Metabolomic profiling of human serum in lung cancer patients using liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry and gas chromatography/mass spectrometry

Journal of Cancer Research and Clinical Oncology

Volumn 141, Issue 4, 2015, Pages 705-718

  Chen, Yingrong ^a   Ma, Zhihong ^a   Li, Aiying ^a   Li, Hongwei ^a   Wang, Bin ^a   Zhong, Jing ^a   Min, Lishan ^a   Dai, Licheng ^a  

^a HUZHOU CENTRAL HOSPITAL   (China)

Author keywords

Biomarker; Gas chromatography mass spectrometry; Liquid chromatography hybrid quadrupole time of flight mass spectrometry; Lung cancer; Metabolomics

Indexed keywords

2,3,4 TRIHYDROXYBUTYRIC ACID; ALANINE; ALPHA HYDROXYISOBUTYRIC ACID; ALPHA HYDROXYVALERIC ACID; BIOLOGICAL MARKER; BUTYRIC ACID DERIVATIVE; CHOLESTEROL; ETHANOLAMINE DERIVATIVE; GALACTOSE; GAMMA LINOLENIC ACID; GLUCONIC ACID; GLUCOSE; GLUTAMINE; GLYCEROPHOSPHO N ARACHIDONOYL ETHANOLAMINE; LACTIC ACID; LINOLEIC ACID; OLEIC ACID; OXALIC ACID; PHENYLALANINE; PHOSPHATE; PHOSPHORYLCHOLINE; PRASTERONE SULFATE; PROLINE; PYROGLUTAMIC ACID; RIBITOL; SERINE; SPHINGOSINE; TYROSINE; UNCLASSIFIED DRUG; UREA; VALERIC ACID DERIVATIVE; TUMOR MARKER;

ADULT; ARTICLE; CANCER DIAGNOSIS; CANCER PATIENT; CANCER SURGERY; CLINICAL ARTICLE; CONTROLLED STUDY; EARLY DIAGNOSIS; FEMALE; FLOW RATE; HUMAN; LIQUID CHROMATOGRAPHY; LUNG CANCER; MALE; MASS FRAGMENTOGRAPHY; METABOLITE; METABOLOMICS; MOLECULAR DIAGNOSIS; PATTERN RECOGNITION; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; SERUM; TIME OF FLIGHT MASS SPECTROMETRY; AGED; BLOOD; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LUNG NEOPLASMS; MASS SPECTROMETRY; MIDDLE AGED; PROCEDURES;

AGED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; LUNG NEOPLASMS; MASS SPECTROMETRY; METABOLOMICS; MIDDLE AGED; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; TUMOR MARKERS, BIOLOGICAL;

EID: 84925516170     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-014-1846-5     Document Type: Article

References (23)

