메뉴 건너뛰기




Volumn 64, Issue 3, 2015, Pages 381-388

Long-term clinical outcome of melanoma patients treated with messenger RNA-electroporated dendritic cell therapy following complete resection of metastases

Author keywords

Dendritic cell; Immunotherapy; Interferon alpha 2b; Melanoma; mRNA

Indexed keywords

ALPHA2B INTERFERON; DENDRITIC CELL VACCINE; GLYCOPROTEIN GP 100; HLA ANTIGEN CLASS 2; MELAN A; MELANOMA ANTIGEN 1; MELANOMA ANTIGEN 3; MESSENGER RNA; MONOPHENOL MONOOXYGENASE; ALPHA INTERFERON; CANCER VACCINE; MELANOMA ANTIGEN; MLANA PROTEIN, HUMAN; RECOMBINANT PROTEIN;

EID: 84925493908     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-014-1642-8     Document Type: Article
Times cited : (69)

References (40)
  • 1
    • 74949143594 scopus 로고    scopus 로고
    • Final version of 2009 AJCC melanoma staging and classification
    • PID: 19917835
    • Balch CM, Gershenwald JE, Soong SJ et al (2009) Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 27:6199–6206
    • (2009) J Clin Oncol , vol.27 , pp. 6199-6206
    • Balch, C.M.1    Gershenwald, J.E.2    Soong, S.J.3
  • 2
    • 84869212118 scopus 로고    scopus 로고
    • Long-term results of the randomized phase III trial EORTC 18991 of adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma
    • COI: 1:CAS:528:DC%2BC3sXosVCksg%3D%3D, PID: 23008300
    • Eggermont AM, Suciu S, Testori A et al (2012) Long-term results of the randomized phase III trial EORTC 18991 of adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma. J Clin Oncol 30:3810–3818
    • (2012) J Clin Oncol , vol.30 , pp. 3810-3818
    • Eggermont, A.M.1    Suciu, S.2    Testori, A.3
  • 3
    • 84868088932 scopus 로고    scopus 로고
    • Pegylated interferon for the adjuvant treatment of melanoma: FDA approved, but what is its role?
    • COI: 1:CAS:528:DC%2BC38XhslSkurvO, PID: 23002125
    • Sondak VK, Kudchadkar R (2012) Pegylated interferon for the adjuvant treatment of melanoma: FDA approved, but what is its role? Oncologist 17:1223–1224
    • (2012) Oncologist , vol.17 , pp. 1223-1224
    • Sondak, V.K.1    Kudchadkar, R.2
  • 4
    • 77950576363 scopus 로고    scopus 로고
    • Interferon alpha adjuvant therapy in patients with high-risk melanoma: a systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC3cXks1GgtrY%3D, PID: 20179267
    • Mocellin S, Pasquali S, Rossi CR, Nitti D (2010) Interferon alpha adjuvant therapy in patients with high-risk melanoma: a systematic review and meta-analysis. J Natl Cancer Inst 102:493–501
    • (2010) J Natl Cancer Inst , vol.102 , pp. 493-501
    • Mocellin, S.1    Pasquali, S.2    Rossi, C.R.3    Nitti, D.4
  • 5
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • COI: 1:CAS:528:DC%2BC3MXosVeitbs%3D, PID: 21639808
    • Chapman PB, Hauschild A, Robert C et al (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364:2507–2516
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 6
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
    • COI: 1:CAS:528:DC%2BC38Xpt1SgtLg%3D, PID: 22735384
    • Hauschild A, Grob JJ, Demidov LV et al (2012) Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 380:358–365
    • (2012) Lancet , vol.380 , pp. 358-365
    • Hauschild, A.1    Grob, J.J.2    Demidov, L.V.3
  • 7
    • 84863673204 scopus 로고    scopus 로고
    • Improved survival with MEK inhibition in BRAF-mutated melanoma
    • COI: 1:CAS:528:DC%2BC38XhtFKjs7zN, PID: 22663011
    • Flaherty KT, Robert C, Hersey P et al (2012) Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med 367:107–114
    • (2012) N Engl J Med , vol.367 , pp. 107-114
    • Flaherty, K.T.1    Robert, C.2    Hersey, P.3
