2008, 29:S51-S61.
11. Kirkland K.B., Briggs J.P., Trivette S.L., et al. The impact of surgical-site infections in the 1990s: attributable mortality, excess length of hospitalization, and extra costs. Infect Control Hosp Epidemiol 1999, 20(11):725-730.
12. Anthony T., Long J., Hynan L.S., et al. Surgical complications exert a lasting effect on disease-specific health-related quality of life for patients with colorectal cancer. Surgery 2003, 134(2):119-125.
13. Urban J.A. Cost analysis of surgical site infections. Surg Infect (Larchmt) 2006, 7(Suppl l):S19.
14. Stone P.W., Braccia D., Larson E. Systematic review of economic analyses of health care-associated infections. Am J Infect Control 2005, 33:501-509.
15. Healthcare associated infections: surgical site infections. Centers for Disease Control and Prevention. Available at: Accessed July 3, 2014. http://www.cdc.gov/HAI/ssi/ssi.html.
16. CDC. About the National Healthcare Safety Network, 2014. Available at: Accessed May 30, 2014. http://www.cdc.gov/nhsn/about.html.
17. April 2013 CDC/NHSN protocol corrections, clarification, and additions. Available at: Accessed May 30, 2014. http://www.cdc.gov/nhsn/PDFs/pscManual/9pscSSIcurrent.pdf.
18. American College of Surgeons. National Surgical Quality Improvement Program Operations Manual. Effective Jan. 1 2014 - June 30 2014.
19. Horan T.C., Gaynes R.P., Martone W.J., et al. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol 1992, 13(10):606-608.
20. Bratzler D.W., Hunt D.R. The surgical infection prevention and surgical care improvement projects: national initiatives to improve outcomes for patients having surgery. Clin Infect Dis 2006, 43:322.
21. Jarvis W.R. Epidemiology of nosocomial fungal infections, with emphasis on Candida species. Clin Infect Dis 1995, 20:1526.
22. Hidron A.I., Edwards J.R., Patel J., et al. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol 2008, 29:996.
23. Classen D.C., Evans R.S., Pestotnik S.L., et al. The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection. NEngl J Med 1992, 326:281.
24. Hawn M.T., Richman J.S., Vick C.C., et al. Timing of surgical antibiotic prophylaxis and the risk of surgical site infection. JAMA Surg 2013, 148:649-657.
25. Steinberg J.P., Braun B.I., Hellinger W.C., et al. Timing of antimicrobial prophylaxis and the risk of surgical site infection: results from the trial to reduce antimicrobial prophylaxis errors. Ann Surg 2009, 250:10-16.
26. Nelson R.L., Glenny A.M., Song F. Antimicrobial prophylaxis for colorectal surgery. Cochrane Database Syst Rev 2009, (1). CD001181.
27. Englesbe M.J., Brooks L., Kubus J., et al. Astatewide assessment of surgical site infection following colectomy: the role of oral antibiotics. Ann Surg 2010, 252:514-520.
28. Guenaga K.F., Matos D., Wille-Jorgensen P. Mechanical bowel preparation for elective colorectal surgery. Cochrane Database Syst Rev 2011, (9). CD001544.
29. Dahabreh I.J., Steele D.W., Shah N., et al. Oral mechanical bowel preparation for colorectal surgery. Comparative effectiveness review No. 128. (Prepared by the Brown University Evidence-Based Practice Center under Contract No. 290-2012-00012-I.) 2014, Agency for Healthcare Research and Quality, Rockville (MD), AHRQ Publication No. 14-EHC018-EF.
30. Haynes A.B., Weiser T.G., Berry W.R., et al. Asurgical safety checklist to reduce morbidity and mortality in a global population. NEngl J Med 2009, 360:491-499.
31. de Vries E.N., Dijkstra L., Smorenburg S.M., et al. The SURgical PAtient Safety System (SURPASS) checklist optimizes timing of antibiotic prophylaxis. Patient Saf Surg 2010, 4:6.
32. Urbach D.A., Govindarajan A., Saskin R., et al. Introduction of surgical safety checklists in Ontario, Canada. NEngl J Med 2014, 370:1029-1038.
33. Webster J. Preoperative bathing or showering with skin antiseptics to prevent surgical site infection. Cochrane Database Syst Rev 2007, (2). CD004985.
34. Lynch W., Davey P.G., Malek M., et al. Cost-effectiveness analysis of the use of chlorhexidine detergent in preoperative whole-body disinfection in wound infection prophylaxis. JHosp Infect 1992, 21:179-191.
35. Kapadia B.H., Johnson A.J., Issa K., et al. Economic evaluation of chlorhexidine cloths on healthcare costs due to surgical site infections following total knee arthroplasty. JArthroplasty 2013, 28(7):1061.
36. Darouiche R.O., Wall M.J., Itani K.M., et al. Chlorhexidine-alcohol versus povidone-iodine for surgical-site antisepsis. NEngl J Med 2010, 362(1):18-26.
37. Hebert C., Robicsek A. Decolonization therapy in infection control. Curr Opin Infect Dis 2010, 23:340.
38. Tanner J., Woodings D., Moncaster K. Preoperative hair removal to reduce surgical site infection. Cochrane Database Syst Rev 2006, (3). CD004122.
