-
1
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growthfactorreceptor(WJTOG3405):An open label, randomised phase 3 trial
-
Mitsudomi T, Morita S, Yatabe Y et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growthfactorreceptor(WJTOG3405):An open label, randomised phase 3 trial. Lancet Oncol 2010;11:121–128.
-
(2010)
Lancet Oncol
, vol.11
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
-
2
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
Maemondo M, Inoue A, Kobayashi K et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010;362: 2380–2388.
-
(2010)
N Engl J Med
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
-
3
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multi-centre, open-label, randomised, phase 3 study
-
Zhou C, Wu YL, Chen G et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multi-centre, open-label, randomised, phase 3 study. Lancet Oncol 2011;12:735–742.
-
(2011)
Lancet Oncol
, vol.12
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
-
4
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-celllung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
-
Rosell R, Carcereny E, Gervais R et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-celllung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012;13:239–246.
-
(2012)
Lancet Oncol
, vol.13
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
-
5
-
-
84884736973
-
Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
-
Sequist LV, Yang JC, Yamamoto N et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol 2013;31:3327–3334.
-
(2013)
J Clin Oncol
, vol.31
, pp. 3327-3334
-
-
Sequist, L.V.1
Yang, J.C.2
Yamamoto, N.3
-
6
-
-
84892997539
-
Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancerharbouring EGFR mutations (LUX-Lung 6):An open-label, randomised phase 3 trial
-
6.Wu YL, Zhou C, Hu CP et al. Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancerharbouring EGFR mutations (LUX-Lung 6):An open-label, randomised phase 3 trial. Lancet Oncol 2014;15:213–222.
-
(2014)
Lancet Oncol
, vol.15
, pp. 213-222
-
-
Yl, 6.WU.1
Zhou, C.2
Hu, C.P.3
-
7
-
-
84895501505
-
First-line erlotinib versus cisplatin/gemcitabine (GP) in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC): Interim analysis from the phase 3, open-label, ENSURE study
-
7.Wu YL, Liam CK, Zhou C et al. First-line erlotinib versus cisplatin/gemcitabine (GP) in patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC): Interim analysis from the phase 3, open-label, ENSURE study. J Thorac Oncol 2013;8(suppl 2):S603.
-
(2013)
J Thorac Oncol
, vol.8
, pp. 603
-
-
Yl, 7.WU.1
Liam, C.K.2
Zhou, C.3
-
8
-
-
84884959620
-
Lung cancer in never-smokers: Does smoking history matter in the era of molecular diagnostics and targeted therapy?
-
Ou SH. Lung cancer in never-smokers: Does smoking history matter in the era of molecular diagnostics and targeted therapy? J Clin Pathol 2013;66:839–846.
-
(2013)
J Clin Pathol
, vol.66
, pp. 839-846
-
-
Ou, S.H.1
-
9
-
-
84862880250
-
Quality of life with gefitinib in patients with EGFR-mutated non-small cell lung cancer: Quality of life analysis of North East Japan Study Group 002 Trial
-
Oizumi S, Kobayashi K, Inoue A et al. Quality of life with gefitinib in patients with EGFR-mutated non-small cell lung cancer: Quality of life analysis of North East Japan Study Group 002 Trial. The Oncologist 2012;17:863–870.
-
(2012)
The Oncologist
, vol.17
, pp. 863-870
-
-
Oizumi, S.1
Kobayashi, K.2
Inoue, A.3
-
10
-
-
84871597401
-
Updated overall survival results from a randomized phase III trial comparing gefitinib with carboplatin-paclitaxel for chemo-näıve non-small cell lung cancer with sensitive EGFR gene mutations (NEJ002)
-
Inoue A, Kobayashi K, Maemondo M et al. Updated overall survival results from a randomized phase III trial comparing gefitinib with carboplatin-paclitaxel for chemo-näıve non-small cell lung cancer with sensitive EGFR gene mutations (NEJ002). Ann Oncol 2013;24:54–59.
-
(2013)
Ann Oncol
, vol.24
, pp. 54-59
-
-
Inoue, A.1
Kobayashi, K.2
Maemondo, M.3
-
11
-
-
84866410479
-
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
-
Imielinski M, Berger AH, Hammerman PS etal. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 2012;150: 1107–1120.
-
(2012)
Cell
, vol.150
, pp. 1107-1120
-
-
Imielinski, M.1
Berger, A.H.2
Hammerman, P.S.3
-
12
-
-
84866434919
-
Genomic landscape of non-small cell lung cancer in smokers and never-smokers
-
Govindan R, Ding L, Griffith M et al. Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell 2012;150:1121-1134.
-
(2012)
Cell
, vol.150
, pp. 1121-1134
-
-
Govindan, R.1
Ding, L.2
Griffith, M.3
-
13
-
-
84882257259
-
Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells
-
Filosto S, Baston DS, Chung S et al. Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells. Mol Cancer Ther 2013;12:1579-1590.
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 1579-1590
-
-
Filosto, S.1
Baston, D.S.2
Chung, S.3
-
14
-
-
84879506069
-
Nicotine induces resistance to epidermal growth factor receptor tyrosine kinase inhibitor by a1 nicotinic acetylcholine receptor-mediated activation in PC9 cells
-
Wang S, Takayama K, Tanaka K et al. Nicotine induces resistance to epidermal growth factor receptor tyrosine kinase inhibitor by a1 nicotinic acetylcholine receptor-mediated activation in PC9 cells. J Thorac Oncol 2013;8:719-725.
