Premenopausal endogenous steroid hormones and breast cancer risk: Results from the Nurses' Health Study II

Breast Cancer Research

Volumn 15, Issue 2, 2013, Pages

  Fortner, Renée T ^a,b   Eliassen, A Heather ^a,b,c   Spiegelman, Donna ^b   Willett, Walter C ^a,b,c   Barbieri, Robert L ^a,c   Hankinson, Susan E ^a,b,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; ESTRONE; PRASTERONE SULFATE; PROGESTERONE; PROGESTERONE RECEPTOR; SEX HORMONE BINDING GLOBULIN; TUMOR MARKER;

ADULT; ARTICLE; BLOOD SAMPLING; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; FEMALE; FOLLICULAR PHASE; HUMAN; LUTEAL PHASE; MENOPAUSE; PREMENOPAUSE; BLOOD; BREAST NEOPLASMS; CANCER STAGING; CASE CONTROL STUDY; COMPARATIVE STUDY; FOLLOW UP; METABOLISM; MIDDLE AGED; NURSE; PATHOLOGY; PROGNOSIS; RADIOIMMUNOASSAY; RISK FACTOR; STATISTICS AND NUMERICAL DATA; WOMEN'S HEALTH;

ADULT; ANDROGENS; BREAST NEOPLASMS; CASE-CONTROL STUDIES; ESTRADIOL; FEMALE; FOLLOW-UP STUDIES; HUMANS; MIDDLE AGED; NEOPLASM STAGING; NURSES; PREMENOPAUSE; PROGESTERONE; PROGNOSIS; RADIOIMMUNOASSAY; RISK FACTORS; SEX HORMONE-BINDING GLOBULIN; TUMOR MARKERS, BIOLOGICAL; WOMEN'S HEALTH;

EID: 84874514034     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr3394     Document Type: Article

References (43)

