메뉴 건너뛰기




Volumn 89, Issue 8, 2015, Pages 4126-4142

PA-X decreases the pathogenicity of highly pathogenic H5N1 influenza A virus in avian species by inhibiting virus replication and host response

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED RNA POLYMERASE; HYBRID PROTEIN; PA X PROTEIN; UNCLASSIFIED DRUG; LUCIFERASE; PA-X PROTEIN, INFLUENZA A VIRUS; REPRESSOR PROTEIN; VIRAL PROTEIN;

EID: 84925424679     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02132-14     Document Type: Article
Times cited : (83)

References (44)
  • 1
    • 0017326035 scopus 로고
    • The genes of influenza virus
    • Palese P. 1977. The genes of influenza virus. Cell 10:1-10. http://dx.doi.org/10.1016/0092-8674(77)90133-7.
    • (1977) Cell , vol.10 , pp. 1-10
    • Palese, P.1
  • 2
    • 0018973537 scopus 로고
    • Sequence of interrupted and uninterrupted mRNAs and cloned DNA coding for the two overlapping nonstructural proteins of influenza virus
    • Lamb RA, Lai CJ. 1980. Sequence of interrupted and uninterrupted mRNAs and cloned DNA coding for the two overlapping nonstructural proteins of influenza virus. Cell 21:475-485. http://dx.doi.org/10.1016/0092-8674(80)90484-5.
    • (1980) Cell , vol.21 , pp. 475-485
    • Lamb, R.A.1    Lai, C.J.2
  • 3
    • 0019859896 scopus 로고
    • Sequences of mRNAs derived from genome RNA segment 7 of influenza virus: colinear and interrupted mRNAs code for overlapping proteins
    • Lamb RA, Lai CJ, Choppin PW. 1981. Sequences of mRNAs derived from genome RNA segment 7 of influenza virus: colinear and interrupted mRNAs code for overlapping proteins. Proc Natl Acad Sci USA 78:4170-4174. http://dx.doi.org/10.1073/pnas.78.7.4170.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 4170-4174
    • Lamb, R.A.1    Lai, C.J.2    Choppin, P.W.3
  • 4
    • 67749133883 scopus 로고    scopus 로고
    • A complicated message: identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA
    • Wise HM, Foeglein A, Sun J, Dalton RM, Patel S, Howard W, Anderson EC, Barclay WS, Digard P. 2009. A complicated message: identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA. J Virol 83:8021-8031. http://dx.doi.org/10.1128/JVI.00826-09.
    • (2009) J Virol , vol.83 , pp. 8021-8031
    • Wise, H.M.1    Foeglein, A.2    Sun, J.3    Dalton, R.M.4    Patel, S.5    Howard, W.6    Anderson, E.C.7    Barclay, W.S.8    Digard, P.9
  • 8
    • 84874044936 scopus 로고    scopus 로고
    • Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing
    • Selman M, Dankar SK, Forbes NE, Jia J-J, Brown EG. 2012. Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing. Emerg Microbes Infect 1:e42. http://dx.doi.org/10.1038/emi.2012.38.
    • (2012) Emerg Microbes Infect , vol.1
    • Selman, M.1    Dankar, S.K.2    Forbes, N.E.3    Jia, J.-J.4    Brown, E.G.5
  • 9
    • 84874676641 scopus 로고    scopus 로고
    • Identification of novel influenza A virus proteins translated from PA mRNA
    • Muramoto Y, Noda T, Kawakami E, Akkina R, Kawaoka Y. 2013. Identification of novel influenza A virus proteins translated from PA mRNA. J Virol 87:2455-2462. http://dx.doi.org/10.1128/JVI.02656-12.
    • (2013) J Virol , vol.87 , pp. 2455-2462
    • Muramoto, Y.1    Noda, T.2    Kawakami, E.3    Akkina, R.4    Kawaoka, Y.5
  • 10
    • 77951059450 scopus 로고    scopus 로고
    • Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1
    • Zamarin D, Garcia-Sastre A, Xiao X, Wang R, Palese P. 2005. Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. PLoS Pathog 1:e4. http://dx.doi.org/10.1371/journal.ppat.0010004.
