Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells

American Journal of Pathology

Volumn 185, Issue 4, 2015, Pages 1135-1144

  Peng, Hui ^a   Li, Tony W H ^a   Yang, Heping ^a,b   Moyer, Mary P ^c   Mato, Jose M ^d   Lu, Shelly C ^a,b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c INCELL Corporation ^*  (United States)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; K RAS PROTEIN; MESSENGER RNA; METHIONINE ADENOSYLTRANSFERASE; METHIONINE ADENOSYLTRANSFERASE 2B; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; P21 ACTIVATED KINASE 1; PROTEIN GIT1; PROTEIN TYROSINE KINASE; RAF PROTEIN; RAS PROTEIN; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; GIT1 PROTEIN, HUMAN; MAT2BETA PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; P21 ACTIVATED KINASE; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON CANCER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; IN VITRO STUDY; LIVER CANCER CELL LINE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; COLON TUMOR; ENZYMOLOGY; LIVER TUMOR; METABOLISM; PATHOLOGY; PROTEIN MULTIMERIZATION; TUMOR CELL LINE; UPREGULATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL CYCLE PROTEINS; CELL LINE, TUMOR; COLONIC NEOPLASMS; ENZYME ACTIVATION; HUMANS; LIVER NEOPLASMS; METHIONINE ADENOSYLTRANSFERASE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; P21-ACTIVATED KINASES; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-RAF; RAS PROTEINS; SRC-FAMILY KINASES; UP-REGULATION;

EID: 84925340586     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2014.12.016     Document Type: Article

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