Stable mixed hematopoietic chimerism permits tolerance of vascularized composite allografts across a full major histocompatibility mismatch in swine

Transplant International

Volumn 27, Issue 10, 2014, Pages 1086-1096

  Mathes, David W ^a   Solari, Mario G ^b   Gazelle, Guy Scott ^c   Butler, Peter E M ^c   Wu, Anette ^c   Nazzal, Adam ^c   Nielsen, Gunnlauger P ^c   Huang, Christene A ^c   Sachs, David H ^c   Lee, Wei Ping Andrew ^d   Randolph, Mark A ^c  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

bone marrow; chimera; fetal; swine; vascularized composite allograft

Indexed keywords

ADULT; ALLELE; ALLOGENEIC BONE; ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEDIATED LYMPHOLYSIS; CHIMERA; COMPOSITE GRAFT; CONTROLLED STUDY; ENGRAFTMENT; EXPERIMENTAL PIG; FEMALE; FETUS; FLOW CYTOMETRY; GESTATIONAL AGE; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; LYMPHOCYTOTOXICITY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MATING; MINIPIG; MIXED LYMPHOCYTE REACTION; NONHUMAN; PRIORITY JOURNAL; SKIN GRAFT; T CELL DEPLETION; VASCULARIZED COMPOSITE ALLOGRAFT; YORKSHIRE PIG; ADVERSE EFFECTS; ALLOGRAFT; ANIMAL; BONE MARROW TRANSPLANTATION; BREEDING; DISEASE MODEL; GRAFT REJECTION; GRAFT SURVIVAL; HISTOCOMPATIBILITY; IMMUNOLOGY; MIXED LYMPHOCYTE CULTURE; PHYSIOLOGY; PIG; PREGNANCY; PROCEDURES; RANDOMIZATION; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SKIN TRANSPLANTATION; TRANSPLANTATION; TRANSPLANTATION TOLERANCE; VASCULARIZATION;

ALLOGRAFTS; ANIMALS; BONE MARROW TRANSPLANTATION; COMPOSITE TISSUE ALLOGRAFTS; DISEASE MODELS, ANIMAL; FEMALE; FLOW CYTOMETRY; GRAFT REJECTION; GRAFT SURVIVAL; HISTOCOMPATIBILITY; IMMUNE TOLERANCE; LYMPHOCYTE CULTURE TEST, MIXED; PREGNANCY; PREGNANCY, ANIMAL; RANDOM ALLOCATION; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SKIN TRANSPLANTATION; SWINE; SWINE, MINIATURE; TRANSPLANTATION CHIMERA; TRANSPLANTATION TOLERANCE;

EID: 84925403158     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/tri.12380     Document Type: Article

References (52)