    • (2005) PLoS Pathog , vol.1
    • Zamarin, D.1    Garcia-Sastre, A.2    Xiao, X.3    Wang, R.4    Palese, P.5
  • 12
    • 77957668538 scopus 로고    scopus 로고
    • PB1-F2 proteins from H5N1 and 20th century pandemic influenza viruses cause immunopathology
    • McAuley JL, Chipuk JE, Boyd KL, Van De Velde N, Green DR, Mc-Cullers JA. 2010. PB1-F2 proteins from H5N1 and 20th century pandemic influenza viruses cause immunopathology. PLoS Pathog 6:e1001014. http://dx.doi.org/10.1371/journal.ppat.1001014.
    • (2010) PLoS Pathog , vol.6
    • McAuley, J.L.1    Chipuk, J.E.2    Boyd, K.L.3    Van De Velde, N.4    Green, D.R.5    Mc-Cullers, J.A.6
  • 13
    • 34848926238 scopus 로고    scopus 로고
    • Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia
    • McAuley JL, Hornung F, Boyd KL, Smith AM, McKeon R, Bennink J, Yewdell JW, McCullers JA. 2007. Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe 2:240-249. http://dx.doi.org/10.1016/j.chom.2007.09.001.
    • (2007) Cell Host Microbe , vol.2 , pp. 240-249
    • McAuley, J.L.1    Hornung, F.2    Boyd, K.L.3    Smith, A.M.4    McKeon, R.5    Bennink, J.6    Yewdell, J.W.7    McCullers, J.A.8
  • 14
    • 84874699713 scopus 로고    scopus 로고
    • Identification of the N-terminal domain of the influenza virus PA responsible for the suppression of host protein synthesis
    • Desmet EA, Bussey KA, Stone R, Takimoto T. 2013. Identification of the N-terminal domain of the influenza virus PA responsible for the suppression of host protein synthesis. J Virol 87:3108-3118. http://dx.doi.org/10.1128/JVI.02826-12.
    • (2013) J Virol , vol.87 , pp. 3108-3118
    • Desmet, E.A.1    Bussey, K.A.2    Stone, R.3    Takimoto, T.4
  • 15
    • 84874792492 scopus 로고    scopus 로고
    • Two highly pathogenic avian influenza H5N1 viruses of clade 2.3.2.1 with similar genetic background but with different pathogenicity in mice and ducks
    • Hu J, Zhao K, Liu X, Wang X, Chen Z. 2013. Two highly pathogenic avian influenza H5N1 viruses of clade 2.3.2.1 with similar genetic background but with different pathogenicity in mice and ducks. Transbound Emerg Dis 60: 127-139. http://dx.doi.org/10.1111/j.1865-1682.2012.01325.x.
    • (2013) Transbound Emerg Dis , vol.60 , pp. 127-139
    • Hu, J.1    Zhao, K.2    Liu, X.3    Wang, X.4    Chen, Z.5
  • 16
    • 84874708826 scopus 로고    scopus 로고
    • The PA-gene-mediated lethal dissemination and excessive innate immune response contribute to the high virulence of H5N1 avian influenza virus in mice
    • Hu J, Hu Z, Song Q, Gu M, Liu X, Wang X, Hu S, Chen C, Liu H, Liu W, Chen S, Peng D. 2013. The PA-gene-mediated lethal dissemination and excessive innate immune response contribute to the high virulence of H5N1 avian influenza virus in mice. J Virol 87:2660-2672. http://dx.doi.org/10.1128/JVI.02891-12.
    • (2013) J Virol , vol.87 , pp. 2660-2672
    • Hu, J.1    Hu, Z.2    Song, Q.3    Gu, M.4    Liu, X.5    Wang, X.6    Hu, S.7    Chen, C.8    Liu, H.9    Liu, W.10    Chen, S.11    Peng, D.12
  • 17
    • 34547779411 scopus 로고    scopus 로고
    • Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks
    • Hulse-Post DJ, Franks J, Boyd K, Salomon R, Hoffmann E, Yen HL, Webby RJ, Walker D, Nguyen TD, Webster RG. 2007. Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks. J Virol 81:8515-8524. http://dx.doi.org/10.1128/JVI.00435-07.
    • (2007) J Virol , vol.81 , pp. 8515-8524
    • Hulse-Post, D.J.1    Franks, J.2    Boyd, K.3    Salomon, R.4    Hoffmann, E.5    Yen, H.L.6    Webby, R.J.7    Walker, D.8    Nguyen, T.D.9    Webster, R.G.10
  • 18
    • 33745158157 scopus 로고
    • A simple method of estimating fifty percent endpoints
    • Reed LJ, Muench H. 1938. A simple method of estimating fifty percent endpoints. Am J Hyg (Lond.) 27:493-497.
