Characterization of the intestinal absorption of seven flavonoids from the flowers of Trollius chinensis using the Caco-2 cell monolayer model

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Liu, Lijia ^a   Guo, Lina ^a   Zhao, Can ^a   Wu, Xiuwen ^a   Wang, Rufeng ^a   Liu, Chen ^a  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2'' O (2''' METHYLBUTANOYL)ISOSWERTISIN; 2'' O BETA LEVO GALACTOPYRANOSYLORIENTIN; 2'' O BETA LEVO GALACTOPYRANOSYLVITEXIN; FLAVONOID; ISOSWERTIAJAPONIN; ISOSWERTISIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN; ORIENTIN; PACLITAXEL; PROBENECID; UNCLASSIFIED DRUG; VERAPAMIL; VITEXIN; APIGENIN; GLUCOSIDE; GLYCOSIDE; ISOSWERTIAJAPONIN 2''-O-ARABINOPYRANOSIDE;

ARTICLE; CACO 2 CELL LINE; CELL DIFFERENTIATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG COMPETITION; DRUG EFFECT; DRUG STRUCTURE; DRUG TRANSPORT; FLOWER; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; MEASUREMENT ACCURACY; MEDICINAL PLANT; MONOLAYER CULTURE; STRUCTURE ACTIVITY RELATION; STRUCTURE PROPERTY RELATION; TROLLIUS CHINENSIS; CACO-2 CELL LINE; CHEMISTRY; DRUG EFFECTS; METABOLISM; RANUNCULACEAE;

TROLLIUS CHINENSIS;

APIGENIN; CACO-2 CELLS; FLAVONOIDS; FLOWERS; GLUCOSIDES; GLYCOSIDES; HUMANS; INTESTINAL ABSORPTION; RANUNCULACEAE;

EID: 84925446650     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0119263     Document Type: Article

References (27)

