Histopathological and biochemical assessment of d-limonene-induced liver injury in rats

Toxicology Reports

Volumn 2, Issue , 2015, Pages 482-488

  Ramos, Carlos Alberto F ^a   Sá, Rita de Cássia da S ^a   Alves, Mateus F ^a   Benedito, Rubens B ^a   de Sousa, Damião P ^a   Diniz, Margareth de Fátima F M ^a   Araújo, Maria Salete T ^a   de Almeida, Reinaldo N ^a  

^a FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

Essential oils; Hepatotoxicity; Histopathology; Limonene; Rodent

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; LIMONENE;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD3+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; D LIMONENE INDUCED LIVER INJURY; HISTOPATHOLOGY; HYDROPIC DEGENERATION; KUPFFER CELL; LIVER DISEASE; LIVER FIBROSIS; LIVER HYPERPLASIA; LIVER INJURY; LIVER NECROSIS; MALE; MICROVESICULAR STEATOSIS; NONHUMAN; RAT;

EID: 84925496005     PISSN: 22147500     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxrep.2015.01.001     Document Type: Article

References (29)

1. Ariyoshi T., Arakaki M., Ideguchi K., Ishizuka Y., Noda K., Ide H. Studies on the metabolism of d-limonene (p-mentha-1,8-diene) III. Effects of d-limonene on the lipids and drug metabolizing enzymes in rat livers. Xenobiotica 1975, 5:33-38.
2. Austin C.A., Shepard E.A., Pike S.F., Rabin B.R., Phillips I.R. The effect of terpenoid compounds on cytochrome P-450 levels in rat liver. Biochem. Pharmacol. 1988, 37:2223-2229.
3. Crowell P.L., Lin S., Vedejs E., Gould M.N. Identification of metabolites of the antitumor agent d-limonene capable of inhibiting protein isoprenylation and cell growth. Cancer Chemother. Pharmacol. 1992, 31:205-212.
4. Crowell P.L., Gould M.N. Chemoprevention of mammary carcinogenesis by hydroxylated derivatives of d-limonene. Crit. Rev. Oncog. 1994, 5:1-22.
5. Gomide M.S., Lemos F.O., Lopes M.T.P., Alves T.M.A., Viccini L.F., Coelho C.M. The effect of the essential oils from five different Lippia species on the viability of tumor cell lines. Rev. Bras. Farmacogn. 2013, 23:895-902.
6. Goodmann Z.D., Ishak K.G. Occlusive venous lesion in alcoholic liver disease. A study of 200 cases. Gastroenterology 1982, 83:786-796.
7. Igimi H., Nishimura M., Kodama R., Ide H. Studies on the metabolism of d-limonene (p-mentha-1,8-diene) I. The absorption, distribution and excretion of d-limonene in rats. Xenobiotica 1974, 4:77-84.
8. Igimi H., Hisatsugu T., Nishimura M. The use of d-limonene preparation as a dissolving agent of gallstones. Am. J. Dig. Dis. 1976, 21:926-939.
9. Jayaprakasha G.K., Murthy K.N.C., Uckoo R.M., Patil B.S. Chemical composition of volatile oil from Citrus limettioides and their inhibition of colon câncer cell proliferation. Ind. Crops Prod. 2013, 45:200-207.
10. JECFA Limonene. Toxicological Evaluation of Certain Food Additives and Contaminants. Annex 4 1993, 299-301. World Health Organization, Joint AO/WHO Expert Committee on Food Additives (WHO Food Additives Series 32), Geneva.
11. Kim Y.W., Kim M.J., Chung B.Y., Bang D.Y., Lim S.K., Choi S.M., Lim D.S., Cho M.C., Yoon K., Kim H.S., Kim K.B., Kim Y.S., Kwack S.J., Lee B.-M. Safety evaluation and risk assessment of d-limonene. J. Toxicol. Environ. Health B: Crit. Rev. 2013, 16:17-38.
12. Kodama R., Yano T., Furukawa K., Noda K., Ide H. Studies on the metabolismo f d-limonene (p-mentha-1,8-diene) IV. Isolation and characterization of new metabolites and species differences in metabolism. Xenobiotica 1976, 6:377-389.
