Breast cancer incidence after hormonal treatments for infertility: systematic review and meta-analysis of population-based studies

Breast Cancer Research and Treatment

Volumn 150, Issue 2, 2015, Pages 405-413

  Gennari, Alessandra ^a   Costa, Mauro ^b   Puntoni, Matteo ^a   Paleari, Laura ^a   De Censi, Andrea ^a   Sormani, Maria Pia ^c   Provinciali, Nicoletta ^a   Bruzzi, Paolo ^d  

^a GALLIERA HOSPITAL   (Italy)

^b Ospedale Evangelico Internazionale   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

Author keywords

Breast cancer risk; Cohort studies; Hormonal infertility treatments

Indexed keywords

FERTILITY PROMOTING AGENT;

ADVERSE EFFECTS; BREAST NEOPLASMS; CASE CONTROL STUDY; CHEMICALLY INDUCED; FEMALE; HUMAN; INCIDENCE; INFERTILITY; META ANALYSIS; OVULATION INDUCTION; RISK FACTOR;

BREAST NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; FERTILITY AGENTS, FEMALE; HUMANS; INCIDENCE; INFERTILITY; OVULATION INDUCTION; RISK FACTORS;

EID: 84925394545     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-015-3328-0     Document Type: Article

References (42)

1. Eliassen AH, Hankinson SE (2008) Endogenous hormone levels and risk of breast, endometrial and ovarian cancers: prospective studies. Adv Exp Med Biol 630:148–165
2. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Writing Group for the Women’s Health Initiative (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative. JAMA 288(3):321–333
3. Chlebowski RT, Hendrix SL, Langer RD, Stefanick ML, Gass M, Lane D et al (2003) Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women. JAMA 289(24):3243–3253
4. Eliassen AH, Missmer SA, Tworoger SS, Spiegelman D, Barbieri RL, Dowsett M et al (2006) Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women. J Natl Cancer Inst 98(19):1406–1415
5. Fortner RT, Eliassen AH, Spiegelman D, Willett WC, Barbieri RL, Hankinson SE (2013) Premenopausal endogenous steroid hormones and breast cancer risk: results from the nurses’ health study II. Breast Cancer Res Treat 15(2):R19
6. Källén B, Finnström O, Lindam A, Nilsson E, Nygren KG, Olausson PO (2011) Malignancies among women who gave birth after in vitro fertilization. Hum Reprod 26(1):253–258
7. Calderon-Margalit R, Friedlander Y, Yanetz R, Kleinhaus K, Perrin MC, Manor O et al (2009) Cancer risk after exposure to treatments for ovulation induction. Am J Epidemiol 169(3):365–375
8. Sunderam S, Kissin DM, Crawford D, Anderson JE, Folger SG, Jamieson DJ et al (2006) Assisted reproductive technology surveillance—United States. Morb Mortal Wly Rep 58:1–25
9. Li LL, Zhou J, Qian XJ, Chen YD (2013) Meta-analysis on the possible association between in vitro fertilization and cancer risk. Int J Gynecol Cancer 23(1):16–24
10. Sergentanis TN, Diamantaras AA, Perlepe C, Kanavidis P, Skalkidou A, Petridou ET (2014) IVF and breast cancer: a systematic review and meta-analysis. Hum Reprod Update 20:106–123
11. Zreik TG, Mazloom A, Chen Y (2010) Fertility drugs and the risk of breast cancer: a meta-analysis and review. Breast Cancer Res Treat 124:13–26
12. Kleinbaum DG, Kupper LL, Morgenstern H (1982) Epidemiologic research. Principles and quantitative methods. Van Nostrand Reinhold, New York
13. Stroup DF, Berlin JA, Morton SC (2000) Meta-analysis of observational studies in epidemiology. A proposal for reporting. JAMA 283:2008–2012
14. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 62:1006–1012
15. DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188
16. Steptoe PC, Edwards RG (1978) Birth after the reimplantation of a human embryo. Lancet 2:366
17. Rossing MA, Daling JR, Weiss NS, Moore DE, Self SG (1996) Risk of breast cancer in a cohort of infertile women. Gynecol Oncol 60:3–7
18. Potashnik G, Lerner-Geva L, Genkin L, Chetrit A, Lunenfeld E, Porath A (1999) Fertility drugs and the risk of breast and ovarian cancers: results of a long-term follow-up study. Fertil Steril 71:853–859
19. Venn A, Watson L, Bruinsma F, Giles G, Healy D (1999) Risk of cancer after use of fertility drugs with in vitro fertilisation. Lancet 354:1586–1590
20. Dor J, Lerner-Geva L, Rabinovici J, Chetrit A, Levran D, Lunenfeld B et al (2002) Cancer incidence in a cohort of infertile women who underwent in vitro fertilization. Fertil Steril 77:324–327
