MitoTimer: a novel protein for monitoring mitochondrial turnover in the heart

Journal of Molecular Medicine

Volumn 93, Issue 3, 2015, Pages 271-278

  Gottlieb, Roberta A ^a   Stotland, Aleksandr ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Fluorescence microscopy; Mitochondrial biogenesis; Mitophagy; MitoTimer

Indexed keywords

MITOCHONDRIAL PROTEIN; MITOTIMER PROTEIN; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; HYBRID PROTEIN; PHOTOPROTEIN;

BIOGENESIS; BIOLOGICAL MONITORING; CYTOLOGY; FLUORESCENCE; HEART MITOCHONDRION; HOMEOSTASIS; MITOCHONDRIAL DYNAMICS; MITOPHAGY; PROTEIN CONFORMATION; PROTEIN QUALITY; PROTEIN TRANSPORT; QUALITY CONTROL; REVIEW; ANIMAL; FLUORESCENCE MICROSCOPY; HUMAN; METABOLISM; PHYSIOLOGY;

ANIMALS; BIOMARKERS; HUMANS; LUMINESCENT PROTEINS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA, HEART; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL PROTEINS; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS;

EID: 84925483162     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-014-1230-6     Document Type: Review

References (45)

1. Menzies RA, Gold PH (1971) The turnover of mitochondria in a variety of tissues of young adult and aged rats. J Biol Chem 246(8):2425–2429
2. Miwa S, Lawless C, Von Zglinicki T (2008) Mitochondrial turnover in liver is fast in vivo and is accelerated by dietary restriction: application of a simple dynamic model. Aging Cell 7(6):920–923
3. Kim TY et al (2012) Metabolic labeling reveals proteome dynamics of mouse mitochondria. Mol Cell Proteomics 11(12):1586–94
4. Kim I, Lemasters JJ (2010) Mitophagy selectively degrades individual damaged mitochondria after photoirradiation. Antioxid Redox Signal 14(10):1919–1928
5. Page E, McCallister LP, Power B (1971) Sterological measurements of cardiac ultrastructures implicated in excitation-contraction coupling. Proc Natl Acad Sci U S A 68(7):1465–1466
6. McDonald K et al (1997) The effect of delayed reperfusion following infarction in the rat on structural changes in viable myocardium. Cardiovasc Res 36(3):347–353
7. Page E, McCallister LP, Power B (1971) Stereological measurements of cardiac ultrastructures implicated in excitation-contraction coupling. Proc Natl Acad Sci 68(7):1465–1466
8. Fawcett DW, McNutt NS (1969) The ultrastructure of the cat myocardium. I. Ventricular papillary muscle. J Cell Biol 42(1):1–45
9. Nouette-Gaulain K, et al. (2005) Time course of differential mitochondrial energy metabolism adaptation to chronic hypoxia in right and left ventricles Cardiovasc Res. 66(1):132-40.
10. Ingwall JS (2002) ATP and the heart. Kluwer Academic Publishers, Norwell
11. Twig G et al (2008) Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 27(2):433–446
12. Bender T, Lewrenz I, Franken S, Baitzel C, Voos W (2011) Mitochondrial enzymes are protected from stress-induced aggregation by mitochondrial chaperones and the Pim1/LON protease. Mol Biol Cell 22(5):541–554
13. Bailey SM, Udoh US, Young ME (2014) Circadian regulation of metabolism. J Endocrinol 222(2):R75–96
14. Carreira RS, Lee Y, Ghochani M, Gustafsson AB, Gottlieb RA (2010) Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells. Autophagy 6(4):462–72
15. Huang C et al (2011) Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1. PLoS One 6(6):e20975
16. Kim I, Lemasters JJ (2011) Mitophagy selectively degrades individual damaged mitochondria after photoirradiation. Antioxid Redox Signal 14(10):1919–1928
17. Crescenzo R et al (2006) Altered skeletal muscle subsarcolemmal mitochondrial compartment during catch-up fat after caloric restriction. Diabetes 55(8):2286–2293
18. Wikstrom JD, Twig G, Shirihai OS (2009) What can mitochondrial heterogeneity tell us about mitochondrial dynamics and autophagy? Int J Biochem Cell Biol 41(10):1914–1927
