Vitamin D and health: The need for more randomized controlled trials

Journal of Steroid Biochemistry and Molecular Biology

Volumn 148, Issue , 2015, Pages 269-274

  Jorde, Rolf ^a,b   Grimnes, Guri ^a,b  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

Author keywords

Randomized controlled trial; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; PARATHYROID HORMONE; VITAMIN D; VITAMIN;

BONE DENSITY; CALCIUM ABSORPTION; CARDIOVASCULAR DISEASE; DIABETES MELLITUS; FALLING; FRACTURE; HEALTH; HUMAN; INTERVENTION STUDY; INTESTINE ABSORPTION; ISCHEMIC HEART DISEASE; MULTIPLE SCLEROSIS; NEOPLASM; NUTRITIONAL STATUS; OBSERVATIONAL STUDY; OSTEOMALACIA; PARATHYROID HORMONE BLOOD LEVEL; PROSTATE CANCER; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RICKETS; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; DIET SUPPLEMENTATION; NEEDS ASSESSMENT; PUBLIC HEALTH;

DIETARY SUPPLEMENTS; HUMANS; NEEDS ASSESSMENT; PUBLIC HEALTH; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VITAMIN D; VITAMIN D DEFICIENCY; VITAMINS;

EID: 84925492058     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2015.01.021     Document Type: Review

References (58)

