Effects of buspirone and the dopamine D3 receptor compound PG619 on cocaine and methamphetamine self-administration in rhesus monkeys using a food-drug choice paradigm

Psychopharmacology

Volumn 232, Issue 7, 2015, Pages 1279-1289

  John, William S ^a   Banala, Ashwini K ^b   Newman, Amy H ^b   Nader, Michael A ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Cocaine; Dopamine D3 receptors; Methamphetamine; Monkeys; Self administration

Indexed keywords

BUSPIRONE; COCAINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR BLOCKING AGENT; METHAMPHETAMINE; PG 619; UNCLASSIFIED DRUG; DOPAMINE 3 RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT;

ANIMAL EXPERIMENT; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG CHOICE; DRUG SELF ADMINISTRATION; FOOD DRUG CHOICE; FORCED CHOICE METHOD; MALE; METHAMPHETAMINE DEPENDENCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REINFORCEMENT; RHESUS MONKEY; AGONISTS; ANIMAL; DECISION MAKING; DOSE RESPONSE; DRUG EFFECTS; FEEDING BEHAVIOR; FOLLOW UP; PHYSIOLOGY;

ANIMALS; BUSPIRONE; CHOICE BEHAVIOR; COCAINE; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDING BEHAVIOR; FOLLOW-UP STUDIES; MACACA MULATTA; MALE; METHAMPHETAMINE; RECEPTORS, DOPAMINE D3; REINFORCEMENT (PSYCHOLOGY); SELF ADMINISTRATION;

EID: 84925519684     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-014-3760-6     Document Type: Article

References (44)

