Cytomegalovirus infection in seropositive unrelated cord blood recipients: a study of 349 Korean patients

Annals of Hematology

Volumn 94, Issue 3, 2015, Pages 481-489

  Park, Meerim ^a   Lee, Young Ho ^b   Lee, Soo Hyun ^c   Yoo, Keon Hee ^c   Sung, Ki Woong ^c   Koo, Hong Hoe ^c   Lee, Ji Won ^d   Kang, Hyoung Jin ^d   Park, Kyung Duk ^d   Shin, Hee Young ^d   Ahn, Hyo Seop ^d   Lee, Jae Wook ^e   Chung, Nack Gyun ^e   Cho, Bin ^e   Kim, Hack Ki ^e   Koh, Kyung Nam ^f   Im, Ho Joon ^f   Seo, Jong Jin ^f   Baek, Hee Jo ^g   Kook, Hoon ^g   Hwang, Tai Ju ^g   Lee, Jae Min ^h   Hah, Jeong Ok ^h   Lim, Yeon Jung ⁱ   Park, Jun Eun ^j   Lyu, Chuhl Joo ^k   Lim, Young Tak ^l   Chong, So Young ^m   Oh, Doyeun ^m   more..

^a Chungbuk National University College of Medicine   (South Korea)

^b Hanyang University Medical Center   (South Korea)

^c Samsung Medical Center   (South Korea)

^d Seoul National University   (South Korea)

^e The Catholic University of Korea   (South Korea)

^f University of Ulsan College of Medicine   (South Korea)

^g Chonnam National University Research Institute of Medical Sciences   (South Korea)

^h Yeungnam University College of Medicine   (South Korea)

ⁱ Chungnam National University   (South Korea)

^j Ajou University School of Medicine   (South Korea)

^k Yonsei University College of Medicine   (South Korea)

^l Pusan National University School of Medicine   (South Korea)

^m CHA University   (South Korea)

more..

Author keywords

Cord blood transplantation; Cytomegalovirus; Outcome; Seropositive

Indexed keywords

ACICLOVIR; CIDOFOVIR; CYTOMEGALOVIRUS ANTIBODY; FOSCARNET; MYCOPHENOLATE MOFETIL; THYMOCYTE ANTIBODY;

ARTICLE; CHILD; CORD BLOOD STEM CELL TRANSPLANTATION; CYTOMEGALOVIRUS INFECTION; ENGRAFTMENT; FEMALE; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HUMAN; KOREAN (PEOPLE); LEUKEMIA RELAPSE; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; UNRELATED CORD BLOOD TRANSPLANTATION; VIRUS REACTIVATION; WHOLE BODY RADIATION; ADOLESCENT; ADULT; AGED; ALLOTRANSPLANTATION; COMPLICATION; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; IMMUNOLOGY; INFANT; LEUKEMIA; MIDDLE AGED; PHYSIOLOGY; PRESCHOOL CHILD; SOUTH KOREA; STATISTICS AND NUMERICAL DATA; UNRELATED DONORS; VIRUS ACTIVATION; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; CORD BLOOD STEM CELL TRANSPLANTATION; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HUMANS; INFANT; LEUKEMIA; MALE; MIDDLE AGED; REPUBLIC OF KOREA; SEROEPIDEMIOLOGIC STUDIES; TRANSPLANT RECIPIENTS; TRANSPLANTATION, HOMOLOGOUS; UNRELATED DONORS; VIRUS ACTIVATION; YOUNG ADULT;

EID: 84925537154     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-014-2222-x     Document Type: Article

References (33)