1. H.F. DeLuca Overview of general physiologic features and functions of vitamin D Am. J. Clin. Nutr. 80 Suppl. 6 2004 1689S 1696S
2. M.F. Holick Vitamin D deficiency N. Engl. J. Med. 357 2007 266 281
3. C.J. Elder, and N.J. Bishop Rickets Lancet 383 9929 2014 1665 1676
4. A.C. Ross, J.E. Manson, S.A. Abrams, J.F. Aloia, P.M. Brannon, S.K. Clinton, R.A. Durazo-Arvizu, J.C. Gallagher, R.L. Gallo, and G. Jones The 2011 report on dietary reference intakes for calcium and vitamin D from the institute of medicine: what clinicians need to know J. Clin. Endocrinol. Metab. 96 2011 53 58
5. M.F. Holick, N.C. Binkley, H.A. Bischoff-Ferrari, C.M. Gordon, D.A. Hanley, R.P. Heaney, M.H. Murad, and C.M. Weaver Endocrine society. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline J. Clin. Endocrinol. Metab. 96 2011 1911 1930
6. B. Schöttker, R. Jorde, A. Peasey, B. Thorand, E.H. Jansen, Ld. Groot, M. Streppel, J. Gardiner, J.M. Ordóñez-Mena, and L. Perna Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States BMJ 348 2014 g3656
7. S. Wang Epidemiology of vitamin D in health and disease Nutr. Res. Rev. 22 2009 188 203
8. J.L. Waldron, H.L. Ashby, M.P. Cornes, J. Bechervaise, C. Razavi, O.L. Thomas, S. Chugh, S. Deshpande, C. Ford, and R. Gama Vitamin D: a negative acute phase reactant J. Clin. Pathol. 66 2013 620 622
9. C.M. Mendel The free hormone hypothesis: a physiologically based mathematical model Endocr. Rev. 10 1989 232 274
10. C.E. Powe, C. Ricciardi, A.H. Berg, D. Erdenesanaa, G. Collerone, E. Ankers, J. Wenger, S.A. Karumanchi, R. Thadhani, and I. Bhan Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship J. Bone Miner. Res. 26 2011 1609 1616
11. B.W. Hollis, and C.L. Wagner Clinical review: the role of the parent compound vitamin D with respect to metabolism and function: why clinical dose intervals can affect clinical outcomes J. Clin. Endocrinol. Metab. 98 2013 4619 4628
12. R.P. Heaney, L.A. Armas, J.R. Shary, N.H. Bell, N. Binkley, and B.W. Hollis 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions Am. J. Clin. Nutr. 87 2008 1738 1742
13. R.P. Heaney, R.L. Horst, D.M. Cullen, and L.A. Armas Vitamin D3 distribution and status in the body J. Am. Coll. Nutr. 28 2009 252 256
14. Institute of Medicine Dietary Reference Intakes for Calcium and Vitamin D 2011 The National Academies Press Washington, D.C
15. M.J. Bolland, A. Grey, G.D. Gamble, and I.R. Reid The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis Lancet Diabetes Endocrinol. 2 2014 307 320
16. M.J. Bolland, A. Grey, G.D. Gamble, and I.R. Reid Vitamin D supplementation and falls: a trial sequential meta-analysis Lancet Diabetes Endocrinol. 2 2014 573 580
17. E. Theodoratou, I. Tzoulaki, L. Zgaga, and J.P. Ioannidis Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials BMJ 348 2014 g2035
18. H.A. Bischoff-Ferrari, E.J. Orav, W.C. Willett, and B. Dawson-Hughes The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes Lancet Diabetes Endocrinol. 2 2014 363 364
19. B.J. Boucher Causal link between vitamin D deficiency and ill health still possible BMJ 348 2014 g2923
20. M. Urashima, T. Segawa, M. Okazaki, M. Kurihara, Y. Wada, and H. Ida Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren Am. J. Clin. Nutr. 91 2010 1255 1260
21. J.M. Lappe, D. Travers-Gustafson, K.M. Davies, R.R. Recker, and R.P. Heaney Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial Am. J. Clin. Nutr. 85 2007 1586 1591
22. M.E. Ooms, P. Lips, J.C. Roos, W.J. van der Vijgh, C. Popp-Snijders, P.D. Bezemer, and L.M. Bouter Vitamin D status and sex hormone binding globulin: determinants of bone turnover and bone mineral density in elderly women J. Bone Miner. Res. 10 1995 1177 1784
23. B. Dawson-Hughes, S.S. Harris, and G.E. Dallal Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women Am. J. Clin. Nutr. 65 1997 67 71
24. A. Benjamin, A. Moriakova, N. Akhter, D. Rao, H. Xie, S. Kukreja, and E. Barengolts Determinants of 25-hydroxyvitamin D levels in African-American and caucasian male veterans Osteoporos. Int. 20 2009 1795 1803
25. C.K. Kramer, B. Swaminathan, A.J. Hanley, P.W. Connelly, M. Sermer, B. Zinman, and R. Retnakaran Prospective associations of vitamin D status with beta-cell function, insulin sensitivity and glycemia: the impact of parathyroid hormone status Diabetes 2014 pii: DB-140489 (Epub ahead of print)
26. H. Alshayeb, A. Showkat, B.M. Wall, G.G. Gyamlani, V. David, and L.D. Quarles Activation of FGF-23 mediated vitamin D degradative pathways by cholecalciferol J. Clin. Endocrinol. Metab. 2014 jc20141308 (Epub ahead of print)
27. A.G. Need, M. Horowitz, H.A. Morris, R. Moore, and C. Nordin Seasonal change in osteoid thickness and mineralization lag time in ambulant patients J. Bone Miner. Res. 22 2007 757 761
28. M. Priemel, C. von Domarus, T.O. Klatte, S. Kessler, J. Schlie, S. Meier, N. Proksch, F. Pastor, C. Netter, and T. Streichert Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients J. Bone Miner. Res. 25 2010 305 312
29. I.R. Reid, M.J. Bolland, and A. Grey Effects of vitamin D supplements on bone mineral density: a systematic review and meta-analysis Lancet 383 2014 146 155
30. H.A. Bischoff-Ferrari, W.C. Willett, E.J. Orav, P. Lips, P.J. Meunier, R.A. Lyons, L. Flicker, J. Wark, R.D. Jackson, and J.A. Cauley A pooled analysis of vitamin D dose requirements for fracture prevention N. Engl. J. Med. 367 2012 40 49
31. H.A. Bischoff-Ferrari The role of falls in fracture prediction Curr. Osteoporos. Rep. 9 2011 116 121