  • 8
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • COI: 1:CAS:528:DC%2BC3cXhtVCrtrbN, PID: 20525992
    • Hodi F, O’Day S, McDermott D et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363:711–723
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.1    O’Day, S.2    McDermott, D.3
  • 9
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • COI: 1:CAS:528:DC%2BC3MXosVegtro%3D, PID: 21639810
    • Robert C, Thomas L, Bondarenko I et al (2011) Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 364:2517–2526
    • (2011) N Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 12
    • 84894559188 scopus 로고    scopus 로고
    • Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy
    • COI: 1:CAS:528:DC%2BC2cXht1eksLs%3D, PID: 24457417
    • Coulie PG, Van den Eynde BJ, van der Bruggen P, Boon T (2014) Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy. Nat Rev Cancer 14:135–146
    • (2014) Nat Rev Cancer , vol.14 , pp. 135-146
    • Coulie, P.G.1    Van den Eynde, B.J.2    van der Bruggen, P.3    Boon, T.4
  • 13
    • 84858780815 scopus 로고    scopus 로고
    • Cancer immunotherapy via dendritic cells
    • COI: 1:CAS:528:DC%2BC38XksVehtrY%3D, PID: 22437871
    • Palucka K, Banchereau J (2012) Cancer immunotherapy via dendritic cells. Nat Rev Cancer 12:265–277
    • (2012) Nat Rev Cancer , vol.12 , pp. 265-277
    • Palucka, K.1    Banchereau, J.2
  • 15
  • 16
    • 33745191238 scopus 로고    scopus 로고
    • Induction of antigen-specific CD8 + cytotoxic T cells by dendritic cells co-electroporated with a dsRNA analogue and tumor antigen mRNA
    • COI: 1:CAS:528:DC%2BD28XlvFGjtr8%3D, PID: 16511519
    • Michiels A, Breckpot K, Corthals J, Tuyaerts S, Bonehill A, Heirman C, Thielemans K, Aerts JL (2006) Induction of antigen-specific CD8 + cytotoxic T cells by dendritic cells co-electroporated with a dsRNA analogue and tumor antigen mRNA. Gene Ther 13:1027–1036
    • (2006) Gene Ther , vol.13 , pp. 1027-1036
    • Michiels, A.1    Breckpot, K.2    Corthals, J.3    Tuyaerts, S.4    Bonehill, A.5    Heirman, C.6    Thielemans, K.7    Aerts, J.L.8
  • 17
    • 44349173032 scopus 로고    scopus 로고
    • Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA
    • COI: 1:CAS:528:DC%2BD1cXmt1Orsrc%3D, PID: 18431362
    • Bonehill A, Tuyaerts S, Van Nuffel AM, Heirman C, Bos TJ, Fostier K, Neyns B, Thielemans K (2008) Enhancing the T-cell stimulatory capacity of human dendritic cells by co-electroporation with CD40L, CD70 and constitutively active TLR4 encoding mRNA. Mol Ther 16:1170–1180
    • (2008) Mol Ther , vol.16 , pp. 1170-1180
    • Bonehill, A.1    Tuyaerts, S.2    Van Nuffel, A.M.3    Heirman, C.4    Bos, T.J.5    Fostier, K.6    Neyns, B.7    Thielemans, K.8
  • 18
    • 0028107616 scopus 로고
    • Increased effectiveness of interferon alfa-2b following active specific immunotherapy for melanoma
    • COI: 1:STN:280:DyaK2c7lslKhsg%3D%3D, PID: 8113848
    • Mitchell M, Jakowatz J, Harel W, Dean G, Stevenson L, Boswell W, Groshen S (1994) Increased effectiveness of interferon alfa-2b following active specific immunotherapy for melanoma. J Clin Oncol 12:402–411
    • (1994) J Clin Oncol , vol.12 , pp. 402-411
    • Mitchell, M.1    Jakowatz, J.2    Harel, W.3    Dean, G.4    Stevenson, L.5    Boswell, W.6    Groshen, S.7
  • 19
    • 10744221302 scopus 로고    scopus 로고
    • Amplification of virus-induced antimelanoma T-cell reactivity by high-dose interferon-alpha2b: implications for cancer vaccines
    • COI: 1:CAS:528:DC%2BD3sXotVShsLk%3D, PID: 14555505
