sCD163 in AOSD: a biomarker for macrophage activation related to hyperferritinemia

Immunologic Research

Volumn 60, Issue 2-3, 2014, Pages 177-183

  Colafrancesco, S ^a   Priori, R ^a   Alessandri, C ^a   Astorri, E ^a   Perricone, C ^a   Blank, M ^b   Agmon Levin, N ^b   Shoenfeld, Y ^b   Valesini, G ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SHEBA MEDICAL CENTER   (Israel)

Author keywords

Adult onset still s disease; Ferritin; Macrophage; sCD163

Indexed keywords

BIOLOGICAL MARKER; CD163 ANTIGEN; FERRITIN; CELL SURFACE RECEPTOR; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN;

ADULT; ADULT ONSET STILL DISEASE; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ACTIVITY; FERRITIN BLOOD LEVEL; HUMAN; HUMAN TISSUE; HYPERFERRITINEMIA; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; LYMPH NODE; MACROPHAGE ACTIVATION; ONSET AGE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; T LYMPHOCYTE; TONSIL; AGED; BLOOD; CASE CONTROL STUDY; COMPLICATION; FEMALE; IMMUNOLOGY; LYMPHOCYTE; MACROPHAGE; MALE; METABOLISM; MIDDLE AGED; PALATINE TONSIL; PATHOLOGY; YOUNG ADULT;

ADULT; AGED; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; FEMALE; FERRITINS; HUMANS; LYMPH NODES; LYMPHOCYTES; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MIDDLE AGED; PALATINE TONSIL; RECEPTORS, CELL SURFACE; SEPSIS; STILL'S DISEASE, ADULT-ONSET; YOUNG ADULT;

EID: 84925491489     PISSN: 0257277X     EISSN: 15590755     Source Type: Journal    
DOI: 10.1007/s12026-014-8563-7     Document Type: Article

References (24)

1. Zandman-Goddard G, Shoenfeld Y. Ferritin in autoimmune diseases. Autoimmun Rev. 2007;6:457–63.
2. Priori R, Colafrancesco S, Picarelli G, Di Franco M, Valesini G. Adult-onset Still’s disease: not always so good. Clin Exp Rheumatol. 2012;30:142.
3. Agmon-Levin N, Rosário C, Katz BS, Zandman-Goddard G, Meroni P, Cervera R, Stojanovich L, Blank M, Pierangeli S, Praprotnik S, Meis Ed, Seguro LP, Ruffatti A, Pengo V, Tincani A, Doria A, Shoenfeld Y. Ferritin in the antiphospholipid syndrome and its catastrophic variant (cAPS). Lupus. 2013;22:1327–35.
4. Rosário C, Zandman-Goddard G, Meyron-Holtz EG, D’Cruz DP, Shoenfeld Y. The hyperferritinemic syndrome: macrophage activation syndrome, Still’s disease, septic shock and catastrophicantiphospholipid syndrome. BMC Med. 2013;22(11):185.
5. Kontzias A, Efthimiou P. Adult-onset Still’s disease: pathogenesis, clinical manifestations and therapeutic advances. Drugs. 2008;68:319–37.
6. Priori R, Colafrancesco S, Alessandri C, Minniti A, Perricone C, Iaiani G, Palazzo D, Valesini G. Interleukin 18: a biomarker for differential diagnosis between adult-onset Still’s disease and sepsis. J Rheumatol. 2014;41:1118–23.
7. Colafrancesco S, Priori R, Alessandri C, Perricone C, Pendolino M, Picarelli G, Valesini G. IL-18 serum level in adult onset Still’s disease: a marker of disease activity. Int J Inflam. 2012;2012:156890. doi:10.1155/2012/156890.
8. Fautrel B, Le Moel G, Saint-Marcoux B, Taupin P, Vignes S, Rozenberg S, et al. Diagnostic value of ferritin and glycosylated ferritin in adult onset still’s disease. J Rheumatol. 2001;28:322–9.
9. Yamaguchi M, Ohta A, Tsunematsu T, Kasukawa R, Mizushima Y, Kashiwagi H, et al. Preliminary criteria for classification of adult still’s disease. J Rheumatol. 1992;19:424–30.
10. Lian F, Wang Y, Yang X, Xu H, Liang L. Clinical features and hyperferritinemia diagnostic cutoff points for AOSD based on ROC curve: a Chinese experience. Rheumatol Int. 2012;32:189–92.
11. Cohen LA, Gutierrez L, Weiss A, Leichtmann-Bardoogo Y, Zhang DL, Crooks DR, Sougrat R, Morgenstern A, Galy B, Hentze MW, Lazaro FJ, Rouault TA, Meyron-Holtz EG. Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Blood. 2010;116:1574–84.
12. Cairo G, Recalcati S, Mantovani A, Locati M. Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype. Trends Immunol. 2011;32:241–7.
13. Møller HJ. Soluble CD163. Scand J Clin Lab Invest. 2012;72:1–13.
14. Rau M, Schiller M, Krienke S, Heyder P, Lorenz H, Blank N. Clinical manifestations but not cytokine profiles differentiate adult-onset-Still’s disease and sepsis. 2010;37:2369–76.
15. American Collage of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definitions for sepsis and organ failure, guide lines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20:864–74.
16. Feng L, Zhou X, Su LX, Feng D, Jia YH, Xie LX. Clinical significance of soluble hemoglobin scavenger receptor CD163 (sCD163) in sepsis, a prospective study. PLoS One. 2012;7:e38400.
17. Bleesing J, Prada A, Siegel DM, Villanueva J, Olson J, Ilowite NT, Brunner HI, Griffin T, Graham TB, Sherry DD, Passo MH, Ramanan AV, Filipovich A, Grom AA. The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis. Arthritis Rheum. 2007;56:965–71.
18. Schaer DJ, Schleiffenbaum B, Kurrer M, Imhof A, Bächli E, Fehr J, Moller HJ, Moestrup SK, Schaffner A. Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome. Eur J Haematol. 2005;74:6–10.
19. Mehta B, Efthimiou P. Ferritin in adult-onset still’s disease: just a useful innocent bystander? Int J Inflam. 2012;2012:298405. doi:10.1155/2012/298405.
20. Torti FM, Torti SV. Regulation of ferritin genes and protein. Blood. 2002;99:3505–16.
21. Torti SV, Kwak EL, Miller SC, et al. The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene. J Biol Chem. 1988;263:12638–44.
22. Recalcati S, Invernizzi P, Arosio P, Cairo G. New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity. J Autoimmun. 2008;30:84–9.
23. Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE. Daws MR.TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med. 2005;202:955–65.
24. Ghosh S, Hevi S, Chuck SL. Regulated secretion of glycosylated human ferritin from hepatocytes. Blood. 2004;103:2369–76.