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Volumn 6, Issue 4, 2014, Pages 2243-2258

Auranofin, an anti-rheumatic gold compound, modulates apoptosis by elevating the intracellular calcium concentration ([Ca2+]i) in MCF-7 breast cancer cells

Author keywords

Anticancer drugs; Apoptosis; Auranofin; Breast cancer; Cytotoxicity; Intracellular calcium

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; AURANOFIN; CAFFEINE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; FLUORESCENT DYE; NIMODIPINE; TRYPAN BLUE;

EID: 84925456023     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers6042243     Document Type: Article
Times cited : (32)

References (32)
  • 2
    • 70349728402 scopus 로고    scopus 로고
    • Anti-cancer drugs interfere with intracellular calcium signaling
    • Florea, A.M.; Büsselberg, D. Anti-cancer drugs interfere with intracellular calcium signaling. Neurotoxicology 2009, 30, 803-810.
    • (2009) Neurotoxicology , vol.30 , pp. 803-810
    • Florea, A.M.1    Büsselberg, D.2
  • 3
    • 80052672049 scopus 로고    scopus 로고
    • Metals and breast cancer: Risk factors or healing agents?
    • 2011
    • Florea, A.M.; Büsselberg, D. Metals and breast cancer: Risk factors or healing agents? J. Toxicol. 2011, 2011, doi:10.1155/2011/159619.
    • (2011) J. Toxicol
    • Florea, A.M.1    Büsselberg, D.2
  • 5
    • 50249190929 scopus 로고
    • Rheumatoid arthritis and its treatment by gold salts
    • Forestier, J. Rheumatoid arthritis and its treatment by gold salts. J. Lab. Clin. Med. 1935, 20, 827-840.
    • (1935) J. Lab. Clin. Med , vol.20 , pp. 827-840
    • Forestier, J.1
  • 6
    • 0018662937 scopus 로고
    • Inhibitory effects of a new oral gold compound on HeLa cells
    • Simon, T.M.; Kunishima, D.H.; Vibert, G.J.; Lorber, A. Inhibitory effects of a new oral gold compound on HeLa cells. Cancer 1979, 44, 1965-1975.
    • (1979) Cancer , vol.44 , pp. 1965-1975
    • Simon, T.M.1    Kunishima, D.H.2    Vibert, G.J.3    Lorber, A.4
  • 8
    • 70349561362 scopus 로고    scopus 로고
    • Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(III) compounds for cancer treatment: A systematic study
    • Casini, A.; Kelter, G.; Gabbiani, C.; Cinellu, M.A.; Minghetti, G.; Fregona, D.; Fiebig, H.H.; Messori, L. Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(III) compounds for cancer treatment: A systematic study. J. Biol. Inorg. Chem. 2009, 14, 1139-1149.
    • (2009) J. Biol. Inorg. Chem , vol.14 , pp. 1139-1149
    • Casini, A.1    Kelter, G.2    Gabbiani, C.3    Cinellu, M.A.4    Minghetti, G.5    Fregona, D.6    Fiebig, H.H.7    Messori, L.8
  • 9
    • 33847014053 scopus 로고    scopus 로고
    • Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells
    • Marzano, C.; Gandin, V.; Folda, A.; Scutari, G.; Bindoli, A.; Rigobello, M.P. Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells. Free Radic. Biol. Med. 2007, 42, 872-881.
    • (2007) Free Radic. Biol. Med , vol.42 , pp. 872-881
    • Marzano, C.1    Gandin, V.2    Folda, A.3    Scutari, G.4    Bindoli, A.5    Rigobello, M.P.6
  • 10
    • 22044444840 scopus 로고    scopus 로고
    • Effect of auranofin on the mitochondrial generation of hydrogen peroxide. Role of thioredoxin reductase. Free Radic
    • Rigobello, M.P.; Folda, A.; Baldoin, M.C.; Scutari, G.; Bindoli, A. Effect of auranofin on the mitochondrial generation of hydrogen peroxide. Role of thioredoxin reductase. Free Radic. Res. 2005, 39, 687-695.
    • (2005) Res , vol.39 , pp. 687-695
    • Rigobello, M.P.1    Folda, A.2    Baldoin, M.C.3    Scutari, G.4    Bindoli, A.5
  • 11
    • 34547870107 scopus 로고    scopus 로고