    • (1938) Am J Hyg (Lond.) , vol.27 , pp. 493-497
    • Reed, L.J.1    Muench, H.2
  • 19
    • 77955661784 scopus 로고    scopus 로고
    • Host response to influenza virus: protection versus immunopathology
    • Peiris JS, Hui KP, Yen HL. 2010. Host response to influenza virus: protection versus immunopathology. Curr Opin Immunol 22:475-481. http://dx.doi.org/10.1016/j.coi.2010.06.003.
    • (2010) Curr Opin Immunol , vol.22 , pp. 475-481
    • Peiris, J.S.1    Hui, K.P.2    Yen, H.L.3
  • 20
    • 84875015344 scopus 로고    scopus 로고
    • Lessons learned and concepts formed from study of the pathogenesis of the two negative-strand viruses lymphocytic choriomeningitis and influenza
    • Oldstone MB. 2013. Lessons learned and concepts formed from study of the pathogenesis of the two negative-strand viruses lymphocytic choriomeningitis and influenza. Proc Natl Acad Sci U S A 110:4180-4183. http://dx.doi.org/10.1073/pnas.1222025110.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 4180-4183
    • Oldstone, M.B.1
  • 22
    • 78650037441 scopus 로고    scopus 로고
    • PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza A viruses in mice
    • Zhou B, Li Y, Halpin R, Hine E, Spiro DJ, Wentworth DE. 2011. PB2 residue 158 is a pathogenic determinant of pandemic H1N1 and H5 influenza A viruses in mice. J Virol 85:357-365. http://dx.doi.org/10.1128/JVI.01694-10.
    • (2011) J Virol , vol.85 , pp. 357-365
    • Zhou, B.1    Li, Y.2    Halpin, R.3    Hine, E.4    Spiro, D.J.5    Wentworth, D.E.6
  • 23
    • 0028278094 scopus 로고
    • Apoptosis: a mechanism of cell killing by influenza A and B viruses
    • Hinshaw VS, Olsen CW, Dybdahl-Sissoko N, Evans D. 1994. Apoptosis: a mechanism of cell killing by influenza A and B viruses. J Virol 68:3667-3673.
    • (1994) J Virol , vol.68 , pp. 3667-3673
    • Hinshaw, V.S.1    Olsen, C.W.2    Dybdahl-Sissoko, N.3    Evans, D.4
  • 24
    • 0034975633 scopus 로고    scopus 로고
    • Human lymphocyte apoptosis after exposure to influenza A virus
    • Nichols JE, Niles JA, Roberts NJ, Jr. 2001. Human lymphocyte apoptosis after exposure to influenza A virus. J Virol 75:5921-5929. http://dx.doi.org/10.1128/JVI.73.13.5921-5929.2001.
    • (2001) J Virol , vol.75 , pp. 5921-5929
    • Nichols, J.E.1    Niles, J.A.2    Roberts, N.J.3
  • 25
    • 40149111112 scopus 로고    scopus 로고
    • Avian influenza virus A/HK/483/97(H5N1) NS1 protein induces apoptosis in human airway epithelial cells
    • Lam WY, Tang JW, Yeung AC, Chiu LC, Sung JJ, Chan PK. 2008. Avian influenza virus A/HK/483/97(H5N1) NS1 protein induces apoptosis in human airway epithelial cells. J Virol 82:2741-2751. http://dx.doi.org/10.1128/JVI.01712-07.
    • (2008) J Virol , vol.82 , pp. 2741-2751
    • Lam, W.Y.1    Tang, J.W.2    Yeung, A.C.3    Chiu, L.C.4    Sung, J.J.5    Chan, P.K.6
  • 26
    • 0042854788 scopus 로고    scopus 로고
    • Influenza A virus-induced apoptosis in bronchiolar epithelial (NCI-H292) cells limits pro-inflammatory cytokine release
    • Brydon EW, Smith H, Sweet C. 2003. Influenza A virus-induced apoptosis in bronchiolar epithelial (NCI-H292) cells limits pro-inflammatory cytokine release. J Gen Virol 84:2389-2400. http://dx.doi.org/10.1099/vir.0.18913-0.