    • Astsaturov I, Petrella T, Bagriacik E et al (2003) Amplification of virus-induced antimelanoma T-cell reactivity by high-dose interferon-alpha2b: implications for cancer vaccines. Clin Cancer Res 9:4347–4355
    • (2003) Clin Cancer Res , vol.9 , pp. 4347-4355
    • Astsaturov, I.1    Petrella, T.2    Bagriacik, E.3
  • 20
    • 33646400810 scopus 로고    scopus 로고
    • Immunization of stage IV melanoma patients with Melan-A/MART-1 and gp100 peptides plus IFN-alpha results in the activation of specific CD8(+) T cells and monocyte/dendritic cell precursors
    • PID: 16651452
    • Di Pucchio T, Pilla L, Capone I et al (2006) Immunization of stage IV melanoma patients with Melan-A/MART-1 and gp100 peptides plus IFN-alpha results in the activation of specific CD8(+) T cells and monocyte/dendritic cell precursors. Cancer Res 66:4943–4951
    • (2006) Cancer Res , vol.66 , pp. 4943-4951
    • Di Pucchio, T.1    Pilla, L.2    Capone, I.3
  • 21
    • 34249941065 scopus 로고    scopus 로고
    • Randomized trial of an allogeneic melanoma lysate vaccine with low-dose interferon Alfa-2b compared with high-dose interferon Alfa-2b for Resected stage III cutaneous melanoma
    • COI: 1:CAS:528:DC%2BD2sXmvVWms7w%3D, PID: 17513813
    • Mitchell M, Abrams J, Thompson J et al (2007) Randomized trial of an allogeneic melanoma lysate vaccine with low-dose interferon Alfa-2b compared with high-dose interferon Alfa-2b for Resected stage III cutaneous melanoma. J Clin Oncol 25:2078–2085
    • (2007) J Clin Oncol , vol.25 , pp. 2078-2085
    • Mitchell, M.1    Abrams, J.2    Thompson, J.3
  • 22
    • 63149171153 scopus 로고    scopus 로고
    • Immunogenicity and antitumor effects of vaccination with peptide vaccine ± granulocyte–monocyte colony-stimulating factor and/or IFN-alpha2b in advanced metastatic melanoma: Eastern Cooperative Oncology Group Phase II Trial E1696
    • COI: 1:CAS:528:DC%2BD1MXitVOktL0%3D, PID: 19228745
    • Kirkwood JM, Lee S, Moschos SJ, Albertini MR, Michalak JC, Sander C, Whiteside T, Butterfield LH, Weiner L (2009) Immunogenicity and antitumor effects of vaccination with peptide vaccine ± granulocyte–monocyte colony-stimulating factor and/or IFN-alpha2b in advanced metastatic melanoma: Eastern Cooperative Oncology Group Phase II Trial E1696. Clin Cancer Res 15:1443–1451
    • (2009) Clin Cancer Res , vol.15 , pp. 1443-1451
    • Kirkwood, J.M.1    Lee, S.2    Moschos, S.J.3    Albertini, M.R.4    Michalak, J.C.5    Sander, C.6    Whiteside, T.7    Butterfield, L.H.8    Weiner, L.9
  • 23
    • 79957831345 scopus 로고    scopus 로고
    • gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma
    • COI: 1:CAS:528:DC%2BC3MXnt1Cmt7Y%3D, PID: 21631324
    • Schwartzentruber DJ, Lawson DH, Richards JM et al (2011) gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. N Engl J Med 364:2119–2127
    • (2011) N Engl J Med , vol.364 , pp. 2119-2127
    • Schwartzentruber, D.J.1    Lawson, D.H.2    Richards, J.M.3
  • 24
    • 58149483422 scopus 로고    scopus 로고
    • CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit
    • COI: 1:CAS:528:DC%2BD1MXhsFWktA%3D%3D, PID: 19074257
    • Yuan J, Gnjatic S, Li H et al (2008) CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit. Proc Natl Acad Sci USA 105:20410–20415
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20410-20415
    • Yuan, J.1    Gnjatic, S.2    Li, H.3
  • 25
    • 70349680756 scopus 로고    scopus 로고
    • Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma
    • COI: 1:CAS:528:DC%2BD1MXhtF2lurjE, PID: 19789309
    • Ribas A, Comin-Anduix B, Chmielowski B et al (2009) Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma. Clin Cancer Res 15:6267–6276
