Onset of asphyxial state in nonrespiring interval between cord clamping and ventilation increases hemodynamic lability of birth transition in preterm lambs

Journal of Applied Physiology

Volumn 118, Issue 6, 2015, Pages 675-683

  Smolich, Joseph J ^a,c   Kenna, Kelly R ^a   Cheung, Michael M ^a,b,c  

^a MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Cardiovascular stability; Perinatal hemodynamics; Preterm birth; Umbilical cord clamping; Ventricular outputs

Indexed keywords

AIR CONDITIONING; ANIMAL; ASPHYXIA; BLOOD PRESSURE; BRADYCARDIA; BRAIN CIRCULATION; BREATHING; DUCTUS ARTERIOSUS; FETUS; HEART OUTPUT; HEART RATE; HEART VENTRICLE; HEMODYNAMICS; LIGATION; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; PULMONARY ARTERY; SHEEP; TACHYCARDIA;

ANIMALS; ANIMALS, NEWBORN; ASPHYXIA; BLOOD PRESSURE; BRADYCARDIA; CARDIAC OUTPUT; CEREBROVASCULAR CIRCULATION; CONSTRICTION; DUCTUS ARTERIOSUS; FETUS; HEART RATE; HEART VENTRICLES; HEMODYNAMICS; PULMONARY ARTERY; RESPIRATION; SHEEP; TACHYCARDIA; VENTILATION;

EID: 84925373052     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01147.2014     Document Type: Article

References (40)