    • Ip(3) receptor antagonist, 2-APB, attenuates cisplatin induced Ca2+-influx in HeLa-S3 cells and prevents activation of calpain and induction of apoptosis
    • Splettstoesser, F.; Florea, A.M.; Büsselberg, D. Ip(3) receptor antagonist, 2-APB, attenuates cisplatin induced Ca2+-influx in HeLa-S3 cells and prevents activation of calpain and induction of apoptosis. Br. J. Pharmacol. 2007, 151, 1176-1186.
    • (2007) Br. J. Pharmacol , vol.51 , pp. 1176-1186
    • Splettstoesser, F.1    Florea, A.M.2    Büsselberg, D.3
  • 13
    • 84874085244 scopus 로고    scopus 로고
    • Stimulation of human TRPA1 channels by clinical concentrations of the antirheumatic drug auranofin
    • Hatano, N.; Suzuki, H.; Muraki, Y.; Muraki, K. Stimulation of human TRPA1 channels by clinical concentrations of the antirheumatic drug auranofin. Am. J. Physiol. Cell Physiol. 2013, 304, C354-C361.
    • (2013) Am. J. Physiol. Cell Physiol , vol.304 , pp. C354-C361
    • Hatano, N.1    Suzuki, H.2    Muraki, Y.3    Muraki, K.4
  • 14
    • 0025689167 scopus 로고
    • Auranofin modulated cytoplasmic free calcium in neutrophils by mobilizing intracellular calcium and inhibiting protein kinase
    • Wong, K.; Parente, J.; Prasad, K.V.; Ng, D. Auranofin modulated cytoplasmic free calcium in neutrophils by mobilizing intracellular calcium and inhibiting protein kinase. J. Biol. Chem. 1990, 265, 21454-21461.
    • (1990) J. Biol. Chem. , vol.265 , pp. 21454-21461
    • Wong, K.1    Parente, J.2    Prasad, K.V.3    Ng, D.4
  • 15
    • 84872284719 scopus 로고    scopus 로고
    • Enhancement of auranofin-induced apoptosis in MCF-7 human breast cells by selenocystine, a synergistic inhibitor of thioredoxin reductase
    • Liu, C.; Liu, Z.; Li, M.; Li, X.; Wong, Y.-S.; Ngai, S.-M.; Zheng, W.; Zhang, Y.; Chen, T. Enhancement of auranofin-induced apoptosis in MCF-7 human breast cells by selenocystine, a synergistic inhibitor of thioredoxin reductase. PLoS One 2013, doi:10.1371/journal.pone.0053945.
    • (2013) Plos One
    • Liu, C.1    Liu, Z.2    Li, M.3    Li, X.4    Wong, Y.-S.5    Ngai, S.-M.6    Zheng, W.7    Zhang, Y.8    Chen, T.9
  • 18
    • 84869064515 scopus 로고    scopus 로고
    • Modulation of doxorubicin cytotoxicity by resveratrol in a human breast cancer cell line
    • Osman, A.M.; Bayoumi, H.M.; Al-Harthi, S.E.; Damanhouri, Z.A.; Elshal, M.F. Modulation of doxorubicin cytotoxicity by resveratrol in a human breast cancer cell line. Cancer Cell Int. 2012, doi:10.1186/1475-2867-12-47.
    • (2012) Cancer Cell Int
    • Osman, A.M.1    Bayoumi, H.M.2    Al-Harthi, S.E.3    Damanhouri, Z.A.4    Elshal, M.F.5
  • 20
    • 78751705649 scopus 로고    scopus 로고
    • The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-κB activity
    • Nakaya, A.; Sagawa, M.; Muto, A.; Uchida, H.; Ikeda, Y.; Kizaki, M. The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-κB activity. Leuk. Res. 2011, 35, 243-249.
    • (2011) Leuk. Res , vol.35 , pp. 243-249
    • Nakaya, A.1    Sagawa, M.2    Muto, A.3    Uchida, H.4    Ikeda, Y.5    Kizaki, M.6
  • 22
    • 84869873440 scopus 로고    scopus 로고
    • New target for gold(I) compounds: Glutathione-S-transferase inhibition by auranofin
    • De Luca, A.; Hartinger, C.G.; Dyson, P.J.; lo Bello, M.; Casini, A. A new target for gold(I) compounds: Glutathione-S-transferase inhibition by auranofin. J. Inorg. Biochem. 2013, 119, 38-42.
    • (2013) J. Inorg. Biochem , vol.119 , pp. 38-42
    • De Luca, A.1    Hartinger, C.G.2    Dyson, P.J.3    Lo Bello, M.4    Casini, A.A.5
  • 23
    • 0029954846 scopus 로고    scopus 로고
    • Glutathione and related enzymes in multidrug resistance
    • O’Brien, M.L.; Tew, K.D. Glutathione and related enzymes in multidrug resistance. Eur. J. Cancer 1996, 32A, 967-978.
