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Volumn 21, Issue 9, 2015, Pages 2807-2815

Prognostic significance of neutrophil to lymphocyte ratio in pancreatic cancer: A meta-analysis

Author keywords

Cancer specific survival; Clinicopathological features; Meta analysis; Neutrophil to lymphocyte ratio; Overall survival; Pancreatic cancer

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN;

EID: 84925381613     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v21.i9.2807     Document Type: Article
Times cited : (173)

References (49)
  • 1
    • 84855792427 scopus 로고    scopus 로고
    • Cancer statistics, 2012
    • 22237781
    • Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012; 62: 10-29 [PMID: 22237781 DOI: 10.3322/caac.20138].
    • (2012) CA Cancer J Clin , vol.62 , pp. 10-29
    • Siegel, R.1    Naishadham, D.2    Jemal, A.3
  • 8
    • 84899933323 scopus 로고    scopus 로고
    • Clinical significance of elevated serum soluble CD40 ligand levels as a diagnostic and prognostic tumor marker for pancreatic ductal adenocarcinoma
    • 24745825
    • Chung HW, Lim JB. Clinical significance of elevated serum soluble CD40 ligand levels as a diagnostic and prognostic tumor marker for pancreatic ductal adenocarcinoma. J Transl Med 2014; 12: 102 [PMID: 24745825 DOI: 10.1186/1479-5876-12-102].
    • (2014) J Transl Med , vol.12 , pp. 102
    • Chung, H.W.1    Lim, J.B.2
  • 9
    • 84871990400 scopus 로고    scopus 로고
    • Targeting the hallmarks of cancer: Towards a rational approach to next-generation cancer therapy
    • 23150341
    • Hainaut P, Plymoth A. Targeting the hallmarks of cancer: towards a rational approach to next-generation cancer therapy. Curr Opin Oncol 2013; 25: 50-51 [PMID: 23150341 DOI: 10.1097/CCO.0b013e32835b651e].
    • (2013) Curr Opin Oncol , vol.25 , pp. 50-51
    • Hainaut, P.1    Plymoth, A.2
  • 10
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • 21376230
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674 [PMID: 21376230 DOI: 10.1016/j.cell.2011.02.013].
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 11
    • 0033969322 scopus 로고    scopus 로고
    • Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism
    • 10646872
    • Jaiswal M, LaRusso NF, Burgart LJ, Gores GJ. Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism. Cancer Res 2000; 60: 184-190 [PMID: 10646872].
    • (2000) Cancer Res , vol.60 , pp. 184-190
    • Jaiswal, M.1    LaRusso, N.F.2    Burgart, L.J.3    Gores, G.J.4
  • 13
    • 84898665929 scopus 로고    scopus 로고
    • Prognostic role of NLR in urinary cancers: A meta-analysis
    • 24642859
    • Wei Y, Jiang YZ, Qian WH. Prognostic role of NLR in urinary cancers: a meta-analysis. PLoS One 2014; 9: e92079 [PMID: 24642859 DOI: 10.1371/journal.pone.0092079].
    • (2014) PLoS One , vol.9 , pp. e92079
    • Wei, Y.1    Jiang, Y.Z.2    Qian, W.H.3
  • 14
    • 84898847636 scopus 로고    scopus 로고
    • The modified Glasgow prognostic score as a predictor of survival after hepatectomy for colorectal liver metastases
    • 24452408
    • Nakagawa K, Tanaka K, Nojiri K, Kumamoto T, Takeda K, Ueda M, Endo I. The modified Glasgow prognostic score as a predictor of survival after hepatectomy for colorectal liver metastases. Ann Surg Oncol 2014; 21: 1711-1718 [PMID: 24452408 DOI: 10.1245/s10434-013-3342-6].
    • (2014) Surg Oncol , vol.21 , pp. 1711-1718
    • Nakagawa, K.1    Tanaka, K.2    Nojiri, K.3    Kumamoto, T.4    Takeda, K.5    Ueda, M.6    Endo, I.7
  • 15
    • 54849431185 scopus 로고    scopus 로고
    • Pretreatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment
    • 18414853
    • Cho H, Hur HW, Kim SW, Kim SH, Kim JH, Kim YT, Lee K. Pretreatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment. Cancer Immunol Immunother 2009; 58: 15-23 [PMID: 18414853 DOI: 10.1007/s00262-008-0516-3].
