The pearl necklace sign: A novel spectral domain optical coherence tomography finding in exudative macular disease

Retina

Volumn 34, Issue 10, 2014, Pages 2088-2095

  Gelman, Susan K ^a,b   Freund, K Bailey ^c   Shah, Vinnie P ^c   Sarraf, David ^a,b  

^a JULES STEIN EYE INSTITUTE   (United States)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^c VITREOUS RETINA MACULA CONSULTANTS OF NEW YORK   (United States)

Author keywords

Coats disease; diabetic macular edema; exudative maculopathy; hard exudates; lipid; neovascular age related macular degeneration; retinal arterial macroaneurysm; spectral domain optical coherence tomography

Indexed keywords

BEVACIZUMAB; LIPOPROTEIN; VASCULOTROPIN INHIBITOR; ANGIOGENESIS INHIBITOR; MONOCLONAL ANTIBODY; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ADULT; AGE RELATED MACULAR DEGENERATION; AGED; ARTICLE; BRANCH RETINAL VEIN OCCLUSION; CHRONICITY; CLINICAL ARTICLE; COLON CANCER; DIABETIC MACULAR EDEMA; EXUDATIVE MACULAR DISEASE; EXUDATIVE RETINITIS; FEMALE; FOLLOW UP; HUMAN; LASER COAGULATION; MACULAR EDEMA; MALE; MIDDLE AGED; OPHTHALMOSCOPY; PROGNOSIS; RENAL ARTERY ANEURYSM; RETINA MACULOPATHY; RETINAL ARTERIAL MACROANEURYSM; RETROSPECTIVE STUDY; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; TREATMENT RESPONSE; VERY ELDERLY; VISUAL ACUITY; ANTAGONISTS AND INHIBITORS; CASE REPORT; CHRONIC DISEASE; CLINICAL TRIAL; EXUDATE; FLUORESCENCE ANGIOGRAPHY; INTRAVITREAL DRUG ADMINISTRATION; MACULAR DEGENERATION; MULTICENTER STUDY; OPTICAL COHERENCE TOMOGRAPHY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; RETINA;

AGED; AGED, 80 AND OVER; ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL, HUMANIZED; CHRONIC DISEASE; EXUDATES AND TRANSUDATES; FEMALE; FLUORESCEIN ANGIOGRAPHY; HUMANS; INTRAVITREAL INJECTIONS; MACULAR DEGENERATION; MACULAR EDEMA; MALE; MIDDLE AGED; RETINA; RETROSPECTIVE STUDIES; TOMOGRAPHY, OPTICAL COHERENCE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VISUAL ACUITY;

EID: 84925285546     PISSN: 0275004X     EISSN: 15392864     Source Type: Journal    
DOI: 10.1097/IAE.0000000000000207     Document Type: Article

References (29)