    • (2003) J Gen Virol , vol.84 , pp. 2389-2400
    • Brydon, E.W.1    Smith, H.2    Sweet, C.3
  • 28
    • 0030704753 scopus 로고    scopus 로고
    • Differential induction of cytotoxicity and apoptosis by influenza virus strains of differing virulence
    • Price GE, Smith H, Sweet C. 1997. Differential induction of cytotoxicity and apoptosis by influenza virus strains of differing virulence. J Gen Virol 78(Part 11):2821-2829.
    • (1997) J Gen Virol , vol.78 , pp. 2821-2829
    • Price, G.E.1    Smith, H.2    Sweet, C.3
  • 29
    • 0034872412 scopus 로고    scopus 로고
    • Influenza virus NS1 protein induces apoptosis in cultured cells
    • Schultz-Cherry S, Dybdahl-Sissoko N, Neumann G, Kawaoka Y, Hinshaw VS. 2001. Influenza virus NS1 protein induces apoptosis in cultured cells. J Virol 75:7875-7881. http://dx.doi.org/10.1128/JVI.75.17.7875-7881.2001.
    • (2001) J Virol , vol.75 , pp. 7875-7881
    • Schultz-Cherry, S.1    Dybdahl-Sissoko, N.2    Neumann, G.3    Kawaoka, Y.4    Hinshaw, V.S.5
  • 30
    • 0027382362 scopus 로고
    • Induction of programmed cell death (apoptosis) by influenza virus infection in tissue culture cells
    • Takizawa T, Matsukawa S, Higuchi Y, Nakamura S, Nakanishi Y, Fukuda R. 1993. Induction of programmed cell death (apoptosis) by influenza virus infection in tissue culture cells. J Gen Virol 74(Part 11): 2347-2355. http://dx.doi.org/10.1099/0022-1317-74-11-2347.
    • (1993) J Gen Virol , vol.74 , pp. 2347-2355
    • Takizawa, T.1    Matsukawa, S.2    Higuchi, Y.3    Nakamura, S.4    Nakanishi, Y.5    Fukuda, R.6
  • 31
    • 23744512890 scopus 로고    scopus 로고
    • Role of apoptosis and cytokines in influenza virus morbidity
    • Brydon EW, Morris SJ, Sweet C. 2005. Role of apoptosis and cytokines in influenza virus morbidity. FEMS Microbiol Rev 29:837-850. http://dx.doi.org/10.1016/j.femsre.2004.12.003.
    • (2005) FEMS Microbiol Rev , vol.29 , pp. 837-850
    • Brydon, E.W.1    Morris, S.J.2    Sweet, C.3
  • 33
    • 0034051290 scopus 로고    scopus 로고
    • Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans
    • Tumpey TM, Lu X, Morken T, Zaki SR, Katz JM. 2000. Depletion of lymphocytes and diminished cytokine production in mice infected with a highly virulent influenza A (H5N1) virus isolated from humans. J Virol 74:6105-6116. http://dx.doi.org/10.1128/JVI.74.13.6105-6116.2000.
    • (2000) J Virol , vol.74 , pp. 6105-6116
    • Tumpey, T.M.1    Lu, X.2    Morken, T.3    Zaki, S.R.4    Katz, J.M.5
  • 34
    • 11444262203 scopus 로고    scopus 로고
    • Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1β and 18
    • Stasakova J, Ferko B, Kittel C, Sereinig S, Romanova J, Katinger H, Egorov A. 2005. Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1β and 18. J Gen Virol 86:185-195. http://dx.doi.org/10.1099/vir.0.80422-0.
    • (2005) J Gen Virol , vol.86 , pp. 185-195
    • Stasakova, J.1    Ferko, B.2    Kittel, C.3    Sereinig, S.4    Romanova, J.5    Katinger, H.6    Egorov, A.7
  • 35
    • 0036558369 scopus 로고    scopus 로고
    • Interaction of influenza A virus M1 matrix protein with caspases
    • Zhirnov OP, Ksenofontov AL, Kuzmina SG, Klenk HD. 2002. Interaction of influenza A virus M1 matrix protein with caspases. Biochemistry (Mosc.) 67:534-539. http://dx.doi.org/10.1023/A:1015542110798.