    • (2009) Immunol Immunother , vol.58 , pp. 15-23
    • Cho, H.1    Hur, H.W.2    Kim, S.W.3    Kim, S.H.4    Kim, J.H.5    Kim, Y.T.6    Lee, K.7
  • 16
    • 79951772403 scopus 로고    scopus 로고
    • The effect of peripheral blood values on prognosis of patients with locally advanced gastric cancer before treatment
    • 19847679
    • Aliustaoglu M, Bilici A, Ustaalioglu BB, Konya V, Gucun M, Seker M, Gumus M. The effect of peripheral blood values on prognosis of patients with locally advanced gastric cancer before treatment. Med Oncol 2010; 27: 1060-1065 [PMID: 19847679 DOI: 10.1007/s12032-009-9335-4].
    • (2010) Med Oncol , vol.27 , pp. 1060-1065
    • Aliustaoglu, M.1    Bilici, A.2    Ustaalioglu, B.B.3    Konya, V.4    Gucun, M.5    Seker, M.6    Gumus, M.7
  • 17
    • 84895918314 scopus 로고    scopus 로고
    • Prognostic role of neutrophilto-lymphocyte ratio in colorectal cancer: A systematic review and meta-analysis
    • 24122750
    • Li MX, Liu XM, Zhang XF, Zhang JF, Wang WL, Zhu Y, Dong J, Cheng JW, Liu ZW, Ma L, Lv Y. Prognostic role of neutrophilto-lymphocyte ratio in colorectal cancer: a systematic review and meta-analysis. Int J Cancer 2014; 134: 2403-2413 [PMID: 24122750 DOI: 10.1002/ijc.28536].
    • (2014) Int J Cancer , vol.134 , pp. 2403-2413
    • Li, M.X.1    Liu, X.M.2    Zhang, X.F.3    Zhang, J.F.4    Wang, W.L.5    Zhu, Y.6    Dong, J.7    Cheng, J.W.8    Liu, Z.W.9    Ma, L.10    Lv, Y.11
  • 19
    • 34547450763 scopus 로고    scopus 로고
    • Practical methods for incorporating summary time-to-event data into meta-analysis
    • 17555582
    • Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials 2007; 8: 16 [PMID: 17555582 DOI: 10.1186/1745-6215-8-16].
    • (2007) Trials , vol.8 , pp. 16
    • Tierney, J.F.1    Stewart, L.A.2    Ghersi, D.3    Burdett, S.4    Sydes, M.R.5
  • 20
    • 79952183487 scopus 로고    scopus 로고
    • Preoperative neutrophil-to-lymphocyte ratio (NLR) is associated with reduced disease-free survival following curative resection of pancreatic adenocarcinoma
    • 21312035
    • Garcea G, Ladwa N, Neal CP, Metcalfe MS, Dennison AR, Berry DP. Preoperative neutrophil-to-lymphocyte ratio (NLR) is associated with reduced disease-free survival following curative resection of pancreatic adenocarcinoma. World J Surg 2011; 35: 868-872 [PMID: 21312035 DOI: 10.1007/s00268-011-0984-z].
    • (2011) World J Surg , vol.35 , pp. 868-872
    • Garcea, G.1    Ladwa, N.2    Neal, C.P.3    Metcalfe, M.S.4    Dennison, A.R.5    Berry, D.P.6
  • 21
    • 84903825223 scopus 로고    scopus 로고
    • Prognostic value of systemic inflammation-based markers in advanced pancreatic cancer
    • 24750233
    • Martin HL, Ohara K, Kiberu A, Van Hagen T, Davidson A, Khattak MA. Prognostic value of systemic inflammation-based markers in advanced pancreatic cancer. Intern Med J 2014; 44: 676-682 [PMID: 24750233 DOI: 10.1111/imj.12453].
    • (2014) Intern Med J , vol.44 , pp. 676-682
    • Martin, H.L.1    Ohara, K.2    Kiberu, A.3    Van Hagen, T.4    Davidson, A.5    Khattak, M.A.6
  • 22
    • 84880314861 scopus 로고    scopus 로고
    • Comparison of the prognostic values of various inflammation based factors in patients with pancreatic cancer
    • 22476808
    • Wang DS, Luo HY, Qiu MZ, Wang ZQ, Zhang DS, Wang FH, Li YH, Xu RH. Comparison of the prognostic values of various inflammation based factors in patients with pancreatic cancer. Med Oncol 2012; 29: 3092-3100 [PMID: 22476808 DOI: 10.1007/s12032-012-0226-8].