32. H.A. Bischoff-Ferrari, B. Dawson-Hughes, H.B. Staehelin, J.E. Orav, A.E. Stuck, R. Theiler, J.B. Wong, A. Egli, D.P. Kiel, and J. Henschkowski Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials BMJ 339 2009 b3692
33. L.D. Gillespie, M.C. Robertson, W.J. Gillespie, C. Sherrington, S. Gates, L.M. Clemson, and S.E. Lamb Interventions for preventing falls in older people living in the community Cochrane Database Syst. Rev. 9 2012 CD007146
34. J.F. Aloia, R. Dhaliwal, A. Shieh, M. Mikhail, M. Fazzari, L. Ragolia, and S.A. Abrams Vitamin D supplementation increases calcium absorption without a threshold effect Am. J. Clin. Nutr. 99 2014 624 631
35. J.C. Gallagher, V. Yalamanchili, and L.M. Smith The effect of vitamin D on calcium absorption in older women J. Clin. Endocrinol. Metab. 97 2012 3550 3556
36. J.C. Gallagher, P.S. Jindal, and L.M. Smith Vitamin D does not increase calcium absorption in young women: a randomized clinical trial J. Bone Miner. Res. 29 2014 1081 1087
37. I.R. Reid, and M.J. Bolland Calcium risk-benefit updated-new WHI analyses Maturitas 77 2014 1 3
38. A.G. Pittas, M. Chung, T. Trikalinos, J. Mitri, M. Brendel, K. Patel, A.H. Lichtenstein, J. Lau, and E.M. Balk Systematic review: vitamin D and cardiometabolic outcomes Ann. Intern. Med. 152 2010 307 314
39. R. Jorde, and G. Grimnes Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids Prog. Lipid Res. 50 2011 303 312
40. P.S. George, E.R. Pearson, and M.D. Witham Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis Diabet. Med. 29 2012 e142 e150
41. R. Jorde, Y. Figenschau, N. Emaus, M. Hutchinson, and G. Grimnes Serum 25-hydroxyvitamin D levels are strongly related to systolic blood pressure but do not predict future hypertension Hypertension 55 2010 792 798
42. J.M. Lappe, and R.P. Heaney Why randomized controlled trials of calcium and vitamin D sometimes fail Dermatoendocrinology 4 2012 95 100
43. R.P. Heaney Vitamin D-baseline status and effective dose N. Engl. J. Med. 367 2012 77 78
44. H.A. Bischoff-Ferrari, W.C. Willett, J.B. Wong, A.E. Stuck, H.B. Staehelin, E.J. Orav, A. Thoma, D.P. Kiel, and J. Henschkowski Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials Arch. Intern. Med. 169 2009 551 561
45. K. Kupferschmidt Uncertain verdict as vitamin D goes on trial Science 337 2012 1476 1478
46. K. Amrein, S.A. Quraishi, A.A. Litonjua, F.K. Gibbons, T.R. Pieber, C.A. Camargo Jr., E. Giovannucci, and K.B. Christopher Evidence for a U-shaped relationship between prehospital vitamin D status and mortality: a cohort study J. Clin. Endocrinol. Metab. 99 2014 1461 1469
47. D. Durup, H.L. Jørgensen, J. Christensen, P. Schwarz, A.M. Heegaard, and B. Lind A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice: the CopD study J. Clin. Endocrinol. Metab. 97 2012 2644 2652
48. K. Michaëlsson, J.A. Baron, G. Snellman, R. Gedeborg, L. Byberg, J. Sundström, L. Berglund, J. Arnlöv, P. Hellman, and R. Blomhoff Plasma vitamin D and mortality in older men: a community-based prospective cohort study Am. J. Clin. Nutr. 92 2010 841 848
49. A. Didriksen, G. Grimnes, M.S. Hutchinson, M. Kjærgaard, J. Svartberg, R.M. Joakimsen, and R. Jorde The serum 25-hydroxyvitamin D response to vitamin D supplementation is related to genetic factors, BMI, and baseline levels Eur. J. Endocrinol. 169 2013 559 567
50. M. Waterhouse, B. Tran, B.K. Armstrong, C. Baxter, P.R. Ebeling, D.R. English, V. Gebski, C. Hill, M.G. Kimlin, and R.M. Lucas Environmental, personal and genetic determinants of response to vitamin D supplementation in older adults J. Clin. Endocrinol. Metab. 2014 jc20134101 (Epub ahead of print)
51. S. Pilz, F. Rutters, and J.M. Dekker Disease prevention: vitamin D trials Science 338 2012 883
52. T.J. Wang, F. Zhang, J.B. Richards, B. Kestenbaum, J.B. van Meurs, D. Berry, D.P. Kiel, E.A. Streeten, C. Ohlsson, and D.L. Koller Common genetic determinants of vitamin D insufficiency: a genome-wide association study Lancet 376 2010 180 188
53. S. Afzal, P. Brøndum-Jacobsen, S.E. Bojesen, and B.G. Nordestgaard Vitamin D concentration, obesity, and risk of diabetes: a mendelian randomisation study Lancet Diabetes Endocrinol. 2 2014 298 306
54. K.S. Vimaleswaran, A. Cavadino, D.J. Berry, LifeLines Cohort Study Investigators, R. Jorde, A.K. Dieffenbach, C. Lu, A.C. Alves, H.J. Heerspink, and E. Tikkanen Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study Lancet Diabetes Endocrinol. 2014 http://dx.doi.org/10.1016/S2213-8587(14)70113-5 pii: S2213-8587(14)70113-5 (Epub ahead of print)
55. G.P. Levin, C. Robinson-Cohen, I.H. de Boer, D.K. Houston, K. Lohman, Y. Liu, S.B. Kritchevsky, J.A. Cauley, T. Tanaka, and L. Ferrucci Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes JAMA 308 2012 1898 1905
56. G. Bjelakovic, D. Nikolova, L.L. Gluud, R.G. Simonetti, and C. Gluud Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases Cochrane Database Syst. Rev. 3 2012 CD007176
57. S.P. Fortmann, B.U. Burda, C.A. Senger, J.S. Lin, and E.P. Whitlock Vitamin and mineral supplements in the primary prevention of cardiovascular disease and cancer: an updated systematic evidence review for the US Preventive Services Task Force Ann. Intern. Med. 159 2013 824 834
58. M. Ebbing, K.H. Bønaa, O. Nygård, E. Arnesen, P.M. Ueland, J.E. Nordrehaug, K. Rasmussen, I. Njølstad, H. Refsum, and D.W. Nilsen Cancer incidence and mortality after treatment with folic acid and vitamin B12 JAMA 302 2009 2119 2126