1. Albano MS, Taylor P, Pass RF, Scaradavou A, Ciubotariu R, Carrier C, Dobrila L, Rubinstein P, Stevens CE (2006) Umbilical cord blood transplantation and cytomegalovirus: posttransplantation infection and donor screening. Blood 108:4275–4282
2. Beck JC, Wagner JE, DeFor TE, Brunstein CG, Schleiss MR, Young JA, Weisdorf DH, Cooley S, Miller JS, Verneris MR (2010) Impact of cytomegalovirus (CMV) reactivation after umbilical cord blood transplantation. Biol Blood Marrow Transplant 16:215–222
3. D'Arena G, Musto P, Cascavilla N, Di Giorgio G, Fusilli S, Zendoli F, Carotenuto M (1998) Flow cytometric characterization of human umbilical cord blood lymphocytes: immunophenotypic features. Haematologica 83:197–203
4. Komanduri KV, St John LS, de Lima M, McMannis J, Rosinski S, McNiece I, Bryan SG, Kaur I, Martin S, Wieder ED, Worth L, Cooper LJ, Petropoulos D, Molldrem JJ, Champlin RE, Shpall EJ (2007) Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing. Blood 110:4543–4551
5. Boeckh M, Nichols WG, Papanicolaou G, Rubin R, Wingard JR, Zaia J (2003) Cytomegalovirus in hematopoietic stem cell transplant recipients: current status, known challenges, and future strategies. Biol Blood Marrow Transplant 9:543–558
6. Broers AE, van Der Holt R, van Esser JW, Gratama JW, Henzen-Logmans S, Kuenen-Boumeester V, Lowenberg B, Cornelissen JJ (2000) Increased transplant-related morbidity and mortality in CMV-seropositive patients despite highly effective prevention of CMV disease after allogeneic T-cell-depleted stem cell transplantation. Blood 95:2240–2245
7. Ljungman P, Hakki M, Boeckh M (2010) Cytomegalovirus in hematopoietic stem cell transplant recipients. Infect Dis Clin N Am 24:319–337
8. Walker CM, van Burik JA, De For TE, Weisdorf DJ (2007) Cytomegalovirus infection after allogeneic transplantation: comparison of cord blood with peripheral blood and marrow graft sources. Biol Blood Marrow Transplant 13:1106–1115
9. George B, Kerridge I, Gilroy N, Huang G, Hertzberg M, Gottlieb D, Bradstock K (2010) Fludarabine-based reduced intensity conditioning transplants have a higher incidence of cytomegalovirus reactivation compared with myeloablative transplants. Bone Marrow Transplant 45:849–855
10. Yoo KH, Lee SH, Sung KW, Koo HH, Chung NG, Cho B, Kim HK, Kang HJ, Shin HY, Ahn HS, Baek HJ, Han DK, Kook H, Hwang TJ, Kim SY, Lee YH, Hah JO, Im HJ, Seo JJ, Park SK, Jung HJ, Park JE, Lim YJ, Park SS, Lim YT, Yoo ES, Ryu KH, Park HJ, Park BK (2011) Current status of pediatric umbilical cord blood transplantation in Korea: a multicenter retrospective analysis of 236 cases. Am J Hematol 86:12–17
11. Ljungman P, Griffiths P, Paya C (2002) Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 34:1094–1097
12. Frangoul H, Wang L, Harrell FE Jr, Ho R, Domm J (2009) Preengraftment syndrome after unrelated cord blood transplant is a strong predictor of acute and chronic graft-versus-host disease. Biol Blood Marrow Transplant: J Am Soc Blood Marrow Transplant 15:1485–1488
13. Bacigalupo A, Ballen K, Rizzo D, Giralt S, Lazarus H, Ho V, Apperley J, Slavin S, Pasquini M, Sandmaier BM, Barrett J, Blaise D, Lowski R, Horowitz M (2009) Defining the intensity of conditioning regimens: working definitions. Biol Blood Marrow Transplant 15:1628–1633
14. Patel KJ, Rice RD, Hawke R, Abboud M, Heller G, Scaradavou A, Young JW, Barker JN (2010) Pre-engraftment syndrome after double-unit cord blood transplantation: a distinct syndrome not associated with acute graft-versus-host disease. Biol Blood Marrow Transplant 16:435–440
15. Przepiorka D, Weisdorf D, Martin P, Klingemann HG, Beatty P, Hows J, Thomas ED (1995) 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant 15:825–828
16. Vigorito AC, Campregher PV, Storer BE, Carpenter PA, Moravec CK, Kiem HP, Fero ML, Warren EH, Lee SJ, Appelbaum FR, Martin PJ, Flowers ME (2009) Evaluation of NIH consensus criteria for classification of late acute and chronic GVHD. Blood 114:702–708
17. Tomonari A, Takahashi S, Ooi J, Tsukada N, Konuma T, Kato S, Kasahara S, Iseki T, Yamaguchi T, Tojo A, Asano S (2008) Impact of cytomegalovirus serostatus on outcome of unrelated cord blood transplantation for adults: a single-institute experience in Japan. Eur J Haematol 80:251–257