    • (2012) Med Oncol , vol.29 , pp. 3092-3100
    • Wang, D.S.1    Luo, H.Y.2    Qiu, M.Z.3    Wang, Z.Q.4    Zhang, D.S.5    Wang, F.H.6    Li, Y.H.7    Xu, R.H.8
  • 24
    • 84892368842 scopus 로고    scopus 로고
    • Elevated preoperative neutrophil-to-lymphocyte ratio as a predictor of survival after gastroenterostomy in patients with advanced pancreatic adenocarcinoma
    • 23982254
    • Sugiura T, Uesaka K, Kanemoto H, Mizuno T, Okamura Y. Elevated preoperative neutrophil-to-lymphocyte ratio as a predictor of survival after gastroenterostomy in patients with advanced pancreatic adenocarcinoma. Ann Surg Oncol 2013; 20: 4330-4337 [PMID: 23982254 DOI: 10.1245/s10434-013-3227-8].
    • (2013) Ann Surg Oncol , vol.20 , pp. 4330-4337
    • Sugiura, T.1    Uesaka, K.2    Kanemoto, H.3    Mizuno, T.4    Okamura, Y.5
  • 25
    • 77955894120 scopus 로고    scopus 로고
    • Preoperative hematologic markers as independent predictors of prognosis in resected pancreatic ductal adenocarcinoma: Neutrophil-lymphocyte versus platelet-lymphocyte ratio
    • 20122680
    • Bhatti I, Peacock O, Lloyd G, Larvin M, Hall RI. Preoperative hematologic markers as independent predictors of prognosis in resected pancreatic ductal adenocarcinoma: neutrophil-lymphocyte versus platelet-lymphocyte ratio. Am J Surg 2010; 200: 197-203 [PMID: 20122680 DOI: 10.1016/j.amjsurg.2009.08.041].
    • (2010) Am J Surg , vol.200 , pp. 197-203
    • Bhatti, I.1    Peacock, O.2    Lloyd, G.3    Larvin, M.4    Hall, R.I.5
  • 27
    • 84890885973 scopus 로고    scopus 로고
    • Prognostic role of neutrophil-to-lymphocyte ratio in advanced pancreatic ductal adenocarcinoma: Impact of baseline fluctuation and changes during chemotherapy
    • 24326841
    • Teo M, Mohd Sharial MS, McDonnell F, Conlon KC, Ridgway PF, McDermott RS. Prognostic role of neutrophil-to-lymphocyte ratio in advanced pancreatic ductal adenocarcinoma: impact of baseline fluctuation and changes during chemotherapy. Tumori 2013; 99: 516-522 [PMID: 24326841 DOI: 10.1700/1361.15104].
    • (2013) Tumori , vol.99 , pp. 516-522
    • Teo, M.1    Mohd Sharial, M.S.2    McDonnell, F.3    Conlon, K.C.4    Ridgway, P.F.5    McDermott, R.S.6
  • 28
    • 77955862760 scopus 로고    scopus 로고
    • Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer
    • 20602543
    • An X, Ding PR, Li YH, Wang FH, Shi YX, Wang ZQ, He YJ, Xu RH, Jiang WQ. Elevated neutrophil to lymphocyte ratio predicts survival in advanced pancreatic cancer. Biomarkers 2010; 15: 516-522 [PMID: 20602543 DOI: 10.3109/1354750x.2010.491557].
    • (2010) Biomarkers , vol.15 , pp. 516-522
    • An, X.1    Ding, P.R.2    Li, Y.H.3    Wang, F.H.4    Shi, Y.X.5    Wang, Z.Q.6    He, Y.J.7    Xu, R.H.8    Jiang, W.Q.9
  • 31
    • 0026907926 scopus 로고
    • Tumor-infiltrating lymphocytes and prognosis of hepatocellular carcinoma
    • 1331571
    • Kawata A, Une Y, Hosokawa M, Uchino J, Kobayashi H. Tumor-infiltrating lymphocytes and prognosis of hepatocellular carcinoma. Jpn J Clin Oncol 1992; 22: 256-263 [PMID: 1331571].
    • (1992) Jpn J Clin Oncol , vol.22 , pp. 256-263
    • Kawata, A.1    Une, Y.2    Hosokawa, M.3    Uchino, J.4    Kobayashi, H.5
  • 32
    • 0028911185 scopus 로고
    • Free-form neutrophil elastase is an independent marker predicting recurrence in primary breast cancer
    • 7884307
    • Yamashita J, Ogawa M, Shirakusa T. Free-form neutrophil elastase is an independent marker predicting recurrence in primary breast cancer. J Leukoc Biol 1995; 57: 375-378 [PMID: 7884307].