19. Moon K-H, Kim B-J, Song BJ (2005) Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylation. FEBS Lett 579(27):6115–6120
20. Paradies G, Petrosillo G, Pistolese M, Ruggiero FM (2002) Reactive oxygen species affect mitochondrial electron transport complex I activity through oxidative cardiolipin damage. Gene 286(1):135–141
21. Lehman JJ et al (2000) Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest JID 7802877 106(7):847–856
22. Scarpulla RC (2008) Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol Rev 88(2):611–638
23. Wende AR et al (2007) A role for the transcriptional coactivator PGC-1α in muscle refueling. J Biol Chem 282(50):36642–36651
24. Iwabu M et al (2010) Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca (2+) and AMPK/SIRT1. Nature 464(7293):1313–1319
25. Sengupta A, Molkentin JD, Yutzey KE (2009) FoxO transcription factors promote autophagy in cardiomyocytes. J Biol Chem 284(41):28319–28331
26. Shin JH et al (2011) PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson’s disease. Cell 144(5):689–702
27. Haynes CM, Yang Y, Blais SP, Neubert TA, Ron D (2010) The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Mol Cell 37(4):529–540
28. Aldridge JE, Horibe T, Hoogenraad NJ (2007) Discovery of genes activated by the mitochondrial unfolded protein response (mtUPR) and cognate promoter elements. PLoS One 2(9):e874
29. Haynes CM, Ron D (2010) The mitochondrial UPR—protecting organelle protein homeostasis. J Cell Sci 123(Pt 22):3849–3855
30. Mottis A, Jovaisaite V, Auwerx J (2014) The mitochondrial unfolded protein response in mammalian physiology. Genome, Mamm
31. Katayama H, Kogure T, Mizushima N, Yoshimori T, Miyawaki A (2011) A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery. Chem Biol 18(8):1042–1052
32. Laker RC et al (2014) A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo. J Biol Chem 289(17):12005–12015
33. Hernandez G et al (2013) MitoTimer: a novel tool for monitoring mitochondrial turnover. Autophagy 9(11):1852–1861
34. Ferree AW et al (2013) MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age. Autophagy 9(11):1887–1896
35. Terskikh A et al (2000) “Fluorescent timer”: protein that changes color with time. Science 290(5496):1585–1588
36. Loson OC, Ha CM, Parpura V (2011) Age-dependent spatial segregation of synaptobrevin 2-containing vesicles in astrocytes. J Neurochem 116(5):909–15
37. Kozel BA et al (2006) Elastic fiber formation: a dynamic view of extracellular matrix assembly using timer reporters. J Cell Physiol 207(1):87–96
38. Verkhusha VV et al (2001) An enhanced mutant of red fluorescent protein DsRed for double labeling and developmental timer of neural fiber bundle formation. J Biol Chem 276(32):29621–29624
39. Robinson SM et al (2014) Coxsackie virus B exits the host cell in shed microvesicles displaying autophagosomal markers. PLoS Pathog 10(4):e1004045
40. Weis BL, Schleiff E, Zerges W (2013) Protein targeting to subcellular organelles via mRNA localization. Biochim Biophys Acta 1833(2):260–273
41. Maday S, Wallace KE, Holzbaur EL (2012) Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons. J Cell Biol 196(4):407–417
42. Neupert W, Herrmann JM (2007) Translocation of proteins into mitochondria. Annu Rev Biochem 76(1):723–749
43. Aoi W, Naito Y, Yoshikawa T (2014) Potential role of oxidative protein modification in energy metabolism in exercise. Subcell Biochem 77:175–187
44. Wikstrom JD et al (2007) {Beta}-Cell mitochondria exhibit membrane potential heterogeneity that Can Be altered by stimulatory or toxic fuel levels. Diabetes 56(10):2569–2578
45. Oka T et al (2012) Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature 485(7397):251–255