메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection

Author keywords

[No Author keywords available]

Indexed keywords

EUGENOL; PLANT MEDICINAL PRODUCT; RNA 16S;

EID: 84925357573     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep09253     Document Type: Article
Times cited : (134)

References (52)
  • 1
    • 84865477413 scopus 로고    scopus 로고
    • Antibiotics in early life alter the murine colonic microbiome and adiposity
    • Cho, I. et al. Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature 488, 621-626 (2012).
    • (2012) Nature , vol.488 , pp. 621-626
    • Cho, I.1
  • 2
    • 84882629410 scopus 로고    scopus 로고
    • Extension Education Symposium: The future of biosecurity and antimicrobial use in livestock production in the United States and the role of extension
    • Clark, S. et al . Extension Education Symposium: The future of biosecurity and antimicrobial use in livestock production in the United States and the role of extension. J. Anim. Sci. 90, 2861-2872 (2012).
    • (2012) J. Anim. Sci. , vol.90 , pp. 2861-2872
    • Clark, S.1
  • 3
    • 79952357025 scopus 로고    scopus 로고
    • Dose Imprecision and Resistance: Free-Choice Medicated Feeds in Industrial Food Animal Production in the United States
    • Love, D. C., Davis, M. F., Bassett, A., Gunther, A. & Nachman, K. E. Dose Imprecision and Resistance: Free-Choice Medicated Feeds in Industrial Food Animal Production in the United States. Environ. Health Perspect. 119, 279-283 (2011).
    • (2011) Environ. Health Perspect. , vol.119 , pp. 279-283
    • Love, D.C.1    Davis, M.F.2    Bassett, A.3    Gunther, A.4    Nachman, K.E.5
  • 5
    • 8844239121 scopus 로고    scopus 로고
    • Evaluation of carvacrol and eugenol as prophylaxis and treatment of vaginal candidiasis in an immunosuppressed rat model
    • Chami, F., Chami, N., Bennis, S., Trouillas, J. & Remmal, A. Evaluation of carvacrol and eugenol as prophylaxis and treatment of vaginal candidiasis in an immunosuppressed rat model. J. Antimicrob. Chemother. 54, 909-914 (2004).
    • (2004) J. Antimicrob. Chemother. , vol.54 , pp. 909-914
    • Chami, F.1    Chami, N.2    Bennis, S.3    Trouillas, J.4    Remmal, A.5
  • 6
    • 28644440641 scopus 로고    scopus 로고
    • Growth inhibition of Escherichia coli O157:H7 and Listeria monocytogenes by carvacrol and eugenol encapsulated in surfactant micelles
    • Gaysinsky, S., Davidson, P. M., Bruce, B. D. & Weiss, J. Growth inhibition of Escherichia coli O157:H7 and Listeria monocytogenes by carvacrol and eugenol encapsulated in surfactant micelles. J. Food Prot. 68, 2559-2566 (2005).
    • (2005) J. Food Prot. , vol.68 , pp. 2559-2566
    • Gaysinsky, S.1    Davidson, P.M.2    Bruce, B.D.3    Weiss, J.4
  • 7
    • 33645418479 scopus 로고    scopus 로고
    • Disruption of Escherichia coli, Listeria monocytogenes and Lactobacillus sakei cellular membranes by plant oil aromatics
    • Gill, A. O. & Holley, R. A. Disruption of Escherichia coli, Listeria monocytogenes and Lactobacillus sakei cellular membranes by plant oil aromatics. Int. J. Food Microbiol. 108, 1-9 (2006).
    • (2006) Int. J. Food Microbiol. , vol.108 , pp. 1-9
    • Gill, A.O.1    Holley, R.A.2
  • 8
    • 84874805377 scopus 로고    scopus 로고
    • Eugenol inhibits quorum sensing at sub-inhibitory concentrations
    • Zhou, L., Zheng, H., Tang, Y., Yu, W. & Gong, Q. Eugenol inhibits quorum sensing at sub-inhibitory concentrations. Biotechnol. Lett. 35, 631-637 (2013).
    • (2013) Biotechnol. Lett. , vol.35 , pp. 631-637
    • Zhou, L.1    Zheng, H.2    Tang, Y.3    Yu, W.4    Gong, Q.5
  • 9
    • 34948890007 scopus 로고    scopus 로고
    • Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems
    • Makkar, H. P. S., Francis, G. & Becker, K. Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems. Anim. Int. J. Anim. Biosci. 1, 1371-1391 (2007).
