Discriminative and locomotor effects of five synthetic cathinones in rats and mice

Psychopharmacology

Volumn 232, Issue 7, 2015, Pages 1197-1205

  Gatch, Michael B ^a   Rutledge, Margaret A ^a   Forster, Michael J ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Abuse liability; Cathinones; Drug discrimination; Locomotor activity; Mouse; Rat

Indexed keywords

3 FLUOROMETHCATHINONE; 4 METHYLETHCATHINONE; CATHINONE; COCAINE; METHAMPHETAMINE; METHCATHINONE; PENTEDRONE; PENTYLONE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; ALKALOID; AMPHETAMINE DERIVATIVE; CENTRAL STIMULANT AGENT; STREET DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CONVULSION; DISCRIMINATIVE STIMULUS; DOSE RESPONSE; DRUG DISCRIMINATION TEST; DRUG EFFECT; LETHALITY; MALE; MOTOR ACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; DISCRIMINATION LEARNING; DRUG EFFECTS; PHYSIOLOGY; SPRAGUE DAWLEY RAT; SYNTHESIS;

ALKALOIDS; AMPHETAMINES; ANIMALS; CENTRAL NERVOUS SYSTEM STIMULANTS; COCAINE; DISCRIMINATION LEARNING; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; METHAMPHETAMINE; MICE; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; STREET DRUGS;

EID: 84925508408     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-014-3755-3     Document Type: Article

References (34)

