Rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 11, 2015, Pages 3338-3343

  To, Tsz Leung ^a   Piggott, Beverly J ^a   Makhijani, Kalpana ^a   Yu, Dan ^a   Jan, Yuh Nung ^a   Shu, Xiaokun ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Bacterial phytochrome; Fluorogenic reporters; Protease; Tumor development

Indexed keywords

CASPASE; PROTEINASE; FLUORESCENT DYE; PEPTIDE HYDROLASE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CHROMATOPHORE; CONTROLLED STUDY; COVALENT BOND; DROSOPHILA; EMBRYO; EMBRYONIC STEM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IN VIVO STUDY; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; REPORTER GENE; SEQUENCE ANALYSIS; SPATIOTEMPORAL ANALYSIS; ANIMAL; CYTOLOGY; DROSOPHILA MELANOGASTER; EMBRYO DEVELOPMENT; EMBRYOLOGY; HEK293 CELL LINE; INFRARED RADIATION; METABOLISM; NONMAMMALIAN EMBRYO; PATHOLOGY; TIME FACTOR;

BACTERIA (MICROORGANISMS);

ANIMALS; APOPTOSIS; CARCINOGENESIS; CASPASES; DROSOPHILA MELANOGASTER; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; FLUORESCENT DYES; GENES, REPORTER; HEK293 CELLS; HUMANS; INFRARED RAYS; PEPTIDE HYDROLASES; TIME FACTORS;

EID: 84925372995     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1502857112     Document Type: Article

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