1. Achat-Mendes C, Platt DM, Newman AH, Spealman RD (2009) The dopamine D3 receptor partial agonist CJB 090 inhibits the discriminative stimulus but not the reinforcing or priming effects of cocaine in squirrel monkeys. Psychopharmacology 206:73-84
2. Baladi MG, Newman AH, France CP (2014) Feeding condition and the relative contribution of different dopamine receptor subtypes to the discriminative stimulus effects of cocaine in rats. Psychopharmacology 231:581-591
3. Banks ML, Negus SS (2012) Preclinical determinants of drug choice under concurrent schedules of drug self-administration. Adv Pharmacol Sci 2012:281768
4. Bennett BA, Hollingsworth CK, Martin RS, Harp JJ (1993) Methamphetamine-induced alterations in dopamine transporter function. Brain Res 782:219-227
5. Bergman J, Roof RA, Furman CA, Conroy JL, Mello NK, Sibley DR, Skolnick P (2013) Modification of cocaine self-administration by buspirone (buspar®): potential involvement of D3 and D4 dopamine receptors. Int J Neuropsychopharmacol 16:445-458
6. 3 receptor-selective compounds in monkeys. Neuropsychopharmacology 36:1104-1113
7. 11C]-(+)-propyl-hexahydro-naphtho-oxazin in methamphetamine polydrug users: a positron emission tomography study. J Neurosci 32:1353-1359
8. Coffin PO, Santos GM, Das M, Santos DM, Huffaker S, Matheson T, Gasper J, Vittinghoff E, Colfax GN (2013) Aripiprazole for the treatment of methamphetamine dependence: a randomized, double-blind, placebo-controlled trial. Addiction 108:751-761
9. Czoty PW, Nader MA (2013) Effects of dopamine D2/D3 receptor ligands on food-cocaine choice in socially housed male cynomolgus monkeys. J Pharmacol Exp Ther 344:329-338
10. 1A agonist (±)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on cocaine choice in cynomolgus. Behav Pharmacol 16:187-191
11. Grundt P, Prevatt KM, Cao J, Taylor J, Floresca CZ, Choi J-K, Jenkins BG, Luedtke RR, Newman AH (2007) Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-butyl)-aryl-carboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents. J Med Chem 50:4135-4146
12. Haile CN, Kosten TR (2013) Pharmacotherapy for stimulant-related disorders. Curr Psychiatry Rep 15:415
13. Haney M, Spealman R (2008) Controversies in translational research: drug self-administration. Psychopharmacology 199:403-419
14. Haney M, Rubin R, Fotin RW (2011) Aripiprazole maintencance increases smoked cocaine self-administration in humans. Psychopharmacology 216:379-387
15. Heidbreder C (2013) Rationale in support of the use of selective dopamine D3 receptor antagonists for the pharmacotherapeutic management of substance use disorders. Naunyn-Schmiedeberg's Arch Pharmacol 386:167-176
16. Heidbreder CA, Newman AH (2010) Current perspectives on selective dopamine D3 receptor antagonists as pharmacotherapeutics for addictions and related disorders. Ann NY Acad Sci 1187:4-34
17. Heyman GH (2009) Addiction: a disorder of choice. Harvard University Press, Cambridge
18. Johnson BA, Roache JD, Ait-Daoud N, Wells LT, Wallace CL, Dawes MA, Liu L, Wang X-Q (2007) Effects of acute topiramate dosing on methamphetamine-induced subjective mood. Int J Neuropsychopharmacol 10:85-98
19. Jones SR, Gainetdinov RR, Wightman RM, Caron MG (1998) Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. J Neurosci 18:1979-1986
20. Kampman KM, Pettinati H, Lynch KG, Dackis C, Sparkman T, Weigley C, O'Brien CP (2004) A pilot trial of topiramate for the treatment of cocaine dependence. Drug Alcohol Dep 75:233-240
21. Koffarnus MN, Collins GT, Rice KC, Chen J, Woods JH, Winger G (2012) Self-administration of agonists selective for dopamine D2, D3, and D4 receptors by rhesus monkeys. Behav Pharmacol 23:331-338
22. Martelle JL, Claytor R, Ross JT, Newman AH, Nader MA (2007) Effects of two novel D3-selective compounds, NGB 2904 and CJB 090, on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys. J Pharmacol Exp Ther 321:573-582
23. Martelle SE, Nader SH, Czoty PW, John W, Duke AN, Garg PK et al. (2014) Quinpirole-elicited yawning in monkeys: Relationship with D3 receptor availability, sex differences and effects of chronic drug exposure. J Pharmacol Exp Ther 350:205-211
24. McMillen BA, Mathews RT, Sanghera MK, Shepard PD, German DC (1983) Dopamine receptor antagonism by the novel anti-anxiety drug, buspirone. J Neurosci 3:733-738
25. Mello NK, Fivel PA, Kohut SJ, Bergman J (2013) Effects of chronic buspirone treatment on cocaine self-administration. Neuropsychopharmacology 38:455-467
26. Munzar P, Goldberg SR (2000) Dopaminergic involvement in the discriminative-stimulus effects of methamphetamine in rats. Psychopharmacology 148:209-216
27. Nader MA, Barrett JE (1990) Effects of chlordiazepoxide, buspirone and serotonin receptor agonists and antagonists on responding of squirrel monkeys maintained under second-order schedules of intramuscular cocaine injection or food presentation. Drug Dev Res 20:5-17
28. Negus SS (2003) Rapid assessment of choice between cocaine and food in rhesus monkeys: effects of environmental manipulations and treatment with d-amphetamine and flupenthixol. Neuropsychopharmacology 28:919-931
29. Newman AH, Grundt P, Nader MA (2005) Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents. J Med Chem 48:3664-3679
30. Newman AH, Blaylock BL, Nader MA, Bergman J, Sibley DR, Skolnick P (2012) Medication discovery for addiction: translating the dopamine D3 receptor hypothesis. Biochem Pharmacol 84:882-890
31. Orio L, Wee S, Newman AH, Pulvirenti L, Koob GF (2010) The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access. Addict Biol 15:312-323
32. 11C]-(+)-PHNO. Neuropsychopharmacology, in press
33. 3 receptor agonist. Nature 400:371-375
34. Pulvirenti L, Koob GF (1994) Dopamine receptor agonists, partial agonists and psychostimulant addiction. Trends Pharmacol Sci 15:374-379
35. Raiteri M, Del Carmine R, Bertollini A, Levi G (1977) Effect of sympathomimetic amines on the synaptosomal transport of noradrenaline, dopamine and 5-hydroxytryptamine. Eur J Pharmacol 41:133-143
36. Russo SJ, Nestler EJ (2013) The brain reward circuitry in mood disorders. Nat Rev Neurosci 14:609-625
37. SAMHSA (2013) Substance abuse and mental health services administration. Reliability of key measures in the national survey on drug use and health. Substance abuse and mental health services administration. U.S. Dept. of Health and Human Services, Rockville
38. Sasaki JE, Tatham TA, Barrett JE (1995) The discriminative stimulus effects of methamphetamine in pigeons. Psychopharmacology 120:303-310
39. 3 receptors in the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys. Drug Alcohol Dep 54:97-110
40. Skolnick P, Paul S, Weissman BA (1984) Preclinical pharmacology of buspirone hydrochloride. Pharmacotherapy 4:308-314
41. Sonders MS, Zhu SJ, Zahniser NR, Kavanaugh MP, Amara SG (1997) Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants. J Neurosci 17:960-974
42. Winchell C, Rappaport BA, Roca R, Rosebraugh CJ (2012) Reanalysis of methamphetamine dependence treatment trial. CNS Neurosci Ther 18:367-368
43. Winhusen TM, Kropp F, Lindblad R, Douaihy A, Haynes L, Hodgkins C et al. (2014) Multisite, randomized, double-blind, placebo-controlled pilot clinical trial to evaluate the efficacy of buspirone as a relapse-prevention treatment for cocaine dependence. J Clin Psychiatry, in press
44. Woolverton WL, Balster RL (1981) Effects of antipsychotic compounds in rhesus monkeys given a choice between cocaine and food. Drug Alcohol Dep 8:69-78