    • (2007) Anim. Int. J. Anim. Biosci. , vol.1 , pp. 1371-1391
    • Makkar, H.P.S.1    Francis, G.2    Becker, K.3
  • 10
    • 84872008426 scopus 로고    scopus 로고
    • Improved resistance to Eimeria acervulina infection in chickens due to dietary supplementation with garlic metabolites
    • Kim, D. K., Lillehoj, H. S., Lee, S. H., Lillehoj, E. P.&Bravo, D. Improved resistance to Eimeria acervulina infection in chickens due to dietary supplementation with garlic metabolites. Br. J. Nutr. 109, 76-88 (2013).
    • (2013) Br. J. Nutr. , vol.109 , pp. 76-88
    • Kim, D.K.1    Lillehoj, H.S.2    Lee, S.H.3    Lillehoj, E.P.4    Bravo, D.5
  • 11
    • 80052520492 scopus 로고    scopus 로고
    • Effects of dietary supplementation with phytonutrients on vaccine-stimulated immunity against infection with Eimeria tenella
    • Lee, S. H. et al. Effects of dietary supplementation with phytonutrients on vaccine-stimulated immunity against infection with Eimeria tenella. Vet. Parasitol. 181, 97-105 (2011).
    • (2011) Vet. Parasitol. , vol.181 , pp. 97-105
    • Lee, S.H.1
  • 12
    • 84859738431 scopus 로고    scopus 로고
    • Effects of dietary plant-derived phytonutrients on the genome-wide profiles and coccidiosis resistance in the broiler chickens
    • Lillehoj, H. S., Kim, D. K., Bravo, D. M.&Lee, S. H. Effects of dietary plant-derived phytonutrients on the genome-wide profiles and coccidiosis resistance in the broiler chickens. BMC Proc. 5, 1-8 (2011).
    • (2011) BMC Proc. , vol.5 , pp. 1-8
    • Lillehoj, H.S.1    Kim, D.K.2    Bravo, D.M.3    Lee, S.H.4
  • 13
    • 84899946029 scopus 로고    scopus 로고
    • Dietary plant extracts modulate gene expression profiles in ileal mucosa of weaned pigs after an Escherichia coli infection
    • Liu, Y. et al. Dietary plant extracts modulate gene expression profiles in ileal mucosa of weaned pigs after an Escherichia coli infection. J. Anim. Sci. 92, 2050-2062 (2014).
    • (2014) J. Anim. Sci. , vol.92 , pp. 2050-2062
    • Liu, Y.1
  • 14
    • 84888172681 scopus 로고    scopus 로고
    • Dietary plant extracts improve immune responses and growth efficiency of pigs experimentally infected with porcine reproductive and respiratory syndrome virus
    • Liu, Y. et al. Dietary plant extracts improve immune responses and growth efficiency of pigs experimentally infected with porcine reproductive and respiratory syndrome virus. J. Anim. Sci. 91, 5668-5679 (2013).
    • (2013) J. Anim. Sci. , vol.91 , pp. 5668-5679
    • Liu, Y.1
  • 15
    • 77952894880 scopus 로고    scopus 로고
    • Food-based strategies to modulate the composition of the intestinal microbiota and their associated health effects
    • Bosscher, D., Breynaert, A., Pieters, L. & Hermans, N. Food-based strategies to modulate the composition of the intestinal microbiota and their associated health effects. J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc. 60 Suppl 6, 5-11 (2009).
    • (2009) J. Physiol. Pharmacol. Off. J. Pol. Physiol. Soc. , vol.60 , pp. 5-11
    • Bosscher, D.1    Breynaert, A.2    Pieters, L.3    Hermans, N.4
  • 16
    • 54449083567 scopus 로고    scopus 로고
    • The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
    • Johansson, M. E. V. et al. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc. Natl. Acad. Sci. U. S. A. 105, 15064-15069 (2008).
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 15064-15069
    • Johansson, M.E.V.1
  • 17
    • 5444248493 scopus 로고    scopus 로고
    • Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
    • Derrien, M., Vaughan, E. E., Plugge, C. M. & de Vos, W. M. Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. Int. J. Syst. Evol. Microbiol. 54, 1469-1476 (2004).
