Expression of TLR4 protein is reduced in chronic renal failure: Evidence from an experimental model of nephron reduction

Romanian Journal of Morphology and Embryology

Volumn 56, Issue 1, 2015, Pages 93-99

  Kacsó, Ina Maria ^a   Borza, Gabriel Mircea ^b   Ciuce, Cătălin C ^c   Bîrsan, Andrei ^c   Apostu, Raluca Cristina ^c   Dindelegan, George Călin ^a   Bondor, Cosmina Ioana ^a   Potra, Alina Ramona ^a   Netea, Mihai G ^d   Cătoi, Cornel ^b  

^a IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^b UNIVERSITY OF AGRICULTURAL SCIENCES AND VETERINARY MEDICINE   (Romania)

^c EMERGENCY COUNTY HOSPITAL   (Romania)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Chronic kidney disease; Experimental; Fibrosis; Inflammation; Toll like receptor

Indexed keywords

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

TLR4 PROTEIN, RAT; TOLL LIKE RECEPTOR 4;

ANIMAL; CHRONIC KIDNEY FAILURE; FIBROSIS; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KIDNEY; KIDNEY TUBULE; MALE; METABOLISM; NEPHRECTOMY; NEPHRON; PATHOLOGY; PROTEINURIA; RAT; SIGNAL TRANSDUCTION; WISTAR RAT;