1. Dubernard JM, Owen E, Herzberg G, et al,. Human hand allograft: report on first 6 months. Lancet 1999; 353: 1315.
2. Petruzzo P, Testelin S, Kanitakis J, et al,. First human face transplantation: 5 years outcomes. Transplantation 2012; 93: 236.
3. Pomahac B, Pribaz J, Eriksson E, et al,. Restoration of facial form and function after severe disfigurement from burn injury by a composite facial allograft. Am J Transplant 2011; 11: 386.
4. Pomahac B, Pribaz J, Eriksson E, et al,. Three patients with full facial transplantation. N Engl J Med 2012; 366: 715.
5. Huang CA, Fuchimoto Y, Scheier-Dolberg R, Murphy MC, Neville DM Jr, Sachs DH,. Stable mixed chimerism and tolerance using a nonmyeloablative preparative regimen in a large-animal model. J Clin Invest 2000; 105: 173.
6. Fuchimoto Y, Huang CA, Yamada K, et al,. Mixed chimerism and tolerance without whole body irradiation in a large animal model. J Clin Invest 2000; 105: 1779.
7. Fuchimoto Y, Huang CA, Gleit ZL, et al,. Mixed chimerism using a nonmyelosuppressive regimen in miniature swine. Transplant Proc 2001; 33: 118.
8. Cina RA, Wikiel KJ, Lee PW, et al,. Stable multilineage chimerism without graft versus host disease following nonmyeloablative haploidentical hematopoietic cell transplantation. Transplantation 2006; 81: 1677.
9. Horner BM, Cina RA, Wikiel KJ, et al,. Predictors of organ allograft tolerance following haematopoietic cell transplantation. Am J Transplant 2006; 6: 2894.
10. Schwarze ML, Menard MT, Fuchimoto Y, et al,. Mixed hematopoietic chimerism induces long-term tolerance to cardiac allografts in miniature swine. Ann Thorac Surg 2000; 70: 131; discussion 138.
11. Hettiaratchy S, Melendy E, Randolph MA, et al,. Tolerance to composite tissue allografts across a major histocompatibility barrier in miniature swine. Transplantation 2004; 77: 514.
12. Horner BM, Randolph MA, Duran-Struuck R, et al,. Induction of tolerance to an allogeneic skin flap transplant in a preclinical large animal model. Transplant Proc 2009; 41: 539.
13. Leonard DA, Kurtz JM, Mallard C, et al,. Vascularized composite allograft tolerance across MHC barriers in a large animal model. Am J Transplant. 2014; 14: 343.
14. Kuo YR, Goto S, Shih HS, et al,. Mesenchymal stem cells prolong composite tissue allotransplant survival in a swine model. Transplantation 2009; 87: 1769.
15. Carrier E, Lee TH, Busch MP, Cowan MJ,. Induction of tolerance in nondefective mice after in utero transplantation of major histocompatibility complex-mismatched fetal hematopoietic stem cells. Blood 1995; 86: 4681.
16. Hajdu K, Tanigawara S, McLean LK, Cowan MJ, Golbus MS,. In Utero allogeneic hematopoietic stem cell transplantation to induce tolerance. Fetal Diagn Ther 1996; 11: 241.
17. Flake AW, Harrison MR, Adzick NS, Zanjani ED,. Transplantation of fetal hematopoietic stem cells in utero: the creation of hematopoietic chimeras. Science 1986; 233: 776.
18. Harrison MR, Slotnick RN, Crombleholme TM, Golbus M, Tarantal AF, Zanjani ED,. In-utero transplantation of fetal liver haemopoietic stem cells in monkeys. Lancet 1989; 2: 1425.
19. Kim HB, Shaaban AF, Yang EY, Liechty KW, Flake AW,. Microchimerism and tolerance after in utero bone marrow transplantation in mice. J Surg Res 1998; 77: 1.
20. Fleischman RA, Mintz B,. Development of adult bone marrow stem cells in H-2 compatible and incompatible mouse fetuses. J Exp Med 1984; 159: 731.
21. Blazar BR, Taylor PA, Vallera DA,. In Utero transfer of adult bone marrow cells into recipients with severe combined immunodeficiency disorder yields lymphoid progeny with T- and B-cell functional capabilities. Blood 1995; 86: 4353.
22. Crombleholme TM, Harrison MR, Zanjani ED,. In utero transplantation of hematopoietic stem cells in sheep: the role of the T cells in engraftment and graft-versus-host disease. J Pediatr Surg 1990; 25: 885.
23. Cowan MJ, Tarantal AF, Capper J, Harrison M, Garovoy M,. Long term engraftment following in utero T cell depleted parental marrow transplantation into fetal rhesus monkeys. Bone Marrow Transplant 1996; 17: 1157.
24. Shields LE, Guar LK, Gough M, Potter J, Sieverkropp A, Andrews RG,. In utero hematopoietic stem cell transplantation in nonhuman primates: the role of T cells. Stem Cells 2003; 21: 304.
25. Mychaliska GB, Rice HE, Tarantal AF, et al,. In Utero hematopoietic stem cell transplants prolong survival of postnatal kidney transplantation in monkeys. J Pediatr Surg 1997; 32: 976.
26. Rubin JP, Cober SR, Butler PE, et al,. Injection of allogeneic bone marrow cells into the portal vein of swine in utero. J Surg Res 2001; 95: 188.
27. Mathes DW, Yamada K, Randolph MA, et al,. In utero induction of transplantation tolerance. Transplant Proc 2001; 33: 98.
