Association of high CD4-positive T cell infiltration with mutations in HLA class II-regulatory genes in microsatellite-unstable colorectal cancer

Cancer Immunology, Immunotherapy

Volumn 64, Issue 3, 2015, Pages 357-366

  Surmann, Eva Maria ^a,b,c,e   Voigt, Anita Y ^a,b,c   Michel, Sara ^a,b,c   Bauer, Kathrin ^a,b,c   Reuschenbach, Miriam ^a,b,c   Ferrone, Soldano ^d   von Knebel Doeberitz, Magnus ^a,b,c   Kloor, Matthias ^a,b,c  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Colorectal cancer; HLA class II antigens; Immune evasion; Microsatellite instability; Tumor infiltrating lymphocytes

Indexed keywords

GENOMIC DNA; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; MICROSATELLITE DNA; TUMOR ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CANCER GROWTH; CANCER STAGING; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DESTRUCTION; CIITA GENE; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FRAMESHIFT MUTATION; GENE; GENE CONTROL; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENETIC ASSOCIATION; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MUTATION RATE; PRIORITY JOURNAL; REGULATOR GENE; RFX ANK GENE; RFX5 GENE; RFXAP GENE; TUMOR IMMUNOLOGY; BIOSYNTHESIS; COLORECTAL TUMOR; GENETICS; IMMUNOLOGY; MIDDLE AGED; MUTATION; TUMOR ASSOCIATED LEUKOCYTE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, NEOPLASM; CD4-POSITIVE T-LYMPHOCYTES; COLORECTAL NEOPLASMS; FEMALE; GENES, MHC CLASS II; HUMANS; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MUTATION;

EID: 84925497108     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-014-1638-4     Document Type: Article

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