1. Araújo AM, Valente MJ, Carvalho M, Dias da Silva D, Gaspar H, Carvalho F, de Lourdes Bastos M, Guedes de Pinho P (2014) Raising awareness of new psychoactive substances: chemical analysis and in vitro toxicity screening of 'legal high' packages containing synthetic cathinones. Arch Toxicol
2. Bonano JS, Glennon RA, De Felice LJ, Banks ML, Negus SS (2014) Abuse-related and abuse-limiting effects of methcathinone and the synthetic "bath salts" cathinone analogs methylenedioxypyrovalerone (MDPV), methylone and mephedrone on intracranial self-stimulation in rats. Psychopharmacology (Berlin) 231:199-207
3. Bondareva TS, Young R, Glennon RA (2002) Central stimulants as discriminative stimuli. Asymmetric generalization between (-)ephedrine and S(+)methamphetamine. Pharmacol Biochem Behav 74:157-162
4. Calkins RF, Aktan GB, Hussain KL (1995) Methcathinone: the next illicit stimulant epidemic? J Psychoactive Drugs 27:277-285
5. Carroll FI, Blough BE, Abraham P, Mills AC, Holleman JA, Wolckenhauer SA, Decker AM, Landavazo A, McElroy KT, Navarro HA, Gatch MB, Forster MJ (2009) Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for cocaine addiction. J Med Chem 52:6768-6781
6. Cozzi NV, Brandt SD, Daley PF, Partilla JS, Rothman RB, Tulzer A, Sitte HH, Baumann MH (2013) Pharmacological examination of trifluoromethyl ring-substituted methcathinone analogs. Eur J Pharmacol 699:180-187
7. Dal Cason TA, Young R, Glennon RA (1997) Cathinone: an investigation of several N-alkyl and methylenedioxy analogs. Pharmacol Biochem Behav 58:1109-1116
8. Drug Enforcement Administration DJ (2014) Schedules of controlled substances: temporary placement of 10 synthetic cathinones into Schedule I. Final order. Fed Regist 79:12938-12943
9. Elliott S, Evans J (2014) A 3-year review of new psychoactive substances in casework. Forensic Sci Int 243C:55-60
10. Emerson TS, Cisek JE (1993) Methcathinone: a Russian designer amphetamine infiltrates the rural midwest. Ann Emerg Med 22:1897-1903
11. Eshleman AJ, Wolfrum KM, Hatfield MG, Johnson RA, Murphy KV, Janowsky A (2013) Substituted methcathinones differ in transporter and receptor interactions. Biochem Pharmacol
12. Fantegrossi WE, Gannon BM, Zimmerman SM, Rice KC (2013) In vivo effects of abused 'bath salt' constituent 3,4-methylenedioxypyrovalerone (MDPV) in mice: drug discrimination, thermoregulation, and locomotor activity. Neuropsychopharmacol 38:563-573
13. Gatch MB, Forster MJ, Janowsky A, Eshleman AJ (2011) Abuse liability profile of three substituted tryptamines. J Pharmacol Exp Ther 338:280-289
14. Gatch MB, Taylor CM, Forster MJ (2013) Locomotor stimulant and discriminative stimulus effects of 'bath salt' cathinones. Behav Pharmacol 24:437-447
15. Gil D, Adamowicz P, Skulska A, Tokarczyk B, Stanaszek R (2013) Analysis of 4-MEC in biological and non-biological material-three case reports. Forensic Sci Int 228:e11-e15
16. Glennon RA (2014) Bath salts, mephedrone, and methylenedioxypyrovalerone as emerging illicit drugs that will need targeted therapeutic intervention. Adv Pharmacol 69:581-620
17. Glennon RA, Yousif M, Naiman N, Kalix P (1987) Methcathinone: a new and potent amphetamine-like agent. Pharmacol Biochem Behav 26:547-551
18. Kaminski BJ, Griffiths RR (1994) Intravenous self-injection of methcathinone in the baboon. Pharmacol Biochem Behav 47:981-983
19. Katz JL, Agoston GE, Alling KL, Kline RH, Forster MJ, Woolverton WL, Kopajtic TA, Newman AH (2001) Dopamine transporter binding without cocaine-like behavioral effects: synthesis and evaluation of benztropine analogs alone and in combination with cocaine in rodents. Psychopharmacology (Berl) 154:362-374
20. Kohut SJ, Fivel PA, Blough BE, Rothman RB, Mello NK (2013) Effects of methcathinone and 3-Cl-methcathinone (PAL-434) in cocaine discrimination or self-administration in rhesus monkeys. Int J Neuropsychopharmacol 16:1985-1998
21. Li SM, Campbell BL, Katz JL (2006) Interactions of cocaine with dopamine uptake inhibitors or dopamine releasers in rats discriminating cocaine. J Pharmacol Exp Ther 317:1088-1096
22. López-Arnau R, Martínez-Clemente J, Pubill D, Escubedo E, Camarasa J (2012) Comparative neuropharmacology of three psychostimulant cathinone derivatives: butylone, mephedrone and methylone. Br J Pharmacol 167:407-420
23. Marinetti LJ, Antonides HM (2013) Analysis of synthetic cathinones commonly found in bath salts in human performance and postmortem toxicology: method development, drug distribution and interpretation of results. J Anal Toxicol 37:135-146
24. Marusich JA, Grant KR, Blough BE, Wiley JL (2012) Effects of synthetic cathinones contained in "bath salts" on motor behavior and a functional observational battery in mice. Neurotoxicology 33:1305-1313
25. Meyer MR, Vollmar C, Schwaninger AE, Wolf E, Maurer HH (2012) New cathinone-derived designer drugs 3-bromomethcathinone and 3-fluoromethcathinone: studies on their metabolism in rat urine and human liver microsomes using GC-MS and LC-high-resolution MS and their detectability in urine. J Mass Spectrom 47:253-262
26. National Research Council (2011) Guide for the care and Use of laboratory animals, 8th edn. The National Academies Press, Washington, D.C
27. Schechter MD (1997a) Discriminative characteristics of high and low cocaine administration: effect of other psychostimulants. Pharmacol Biochem Behav 56:457-463
28. Schechter MD (1997b) Drug-drug discrimination: stimulus properties of drugs of abuse upon a serotonergic-dopaminergic continuum. Pharmacol Biochem Behav 56:89-96
29. Simmler LD, Rickli A, Hoener MC, Liechti ME (2014) Monoamine transporter and receptor interaction profiles of a new series of designer cathinones. Neuropharmacology 79:152-160
30. UNODC (2013) The challenge of new psychoactive substances. United Nations Office on Drugs and Crime, Vienna, Austria, pp 20131-108
31. Uralets V, Rana S, Morgan S, Ross W (2014) Testing for designer stimulants: metabolic profiles of 16 synthetic cathinones excreted free in human urine. J Anal Toxicol 38:233-241
32. van der Schoot JB, Ariens EJ, van Rossum JM, Hurkmans JATM (1962) Phenylisopropylamine derivatives, structure and action. Arznemittel-Forschung 12:902-907
33. Varner KJ, Daigle K, Weed PF, Lewis PB, Mahne SE, Sankaranarayanan A, Winsauer PJ (2012) Comparison of the behavioral and cardiovascular effects of mephedrone with other drugs of abuse in rats. Psychopharmacology (Berlin) 225:675-685
34. Young R, Glennon RA (1998) Discriminative stimulus effects of S(-)-methcathinone (CAT): a potent stimulant drug of abuse. Psychopharmacology (Berl) 140:250-256