    • (2004) Int. J. Syst. Evol. Microbiol. , vol.54 , pp. 1469-1476
    • Derrien, M.1    Vaughan, E.E.2    Plugge, C.M.3    De Vos, W.M.4
  • 18
    • 84878465280 scopus 로고    scopus 로고
    • Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
    • Everard, A. et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc. Natl. Acad. Sci. U. S. A. 110, 9066-9071 (2013).
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 9066-9071
    • Everard, A.1
  • 19
    • 67650538066 scopus 로고    scopus 로고
    • Coordinate regulation of glycan degradation and polysaccharide capsule biosynthesis by a prominent human gut symbiont
    • Martens, E. C., Roth, R., Heuser, J. E. & Gordon, J. I. Coordinate regulation of glycan degradation and polysaccharide capsule biosynthesis by a prominent human gut symbiont. J. Biol. Chem. 284, 18445-18457 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 18445-18457
    • Martens, E.C.1    Roth, R.2    Heuser, J.E.3    Gordon, J.I.4
  • 20
    • 15544376418 scopus 로고    scopus 로고
    • Glycan foraging in vivo by an intestine-adapted bacterial symbiont
    • Sonnenburg, J. L. et al. Glycan foraging in vivo by an intestine-adapted bacterial symbiont. Science 307, 1955-1959 (2005).
    • (2005) Science , vol.307 , pp. 1955-1959
    • Sonnenburg, J.L.1
  • 22
    • 2942691956 scopus 로고    scopus 로고
    • Getting a grip on things: How do communities of bacterial symbionts become established in our intestine?
    • Sonnenburg, J. L., Angenent, L. T. & Gordon, J. I. Getting a grip on things: how do communities of bacterial symbionts become established in our intestine? Nat. Immunol. 5, 569-573 (2004).
    • (2004) Nat. Immunol. , vol.5 , pp. 569-573
    • Sonnenburg, J.L.1    Angenent, L.T.2    Gordon, J.I.3
  • 23
    • 70349911044 scopus 로고    scopus 로고
    • Role of intestinal mucins in innate host defense mechanisms against pathogens
    • Dharmani, P., Srivastava, V., Kissoon-Singh, V. & Chadee, K. Role of intestinal mucins in innate host defense mechanisms against pathogens. J. Innate Immun. 1, 123-135 (2009).
    • (2009) J. Innate Immun. , vol.1 , pp. 123-135
    • Dharmani, P.1    Srivastava, V.2    Kissoon-Singh, V.3    Chadee, K.4
  • 25
    • 0038363378 scopus 로고    scopus 로고
    • The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
    • Brown, A. J. et al. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J. Biol. Chem. 278, 11312-11319 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 11312-11319
    • Brown, A.J.1
  • 26
    • 66549120804 scopus 로고    scopus 로고
    • The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: Implications for epithelial protection
    • Burger-van Paassen,N. et al. The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection. Biochem. J. 420, 211-219 (2009).
    • (2009) Biochem. J. , vol.420 , pp. 211-219
    • Burger-van Paassen, N.1
  • 28
    • 33751562099 scopus 로고    scopus 로고
    • Selective induction ofmucin-3 by hypoxia in intestinal epithelia
    • Louis, N. A. et al. Selective induction ofmucin-3 by hypoxia in intestinal epithelia. J. Cell. Biochem. 99, 1616-1627 (2006).
    • (2006) J. Cell. Biochem. , vol.99 , pp. 1616-1627
    • Louis, N.A.1
  • 29
    • 0031449635 scopus 로고    scopus 로고
    • Trefoil peptides: From structure to function
    • Thim, L. Trefoil peptides: from structure to function. Cell. Mol. Life Sci. CMLS 53, 888-903 (1997).
    • (1997) Cell. Mol. Life Sci. CMLS , vol.53 , pp. 888-903
    • Thim, L.1
  • 30
    • 37349016681 scopus 로고    scopus 로고
    • Multifaceted transcriptional regulation of the murine intestinal mucus layer by endogenous microbiota
    • Comelli, E. M. et al. Multifaceted transcriptional regulation of the murine intestinal mucus layer by endogenous microbiota. Genomics 91, 70-77 (2008).
    • (2008) Genomics , vol.91 , pp. 70-77
    • Comelli, E.M.1
  • 31
    • 84877913270 scopus 로고    scopus 로고
    • Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent
    • Wrzosek, L. et al. Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent. BMC Biol. 11, 61 (2013).
    • (2013) BMC Biol. , vol.11 , pp. 61
    • Wrzosek, L.1
  • 32
    • 79952763437 scopus 로고    scopus 로고
    • Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis
    • Wlodarska, M. et al. Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis. Infect. Immun. 79, 1536-1545 (2011).