1. Abman SH, Accurso FJ, Wilkening RB, Meschia G. Persistent fetal pulmonary hypoperfusion after acute hypoxia. Am J Physiol Heart Circ Physiol 253: H941-H948, 1987.
2. Bennet L, Booth LC, Drury PP, Quaedackers JS, Gunn AJ. Preterm neonatal cardiovascular instability: does understanding the fetus help evaluate the newborn? Clin Exp Pharmacol Physiol 39: 965-972, 2012.
3. Bhatt S, Alison BJ, Wallace EM, Crossley KJ, Gill AW, Kluckow M, Te Pas AB, Morley CJ, Polglase GR, Hooper SB. Delaying cord clamping until ventilation onset improves cardiovascular function at birth in preterm lambs. J Physiol 591: 2113-2126, 2013.
4. Bhatt S, Polglase GR, Wallace EM, te Pas AB, Hooper SB. Ventilation before umbilical cord clamping improves the physiological transition at birth. Front Pediatr 2: 113, 2014.
5. Bonnin P, Fouron JC, Teyssier G, Sonesson SE, Skoll A. Quantitative assessment of circulatory changes in the fetal aortic isthmus during progressive increase of resistance to umbilical blood flow. Circulation 88: 216-222, 1993.
6. Brady JP, James LS. Heart rate changes in the fetus and newborn infant during labor, delivery, and the immediate neonatal period. Am J Obstet Gynecol 84: 1-12, 1962.
7. Brew N, Walker D, Wong FY. Cerebral vascular regulation and brain injury in preterm infants. Am J Physiol Regul Integr Comp Physiol 306: R773-R786, 2014.
8. Chow SS. Report of the Australian and New Zealand Neonatal Network 2010. Sydney: ANZNN, 2013.
9. Cohn HE, Sacks EJ, Heymann MA, Rudolph AM. Cardiovascular responses to hypoxemia and acidemia in fetal lambs. Am J Obstet Gynecol 120: 817-824, 1974.
10. Crossley KJ, Allison BJ, Polglase GR, Morley CJ, Davis PG, Hooper SB. Dynamic changes in the direction of blood flow through the ductus arteriosus at birth. J Physiol 587: 4695-4704, 2009.
11. Dawson JA, Kamlin CO, Wong C, te Pas AB, Vento M, Cole TJ, Donath SM, Hooper SB, Davis PG, Morley CJ. Changes in heart rate in the first minutes after birth. Arch Dis Child Fetal Neonatal Ed 95: F177-F181, 2010.
12. de Haan HH, Gunn AJ, Williams CE, Heymann MA, Gluckman PD. Magnesium sulfate therapy during asphyxia in near-term fetal lambs does not compromise the fetus but does not reduce cerebral injury. Am J Obstet Gynecol 176: 18-27, 1997.
13. Evans JR, Lou Short B, Van Meurs K, Cheryl Sachs H. Cardiovascular support in preterm infants. Clin Ther 28: 1366-1384, 2006.
14. Fineman JR, Soifer SJ, Heymann MA. Regulation of pulmonary vascular tone in the perinatal period. Annu Rev Physiol 57: 115-134, 1995.
15. Fouron JC. The unrecognized physiological and clinical significance of the fetal aortic isthmus. Ultrasound Obstet Gynecol 22: 441-447, 2003.
16. Galinsky R, Jensen EC, Bennet L, Mitchell CJ, Gunn ER, Wassink G, Fraser M, Westgate JA, Gunn AJ. Sustained sympathetic nervous system support of arterial blood pressure during repeated brief umbilical cord occlusions in near-term fetal sheep. Am J Physiol Regul Integr Comp Physiol 306: R787-R795, 2014.
17. Greisen G. Autoregulation of cerebral blood flow in newborn babies. Early Hum Dev 81: 423-428, 2005.
18. Hillman NH, Kallapur SG, Jobe AH. Physiology of transition from intrauterine to extrauterine life. Clin Perinatol 39: 769-783, 2012.
19. Hooper SB, Polglase GR, Te Pas AB. A physiological approach to the timing of umbilical cord clamping at birth. Arch Dis Child Fetal Neonatal Ed. In press.
20. Hunter CJ, Blood AB, Power GG. Cerebral metabolism during cord occlusion and hypoxia in the fetal sheep: a novel method of continuous measurement based on heat production. J Physiol 552: 241-251, 2003.
21. Jensen A, Berger R. Fetal circulatory responses to oxygen lack. J Dev Physiol 16: 181-207, 1991.
22. Jensen A, Hanson MA. Circulatory responses to acute asphyxia in intact and chemodenervated fetal sheep near term. Reprod Fertil Dev 7: 1351-1359, 1995.
23. Jensen A, Hohmann M, Kunzel W. Dynamic changes in organ blood flow and oxygen consumption during acute asphyxia in fetal sheep. J Dev Physiol 9: 543-559, 1987.
24. Lagercrantz H, Slotkin TA. The "stress" of being born. Sci Am 254: 100-107, 1986.
25. Moore PJ, Hanson MA. The role of peripheral chemoreceptors in the rapid response of the pulmonary vasculature of the late gestation sheep fetus to changes in PaO2. J Dev Physiol 16: 133-138, 1991.
26. Morrow RJ, Bull SB, Adamson SL. Experimentally induced changes in heart rate alter umbilicoplacental hemodynamics in fetal sheep. Ultrasound Med Biol 19: 309-318, 1993.
27. Niermeyer S, Velaphi S. Promoting physiologic transition at birth: re-examining resuscitation and the timing of cord clamping. Semin Fetal Neonatal Med 18: 385-392, 2013.
28. Polglase GR, Morley CJ, Crossley KJ, Dargaville P, Harding R, Morgan DL, Hooper SB. Positive end-expiratory pressure differentially alters pulmonary hemodynamics and oxygenation in ventilated, very premature lambs. J Appl Physiol 99: 1453-1461, 2005.
29. Rudolph AM. Distribution and regulation of blood flow in the fetal and neonatal lamb. Circ Res 57: 811-821, 1985.
30. Rudolph AM. Fetal and neonatal pulmonary circulation. Annu Rev Physiol 41: 383-395, 1979.
31. Smolich JJ. Enhanced ventricular pump function and decreased reservoir backflow sustain rise in pulmonary blood flow after reduction of lung liquid volume in fetal lambs. Am J Physiol Regul Integr Comp Physiol 306: R273-R280, 2014.
32. Smolich JJ. Ultrastructural and functional features of the developing mammalian heart: a brief overview. Reprod Fertil Dev 7: 451-461, 1995.
33. Smolich JJ, Cox HS, Eisenhofer G, Esler MD. Increased spillover and reduced clearance both contribute to rise in plasma catecholamines after birth in lambs. Am J Physiol Heart Circ Physiol 270: H668-H677, 1996.
34. Smolich JJ, Mynard JP, Penny DJ. Ductus arteriosus wave intensity analysis in fetal lambs: midsystolic ductal flow augmentation is due to antegrade pulmonary arterial wave transmission. Am J Physiol Regul Integr Comp Physiol 297: R1171-R1179, 2009.
35. Smolich JJ, Mynard JP, Penny DJ. Pulmonary trunk, ductus arteriosus and pulmonary arterial phasic blood flow interactions during systole and diastole in the fetus. J Appl Physiol 110: 1362-1373, 2011.
36. Smolich JJ, Penny DJ, Mynard JP. Enhanced central and conduit pulmonary arterial reservoir function offsets reduced ductal systolic outflow during constriction of the fetal ductus arteriosus. Am J Physiol Regul Integr Comp Physiol 302: R175-R183, 2012.
37. van Bel F, Roman C, Klautz RJ, Teitel DF, Rudolph AM. Relationship between brain blood flow and carotid arterial flow in the sheep fetus. Pediatr Res 35: 329-333, 1994.
38. van Vonderen JJ, Hooper SB, Kroese JK, Roest AA, Narayen IC, van Zwet EW, Te Pas AB. Pulse oximetry measures a lower heart rate at birth compared with electrocardiography. J Pediatr 166: 49-53, 2015.
39. Wassink G, Bennet L, Booth LC, Jensen EC, Wibbens B, Dean JM, Gunn AJ. The ontogeny of hemodynamic responses to prolonged umbilical cord occlusion in fetal sheep. J Appl Physiol 103: 1311-1317, 2007.
40. Wibbens B, Westgate JA, Bennet L, Roelfsema V, De Haan HH, Hunter CJ, Gunn AJ. Profound hypotension and associated electrocardiographic changes during prolonged cord occlusion in the near term fetal sheep. Am J Obstet Gynecol 193: 803-810, 2005.