1. Henderson BE, Feigelson HS. Hormonal carcinogenesis. Carcinogenesis 2000, 21:427-433. 10.1093/carcin/21.3.427, 10688862.
2. Macedo LF. Role of androgens on MCF-7 breast cancer cell growth and on the inhibitory effect of letrozole. Cancer Res 2006, 66:7775-7782. 10.1158/0008-5472.CAN-05-3984, 16885381.
3. Birrell SN, Bentel JM, Hickey TE, Ricciardelli C, Weger MA, Horsfall DJ, Tilley WD. Androgens induce divergent proliferative responses in human breast cancer cell lines. J Steroid Biochem Mol Biol 1995, 52:459-467. 10.1016/0960-0760(95)00005-K, 7748811.
4. Key T, Appleby P, Barnes I, Reeves G,. Endogenous Hormones and Breast Cancer Collaborative Group Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 2002, 94:606-616. 10.1093/jnci/94.8.606, 11959894, Endogenous Hormones and Breast Cancer Collaborative Group.
5. Dorgan JF, Stanczyk FZ, Kahle LL, Brinton LA. Prospective case-control study of premenopausal serum estradiol and testosterone levels and breast cancer risk. Breast Cancer Res 2010, 12:R98. 10.1186/bcr2779, 3046441, 21087481.
6. Thomas H, Key T, Allen D, Moore J, Dowsett M, Fentiman I, Wang D. A prospective study of endogenous serum hormone concentrations and breast cancer risk in premenopausal women on the island of Guernsey. Br J Cancer 1997, 75:1075. 10.1038/bjc.1997.183, 2222732, 9083346.
7. Helzlsouer KJ, Alberg AJ, Bush TL, Longcope C, Gordon GB, Comstock GW. A prospective study of endogenous hormones and breast cancer. Cancer Detect Prev 1994, 18:79-85.
8. Micheli A, Muti P, Secreto G, Krogh V, Meneghini E, Venturelli E, Sieri S, Pala V, Berrino F. Endogenous sex hormones and subsequent breast cancer in premenopausal women. Int J Cancer 2004, 112:312-318. 10.1002/ijc.20403, 15352045.
9. Rosenberg CR, Pasternack BS, Shore RE, Koenig KL, Toniolo PG. Premenopausal estradiol levels and the risk of breast cancer: a new method of controlling for day of the menstrual cycle. Am J Epidemiol 1994, 140:518-525.
10. Wysowski DK, Comstock GW, Helsing KJ, Lau HL. Sex hormone levels in serum in relation to the development of breast cancer. Am J Epidemiol 1987, 125:791-799.
11. Kabuto M, Akiba S, Stevens RG, Neriishi K, Land CE. A prospective study of estradiol and breast cancer in Japanese women. Cancer Epidemiol Biomarkers Prev 2000, 9:575-579.
12. Kaaks R, Berrino F, Key T, Rinaldi S, Dossus L, Biessy C, Secreto G, Amiano P, Bingham S, Boeing H, de Mesquita HB, Chang-Claude J, Clavel-Chapelon F, Fournier A, van Gils CH, Gonzalez CA, Gurrea AB, Critselis E, Khaw KT, Krogh V, Lahmann PH, Nagel G, Olsen A, Onland-Moret NC, Overvad K, Palli D, Panico S, Peeters P, Quiros JR, Roddam A, et al. Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). J Natl Cancer Inst 2005, 97:755-765. 10.1093/jnci/dji132, 15900045.
13. Eliassen AH, Missmer SA, Tworoger SS, Spiegelman D, Barbieri RL, Dowsett M, Hankinson SE. Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women. J Natl Cancer Inst 2006, 98:1406-1415. 10.1093/jnci/djj376, 17018787.
14. Tworoger SS, Missmer SA, Eliassen AH, Spiegelman D, Folkerd E, Dowsett M, Barbieri RL, Hankinson SE. The association of plasma DHEA and DHEA sulfate with breast cancer risk in predominantly premenopausal women. Cancer Epidemiol Biomarkers Prev 2006, 15:967-971. 10.1158/1055-9965.EPI-05-0976, 16702378.
15. Zeleniuch-Jacquotte A, Afanasyeva Y, Kaaks R, Rinaldi S, Scarmo S, Liu M, Arslan A, Toniolo P, Shore RE, Koenig KL. Premenopausal serum androgens and breast cancer risk: a nested case-control study. Breast Cancer Res 2012, 14:R32. 10.1186/bcr3117, 3496150, 22339988.
16. Rosenberg LU, Einarsdóttir K, Friman EI, Wedrén S, Dickman PW, Hall P, Magnusson C. Risk factors for hormone receptor-defined breast cancer in postmenopausal women. Cancer Epidemiol Biomarkers Prev 2006, 15:2482-2488. 10.1158/1055-9965.EPI-06-0489, 17164374.
17. Yang XR, Sherman ME, Rimm DL, Lissowska J, Brinton LA, Peplonska B, Hewitt SM, Anderson WF, Szeszenia-Dabrowska N, Bardin-Mikolajczak A, Zatonski W, Cartun R, Mandich D, Rymkiewicz G, Ligaj M, Lukaszek S, Kordek R, Garcia-Closas M. Differences in risk factors for breast cancer molecular subtypes in a population-based study. Cancer Epidemiol Biomarkers Prev 2007, 16:439-443. 10.1158/1055-9965.EPI-06-0806, 17372238.
18. Yang XR, Chang-Claude J, Goode EL, Couch FJ, Nevanlinna H, Milne RL, Gaudet M, Schmidt MK, Broeks A, Cox A, Fasching PA, Hein R, Spurdle AB, Blows F, Driver K, Flesch-Janys D, Heinz J, Sinn P, Vrieling A, Heikkinen T, Aittomäki K, Heikkilä P, Blomqvist C, Lissowska J, Peplonska B, Chanock S, Figueroa J, Brinton L, Hall P, Czene K, et al. Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. J Natl Cancer Inst 2011, 103:250-263. 10.1093/jnci/djq526, 3107570, 21191117.
19. Colditz GA, Rosner BA. What can be learnt from models of incidence rates?. Breast Cancer Res 2006, 8:208. 10.1186/bcr1414, 1557732, 16762045.