    • (2002) Biochemistry (Mosc.) , vol.67 , pp. 534-539
    • Zhirnov, O.P.1    Ksenofontov, A.L.2    Kuzmina, S.G.3    Klenk, H.D.4
  • 36
    • 0036148072 scopus 로고    scopus 로고
    • NS1 protein of influenza A virus down-regulates apoptosis
    • Zhirnov OP, Konakova TE, Wolff T, Klenk HD. 2002. NS1 protein of influenza A virus down-regulates apoptosis. J Virol 76:1617-1625. http://dx.doi.org/10.1128/JVI.76.4.1617-1625.2002.
    • (2002) J Virol , vol.76 , pp. 1617-1625
    • Zhirnov, O.P.1    Konakova, T.E.2    Wolff, T.3    Klenk, H.D.4
  • 39
    • 67650930744 scopus 로고    scopus 로고
    • Association of increased pathogenicity of Asian H5N1 highly pathogenic avian influenza viruses in chickens with highly efficient viral replication accompanied by early destruction of innate immune responses
    • Suzuki K, Okada H, Itoh T, Tada T, Mase M, Nakamura K, Kubo M, Tsukamoto K. 2009. Association of increased pathogenicity of Asian H5N1 highly pathogenic avian influenza viruses in chickens with highly efficient viral replication accompanied by early destruction of innate immune responses. J Virol 83:7475-7486. http://dx.doi.org/10.1128/JVI.01434-08.
    • (2009) J Virol , vol.83 , pp. 7475-7486
    • Suzuki, K.1    Okada, H.2    Itoh, T.3    Tada, T.4    Mase, M.5    Nakamura, K.6    Kubo, M.7    Tsukamoto, K.8
  • 40
    • 84873026459 scopus 로고    scopus 로고
    • The PB2, PA, HA, NP, and NS genes of a highly pathogenic avian influenza virus A/whooper swan/Mongolia/3/2005 (H5N1) are responsible for pathogenicity in ducks
    • Kajihara M, Sakoda Y, Soda K, Minari K, Okamatsu M, Takada A, Kida H. 2013. The PB2, PA, HA, NP, and NS genes of a highly pathogenic avian influenza virus A/whooper swan/Mongolia/3/2005 (H5N1) are responsible for pathogenicity in ducks. Virol J 10:45. http://dx.doi.org/10.1186/1743-422X-10-45.
    • (2013) Virol J , vol.10 , pp. 45
    • Kajihara, M.1    Sakoda, Y.2    Soda, K.3    Minari, K.4    Okamatsu, M.5    Takada, A.6    Kida, H.7
  • 41
    • 70449368433 scopus 로고    scopus 로고
    • Infection studies with two highly pathogenic avian influenza strains (Vietnamese and Indonesian) in Pekin ducks (Anas platyrhynchos), with particular reference to clinical disease, tissue tropism and viral shedding
    • Bingham J, Green DJ, Lowther S, Klippel J, Burggraaf S, Anderson DE, Wibawa H, Hoa DM, Long NT, Vu PP, Middleton DJ, Daniels PW. 2009. Infection studies with two highly pathogenic avian influenza strains (Vietnamese and Indonesian) in Pekin ducks (Anas platyrhynchos), with particular reference to clinical disease, tissue tropism and viral shedding. Avian Pathol 38:267-278. http://dx.doi.org/10.1080/03079450903055371.
    • (2009) Avian Pathol , vol.38 , pp. 267-278
    • Bingham, J.1    Green, D.J.2    Lowther, S.3    Klippel, J.4    Burggraaf, S.5    Anderson, D.E.6    Wibawa, H.7    Hoa, D.M.8    Long, N.T.9    Vu, P.P.10    Middleton, D.J.11    Daniels, P.W.12
  • 42
    • 56749133264 scopus 로고    scopus 로고
    • Pathogenesis of highly pathogenic avian influenza A/turkey/Turkey/1/2005 H5N1 in Pekin ducks (Anas platyrhynchos) infected experimentally
    • Löndt BZ, Nunez A, Banks J, Nili H, Johnson LK, Alexander DJ. 2008. Pathogenesis of highly pathogenic avian influenza A/turkey/Turkey/1/2005 H5N1 in Pekin ducks (Anas platyrhynchos) infected experimentally. Avian Pathol 37:619-627. http://dx.doi.org/10.1080/03079450802499126.
    • (2008) Avian Pathol , vol.37 , pp. 619-627
    • Löndt, B.Z.1    Nunez, A.2    Banks, J.3    Nili, H.4    Johnson, L.K.5    Alexander, D.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.