13. Kosif R., Yilmaz F., Evrendilek G.A., Diramali M. Histopathological effects of Aloe barbadensis and soybean oil on rat liver. Int. J. Morphol. 2010, 28:1101-1106.
14. Lehman-Mckeeman L.D., Rodriguez P.A., Takigiku R., Caudill D., Fey M.L. d-Limonene-induced male rat-specific nephrotoxicity: evaluation of the association between d-limonene and α2u-globulin. Toxicol. Appl. Pharmacol. 1989, 99:250-259.
15. Maddrey W.C. Drug-induced hepatotoxicity. J. Clin. Gastroenterol. 2005, 39:83-89.
16. Njoku D.B., Greenberg R.S., Bourdi M., Borkowf C.B., Dake E.M., Martin J.L., Pohl L.R. Autoantibodies associated with volatile anesthetic hepatitis found in the sera of a large cohort of pediatric anesthesiologists. Anesth. Analg. 2002, 94:243-249.
17. Poon G.K., Vigushin D., Griggs L.J. Identification and characterization of limonene metabolites in patients with advanced cancer by liquid chromatography/mass spectrometry. Drug Metab. Dispos. 1996, 24:565-571.
18. Robin M.A., Le Rot M., Descatoire V., Pessayre D. Plasma membrane cytochromes P450 as neoantigens and autoimmune targets in drug-induced hepatitis. J. Hepatol. 1997, 26(Suppl. 1):23-30.
19. Safari M.R., Heidari A.A., Shams S. The effects of volatile oils on low density lipoprotein glycation by model system in vitro. Clin. Chem. Lab. Med. 2001, 45:S1-S473.
20. Schmidt L., Belov V.N., Göen T. Sensitive monitoring of monoterpene metabolites in human urine using two-step derivatisation and positive chemical ionisation-tandem mass spectrometry. Anal. Chim. Acta 2013, 793:26-36.
21. Searle J., Leggett B.A., Crawford D.H.G., et al. Iron storage disease. Pathology of the Liver 2002, 257-272. Churchill Livingstone, Edinburgh. 4th ed. R.N.M. MacSween, A.D. Burt, B.C. Portmann, K.G. Ishak, P.J. Scheuer, P.P. Anthony (Eds.).
22. Shimada T., Shindo M., Miyazawa M. Species differences in the matabolism of (+)- and (-)-limonenes and their metabolites, carveols and carvones, by cytochrome P450 enzymes in liver microsomes of mice, rats, guinea pigs, rabbits dogs, monkeys, and humans. Drug Metab. Pharmacokinet. 2002, 17:507-515.
23. Sun J. d-Limonene: safety and clinical applications. Altern. Med. Rev. 2007, 12:259-262.
24. Tipoe G.L., Liong E.C., Leung T.M., Nanji A.A. A voluntary oral-feeding rat model for pathological alcoholic liver injury. Methods Mol. Biol. 2008, 447:11-31.
25. Tipoe G.L., Liong E.C., Casey C.A., Donohue T.M., Eagon P.K., So H., Leung T.M., Fogt F., Nanji A.A. A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury. Alcohol Clin. Exp. Res. 2008, 32:669-682.
26. Vigushin D.M., Poon G.K., Bodd Y.A. Phase I and pharmacokinetic study of d-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee. Cancer Chemother. Pharmacol. 1998, 42:111-117.
27. World Health Organization International Programme On Chemical Safety. Concise International Chemical Assessment Document 1998, World Health Organization.
28. Yang X., Zhao H., Wang J., Meng Q., Zhang H., Yao L., Zhang Y., Dong A., Ma Y., Wang Z. Chemical composition and antioxidant activity of essential oil of pine cones of Pinus armandii from the southwest region of China. J. Med. Plants Res. 2010, 4:1668-1672.
29. Zhang Z., Vriesekoop F., Yuan Q., Liang H. Effects of nisin on the antimicrobial activity of d-limonene and its nanoemulsion. Food Chem. 2014, 150:307-312.