    • (2011) Infect. Immun. , vol.79 , pp. 1536-1545
    • Wlodarska, M.1
  • 33
    • 77953610970 scopus 로고    scopus 로고
    • Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa
    • Bergstrom, K. S. B. et al. Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa. PLoS Pathog 6, e1000902 (2010).
    • (2010) PLoS Pathog , vol.6 , pp. e1000902
    • Bergstrom, K.S.B.1
  • 34
    • 39149134612 scopus 로고    scopus 로고
    • Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen
    • Bergstrom, K. S. B. et al. Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen. Infect. Immun. 76, 796-811 (2008).
    • (2008) Infect. Immun. , vol.76 , pp. 796-811
    • Bergstrom, K.S.B.1
  • 35
    • 41549092745 scopus 로고    scopus 로고
    • Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
    • Heazlewood, C. K. et al. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med. 5, e54 (2008).
    • (2008) PLoS Med. , vol.5 , pp. e54
    • Heazlewood, C.K.1
  • 36
    • 33745746660 scopus 로고    scopus 로고
    • Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection
    • Van der Sluis, M. et al. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 131, 117-129 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 117-129
    • Van Der Sluis, M.1
  • 37
    • 84896691062 scopus 로고    scopus 로고
    • NLRP6 inflammasome orchestrates the colonic hostmicrobial interface by regulating goblet cell mucus secretion
    • Wlodarska, M. et al. NLRP6 inflammasome orchestrates the colonic hostmicrobial interface by regulating goblet cell mucus secretion. Cell 156, 1045-1059 (2014).
    • (2014) Cell , vol.156 , pp. 1045-1059
    • Wlodarska, M.1
  • 38
    • 84862637797 scopus 로고    scopus 로고
    • Gut Immune Maturation Depends on Colonization with a Host- Specific Microbiota
    • Chung, H. et al. Gut Immune Maturation Depends on Colonization with a Host- Specific Microbiota. Cell 149, 1578-1593 (2012).
    • (2012) Cell , vol.149 , pp. 1578-1593
    • Chung, H.1
  • 39
    • 53349173070 scopus 로고    scopus 로고
    • Specific microbiota direct the differentiation of Th17 cells in the mucosa of the small intestine
    • Ivanov, I. I. et al. Specific microbiota direct the differentiation of Th17 cells in the mucosa of the small intestine. Cell Host Microbe 4, 337-349 (2008).
    • (2008) Cell Host Microbe , vol.4 , pp. 337-349
    • Ivanov, I.I.1
  • 40
    • 53649106826 scopus 로고    scopus 로고
    • Antibiotic-Induced Perturbations of the Intestinal Microbiota Alter Host Susceptibility to Enteric Infection
    • Sekirov, I. et al. Antibiotic-Induced Perturbations of the Intestinal Microbiota Alter Host Susceptibility to Enteric Infection. Infect. Immun. 76, 4726-4736 (2008).
    • (2008) Infect. Immun. , vol.76 , pp. 4726-4736
    • Sekirov, I.1
  • 41
    • 8144219709 scopus 로고    scopus 로고
    • Mechanisms of Bactericidal Action of Cinnamaldehyde against Listeria monocytogenes and of Eugenol against L. monocytogenes and Lactobacillus sakei
    • Gill, A. O. & Holley, R. A. Mechanisms of Bactericidal Action of Cinnamaldehyde against Listeria monocytogenes and of Eugenol against L. monocytogenes and Lactobacillus sakei. Appl. Environ. Microbiol. 70, 5750-5755 (2004).
    • (2004) Appl. Environ. Microbiol. , vol.70 , pp. 5750-5755
    • Gill, A.O.1    Holley, R.A.2
  • 42
    • 1842536905 scopus 로고    scopus 로고
    • Formulation and evaluation of mucoadhesive tablets containing eugenol for the treatment of periodontal diseases
    • Jadhav, B. K., Khandelwal, K. R., Ketkar, A. R. & Pisal, S. S. Formulation and evaluation of mucoadhesive tablets containing eugenol for the treatment of periodontal diseases. Drug Dev. Ind. Pharm. 30, 195-203 (2004).
