Blood flow in the hands of a predefined homogeneous systemic sclerosis population: The presence of digital ulcers and the improvement with bosentan

Rheumatology (United Kingdom)

Volumn 54, Issue 2, 2015, Pages 262-269

  Meijs, Jessica ^a   Voskuyl, Alexandre E ^b   Bloemsaat Minekus, Joanne P J ^c   Vonk, Madelon C ^d  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Medical Department   (Netherlands)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Blood flow; Digital ulcers; Laser Doppler perfusion imaging; Systemic sclerosis

Indexed keywords

BOSENTAN; SULFONAMIDE; VASODILATOR AGENT;

ADULT; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; DOPPLER FLOWMETRY; DRUG EFFECT; FEMALE; FINGER ULCER; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OPEN STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SYSTEMIC SCLEROSIS; TREATMENT DURATION; AGED; ANALYSIS OF VARIANCE; CASE CONTROL STUDY; CLINICAL TRIAL; DRUG ADMINISTRATION; HAND; MIDDLE AGED; PATHOPHYSIOLOGY; SCLERODERMA, SYSTEMIC; SKIN ULCER; TREATMENT OUTCOME; VASCULARIZATION;

ADULT; AGED; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; DRUG ADMINISTRATION SCHEDULE; FEMALE; HAND; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SCLERODERMA, SYSTEMIC; SKIN ULCER; SULFONAMIDES; TREATMENT OUTCOME; VASODILATOR AGENTS;

EID: 84925581497     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/keu300     Document Type: Article

References (31)

1. Strange G, Nash P. The manifestations of vasculopathy in systemic sclerosis and its evidence-based therapy. Int J Rheum Dis 2009;12:192-206.
2. Galluccio F, Matucci-Cerinic M. Two faces of the same coin: Raynaud phenomenon and digital ulcers in systemic sclerosis. Autoimmun Rev 2011;10:241-3.
3. Denton CP, Korn JH. Digital ulceration and critical digital ischaemia in scleroderma. Scleroderma Care Res 2003;1: 12-6.
4. Steen V, Denton CP, Pope JE, Matucci-Cerinic M. Digital ulcers: overt vascular disease in systemic sclerosis. Rheumatology 2009;48(Suppl 3):iii19-24.
5. Berezne A, Seror R, Morell-Dubois S et al. Impact of systemic sclerosis on occupational and professional activity with attention to patients with digital ulcers. Arthritis Care Res 2011;63:277-85.
6. Denton CP, Krieg T, Guillevin L et al. Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry. Ann Rheum Dis 2012;71:718-21.
7. Chung L, Fiorentino D. A pilot trial of treprostinil for the treatment and prevention of digital ulcers in patients with systemic sclerosis. J Am Acad Dermatol 2006;54:880-2.
8. Kawald A, Burmester GR, Huscher D, Sunderkotter C, Riemekasten G. Low versus high-dose iloprost therapy over 21 days in patients with secondary Raynaud's phenomenon and systemic sclerosis: a randomized, open, single-center study. J Rheumatol 2008;35:1830-7.
9. Shenoy PD, Kumar S, Jha LK et al. Efficacy of tadalafil in secondary Raynaud's phenomenon resistant to vasodilator therapy: a double-blind randomized cross-over trial. Rheumatology 2010;49:2420-8.
10. Brueckner CS, Becker MO, Kroencke T et al. Effect of sildenafil on digital ulcers in systemic sclerosis: analysis from a single centre pilot study. Ann Rheum Dis 2010;69: 1475-8.
11. Korn JH, Mayes M, Matucci Cerinic M et al. Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist. Arthritis Rheum 2004;50:3985-93.
12. Matucci-Cerinic M, Denton CP, Furst DE et al. Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial. Ann Rheum Dis 2011;70:32-8.
13. Shi-Wen X, Denton CP, Dashwood MR et al. Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1. J Invest Dermatol 2011;116:417-25.
14. Shi-Wen X, Chen Y, Denton CP et al. Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol Biol Cell 2004;15:2707-19.
15. Channick RN, Simonneau G, Sitbon O et al. Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study. Lancet 2001;358:1119-23.
16. Guiducci S, Bellando RS, Bruni C et al. Bosentan fosters microvascular de-remodelling in systemic sclerosis. Clin Rheumatol 2012;31:1723-5.
17. Cutolo M, Zampogna G, Vremis L et al. Longterm effects of endothelin receptor antagonism on microvascular damage evaluated by nailfold capillaroscopic analysis in systemic sclerosis. J Rheumatol 2013;40:40-5.
18. Rosato E, Molinaro I, Borghese F et al. Bosentan improves skin perfusion of hands in patients with systemic sclerosis with pulmonary arterial hypertension. J Rheumatol 2010; 37:2531-9.
19. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Arthritis Rheum 1980;23:581-90.
20. LeRoy EC, Medsger TA Jr. Criteria for the classification of early systemic sclerosis. J Rheumatol 2001;28:1573-6.
21. Amanzi L, Braschi F, Fiori G et al. Digital ulcers in scleroderma: staging, characteristics and sub-setting through observation of 1614 digital lesions. Rheumatology 2010; 49:1374-82.
22. Rosato E, Borghese F, Pisarri S, Salsano F. Laser Doppler perfusion imaging is useful in the study of Raynaud's phenomenon and improves the capillaroscopic diagnosis. J Rheumatol 2009;36:2257-63.
23. Twisk J, de Vente W. Attrition in longitudinal studies. How to deal with missing data. J Clin Epidemiol 2002;55: 329-37.
24. Ambrózy E, Waczulíkova I, Willfort A et al. Healing process of venous ulcers: the role of microcirculation. Int Wound J 2012;10:57-64.
25. Merz KM, Pfau M, Blumenstock G et al. Cutaneous microcirculatory assessment of the burn wound is associated with depth of injury and predicts healing time. Burns 2010;36:477-82.
26. Murray AK, Moore TL, Manning JB et al. Noninvasive imaging techniques in the assessment of scleroderma spectrum disorders. Arthritis Rheum 2009;61:1103-11.
27. Rosato E, Molinaro I, Rossi C, Pisarri S, Salsano F. The combination of laser Doppler perfusion imaging and photoplethysmography is useful in the characterization of scleroderma and primary Raynaud's phenomenon. Scand J Rheumatol 2011;40:292-8.
28. Hettema ME, Zhang D, Stienstra Y et al. No effects of bosentan on microvasculature in patients with limited cutaneous systemic sclerosis. Clin Rheumatol 2009;28: 825-33.
29. Correa MJ, Andrade LE, Kayser C. Comparison of laser Doppler imaging, fingertip lacticemy test, and nailfold capillaroscopy for assessment of digital microcirculation in systemic sclerosis. Arthritis Res Ther 2010;12:R157.
30. Cutolo M, Ferrone C, Pizzorni C et al. Peripheral blood perfusion correlates with microvascular abnormalities in systemic sclerosis: a laser-Doppler and nailfold videocapillaroscopy study. J Rheumatol 2010;37:1174-80.
31. Rosato E, Rossi C, Molinaro I et al. Laser Doppler perfusion imaging in systemic sclerosis impaired response to cold stimulation involves digits and hand dorsum. Rheumatology 2011;50:1654-8.