    • (2009) Clin Cancer Res , vol.15 , pp. 6267-6276
    • Ribas, A.1    Comin-Anduix, B.2    Chmielowski, B.3
  • 26
    • 79957904174 scopus 로고    scopus 로고
    • Therapeutic vaccination with an autologous mRNA electroporated dendritic cell vaccine in patients with advanced melanoma
    • COI: 1:CAS:528:DC%2BC3MXmt1ymtro%3D, PID: 21577140
    • Wilgenhof S, Van Nuffel AM, Corthals J et al (2011) Therapeutic vaccination with an autologous mRNA electroporated dendritic cell vaccine in patients with advanced melanoma. J Immunother 34:448–456
    • (2011) J Immunother , vol.34 , pp. 448-456
    • Wilgenhof, S.1    Van Nuffel, A.M.2    Corthals, J.3
  • 27
    • 85018153921 scopus 로고    scopus 로고
    • A cohort pilot study on therapeutic vaccination of advanced melanoma patients with dendritic cells loaded with multiple peptides or electroporated with mRNA
    • Neyns B, Corthals J, De Greve J, De Greef C, Coulie PG, Thielemans K (2006) A cohort pilot study on therapeutic vaccination of advanced melanoma patients with dendritic cells loaded with multiple peptides or electroporated with mRNA. ASCO Meeting Abstracts 24: 18011
    • (2006) ASCO Meeting Abstracts , vol.24 , pp. 18011
    • Neyns, B.1    Corthals, J.2    De Greve, J.3    De Greef, C.4    Coulie, P.G.5    Thielemans, K.6
  • 28
    • 73349099791 scopus 로고    scopus 로고
    • Interferon alfa-2b treatment following therapeutic vaccination with mRNA electroporated dendritic cells results in skin depigmentation and tumor regression in patients with advanced melanoma
    • Neyns B, Corthals J, Thielemans K (2007) Interferon alfa-2b treatment following therapeutic vaccination with mRNA electroporated dendritic cells results in skin depigmentation and tumor regression in patients with advanced melanoma. ASCO Meeting Abstracts 25: 8537
    • (2007) ASCO Meeting Abstracts , vol.25 , pp. 8537
    • Neyns, B.1    Corthals, J.2    Thielemans, K.3
  • 30
    • 66149186858 scopus 로고    scopus 로고
    • Single-step antigen loading and activation of dendritic cells by mRNA electroporation for the purpose of therapeutic vaccination in melanoma patients
    • COI: 1:CAS:528:DC%2BD1MXmtVKmu74%3D, PID: 19417017
    • Bonehill A, Van Nuffel A, Corthals J et al (2009) Single-step antigen loading and activation of dendritic cells by mRNA electroporation for the purpose of therapeutic vaccination in melanoma patients. Clin Cancer Res 15:3366–3375
    • (2009) Clin Cancer Res , vol.15 , pp. 3366-3375
    • Bonehill, A.1    Van Nuffel, A.2    Corthals, J.3
  • 31
    • 77954050387 scopus 로고    scopus 로고
    • Immunotherapy of cancer with dendritic cells loaded with tumor antigens and activated through mRNA electroporation
    • PID: 20387165
    • Van Nuffel A, Corthals J, Neyns B, Heirman C, Thielemans K, Bonehill A (2010) Immunotherapy of cancer with dendritic cells loaded with tumor antigens and activated through mRNA electroporation. Methods Mol Biol 629:405–452
    • (2010) Methods Mol Biol , vol.629 , pp. 405-452
    • Van Nuffel, A.1    Corthals, J.2    Neyns, B.3    Heirman, C.4    Thielemans, K.5    Bonehill, A.6
  • 32
  • 33
    • 84860521660 scopus 로고    scopus 로고
    • Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4 + and CD8 + T cells in melanoma patients
    • PID: 22371843
    • Van Nuffel AM, Benteyn D, Wilgenhof S et al (2012) Dendritic cells loaded with mRNA encoding full-length tumor antigens prime CD4 + and CD8 + T cells in melanoma patients. Mol Ther 20:1063–1074
    • (2012) Mol Ther , vol.20 , pp. 1063-1074
    • Van Nuffel, A.M.1    Benteyn, D.2    Wilgenhof, S.3
  • 34
    • 84874640769 scopus 로고    scopus 로고