1. Su LJ, Wang H, Su ZW, Ma YL. Constituents and pharmacological effects of Trollius. Foreign Med Sci. 2005; 20: 14-16.
2. Wang RF, Yang XW, Ma CM, Cai SQ, Li JN, Shoyama Y. A bioactive alkaloid from the flowers of Trollius chinensis. Heterocycles. 2004; 63:1443-1448.
3. Jiangsu New College of Medicine. Chinese materia medica dictionary. Shanghai: Shanghai People's Press; 1997. pp. 1398-1399.
4. Tang JZ, Lu XX, Chen RF. Study on the isolation of total flavonoids in the flowers of Trollius chinensis and their antioxidative activity. Food Sci. 2003; 23: 88-91.
5. Qu CH, Han Y, Tian JM, Yan J, Wang SH, An F. Determination of vitexin and orientin in Trollius chinensis with HPLC. J Hebei North Univ. 2009; 25: 21-28.
6. Liu Z, Wang L, Li W, Huang Y, Xu ZC. Determination of orientin and vitexin in Trollius chinensis preparation by HPLC. Chin J Chin Mat Med. 2004; 29: 1049-1051.
7. Yuan M, Wang RF, Liu LJ, Yang X, Peng YS, Sun ZX. Contribution evaluation of the floral parts to orientin and vitexin concentrations in the flowers of Trollius chinensis. Chin J Nat Med. 2013; 11: 699-704. doi: 10.1016/S1875-5364(13)60082-5 PMID: 24345513
8. Hao YF, Nan ML, Zhao YW, Si XL, He F, Zhao QC. Content determination of three flavonoid C-glycosides in Trollius chinensis by RP-HPLC. J Shenyang Pharm Univ. 2013; 30: 197-200.
9. Yang YX, Zhang GJ. Determination of 2"-O-β-L-galactopyranosylorientin in Trollius chinensis. Chin Med Mat. 2006; 29: 1312-1313.
10. Wang RF, Yang XW, Ma CM, Liu HY, Shang MY, Zhang QY, et al. Trolliside, a new compound from the flowers of Trollius chinensis. J Asian Nat Prod Res. 2004; 6: 139-144. PMID: 15008460
11. Yuan M, Wang RF, Wu XW, An YN, Yang XW. Investigation on Flos Trollii: constituents and bioactivities. Chin J Nat Med. 2013; 11: 449-445. doi: 10.1016/S1875-5364(13)60083-7 PMID: 24359766
12. Cai SQ, Wang RF, Yang XW, Shang MY, Ma CM, Shoyama Y. Antiviral flavonoid-type C-glycosides from the flowers of Trollius chinensis. Chem Biodivers. 2006; 3: 343-348. PMID: 17193271
13. Li YL, Ma SC, Yang YT, Ye SM, But PP. Antiviral activities of flavonoids and organic acid from Trollius chinensis Bunge. J Ethnopharmacol. 2002; 79: 365-368. PMID: 11849843
14. Lin QF, Feng SQ, Li YN, Cen YZ, Yang YT, Wang LY. Study on the antibacterial and antiviral activity compositions of Trollius chinensis Bunge. J Zhejiang Univ (Sci Edit). 2004; 31: 412-415.
15. Wang LY, Zhou YH, Li YL, Cen YZ. Antibacterial activity of flavonol glycosides in Trollius macropetalus Fr. Schmidt and their content determination. Tradit Chin Drug Res Clin Pharm. 2003; 14: 252-253.
16. Lin QF, Li YL, Feng QS, Cen QZ, Wang LY, Ye SM. Study on the active compositions of Trollius chinensis Bunge. Chin J Anal Lab. 2003; 22: 310-311.
17. Specialty of pharmacology and chemistry of Chinese medical herbs, Peking University. Studies on the bacteriostatically active constituents of Trollius chinensis Bge. J Tsinghua Univ (Sci Technol Edit). 1974; 1:165-174.
18. Wu XA, Qin F, Du MQ. The QRAS explore of anti-inflammatory activities on flavonoid C-glycoside. Lishizhen Med Mater Med Res. 2012; 23: 632-633.
19. Wang RF, Geng D, Wu XW, An YN. Anti-inflammatory activity of four major compounds from flowers of Trollius chinensis. Lishizhen Med Mater Med Res. 2012; 23: 2115-2116. doi: 10.1007/s10856-012-4691-6 PMID: 22669282
20. Yee SY. In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man-fact or myth. Pharm Res. 1997; 14: 763-766. PMID: 9210194
21. Gao JN, Hugger ED, Beck-Westermeyer MS, Borchardt RT. Estimating intestinal mucosal permeation of compounds using Caco-2 cell monolayers. Curr Protoc Pharmacol. 2001 May 1. doi: 10.1002/0471141755.ph0702s08
22. Chong S, Dando SA, Morrison RA. Evaluation of Biocoat intestinal epithelium differentiation environment (3-day culture Caco-2 cells) as an absorption screening model with improved productivity. Pharm Res. 1997; 14: 1835-1837. PMID: 9453077
23. Walle UK, French KL, Walgren RA, Walle T. Transport of genistein-7-glucoside by human intestinal Caco-2 cells: potential role for MRP2. Res Commun Mol Pathol Pharmacol. 1999; 103: 45-56. PMID: 10440570
24. Lin JZ, Zou L, Fu CM, Zhang DK, Wang P, Qin L. Octanol/water partition coefficient and absorption kinetics of salidroside and tyrosol in rat intestine. Chin Tradi Pat Med. 2013; 35: 483-486.
25. Wang GJ. Pharmacokinetics. Beijing: Chemical Industry Press; 2005. pp. 6-12.
26. van der Sandt IC, Blom-Roosemalen MC, de Boer AG, Breimer DD. Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1: MDR1 and Caco-2 cell lines. Eur J Pharm Sci. 2000; 11: 207-214. PMID: 11042226
27. Versantvoort CH, Bagrij T, Wright KA, Twentyman PR. On the relationship between the probenecid-sensitive transport of daunorubicin or calcein and the glutathione status of cells overexpressing the multidrug resistance-associated protein (MRP). Int J Cancer. 1995; 63: 855-862. PMID: 8847145