    • (1995) J Leukoc Biol , vol.57 , pp. 375-378
    • Yamashita, J.1    Ogawa, M.2    Shirakusa, T.3
  • 33
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • 11229684
    • Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001; 357: 539-545 [PMID: 11229684 DOI: 10.1016/s0140-6736(00)04046-0]
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 34
    • 3343016654 scopus 로고    scopus 로고
    • Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor
    • 15166496
    • Kusumanto YH, Dam WA, Hospers GA, Meijer C, Mulder NH. Platelets and granulocytes, in particular the neutrophils, form important compartments for circulating vascular endothelial growth factor. Angiogenesis 2003; 6: 283-287 [PMID: 15166496].
    • (2003) Angiogenesis , vol.6 , pp. 283-287
    • Kusumanto, Y.H.1    Dam, W.A.2    Hospers, G.A.3    Meijer, C.4    Mulder, N.H.5
  • 35
    • 33947110880 scopus 로고    scopus 로고
    • Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape
    • 17329145
    • Salazar-Onfray F, López MN, Mendoza-Naranjo A. Paradoxical effects of cytokines in tumor immune surveillance and tumor immune escape. Cytokine Growth Factor Rev 2007; 18: 171-182 [PMID: 17329145 DOI: 10.1016/j.cytogfr.2007.01.015].
    • (2007) Cytokine Growth Factor Rev , vol.18 , pp. 171-182
    • Salazar-Onfray, F.1    López, M.N.2    Mendoza-Naranjo, A.3
  • 36
    • 0032770957 scopus 로고    scopus 로고
    • Tumor-associated transforming growth factor-beta and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients
    • 10433946
    • Bellone G, Turletti A, Artusio E, Mareschi K, Carbone A, Tibaudi D, Robecchi A, Emanuelli G, Rodeck U. Tumor-associated transforming growth factor-beta and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients. Am J Pathol 1999; 155: 537-547 [PMID: 10433946].
    • (1999) Am J Pathol , vol.155 , pp. 537-547
    • Bellone, G.1    Turletti, A.2    Artusio, E.3    Mareschi, K.4    Carbone, A.5    Tibaudi, D.6    Robecchi, A.7    Emanuelli, G.8    Rodeck, U.9
  • 37
    • 0013807039 scopus 로고
    • The fine structure of cerebral fluid accumulation. IX. Edema following silver nitrate implantation
    • 5837731
    • Hirano A, Zimmerman HM, Levine S. The fine structure of cerebral fluid accumulation. IX. Edema following silver nitrate implantation. Am J Pathol 1965; 47: 537-548 [PMID: 5837731].
    • (1965) Am J Pathol , vol.47 , pp. 537-548
    • Hirano, A.1    Zimmerman, H.M.2    Levine, S.3
  • 38
    • 4143141823 scopus 로고    scopus 로고
    • The immunobiology of cancer immunosurveillance and immunoediting
    • 15308095
    • Dunn GP, Old LJ, Schreiber RD. The immunobiology of cancer immunosurveillance and immunoediting. Immunity 2004; 21: 137-148 [PMID: 15308095 DOI: 10.1016/j.immuni.2004.07.017].
    • (2004) Immunity , vol.21 , pp. 137-148
    • Dunn, G.P.1    Old, L.J.2    Schreiber, R.D.3
  • 39
    • 0035902080 scopus 로고    scopus 로고
    • Progress in human tumour immunology and immunotherapy
    • 11357146
    • Rosenberg SA. Progress in human tumour immunology and immunotherapy. Nature 2001; 411: 380-384 [PMID: 11357146 DOI: 10.1038/35077246].
    • (2001) Nature , vol.411 , pp. 380-384
    • Rosenberg, S.A.1
  • 40
    • 79959709842 scopus 로고    scopus 로고
    • Lung T-cell subset composition at the time of surgical resection is a prognostic indicator in non-small cell lung cancer
    • 21373990
    • Zikos TA, Donnenberg AD, Landreneau RJ, Luketich JD, Donnenberg VS. Lung T-cell subset composition at the time of surgical resection is a prognostic indicator in non-small cell lung cancer. Cancer Immunol Immunother 2011; 60: 819-827 [PMID: 21373990 DOI: 10.1007/s00262-011-0996-4].
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 819-827
    • Zikos, T.A.1    Donnenberg, A.D.2    Landreneau, R.J.3    Luketich, J.D.4    Donnenberg, V.S.5
  • 42
    • 0036396275 scopus 로고    scopus 로고
    • Role of blood platelets in infection and inflammation
    • 12396713
    • Klinger MH, Jelkmann W. Role of blood platelets in infection and inflammation. J Interferon Cytokine Res 2002; 22: 913-922 [PMID: 12396713 DOI: 10.1089/10799900260286623].