18. Mikulska M, Raiola AM, Bruzzi P, Varaldo R, Annunziata S, Lamparelli T, Frassoni F, Tedone E, Galano B, Bacigalupo A, Viscoli C (2012) CMV infection after transplant from cord blood compared to other alternative donors: the importance of donor-negative CMV serostatus. Biol Blood Marrow Transplant 18:92–99
19. Buyck HC, Prentice HG, Griffiths PD, Emery VC (2010) The risk of early and late CMV DNAemia associated with Campath use in stem cell transplant recipients. Bone Marrow Transplant 45:1212–1219
20. Pinana JL, Martino R, Barba P, Margall N, Roig MC, Valcarcel D, Sierra J, Rabella N (2010) Cytomegalovirus infection and disease after reduced intensity conditioning allogeneic stem cell transplantation: single-centre experience. Bone Marrow Transplant 45:534–542
21. Barron MA, Gao D, Springer KL, Patterson JA, Brunvand MW, McSweeney PA, Zeng C, Baron AE, Weinberg A (2009) Relationship of reconstituted adaptive and innate cytomegalovirus (CMV)-specific immune responses with CMV viremia in hematopoietic stem cell transplant recipients. Clin Infect Dis 49:1777–1783
22. Yi ES, Kim YJ (2012) Cytomegalovirus infection according to cell source after hematopoietic cell transplantation in pediatric patients. Yonsei Med J 53:393–400
23. Montesinos P, Sanz J, Cantero S, Lorenzo I, Martin G, Saavedra S, Palau J, Romero M, Montava A, Senent L, Martinez J, Jarque I, Salavert M, Cordoba J, Gomez L, Weiss S, Moscardo F, de la Rubia J, Larrea L, Sanz MA, Sanz GF (2009) Incidence, risk factors, and outcome of cytomegalovirus infection and disease in patients receiving prophylaxis with oral valganciclovir or intravenous ganciclovir after umbilical cord blood transplantation. Biol Blood Marrow Transplant 15:730–740
24. Al-Hajjar S, Al Seraihi A, Al Muhsen S, Ayas M, Al Jumaah S, Al Jefri A, Shoukri M, El Solh H (2011) Cytomegalovirus infections in unrelated cord blood transplantation in pediatric patients: incidence, risk factors, and outcomes. Hematol/Oncol Stem Cell Ther 4:67–72
25. Ozdemir E, St John LS, Gillespie G, Rowland-Jones S, Champlin RE, Molldrem JJ, Komanduri KV (2002) Cytomegalovirus reactivation following allogeneic stem cell transplantation is associated with the presence of dysfunctional antigen-specific CD8+ T cells. Blood 100:3690–3697
26. Matsumura T, Narimatsu H, Kami M, Yuji K, Kusumi E, Hori A, Murashige N, Tanaka Y, Masuoka K, Wake A, Miyakoshi S, Kanda Y, Taniguchi S (2007) Cytomegalovirus infections following umbilical cord blood transplantation using reduced intensity conditioning regimens for adult patients. Biol Blood Marrow Transplant 13:577–583
27. Kullberg-Lindh C, Mellgren K, Friman V, Fasth A, Ascher H, Nilsson S, Lindh M (2011) Opportunistic virus DNA levels after pediatric stem cell transplantation: serostatus matching, anti-thymocyte globulin, and total body irradiation are additive risk factors. Transpl Infect Dis 13:122–130
28. Hambach L, Stadler M, Dammann E, Ganser A, Hertenstein B (2002) Increased risk of complicated CMV infection with the use of mycophenolate mofetil in allogeneic stem cell transplantation. Bone Marrow Transplant 29:903–906
29. Lipsky JJ (1996) Mycophenolate mofetil. Lancet 348:1357–1359
30. Heemann U, Azuma H, Hamar P, Schmid C, Tilney N, Philipp T (1996) Mycophenolate mofetil inhibits lymphocyte binding and the upregulation of adhesion molecules in acute rejection of rat kidney allografts. Transpl Immunol 4:64–67
31. Milano F, Pergam SA, Xie H, Leisenring WM, Gutman JA, Riffkin I, Chow V, Boeckh MJ, Delaney C (2011) Intensive strategy to prevent CMV disease in seropositive umbilical cord blood transplant recipients. Blood 118:5689–5696
32. Bacigalupo A, Boyd A, Slipper J, Curtis J, Clissold S (2012) Foscarnet in the management of cytomegalovirus infections in hematopoietic stem cell transplant patients. Expert Rev Anti-Infect Ther 10:1249–1264
33. Shereck EB, Cooney E, van de Ven C, Della-Lotta P, Cairo MS (2007) A pilot phase II study of alternate day ganciclovir and foscarnet in preventing cytomegalovirus (CMV) infections in at-risk pediatric and adolescent allogeneic stem cell transplant recipients. Pediatr Blood Cancer 49:306–312