1. Campochiaro PA, Heier JS, Feiner L, et al; BRAVO Investigators. Ranibizumab for macular edema following branch retinal vein occlusion: six-month primary end point results of a phase III study. Ophthalmology 2010;117:1102-1112.
2. Noma H, Mimura T, Eguchi S. Association of inflammatory factors with macular edema in branch retinal vein occlusion. JAMA Ophthalmol 2013;131:160-165.
3. Nguyen QD, Brown DM, Marcus DM, et al; RISE and RIDE Research Group. Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE. Ophthalmology 2012;119:789-801.
4. Chen X, Zhang L, Sohn EH, et al. Quantification of external limiting membrane disruption caused by diabetic macular edema from SD-OCT. Invest Ophthalmol Vis Sci 2012;53: 8042-8048.
5. Panozzo G, Gusson E, Parolini B, Mercanti A. Role of OCT in the diagnosis and follow up of diabetic macular edema. Semin Ophthalmol 2003;18:74-81. Review.
6. Ramasubramanian A, Shields CL. Bevacizumab for Coats' disease with exudative retinal detachment and risk of vitreoretinal traction. Br J Ophthalmol 2012;96:356-359.
7. Kashani AH, Keane PA, Dustin L, et al. Quantitative subanalysis of cystoid spaces and outer nuclear layer using optical coherence tomography in age-related macular degeneration. Invest Ophthalmol Vis Sci 2009;50:3366-3373.
8. Keane PA, Patel PJ, Liakopoulos S, et al. Evaluation of agerelated macular degeneration with optical coherence tomography. Surv Ophthalmol 2012;57:389-414.
9. Song IS, Shin YU, Lee BR. Time-periodic characteristics in the morphology of idiopathic central serous chorioretinopathy evaluated by volume scan using spectral-domain optical coherence tomography. Am J Ophthalmol 2012;154:366-375.
10. Gass JDM. Stereoscopic Atlas of Macular Diseases, Diagnosis and Treatment. Vol 2. 4th ed. St Louis, MO: Mosby; 1997: 996-999.
11. Yanoff M, Sassani JW. Ocular Pathology. St. Louis, MO: Mosby; 2009:410.
12. Palestine AG, Robertson DM, Goldstein BG. Macroaneurysms of the retinal arteries. Am J Ophthalmol 1982;93:164-171.
13. Coscas F, Coscas G, Souied E, et al. Optical coherence tomography identification of occult choroidal neovascularization in age-related macular degeneration. Am J Ophthalmol 2007;144: 592-599.
14. Barthelmes D, Sutter FK, Gillies MC. Differential optical densities of intraretinal spaces. Invest Ophthalmol Vis Sci 2008; 49:3529-3534.
15. Sulzbacher F, Kiss C, Kaider A, et al. Correlation of SD-OCT features and retinal sensitivity in neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 2012;21:6448-6455.
16. Kim JT, Lee DH, Joe SG, et al. Changes in choroidal thickness in relation to the severity of retinopathy and macular edema in type II diabetic patients. Invest Ophthalmol Vis Sci 2013. Epub ahead of print.
17. Manjunath V, Goren J, Fujimoto JG, Duker JS. Analysis of choroidal thickness in age-related macular degeneration using spectral-domain optical coherence tomography. Am J Ophthalmol 2011;152:663-668.
18. Coscas G, Coscas F, Vismara S, et al. Clinical features and natural history of AMD. In: Coscas G, Coscas F, Vismara S, et al, eds. Optical Coherence Tomography in Age-Related Macular Degeneration. Heidelberg, Germany: Springer; 2009: 171-174.
19. Coscas G, De Benedetto U, Coscas F, et al. Hyperreflective dots: A new spectral-domain optical coherence tomography entity for follow-up and prognosis in exudative age-related macular degeneration. Ophthalmologica 2013;229:32-37.
20. Ogino K, Murakami T, Tsujikawa A, et al. Characteristics of optical coherence tomographic hyperreflective foci in retinal vein occlusion. Retina 2012;32:77-85.
21. Bolz M, Schmidt-Erfurth U, Deak G, et al. Optical coherence tomographic hyperreflective foci: A morphologic sign of lipid extravasation in diabetic macular edema. Ophthalmology 2009; 116:914-920.
22. Framme C, Schweizer P, Imesch M, et al. Behavior of SD-OCT-detected hyperreflective foci in the retina of anti-VEGF-treated patients with diabetic macular edema. Invest Ophthalmol Vis Sci 2012;53:5814-5818.
23. Yamada Y, Suzuma K, Fujikawa A, et al. Imaging of laserphotocoagulated diabetic microaneurysm with spectral domain optical coherence tomography. Retina 2013;33:726-731.
24. Ota M, Nishijima K, Sakamoto A, et al. Optical coherence tomographic evaluation of foveal hard exudates in patients with diabetic maculopathy accompanying macular detachment. Ophthalmology 2010;117:1996-2002.
25. Uji A, Murakami T, Nishijima K, et al. Association between hyperreflective foci in the outer retina, status of photoreceptor layer, and visual acuity in diabetic macular edema. Am J Ophthalmol 2012;153:710-717.
26. Taarnhøj NC, Kjeka O, Larsen M. Kinetics of retinal lipoprotein precipitation and elimination after closure of subretinal new vessels. Invest Ophthalmol Vis Sci 2003;44:1680-1685.
27. Cusick M, Chew EY, Chan CC, et al. Histopathology and regression of retinal hard exudates in diabetic retinopathy after reduction of elevated serum lipid levels. Ophthalmology 2003; 110:2126-2133.
28. Kottke BA. Role of macrophages in lipid metabolism. J Cardiovasc Pharmacol 1987;10(suppl 9):S7-S10. Review.
29. Zweifel SA, Engelbert M, Laud K, et al. Outer retinal tubulation. Arch Ophthalmol 2009;127:1596-1602.