39. Tanner J., Swarbrook S., Stuart J. Surgical hand antisepsis to reduce surgical site infection. Cochrane Database Syst Rev 2008, (1). CD004288.
40. National Institute for Health and Care Excellence. Surgical site infection: Evidence Update June 2013. Available at: Accessed June 1, 2014. https://www.evidence.nhs.uk/evidence-update-43.
41. Golub R., Siddiqui F., Pohl D. Laparoscopic versus open appendectomy: a metaanalysis. JAm Coll Surg 1998, 186:545-553.
42. Centers for Disease Control and Prevention National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2003, issued August 2003. Am J Infect Control 2003, 31(8):481-498.
43. Phatak U.R., Pedroza C., Millas S.G., et al. Revisiting the effectiveness of interventions to decrease surgical site infections in colorectal surgery: a Bayesian perspective. Surgery 2012, 152(2):202-211.
44. Shabanzadeh D.M., Sørensen L.T. Laparoscopic surgery compared with open surgery decreases surgical site infection in obese patients: a systematic review and meta-analysis. Ann Surg 2012, 256(6):934-945.
45. Gandaglia G., Ghani K.R., Sood A., et al. Effect of minimally invasive surgery on the risk for surgical site infections: results from the national surgical quality improvement program (NSQIP) database. JAMA Surg 2014, 149:1039-1044.
46. Kim S.P., Smaldone M.C. Is a minimally invasive approach the solution for reducing surgical site infections?. JAMA Surg 2014, 149:1044.
47. Charoenkwan K., Chotirosniramit N., Rerkasem K. Scalpel versus electrosurgery for abdominal incisions. Cochrane Database Syst Rev 2012, (6). CD005987.
48. Edmiston C.E., Daoud F.C., Leaper D.J. Is there an evidence-based argument for embracing an antimicrobial (triclosan)-coated suture technology to reduce the risk for surgical-site infections?: a meta- analysis. Surgery 2013, 154:89-100.
49. Wang Z.X., Jiang C.P., Cao Y., et al. Systematic review and meta-analysis of triclosan-coated sutures for the prevention of surgical-site infection. Br J Surg 2013, 100:465-473.
50. Dalfino L., Giglio M.T., Puntillo F., et al. Haemodynamic goal-directed therapy and postoperative infections: earlier is better. A systematic review and meta-analysis. Crit Care 2011, 15(3):R154.
51. Kurz A., Sessler D.I., Lenhardt R. Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization. Study of Wound Infection and Temperature Group. NEngl J Med 1996, 334(19):1209-1215.
52. Melling A.C., Ali B., Scott E.M., et al. Effects of preoperative warming on the incidence of wound infection after clean surgery: a randomised controlled trial. Lancet 2001, 358:876.
53. Togioka B., Galvagno S., Sumida S., et al. The role of perioperative high inspired oxygen therapy in reducing surgical site infection: a meta-analysis. Anesth Analg 2012, 114(2):334-342.
54. Munoz-Price L.S., Sands L., Lubarsky D.A. Effect of high perioperative oxygen supplementation on surgical site infections. Clin Infect Dis 2013, 57:1465.
55. McHugh S.M., Collins C.J., Corrigan M.A., et al. The role of topical antibiotics used as prophylaxis in surgical site infection prevention. JAntimicrob Chemother 2011, 66(4):693-701.
56. Sadava E.E., Krpata D.M., Gao Y., et al. Does presoaking synthetic mesh in antibiotic solution reduce mesh infections? An experimental study. JGastrointest Surg 2013, 17(3):562-568.
57. McDonald M., Grabsch E., Marshall C., et al. Single-versus multiple-dose antimicrobial prophylaxis for major surgery: a systematic review. Aust N Z J Surg 1998, 68:388.
58. Vamvakas E.C., Carven J.H., Hibberd P.L. Blood transfusion and infection after colorectal cancer surgery. Transfusion 1996, 36:1000-1008.
59. Vamvakas E.C., Carven J.H. Transfusion of white-cell-containing allogeneic blood components and postoperative wound infection: effect of confounding factors. Transfus Med 1998, 8:29-36.
60. Talbot T.R., D'Agata E.M., Brinsko V., et al. Perioperative blood transfusion is predictive of poststernotomy surgical site infection: marker for morbidity or true immunosuppressant?. Clin Infect Dis 2004, 38:1378-1382.
61. Kao L.S., Meeks D., Moyer V.A., et al. Peri-operative glycaemic control regimens for preventing surgical site infections in adults. Cochrane Database Syst Rev 2009, (3). CD006806.
62. Krieger B.R., Davis D.M., Sanchez J.E., et al. The use of silver nylon in preventing surgical site infections following colon and rectal surgery. Dis Colon Rectum 2011, 54:1014-1019.
63. Dumville J.C., Walter C.J., Sharp C.A., et al. Dressings for the prevention of surgical site infection. Cochrane Database Syst Rev 2011, (7). CD003091.
64. Towfigh S., Clarke T., Yacoub W., et al. Significant reduction of wound infections with daily probing of contaminated wounds: a prospective randomized clinical trial. Arch Surg 2011, 146(4):448-452.