    • (2004) Drug Dev. Ind. Pharm. , vol.30 , pp. 195-203
    • Jadhav, B.K.1    Khandelwal, K.R.2    Ketkar, A.R.3    Pisal, S.S.4
  • 43
    • 1642547209 scopus 로고
    • Toxicity of Eugenol Determination of LD50 on Rats
    • Sober, H. A., Hollander, F. & Sober, E. K. Toxicity of Eugenol Determination of LD50 on Rats. Exp. Biol. Med. 73, 148-151 (1950).
    • (1950) Exp. Biol. Med. , vol.73 , pp. 148-151
    • Sober, H.A.1    Hollander, F.2    Sober, E.K.3
  • 45
    • 0036829267 scopus 로고    scopus 로고
    • Selective growth of mucolytic bacteria including Clostridium perfringens in a neonatal piglet model of total parenteral nutrition
    • Deplancke, B. et al. Selective growth of mucolytic bacteria including Clostridium perfringens in a neonatal piglet model of total parenteral nutrition. Am. J. Clin. Nutr. 76, 1117-1125 (2002).
    • (2002) Am. J. Clin. Nutr. , vol.76 , pp. 1117-1125
    • Deplancke, B.1
  • 46
    • 0035142031 scopus 로고    scopus 로고
    • Toxin Synthesis and Mucin Breakdown Are Related to Swarming Phenomenon in Clostridium septicum
    • Macfarlane, S., Hopkins, M. J. & Macfarlane, G. T. Toxin Synthesis and Mucin Breakdown Are Related to Swarming Phenomenon in Clostridium septicum. Infect. Immun. 69, 1120-1126 (2001).
    • (2001) Infect. Immun. , vol.69 , pp. 1120-1126
    • Macfarlane, S.1    Hopkins, M.J.2    Macfarlane, G.T.3
  • 47
    • 84881270083 scopus 로고    scopus 로고
    • Commensal Clostridia: Leading players in the maintenance of gut homeostasis
    • Lopetuso, L. R., Scaldaferri, F., Petito, V. & Gasbarrini, A. Commensal Clostridia: leading players in the maintenance of gut homeostasis. Gut Pathog. 5, 23 (2013).
    • (2013) Gut Pathog. , vol.5 , pp. 23
    • Lopetuso, L.R.1    Scaldaferri, F.2    Petito, V.3    Gasbarrini, A.4
  • 48
    • 79953025268 scopus 로고    scopus 로고
    • Spatial organization of intestinal microbiota in the mouse ascending colon
    • Nava, G. M., Friedrichsen, H. J. & Stappenbeck, T. S. Spatial organization of intestinal microbiota in the mouse ascending colon. ISME J. 5, 627-638 (2011).
    • (2011) ISME J. , vol.5 , pp. 627-638
    • Nava, G.M.1    Friedrichsen, H.J.2    Stappenbeck, T.S.3
  • 49
    • 0025248420 scopus 로고
    • The T84 human colonic adenocarcinoma cell line produces mucin in culture and releases it in response to various secretagogues
    • McCool, D. J., Marcon, M. A., Forstner, J. F. & Forstner, G. G. The T84 human colonic adenocarcinoma cell line produces mucin in culture and releases it in response to various secretagogues. Biochem. J. 267, 491-500 (1990).
    • (1990) Biochem. J. , vol.267 , pp. 491-500
    • McCool, D.J.1    Marcon, M.A.2    Forstner, J.F.3    Forstner, G.G.4
  • 50
    • 0032958362 scopus 로고    scopus 로고
    • Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression
    • Mack, D. R.,Michail, S., Wei, S., McDougall, L. &Hollingsworth, M. A. Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression. Am. J. Physiol. 276, G941-950 (1999).
    • (1999) Am. J. Physiol. , vol.276 , pp. G941-G950
    • Mack, D.R.1    Michail, S.2    Wei, S.3    McDougall, L.4    Hollingsworth, M.A.5
  • 51
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl, M. W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29, e45-e45 (2001).
    • (2001) Nucleic Acids Res. , vol.29 , pp. e45-e45
    • Pfaffl, M.W.1
  • 52
    • 83355173006 scopus 로고    scopus 로고
    • Reducing the Effects of PCR Amplification and Sequencing Artifacts on 16S rRNA-Based Studies
    • Schloss, P. D., Gevers, D. & Westcott, S. L. Reducing the Effects of PCR Amplification and Sequencing Artifacts on 16S rRNA-Based Studies. PLoS ONE 6, e27310 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e27310
    • Schloss, P.D.1    Gevers, D.2    Westcott, S.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.