28. Mathes DW, Solari MG, Randolph MA, et al,. Long-term acceptance of renal allografts following prenatal inoculation with adult bone marrow. Transplantation 2005; 80: 1300.
29. Lee PW, Cina RA, Randolph MA, et al,. Stable multilineage chimerism across full MHC barriers without graft-versus-host disease following in utero bone marrow transplantation in pigs. Exp Hematol 2005; 33: 371.
30. Lee PW, Cina RA, Randolph MA, et al,. In utero bone marrow transplantation induces kidney allograft tolerance across a full major histocompatibility barrier in swine. Transplantation 2005; 79: 1084.
31. Pennington LR, Lunney JK, Sachs DH,. Transplantation in miniature swine. VIII. Recombination within the major histocompatibility complex of miniature swine. Transplantation 1981; 31: 66.
32. Thistlewaite JR Jr, Auchincloss HJ, Lunney JK, Pennington LR, Pescovitz MD, Sachs DH,. Transplantation in miniature swine: in vitro testing and renal allograft survival in SLA-D matched swine. Transplant Proc 1983; 15: 152.
33. Leight GS, Sachs DH, Rosenberg SA,. Transplantation in miniature swine. II. In vitro parameters of histocompatibility in MSLA homozygous minipigs. Transplantation 1977; 23: 271.
34. Thistlethwaite JR Jr, Auchincloss H Jr, Pescovitz MD, Sachs DH,. Immunologic characterization of MHC recombinant swine: role of class I and II antigens in in vitro immune responses. J Immunogenet 1984; 11: 9.
35. Suzuki T, Sundt TM, Kortz EO,. Bone marrow transplantation across an MHC barrier in miniature swine. Transplant Proc 1989; 21: 3076.
36. Sakamoto K, Sachs DH, Shimada S, et al,. Bone marrow transplantation in miniature swine: III. Graft-versus-host-disease and the effect of T-cell depletion of marrow. Transplantation 1988; 45: 869.
37. Kirkman RL, Colvin RB, Flye MW, et al,. Transplantation in miniature swine. VI. Factors influencing survival of renal allografts. Transplantation 1979; 28: 18.
38. Huang CA, Lorf T, Arn JS, Koo GC, Blake T, Sachs DH,. Characterization of a monoclonal anti-porcine CD3 antibody. Xenotransplantation 1999; 6: 6210.
39. Pescovitz MD, Hsu SM, Katz SI, Lunney JK, Shimada S, Sachs DH,. Characterization of a porcine CD1-specific mAb that distinguishes CD4/CD8 double-positive thymic from peripheral T lymphocytes. Tissue Antigens 1990; 35: 151.
40. Pescovitz MD, Lunney JK, Sachs DH,. Preparation and characterization of monoclonal antibodies reactive with porcine PBL. J Immunol 1984; 133: 368.
41. Fuchimoto Y, Huang C, Shimizu A, Seebach J, Arn S, Sachs DH,. An allelic non-histocompatibility antigen with wide tissue distribution as a marker for chimerism in pigs. Tissue Antigens 1999; 54: 43.
42. Lee WP, Rubin JP, Bourget JL, et al,. Tolerance to limb tissue allografts between swine matched for major histocompatibility complex antigens. Plast Reconstr Surg 2001; 107: 1491.
43. Gianello PR, Sachs DH,. Effect of major histocompatibility complex matching on the development of tolerance to primarily vascularized renal allografts: a study in miniature swine. Hum Immunol 1996; 50: 1.
44. Bourget JL, Mathes DW, Nielsen GP, et al,. Tolerance to musculoskeletal allografts with transient lymphocyte chimerism in miniature swine. Transplantation 2001; 71: 851.
45. Lee WP, Yaremchuk MJ, Pan YC, Randolph MA, Tan CM, Weiland AJ,. Relative antigenicity of components of a vascularized limb allograft. Plast Reconstr Surg 1991; 87: 401.
46. Talmor M, Steinman RM, Codner MA, et al,. Bone marrow-derived chimerism in non-irradiated, cyclosporin-treated rats receiving microvascularized limb transplants: evidence for donor-derived dendritic cells in recipient lymphoid tissues. Immunology 1995; 86: 448.
47. Gianello PR, Blancho G, Fishbein JF, et al,. Mechanism of cyclosporine-induced tolerance to primarily vascularized allografts in miniature swine. J Immunol 1994; 133: 19.
48. Boyse EA, Lance EM, Carswell EA, Cooper S, Old LJ,. Rejection of skin allografts by radiation chimaeras: selective gene action in the specification of cell surface structure. Nature 1970; 227: 901.
49. Boyse EA, Old LJ,. Loss of skin allograft tolerance by chimeras. Transplantation 1968; 6: 619.
50. Silvers WK, Wachtel SS, Poole TW,. The behavior of skin grafts incompatible with respect to skin alloantigens on mice rendered tolerant at birth with lymphoid cells. J Exp Med 1976; 143: 1317.
51. Mathes DW, Randolph MA, Solari MG, et al,. Split tolerance to a composite tissue allograft in a swine model. Transplantation 2003; 75: 25.
52. Steinmuller D, Lofgreen JS,. Differential survival of skin and heart allografts in radiation chimaeras provides further evidence for Sk histocompatibility antigen. Nature 1974; 248: 796.