A randomized, clinical trial comparing the efficacy of continuous nebulized albuterol (15 mg) versus continuous nebulized albuterol (15 mg) plus ipratropium bromide (2 mg) for the treatment of acute asthma

Journal of Emergency Medicine

Volumn 31, Issue 4, 2006, Pages 371-376

  Salo, David ^a   Tuel, Mark ^b   Lavery, Robert F ^c   Reischel, Ulrich ^b   Lebowitz, Jeff ^b   Moore, Terry ^b  

^a MORRISTOWN MEMORIAL HOSPITAL   (United States)

^b NEWARK BETH ISRAEL MEDICAL CENTER   (United States)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

albuterol; asthma; ipratropium

Indexed keywords

IPRATROPIUM BROMIDE; SALBUTAMOL;

ARTICLE; ASTHMA; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; EMERGENCY HEALTH SERVICE; HOSPITAL DISCHARGE; HUMAN; NEBULIZATION; PREDICTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; URBAN AREA;

ADULT; AEROSOLS; ALBUTEROL; ASTHMA; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; IPRATROPIUM; MALE; PEAK EXPIRATORY FLOW RATE;

EID: 33749517309     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2006.05.025     Document Type: Article

References (18)

1. Adams P.F., and Marano M.A. Current estimates from the National Health Interview Survey, 1994. Vital Health Stat 10 (1995) 1-260
2. Centers for Disease Control and Prevention. Asthma mortality and hospitalization among children and young adults-United States, 1990-1993. MMWR Morb Mortal Wkly Rep 45 (1996) 350-353
3. Barnett P.L., Caputo G.L., Baskin M., and Kuppermann N. Intravenous versus oral corticosteroids in the management of acute asthma in children. Ann Emerg Med 29 (1997) 212-217
4. Emond S.D., Camargo C.A., and Nowak R.M. 1997 National Asthma Education and Prevention Program guidelines: a practical summary for emergency physicians. Ann Emerg Med 31 (1998) 579-589
5. Emond S.D., Camargo C.A., and Nowak R.M. Advances, opportunities, and the new asthma guidelines. Ann Emerg Med 31 (1998) 590-594
6. Calvo G.M., Calvo A.M., Marín H.F., and Moya G.J. Is it useful to add an anticholinergic treatment to beta 2-adrenergic medication in acute asthma attack?. J Investig Allergol Clin Immunol 8 (1998) 30-34
7. Dagnone A.J., and Parlow J.L. Effects of inhaled albuterol and ipratropium bromide on autonomic control of the cardiovascular system. Chest 111 (1997) 1514-1518
8. Garrett J.E. Combined anticholinergic therapy in the management of acute asthma. Respirology 2 Suppl 1 (1997) S17-S18
9. Lanes S.F., Garrett J.E., Wentworth III C.E., Fitzgerald J.M., and Karpel J.P. The effect of adding ipratropium bromide to salbutamol in the treatment of acute asthma: a pooled analysis of three trials. Chest 114 (1998) 365-372
10. Lin R.Y., Pesola G.R., Bakalchuk L., et al. Superiority of ipratropium plus albuterol over albuterol alone in the emergency department management of adult asthma: a randomized clinical trial. Ann Emerg Med 31 (1998) 208-213
11. FitzGerald J.M., Grunfeld A., Pare P.D., et al. The clinical efficacy of combination nebulized anticholinergic and adrenergic bronchodilators vs nebulized adrenergic bronchodilator alone in acute asthma. Chest 111 (1997) 311-315
12. Weber E.J., Levitt M.A., Covington J.K., and Gambrioli E. Effect of continuously nebulized ipratropium bromide plus albuterol on emergency department length of stay and hospital admission rates in patients with acute bronchospasm. A randomized, controlled trial. Chest 115 (1999) 937-944
13. Shrestha M., Bidadi K., Gourlay S., and Hayes J. Continuous vs intermittent albuterol, at high and low doses, in the treatment of severe acute asthma in adults. Chest 110 (1996) 42-47
14. Khine H., Fuchs S.M., and Saville A.L. Continuous vs intermittent nebulized albuterol for emergency management of asthma. Acad Emerg Med 3 (1996) 1019-1024
15. Reisner C., Kotch A., and Dworkin G. Continuous versus frequent intermittent nebulization of albuterol in acute asthma: a randomized, prospective study. Ann Allergy Asthma Immunol 75 (1995) 41-47
16. Brophy C., Ahmed B., Bayston S., Arnold A., McGivern D., and Greenstone M. How long should Atrovent be given in acute asthma?. Thorax 53 (1998) 363-367
17. Wilson M.M., Irwin R.S., Connolly A.E., Linden C., and Manno M.M. A prospective evaluation of the 1-hour decision point for admission versus discharge in acute asthma. J Intensive Care Med 18 (2003) 275-285
18. Aaron S.D. The use of ipratropium bromide for the management of acute asthma exacerbation in adults and children: a systematic review. J Asthma 38 (2001) 521-530