    • (1996) Eur. J. Cancer , vol.32 , pp. 967-978
    • O’Brien, M.L.1    Tew, K.D.2
  • 24
    • 61849121336 scopus 로고    scopus 로고
    • Co-application of arsenic trioxide (As2O3) and cisplatin (CDDP) on human SY-5Y neuroblastoma cells has differential effects on the intracellular calcium concentration ([Ca2+]i) and cytotoxicity
    • Gunes, D.A.; Florea, A.M.; Splettstoesser, F.; Büsselberg, D. Co-application of arsenic trioxide (As2O3) and cisplatin (CDDP) on human SY-5Y neuroblastoma cells has differential effects on the intracellular calcium concentration ([Ca2+]i) and cytotoxicity. Neurotoxicology 2009, 30, 194-202.
    • (2009) Neurotoxicology , vol.30 , pp. 194-202
    • Gunes, D.A.1    Florea, A.M.2    Splettstoesser, F.3    Büsselberg, D.4
  • 26
    • 79953700297 scopus 로고    scopus 로고
    • Cisplatin as an anti-tumor drug: Cellular mechanisms of activity, drug resistance and induced side effects
    • Florea, A.M.; Büsselberg, D. Cisplatin as an anti-tumor drug: Cellular mechanisms of activity, drug resistance and induced side effects. Cancers 2011, 3, 1351-1371.
    • (2011) Cancers , vol.3 , pp. 1351-1371
    • Florea, A.M.1    Büsselberg, D.2
  • 27
    • 34247245667 scopus 로고    scopus 로고
    • Arsenic trioxide (As2O3) induced calcium signals and cytotoxicity in two human cell lines: SY-5Y neuroblastoma and 293 embryonic kidney (HEK)
    • Florea, A.M.; Splettstoesser, F.; Büsselberg, D. Arsenic trioxide (As2O3) induced calcium signals and cytotoxicity in two human cell lines: SY-5Y neuroblastoma and 293 embryonic kidney (HEK). Toxicol. Appl. Pharmacol. 2007, 220, 292-301.
    • (2007) Toxicol. Appl. Pharmacol , vol.220 , pp. 292-301
    • Florea, A.M.1    Splettstoesser, F.2    Büsselberg, D.3
  • 29
    • 84907506936 scopus 로고    scopus 로고
    • Cisplatin (CDDP) triggers cell death of MCF-7 cells following disruption of intracellular calcium [Ca2+]i homeostasis
    • Al-Taweel, N.; Varghese, E.; Florea, A.M.; Büsselberg, D. Cisplatin (CDDP) triggers cell death of MCF-7 cells following disruption of intracellular calcium [Ca2+]i homeostasis. J. Toxicol. Sci. 2014, 39, 765-774.
    • (2014) J. Toxicol. Sci , vol.39 , pp. 765-774
    • Al-Taweel, N.1    Varghese, E.2    Florea, A.M.3    Büsselberg, D.4
  • 30
    • 0028824725 scopus 로고
    • Roles of calcium in the regulation of apoptosis in HL-60 promyelocytic leukemia cells
    • Zhu, W.H.; Loh, T.T. Roles of calcium in the regulation of apoptosis in HL-60 promyelocytic leukemia cells. Life Sci. 1995, 57, 2091-2099.
    • (1995) Life Sci , vol.57 , pp. 2091-2099
    • Zhu, W.H.1    Loh, T.T.2
  • 31
    • 0030843234 scopus 로고    scopus 로고
    • 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of ins(1,4,5)p3-induced Ca2+ release
    • Maruyama, T.; Kanaji, T.; Nakade, S.; Kanno, T.; Mikoshiba, K. 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of ins(1,4,5)p3-induced Ca2+ release. J. Biochem. 1997, 122, 498-505.
    • (1997) J. Biochem , vol.122 , pp. 498-505
    • Maruyama, T.1    Kanaji, T.2    Nakade, S.3    Kanno, T.4    Mikoshiba, K.5
  • 32
    • 0036329140 scopus 로고    scopus 로고
    • 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of insp3-induced Ca2+ release
    • Bootman, M.D.; Collins, T.J.; Mackenzie, L.; Roderick, H.L.; Berridge, M.J.; Peppiatt, C.M. 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of insp3-induced Ca2+ release. FASEB J. 2002, 16, 1145-1150.
    • (2002) FASEB J , vol.16 , pp. 1145-1150
    • Bootman, M.D.1    Collins, T.J.2    Mackenzie, L.3    Roderick, H.L.4    Berridge, M.J.5    Peppiatt, C.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.