Effects of intravitreal ranibizumab on retinal hard exudate in diabetic macular edema: Findings from the RIDE and RISE phase III clinical trials

Ophthalmology

Volumn 122, Issue 4, 2015, Pages 779-786

  Domalpally, Amitha ^a   Ip, Michael S ^a   Ehrlich, Jason S ^b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RANIBIZUMAB; ANGIOGENESIS INHIBITOR; MONOCLONAL ANTIBODY; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ADULT; ARTICLE; CONTROLLED STUDY; DIABETIC MACULAR EDEMA; DISEASE SEVERITY; EXPLORATORY RESEARCH; EYE PHOTOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETINA EXUDATE; RETINAL HARD EXUDATE; TREATMENT DURATION; TREATMENT OUTCOME; VISUAL ACUITY; AGED; ANTAGONISTS AND INHIBITORS; CAPILLARY PERMEABILITY; CLINICAL TRIAL; DIABETIC RETINOPATHY; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; FEMALE; INTRAVITREAL DRUG ADMINISTRATION; MACULAR EDEMA; MALE; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; PATHOPHYSIOLOGY; PHASE 3 CLINICAL TRIAL; PHYSIOLOGY; RETINA BLOOD VESSEL; RETINA FOVEA; SUBRETINAL FLUID;

ADULT; AGED; ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL, HUMANIZED; CAPILLARY PERMEABILITY; DIABETIC RETINOPATHY; DOUBLE-BLIND METHOD; FEMALE; FOVEA CENTRALIS; HUMANS; INTRAVITREAL INJECTIONS; MACULAR EDEMA; MALE; MIDDLE AGED; RETINAL VESSELS; SUBRETINAL FLUID; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VISUAL ACUITY;

EID: 84925372046     PISSN: 01616420     EISSN: 15494713     Source Type: Journal    
DOI: 10.1016/j.ophtha.2014.10.028     Document Type: Article

References (30)