21. Doyle P, Maconochie N, Beral V, Swerdlow AJ, Tan SL (2002) Cancer incidence following treatment for infertility at a clinic in the UK. Hum Reprod 17:2209–2213
22. Lerner-Geva L, Geva E, Lessing JB, Chetrit A, Modan B, Amit A (2003) The possible association between in vitro fertilization treatments and cancer development. Int J Gynecol Cancer 13:23–27
23. Gauthier E, Paoletti X, Clavel-Chapelon F, E3N Group (2004) Breast cancer risk associated with being treated for infertility: results from the French E3N cohort study. Hum Reprod 19:2216–2221
24. Terry KL, Willett WC, Rich-Edwards JW, Michels KB (2006) A prospective study of infertility due to ovulatory disorders, ovulation induction, and incidence of breast cancer. Arch Intern Med 166:2484–2489
25. Jensen A, Sharif H, Svare EI, Frederiksen K, Kjaer SK (2007) Risk of breast cancer after exposure to fertility drugs: results from a large Danish cohort study. Cancer Epidemiol Biomark Prev 16:1400–1407
26. Pappo I, Lerner-Geva L, Halevy A, Olmer L, Friedler S, Raziel A et al (2008) The possible association between in vitro fertilization and breast cancer incidence. Ann Surg Oncol 15:1048–1055
27. Van den Belt-Dusebout SAW, Mooij TM, Burger CW, Van Leeuwen FE (2008) Breast cancer risk in a nation-wide cohort of 25,152 subfertile women in the Netherlands. Fertil Steril 90:S74
28. Orgéas CC, Sanner K, Hall P, Conner P, Holte J, Nilsson SJ (2009) Breast cancer incidence after hormonal infertility treatment in Sweden: a cohort study. Am J Obstet Gynecol 200(1):72.e1–72.e7
29. Yli-Kuha AN, Gissler M, Klemetti R, Luoto R, Hemminki E (2012) Cancer morbidity in a cohort of 9175 Finnish women treated for infertility. Hum Reprod 27:1149–1155
30. Stewart LM, Holman CD, Hart R, Bulsara MK, Preen DB, Finn JC (2012) In vitro fertilization and breast cancer: is there cause for concern? Fertil Steril 98:334–340
31. Lerner-Geva L, Rabinovici J, Olmer L, Blumstein T, Mashiach S, Lunenfeld B (2012) Are infertility treatments a potential risk factor for cancer development? Perspective of 30 years of follow-up. Gynecol Endocrinol 28:809–814
32. Brinton LA, Trabert B, Shalev V, Lunenfeld E, Sella T, Chodick G (2013) In vitro fertilization and risk of breast and gynecologic cancers: a retrospective cohort study within the Israeli Maccabi Healthcare Services. Fertil Steril 99:1189–1196
33. Brinton LA, Scoccia B, Moghissi KS, Westhoff CL, Niwa S, Ruggieri D et al (2014) Long-term relationship of ovulation-stimulating drugs to breast cancer risk. Cancer Epidemiol Biomark Prev 23:584–593
34. Reigstad MM, Larsen IK, Myklebust TÅ, Robsahm TE, Oldereid NB, Omland AK et al (2015) Risk of brest cancer following fertility treatment: a registry based cohort study of parous women in Norway. Int J Cancer 136:1140–1148
35. Bruzzi P, Negri E, La Vecchia C, Decarli A, Palli D, Parazzini F et al (1988) Short term increase in risk of breast cancer after full term pregnancy. BMJ 297:1096–1098
36. Adashi EY (1996) Ovulation induction: clomiphene citrate. In: Adashi EY, Rock JA, Rosenwaks Z (eds) Reproductive endocrinology, surgery, and technology. Lippencott-Raven, Philadelphia, pp 1182–1206
37. Hughes E, Brown J, Collins JJ, Vanderkerchove P (2010) Clomiphene citrate for unexplained subfertility in women. Cochrane Database Syst Rev, Issue 1. Art. No.: CD000057. doi:10.1002/14651858.CD000057.pub2
38. The Practice Committee of the American Society for Reproductive Medicine (2013) Use of clomiphene citrate in infertile women: a committee opinion. Fertil Steril 100:341–348
39. National Institute for Health and Care Excellence (2013) Fertility: assessment and treatment for people with fertility problems. http://www.nice.org.uk/cg156. Acccessed 30 Jan 2015
40. Goldstein SR, Siddhanti S, Ciaccia AV, Plouffe L Jr (2000) A pharmacological review of selective oestrogen receptor modulators. Hum Reprod Update 6:212–224
41. Mikkelson TJ, Kroboth PD, Cameron WJ, Dittert LW, Chungi V, Manberg PJ (1986) Single-dose pharmacokinetics of clomiphene citrate in normal volunteers. Fertil Steril 46:392–396
42. le Contonnec JY, Porchet HC, Beltrami V, Khan A, Toon S, Rowland M (1994) Clinical pharmacology of recombinant human follicle-stimulating hormone. II. Single doses and steady state pharmacokinetics. Fertil Steril 61:679–686