    • Characterization of CD8(+) T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC–MEL)
    • PID: 23509826
    • Benteyn D, Van Nuffel AM, Wilgenhof S, Corthals J, Heirman C, Neyns B, Thielemans K, Bonehill A (2013) Characterization of CD8(+) T-cell responses in the peripheral blood and skin injection sites of melanoma patients treated with mRNA electroporated autologous dendritic cells (TriMixDC–MEL). Biomed Res Int 2013:976383
    • (2013) Biomed Res Int , vol.2013 , pp. 976383
    • Benteyn, D.1    Van Nuffel, A.M.2    Wilgenhof, S.3    Corthals, J.4    Heirman, C.5    Neyns, B.6    Thielemans, K.7    Bonehill, A.8
  • 35
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • COI: 1:CAS:528:DC%2BC3cXhtVGlurrN, PID: 20818862
    • Kantoff P, Higano C, Shore N et al (2010) Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 363:411–422
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.1    Higano, C.2    Shore, N.3
  • 36
    • 0033860737 scopus 로고    scopus 로고
    • Dysfunctional regulation of the development of monocyte-derived dendritic cells in cancer patients
    • COI: 1:STN:280:DC%2BD3cvkt1SitA%3D%3D, PID: 10989961
    • Hasebe H, Nagayama H, Sato K, Enomoto M, Takeda Y, Takahashi TA, Hasumi K, Eriguchi M (2000) Dysfunctional regulation of the development of monocyte-derived dendritic cells in cancer patients. Biomed Pharmacother 54:291–298
    • (2000) Biomed Pharmacother , vol.54 , pp. 291-298
    • Hasebe, H.1    Nagayama, H.2    Sato, K.3    Enomoto, M.4    Takeda, Y.5    Takahashi, T.A.6    Hasumi, K.7    Eriguchi, M.8
  • 37
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria
    • COI: 1:CAS:528:DC%2BD1MXhsFSnu7vN, PID: 19934295
    • Wolchok JD, Hoos A, O’Day S et al (2009) Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res 15:7412–7420
    • (2009) Clin Cancer Res , vol.15 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O’Day, S.3
  • 38
    • 84862772889 scopus 로고    scopus 로고
    • Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient
    • PID: 22159452
    • Van Nuffel AM, Benteyn D, Wilgenhof S, Corthals J, Heirman C, Neyns B, Thielemans K, Bonehill A (2012) Intravenous and intradermal TriMix-dendritic cell therapy results in a broad T-cell response and durable tumor response in a chemorefractory stage IV-M1c melanoma patient. Cancer Immunol Immunother 61:1033–1043
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1033-1043
    • Van Nuffel, A.M.1    Benteyn, D.2    Wilgenhof, S.3    Corthals, J.4    Heirman, C.5    Neyns, B.6    Thielemans, K.7    Bonehill, A.8
  • 39
    • 84884721824 scopus 로고    scopus 로고
    • A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients
    • COI: 1:STN:280:DC%2BC3sflsF2jtw%3D%3D, PID: 23904461
    • Wilgenhof S, Van Nuffel AM, Benteyn D et al (2013) A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients. Ann Oncol 24:2686–2693
    • (2013) Ann Oncol , vol.24 , pp. 2686-2693
    • Wilgenhof, S.1    Van Nuffel, A.M.2    Benteyn, D.3
  • 40
    • 60849108348 scopus 로고    scopus 로고
    • Randomized phase III study of 1 month versus 1 year of adjuvant high-dose interferon alfa-2b in patients with resected high-risk melanoma
    • COI: 1:CAS:528:DC%2BD1MXjs1Knt78%3D, PID: 19139440
    • Pectasides D, Dafni U, Bafaloukos D et al (2009) Randomized phase III study of 1 month versus 1 year of adjuvant high-dose interferon alfa-2b in patients with resected high-risk melanoma. J Clin Oncol 27:939–944
    • (2009) J Clin Oncol , vol.27 , pp. 939-944
    • Pectasides, D.1    Dafni, U.2    Bafaloukos, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.