1. S.E. Moss, R. Klein, and B.E. Klein The 14-year incidence of visual loss in a diabetic population Ophthalmology 105 1998 998 1003
2. R. Klein, B.E. Klein, and S.E. Moss The Wisconsin epidemiologic study of diabetic retinopathy. IV. Diabetic macular edema Ophthalmology 91 1984 1464 1474
3. F.L. Ferris 3rd, and A. Patz Macular edema: a complication of diabetic retinopathy Surv Ophthalmol 28 suppl 1984 452 461
4. A. Singh, and J.M. Stewart Pathophysiology of diabetic macular edema Int Ophthalmol Clin 49 2009 1 11
5. Early Treatment Diabetic Retinopathy Study Research Group Grading diabetic retinopathy from stereoscopic color fundus photographs - an extension of the modified Airlie House classification. ETDRS report number 10 Ophthalmology 98(suppl) 1991 786 806
6. E.Y. Chew, M.L. Klein, and F.L. Ferris 3rd Association of elevated serum lipid levels with retinal hard exudate in diabetic retinopathy. Early Treatment Diabetic Retinopathy Study (ETDRS) Report 22 Arch Ophthalmol 114 1996 1079 1084
7. S.J. Ryan, A.P. Schachat, and C.P. Wilkinson Pharmacotherapy of age-related macular degeneration S.J. Ryan, Retina 5th ed. 2013 Elsevier London
8. G.G. Deak, M. Bolz, and K. Kriechbaum Effect of retinal photocoagulation on intraretinal lipid exudates in diabetic macular edema documented by optical coherence tomography Ophthalmology 117 2010 773 779
9. M. Ota, K. Nishijima, and A. Sakamoto Optical coherence tomographic evaluation of foveal hard exudates in patients with diabetic maculopathy accompanying macular detachment Ophthalmology 117 1996 1996 2002
10. D.S. Fong, P.P. Segal, and F. Myers Subretinal fibrosis in diabetic macular edema. ETDRS report 23 Arch Ophthalmol 115 1997 873 877
11. F.L. Ferris 3rd, E.Y. Chew, B.J. Hoogwerf for the Early Treatment Diabetic Retinopathy Study Research Group Serum lipids and diabetic retinopathy Diabetes Care 19 1996 1291 1293
12. M. Cusick, E.Y. Chew, and C.C. Chan Histopathology and regression of retinal hard exudates in diabetic retinopathy after reduction of elevated serum lipid levels Ophthalmology 110 2003 2126 2133
13. A. Gupta, V. Gupta, S. Thapar, and A. Bhansali Lipid-lowering drug atorvastatin as an adjunct in the management of diabetic macular edema Am J Ophthalmol 137 2004 675 682
14. Diabetic Retinopathy Clinical Research Network Writing Committee A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema Ophthalmology 115 2008 1447 1459
15. M. Khairallah, H. Zeghidi, and A. Ladjimi Primary intravitreal triamcinolone acetonide for diabetic massive macular hard exudates Retina 25 2005 835 839
16. A.P. Ciardella, J. Klancnik, and W. Schiff Intravitreal triamcinolone for the treatment of refractory diabetic macular oedema with hard exudates: an optical coherence tomography study Br J Ophthalmol 88 2004 1131 1136
17. Diabetic Retinopathy Clinical Research Network M.J. Elman, L.P. Aiello, and R.W. Beck Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema Ophthalmology 117 2010 1064 1077
18. A.C. Ho, I.U. Scott, and S.J. Kim Anti-vascular endothelial growth factor pharmacotherapy for diabetic macular edema: a report by the American Academy of Ophthalmology Ophthalmology 119 2012 2179 2188
19. G. Virgili, M. Parravano, F. Menchini, and M. Brunetti Antiangiogenic therapy with anti-vascular endothelial growth factor modalities for diabetic macular oedema Cochrane Database Syst Rev 12 2012 CD007419
20. M.S. Ip, A. Domalpally, and J.J. Hopkins Long-term effects of ranibizumab on diabetic retinopathy severity and progression Arch Ophthalmol 130 2012 1145 1152
21. M. Ip, A. Domalpally, J. Sun, and J.S. Ehrlich Long-term effects of therapy with ranibizumab on diabetic retinopathy severity and baseline risk factors for retinopathy worsening Ophthalmology 2014 Epub ahead of print: November 18, 2014 http://dx.doi.org/10.1016/j.ophtha.2014.08.048
22. Q.D. Nguyen, D.M. Brown, D.M. Marcus RISE and RIDE Research Group Ranibizumab for diabetic macular edema. Results from 2 phase III randomized trials: RISE and RIDE Ophthalmology 119 2012 789 801
23. D.M. Brown, Q.D. Nguyen, and D.M. Marcus Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE Ophthalmology 120 2013 2013 2022
24. The Age-Related Eye Disease Study Research Group The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study report number 6 Am J Ophthalmol 132 2001 668 681
25. F.A. Ali A review of diabetic macular edema Digit J Ophthalmol 3 1997 http://www.djo.harvard.edu/site.php?url=/physicians/oa/387 Accessed December 3, 2014
26. S.J. Ryan Retina 5th ed. 2013 Saunders/Elsevier London
27. R.W. Beck, M.G. Maguire, and N.M. Bressler Visual acuity as an outcome measure in clinical trials of retinal diseases Ophthalmology 114 2007 1804 1809
28. S.B. Bressler, H. Qin, R.W. Beck for the Diabetic Retinopathy Clinical Research Network Factors associated with changes in visual acuity and central subfield thickness at 1 year after treatment for diabetic macular edema with ranibizumab Arch Ophthalmol 130 2012 1153 1161
29. H. Takagi, A. Otani, J. Kiryu, and Y. Ogura New surgical approach for removing massive foveal hard exudates in diabetic macular edema Ophthalmology 106 1999 249 256 discussion 56-7
30. S.K. Gelman, K.B. Freund, V.P. Shah, and D. Sarraf The pearl necklace sign: a novel spectral domain optical coherence tomography finding in exudative macular disease Retina 34 2014 2088 2095