    • (2002) J Interferon Cytokine Res , vol.22 , pp. 913-922
    • Klinger, M.H.1    Jelkmann, W.2
  • 43
    • 84900424234 scopus 로고    scopus 로고
    • C-reactive protein as a prognostic factor for human osteosarcoma: A meta-analysis and literature review
    • 24800842
    • Yi JH, Wang D, Li ZY, Hu J, Niu XF, Liu XL. C-reactive protein as a prognostic factor for human osteosarcoma: a meta-analysis and literature review. PLoS One 2014; 9: e94632 [PMID: 24800842 DOI: 10.1371/journal.pone.0094632].
    • (2014) PLoS One , vol.9 , pp. e94632
    • Yi, J.H.1    Wang, D.2    Li, Z.Y.3    Hu, J.4    Niu, X.F.5    Liu, X.L.6
  • 44
    • 84900472812 scopus 로고    scopus 로고
    • Prognostic role of C-reactive protein in prostate cancer: A systematic review and meta-analysis
    • 24589465
    • Liu ZQ, Chu L, Fang JM, Zhang X, Zhao HX, Chen YJ, Xu Q. Prognostic role of C-reactive protein in prostate cancer: a systematic review and meta-analysis. Asian J Androl 2014; 16: 467-471 [PMID: 24589465 DOI: 10.4103/1008-682x.123686].
    • (2014) Asian J Androl , vol.16 , pp. 467-471
    • Liu, Z.Q.1    Chu, L.2    Fang, J.M.3    Zhang, X.4    Zhao, H.X.5    Chen, Y.J.6    Xu, Q.7
  • 45
    • 84875881139 scopus 로고    scopus 로고
    • Prognostic role of C-reactive protein in hepatocellular carcinoma: A systematic review and meta-analysis
    • 23569429
    • Zheng Z, Zhou L, Gao S, Yang Z, Yao J, Zheng S. Prognostic role of C-reactive protein in hepatocellular carcinoma: a systematic review and meta-analysis. Int J Med Sci 2013; 10: 653-664 [PMID: 23569429 DOI: 10.7150/ijms.6050].
    • (2013) Int J Med Sci , vol.10 , pp. 653-664
    • Zheng, Z.1    Zhou, L.2    Gao, S.3    Yang, Z.4    Yao, J.5    Zheng, S.6
  • 46
    • 84892931076 scopus 로고    scopus 로고
    • Prognostic significance of serum albumin in patients with metastatic renal cell carcinoma
    • 24477648
    • Stenman M, Laurell A, Lindskog M. Prognostic significance of serum albumin in patients with metastatic renal cell carcinoma. Med Oncol 2014; 31: 841 [PMID: 24477648 DOI: 10.1007/s12032-014-0841-7].
    • (2014) Med Oncol , vol.31 , pp. 841
    • Stenman, M.1    Laurell, A.2    Lindskog, M.3
  • 47
    • 84876986843 scopus 로고    scopus 로고
    • The systemic inflammation-based Glasgow Prognostic Score: A decade of experience in patients with cancer
    • 22995477
    • McMillan DC. The systemic inflammation-based Glasgow Prognostic Score: a decade of experience in patients with cancer. Cancer Treat Rev 2013; 39: 534-540 [PMID: 22995477 DOI: 10.1016/j.ctrv.2012.08.003].
    • (2013) Cancer Treat Rev , vol.39 , pp. 534-540
    • McMillan, D.C.1
  • 48
    • 65549146877 scopus 로고    scopus 로고
    • Systemic inflammation, nutritional status and survival in patients with cancer
    • 19318937
    • McMillan DC. Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care 2009; 12: 223-226 [PMID: 19318937 DOI: 10.1097/MCO.0b013e32832a7902].
    • (2009) Curr Opin Clin Nutr Metab Care , vol.12 , pp. 223-226
    • McMillan, D.C.1
  • 49
    • 84864866124 scopus 로고    scopus 로고
    • A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer
    • 22828611
    • Proctor MJ, McMillan DC, Morrison DS, Fletcher CD, Horgan PG, Clarke SJ. A derived neutrophil to lymphocyte ratio predicts survival in patients with cancer. Br J Cancer 2012; 107: 695-699 [PMID: 22828611 DOI: 10.1038/bjc.2012.292].
    • (2012) Br J Cancer , vol.107 , pp. 695-699
    • Proctor, M.J.1    McMillan, D.C.2    Morrison, D.S.3    Fletcher, C.D.4    Horgan, P.G.5    Clarke, S.J.6


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