1. An ZL, Chen YH, Zhang RP, Song YM, Sun JH, He JM, Bai JF, Dong LJ, Zhan QM, Chan EC, Koh PK, Mal M, Cheah PY, Eu KW, Backshall A, Cavill R, Nicholson JK, Chen J, Wang W, Lv S, Yin P, Zhao X, Lu X, Zhang F, Xu G (2009) Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations. Anal Chim Acta 650(1):3–9
2. Cerne D, Zitnik IP, Sok M (2010) Increased fatty acid synthase activity in non-small cell lung cancer tissue is a weaker predictor of shorter patient survival than increased lipoprotein lipase activity. Arch Med Res 41(6):405–409
3. Chen JH, Enloe BM, Fletcher CD, Cory DG, Singer S (2001) Biochemical analysis using high-resolution magic angle spinning NMR spectroscopy distinguishes lipoma-like well-differentiated liposarcoma from normal fat. J Am Chem Soc 123(37):9200–9201
4. Chong IG, Jun CH (2005) Performance of some variable selection methods when multicollinearity is present. Chemom Intell Lab Syst 78(1–2):103–112
5. Gosetti F, Mazzucco E, Gennaro MC, Marengo E (2013) Ultra high performance liquid chromatography tandem mass spectrometry determination and profiling of prohibited steroids in human biological matrices. A review. J Chromatogr B Anal Technol Biomed Life Sci 15:22–36
6. Griffin JL, Kauppinen RA (2007) A metabolomics perspective of human brain tumours. FEBS J 274(5):1132–1139
7. Hori S, Nishiumi S, Kobayashi K, Shinohara M, Hatakeyama Y, Kotani Y, Hatano N, Maniwa Y, Nishio W, Bamba T, Fukusaki E, Azuma T, Takenawa T, Nishimura Y, Yoshida M (2011) A metabolomic approach to lung cancer. Lung Cancer 74(2):284–292
8. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ (2008) Cancer statistics. CA Cancer J Clin 58(2):71–96
9. Kuhajda FP (2006) Fatty acid synthase and cancer: new application of an old pathway. Cancer Res 66(12):5977–5980
10. Mashima T, Seimiya H, Tsuruo T (2009) De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy. Br J Cancer 100(9):1369–1372
11. Niu YJ, Jiang YL, Xu CJ, Wang XY, Liu YR, Zhao H, Han BH, Jiang LY (2012) Preliminary results of metabolite in serum and urine of lung cancer patients detected by metabolomics. Zhongguo Fei Ai Za Zhi 15(4):195–201
12. Orita H, Coulter J, Lemmon C, Tully E, Vadlamudi A, Medghalchi SM, Kuhajda FP, Gabrielson E (2007) Selective inhibition of fatty acid synthase for lung cancer treatment. Clin Cancer Res 13(23):7139–7145
13. Pasikanti KK, Ho PC, Chan EC (2008) Gas chromatography/mass spectrometry in metabolic profiling of biological fluids. J Chromatogr B Anal Technol Biomed Life Sci 871(2):202–211
14. Pirozynski M (2006) 100 years of lung cancer. Respir Med 100:2073–2084
15. Postic C, Dentin R, Girard J (2004) Role of the liver in the control of carbohydrate and lipid homeostasis. Diabetes Metab 30(5):398–408
16. Preter VD, Verbeke K (2013) Metabolomics as a diagnostic tool in gastroenterology. World J Gastrointest Pharmacol Ther 4(4):97–107
17. Saddoughi SA, Song P (2008) Ogretmen B. Roles of bioactive sphingolipids in cancer biology and therapeutics. Subcell Biochem 49:413–440
18. Schwartz AG, Prysak GM, Bock CH, Cote ML (2007) The molecular epidemiology of lung cancer. Carcinogenesis 28(3):507–518
19. Swanson MG, Zektzer AS, Tabatabai ZL, Simko J, Jarso S, Keshari KR, Schmitt L, Carroll PR, Shinohara K, Vigneron DB, Kurhanewicz J (2006) Quantitative analysis of prostate metabolites using 1H HR-MAS spectroscopy. Magn Reson Med 55(6):1257–1264
20. Uddin S, Jehan Z, Ahmed M, Alyan A, Ai-Dayel F, Hussain A, Bavi P, Ai-Kuiaya KS (2011) Overexpression of fatty acid synthase in middle eastern epithelial ovarian carcinoma activates AKT and its inhibition potentiates cisplatin-induced apoptosis. Mol Med 17(7–8):635–645
21. Watanabe J, Ishihara K (2008) Establishing ultimate biointerfaces covered with phosphorylcholine groups. Colloid Surf B Biointerfaces 65(2):155–165
22. Yu YY, Pinsky PF, Caporaso NE, Chatterjee N, Baumgarten M, Langenberg P, Furuno JP, Lan Q, Engels EA (2008) Lung cancer risk following detection of pulmonary scarring by chest radiography in the prostate, lung, colorectal, and ovarian cancer screening trial. Arch Intern Med 168(21):2326–2332
23. Yu XW, Wu Q, Lv W, Wang Y, Ma XQ, Chen Z, Yan C (2013) Metabonomics study of lung cancer cells based on liquid chromatography–mass spectrometry. Chin J Chromosom 31(7):691–696