20. Missmer SA, Spiegelman D, Bertone-Johnson ER, Barbieri RL, Pollak MN, Hankinson SE. Reproducibility of plasma steroid hormones, prolactin, and insulin-like growth factor levels among premenopausal women over a 2- to 3-year period. Cancer Epidemiol Biomarkers Prev 2006, 15:972-978. 10.1158/1055-9965.EPI-05-0848, 16702379.
21. Hankinson SE, London SJ, Chute CG, Barbieri RL, Jones L, Kaplan LA, Sacks FM, Stampfer MJ. Effect of transport conditions on the stability of biochemical markers in blood. Clin Chem 1989, 35:2313-2316.
22. Judd HL, Lucas WE, Yen SS. Serum 17 beta-estradiol and estrone levels in postmenopausal women with and without endometrial cancer. J Clin Endocrinol Metab 1976, 43:272-278. 10.1210/jcem-43-2-272, 950362.
23. Mikhail G, Wu CH, Ferin M, Vande Wiele RL. Radioimmunoassay of plasma estrone and estradiol. Steroids 1970, 15:333-352. 10.1016/S0039-128X(70)80053-8, 5416088.
24. Kinouchi T, Pages L, Horton R. A specific radioimmunossay for testosterone in peripheral plasma. J Lab Clin Med 1973, 82:309-316.
25. Södergård R, Bäckström T, Shanbhag V, Carstensen H. Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. J Steroid Biochem 1982, 16:801-810. 10.1016/0022-4731(82)90038-3, 7202083.
26. Rosner B. Percentage points for a generalized ESD many-outlier procedure. Technometrics 1983, 25:165-172.
27. Rosner B, Cook N, Portman R, Daniels S, Falkner B. Determination of blood pressure percentiles in normal-weight children: some methodological issues. Am J Epidemiol 2008, 167:653-666.
28. Marshall RJ, Chisholm EM. Hypothesis testing in the polychotomous logistic model with an application to detecting gastrointestinal cancer. Statist Med 1985, 4:337-344.
29. Rosner B, Spiegelman D, Willett WC. Correction of logistic regression relative risk estimates and confidence intervals for measurement error: the case of multiple covariates measured with error. Am J Epidemiol 1990, 132:734-745.
30. Rosner B, Spiegelman D, Willett WC. Correction of logistic regression relative risk estimates and confidence intervals for random within-person measurement error. Am J Epidemiol 1992, 136:1400-1413.
31. Kaaks R, Rinaldi S, Key TJ, Berrino F, Peeters PH, Biessy C, Dossus L, Lukanova A, Bingham S, Khaw KT, Allen NE, Bueno-de-Mesquita HB, van Gils CH, Grobbee D, Boeing H, Lahmann PH, Nagel G, Chang-Claude J, Clavel-Chapelon F, Fournier A, Thiébaut A, González CA, Quirós JR, Tormo M-J, Ardanaz E, Amiano P, Krogh V, Palli D, Panico S, Tumino R, et al. Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition. Endocr Relat Cancer 2005, 12:1071-1082. 10.1677/erc.1.01038, 16322344.
32. Missmer SA, Eliassen AH, Barbieri RL, Hankinson SE. Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal women. J Natl Cancer Inst 2004, 96:1856-1865. 10.1093/jnci/djh336, 15601642.
33. Zeleniuch-Jacquotte A, Shore RE, Koenig KL, Akhmedkhanov A, Afanasyeva Y, Kato I, Kim MY, Rinaldi S, Kaaks R, Toniolo P. Postmenopausal levels of oestrogen, androgen, and SHBG and breast cancer: long-term results of a prospective study. Br J Cancer 2004, 90:153-159. 10.1038/sj.bjc.6601517, 2395327, 14710223.
34. Yager JD, Davidson NE. Estrogen carcinogenesis in breast cancer. N Engl J Med 2006, 354:270-282. 10.1056/NEJMra050776, 16421368.
35. Peters AA, Ingman WV, Tilley WD, Butler LM. Differential effects of exogenous androgen and an androgen receptor antagonist in the peri- and postpubertal murine mammary gland. Endocrinology 2011, 152:3728-3737. 10.1210/en.2011-1133, 21846805.
36. Zhou J, Ng S, Adesanya-Famuiya O, Anderson K, Bondy CA. Testosterone inhibits estrogen-induced mammary epithelial proliferation and suppresses estrogen receptor expression. FASEB J 2000, 14:1725-1730. 10.1096/fj.99-0863com, 10973921.
37. López-Marure R, Contreras PG, Dillon JS. Effects of dehydroepiandrosterone on proliferation, migration, and death of breast cancer cells. Eur J Pharmacol 2011, 660:268-274. 10.1016/j.ejphar.2011.03.040, 21497598.
38. Jefcoate CR, Liehr JG, Santen RJ, Sutter TR, Yager JD, Yue W, Santner SJ, Tekmal R, Demers L, Pauley R, Naftolin F, Mor G, Berstein L. Tissue-specific synthesis and oxidative metabolism of estrogens. J Natl Cancer Inst Monographs 2000, 95-112.
39. Prasad R, Boland GP, Cramer A, Anderson E, Knox WF, Bundred NJ. Short-term biologic response to withdrawal of hormone replacement therapy in patients with invasive breast carcinoma. Cancer 2003, 98:2539-2546. 10.1002/cncr.11836, 14669271.
40. Eliassen AH, Colditz GA, Rosner B, Willet WC, Hankinson SE. Adult weight change and risk of postmenopausal breast cancer. JAMA 2006, 296:193-201. 10.1001/jama.296.2.193, 16835425.
41. Vrieling A, Buck K, Kaaks R, Chang-Claude J. Adult weight gain in relation to breast cancer risk by estrogen and progesterone receptor status: a meta-analysis. Breast Cancer Res Treat 2010, 123:641-649. 10.1007/s10549-010-1116-4, 20711809.
42. Davison SL, Bell R, Donath S, Montalto JG, Davis SR. Androgen levels in adult females: changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab 2005, 90:3847-3853. 10.1210/jc.2005-0212, 15827095.
43. Kotsopoulos J, Narod SA. Androgens and breast cancer. Steroids 2012, 77:1-9. 10.1016/j.steroids.2011.10.002, 22015396.