-
(2013)
J Thorac Oncol
, vol.8
, pp. 719-725
-
-
Wang, S.1
Takayama, K.2
Tanaka, K.3
-
15
-
-
33646238486
-
Effects of smoking on the pharmacokinetics of erlotinib
-
Hamilton M, Wolf JL, Rusk J et al. Effects of smoking on the pharmacokinetics of erlotinib. Clin Cancer Res 2006;12:2166-2171.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2166-2171
-
-
Hamilton, M.1
Wolf, J.L.2
Rusk, J.3
-
16
-
-
62449241907
-
Overcoming CYP1A1/1A2 mediated induction of metabolism by escalating erlotinib dose in current smokers
-
Hughes AN, O’Brien MER, Petty WJ et al. Overcoming CYP1A1/1A2 mediated induction of metabolism by escalating erlotinib dose in current smokers. J Clin Oncol 2009;27:1220-1226.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1220-1226
-
-
Hughes, A.N.1
O’Brien, M.2
Petty, W.J.3
-
17
-
-
84899475405
-
Impact of cigarette smoking on response to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors in lung adenocarcinoma with activating EGFR mutations
-
Kim MH, Kim HR, Cho BC et al. Impact of cigarette smoking on response to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors in lung adenocarcinoma with activating EGFR mutations. Lung Cancer 2014;84:196-202.
-
(2014)
Lung Cancer
, vol.84
, pp. 196-202
-
-
Kim, M.H.1
Kim, H.R.2
Cho, B.C.3
-
18
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361:947-957.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
19
-
-
84861976809
-
First-SIGNAL: First-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung
-
Han JY, Park K, Kim S W et al. First-SIGNAL: First-line single-agent iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung. J Clin Oncol 2012;30:1122-1128.
-
(2012)
J Clin Oncol
, vol.30
, pp. 1122-1128
-
-
Han, J.Y.1
Park, K.2
Kim, S.W.3
-
20
-
-
33947287270
-
Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib
-
Mulloy R, Ferrand A, Kim Y et al. Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib. Cancer Res 2007; 67:2325-2330.
-
(2007)
Cancer Res
, vol.67
, pp. 2325-2330
-
-
Mulloy, R.1
Ferrand, A.2
Kim, Y.3
-
21
-
-
33748066632
-
Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib
-
Carey KD, Garton AJ, Romero MS et al. Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib. Cancer Res 2006;66: 8163-8171.
-
(2006)
Cancer Res
, vol.66
, pp. 8163-8171
-
-
Carey, K.D.1
Garton, A.J.2
Romero, M.S.3
-
22
-
-
32944481596
-
Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib
-
Riely GJ, Pao W, Pham D et al. Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. Clin Cancer Res 2006;12:839-844.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 839-844
-
-
Riely, G.J.1
Pao, W.2
Pham, D.3
-
23
-
-
33746034167
-
Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib
-
Jackman DM, Yeap BY, Sequist LV et al. Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib. Clin Cancer Res 2006;12: 3908-3914.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3908-3914
-
-
Jackman, D.M.1
Yeap, B.Y.2
Sequist, L.V.3
-
24
-
-
84905585380
-
Exon 19 deletion association with progression-free survival compared to L858R mutation at exon 21 in treatment with first-line EGFR-TKIs: A meta-analysis of subgroup data from eight phase III randomized controlled trials
-
Liang W Sheng J, Wu X et al. Exon 19 deletion association with progression-free survival compared to L858R mutation at exon 21 in treatment with first-line EGFR-TKIs: A meta-analysis of subgroup data from eight phase III randomized controlled trials. J Clin Oncol 2014;32(suppl):8107a.
-
(2014)
J Clin Oncol
, vol.32
, pp. 8107a
-
-
Liang W Sheng, J.1
Wu, X.2
-
25
-
-
84921892043
-
Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): Analysis of overall survival data from two randomised, phase 3 trials
-
[Epub ahead of print]
-
Yang JC, Wu YL, Schuler M et al. Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): Analysis of overall survival data from two randomised, phase 3 trials. Lancet Oncol 2015 [Epub ahead of print].
-
(2015)
Lancet Oncol
-
-
Yang, J.C.1
Wu, Y.L.2
Schuler, M.3
-
26
-
-
84879501751
-
Epidermal growth factor receptor mutations in lung adenocarcinoma in Malaysian patients
-
Liam CK, Wahid MIA, Rajadurai P et al. Epidermal growth factor receptor mutations in lung adenocarcinoma in Malaysian patients. J Thorac Oncol 2013;8:766-772.
-
(2013)
J Thorac Oncol
, vol.8
, pp. 766-772
-
-
Liam, C.K.1
Wahid, M.2
Rajadurai, P.3
-
27
-
-
84893353535
-
A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology (PIONEER)
-
Shi Y, Au JS, Thongprasert S et al. A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology (PIONEER). J Thorac Oncol 2014;9:154-162.
-
(2014)
J Thorac Oncol
, vol.9
, pp. 154-162
-
-
Shi, Y.1
Au, J.S.2
Thongprasert, S.3
|