ANIMALS; FIBROSIS; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KIDNEY; KIDNEY FAILURE, CHRONIC; KIDNEY TUBULES; MALE; NEPHRECTOMY; NEPHRONS; PROTEINURIA; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84925326264     PISSN: 12200522     EISSN: 20668279     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. [1] Anders HJ, Banas B, Schlöndorff D. Signaling danger: tolllike receptors and their potential roles in kidney disease. J Am Soc Nephrol, 2004, 15(4):854–867.
2. [2] Sirisinha S. Insight into the mechanisms regulating immune homeostasis in health and disease. Asian Pac J Allergy Immunol, 2011, 29(1):1–14.
3. [3] Erridge C. Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease. Atherosclerosis, 2011, 216(1):1–6.
4. [4] Zhao H, Perez JS, Lu K, George AJ, Ma D. Role of Toll-like receptor-4 in renal graft ischemia-reperfusion injury. Am J Physiol Renal Physiol, 2014, 306(8):F801–F811.
5. [5] Lim SW, Li C, Ahn KO, Kim J, Moon IS, Ahn C, Lee JR, Yang CW. Cyclosporine-induced renal injury induces tolllike receptor and maturation of dendritic cells. Transplantation, 2005, 80(5):691–699.
6. [6] Pulskens WP, Rampanelli E, Teske GJ, Butter LM, Claessen N, Luirink IK, van der Poll T, Florquin S, Leemans JC. TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury. J Am Soc Nephrol, 2010, 21(8):1299–1308.
7. [7] Campbell MT, Hile KL, Zhang H, Asanuma H, Vanderbrink BA, Rink RR, Meldrum KK. Toll-like receptor 4: a novel signaling pathway during renal fibrogenesis. J Surg Res, 2011, 168(1): e61–e69.
8. [8] He Z, Zhu Y, Jiang H. Inhibiting toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study. Respir Res, 2009, 10:126.
9. [9] Guo J, Friedman SL. Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis. Fibrogenesis Tissue Repair, 2010, 3:21.
10. [10] Wang J, Hori K, Ding J, Huang Y, Kwan P, Ladak A, Tredget EE. Toll-like receptors expressed by dermal fibroblasts contribute to hypertrophic scarring. J Cell Physiol, 2010, 226(5):1265–1273.
11. [11] Tapia E, Franco M, Sánchez-Lozada LG, Soto V, Avila- Casado C, Santamaría J, Quiroz Y, Rodríguez-Iturbe B, Herrera-Acosta J. Mycophenolate mofetil prevents arteriolopathy and renal injury in subtotal ablation despite persistent hypertension. Kidney Int, 2003, 63(3):994–1002.
12. [12] Ots M, Mackenzie HS, Troy JL, Rennke HG, Brenner BM. Effects of combination therapy with enalapril and losartan on the rate of progression of renal injury in rats with 5/6 renal mass ablation. J Am Soc Nephrol, 1998, 9(2):224–230.
13. [13] Ben Mkaddem S, Pedruzzi E, Werts C, Coant N, Bens M, Cluzeaud F, Goujon JM, Ogier-Denis E, Vandewalle A. Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/ reperfusion injury. Cell Death Differ, 2010, 17(9):1474–1485.
14. [14] Lu CY, Hartono J, Senitko M, Chen J. The inflammatory response to ischemic acute kidney injury: a result of the ‘right stuff’ in the ‘wrong place’? Curr Opin Nephrol Hypertens, 2007, 16(2):83–89.
15. [15] Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol, 2001, 2(8):675–680.
16. [16] Erridge C. Endogenous ligands of TLR2 and TLR4: agonists or assistants? J Leukoc Biol, 2010, 87(6):989–999.
17. [17] Brown HJ, Lock HR, Wolfs TG, Buurman WA, Sacks SH, Robson MG. Toll-like receptor 4 ligation on intrinsic renal cells contributes to the induction of antibody-mediated glomerulonephritis via CXCL1 and CXCL2. J Am Soc Nephrol, 2007, 18(6):1732–1739.
18. [18] Banas MC, Banas B, Hudkins KL, Wietecha TA, Iyoda M, Bock E, Hauser P, Pippin JW, Shankland SJ, Smith KD, Stoelcker B, Liu G, Gröne HJ, Krämer BK, Alpers CE. TLR4 links podocytes with the innate immune system to mediate glomerular injury. J Am Soc Nephrol, 2008, 19(4):704–713.
19. [19] Giorgini A, Brown HJ, Sacks SH, Robson MG. Toll-like receptor 4 stimulation triggers crescentic glomerulonephritis by multiple mechanisms including a direct effect on renal cells. Am J Pathol, 2010, 177(2):644–653.
20. [20] Coppo R, Camilla R, Amore A, Peruzzi L, Daprà V, Loiacono E, Vatrano S, Rollino C, Sepe V, Rampino T, Dal Canton A. Toll-like receptor 4 expression is increased in circulating mononuclear cells of patients with immunoglobulin A nephropathy. Clin Exp Immunol, 2010, 159(1):73–81.
21. [21] Wang S, Schmaderer C, Kiss E, Schmidt C, Bonrouhi M, Porubsky S, Gretz N, Schaefer L, Kirschning CJ, Popovic ZV, Gröne HJ. Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling. Dis Model Mech, 2010, 3(1–2):92–103.
22. [22] Kwon J, Park J, Lee D, Kim YS, Jeong HJ. Toll-like receptor expression in patients with renal allograft dysfunction. Transplant Proc, 2008, 40(10):3479–3480.
23. [23] Braudeau C, Ashton-Chess J, Giral M, Dugast E, Louis S, Pallier A, Braud C, Moreau A, Renaudin K, Soulillou JP, Brouard S. Contrasted blood and intragraft toll-like receptor 4 mRNA profiles in operational tolerance versus chronic rejection in kidney transplant recipients. Transplantation, 2008, 86(1): 130–136.
24. [24] Chen J, John R, Richardson JA, Shelton JM, Zhou XJ, Wang Y, Wu QQ, Hartono JR, Winterberg PD, Lu CY. Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury. Kidney Int, 2011, 79(3):288–299.
25. [25] Kim BS, Lim SW, Li C, Kim JS, Sun BK, Ahn KO, Han SW, Kim J, Yang CW. Ischemia-reperfusion injury activates innate immunity in rat kidneys. Transplantation, 2005, 79(10):1370–1377.
26. [26] Zager RA, Johnson AC, Lund S, Randolph-Habecker J. Tolllike receptor (TLR4) shedding and depletion: acute proximal tubular cell responses to hypoxic and toxic injury. Am J Physiol Renal Physiol, 2007, 292(1):F304–F312.
27. [27] Pulskens WP, Teske GJ, Butter LM, Roelofs JJ, van der Poll T, Florquin S, Leemans JC. Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/ reperfusion injury. PLoS One, 2008, 3(10):e3596.
28. [28] Cunningham PN, Wang Y, Guo R, He G, Quigg RJ. Role of Toll-like receptor 4 in endotoxin-induced acute renal failure. J Immunol, 2004, 172(4):2629–2635.
29. [29] Ramesh G, Zhang B, Uematsu S, Akira S, Reeves WB. Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice. Am J Physiol Renal Physiol, 2007, 293(1):F325–F332.
30. [30] Cenedeze MA, Gonçalves GM, Feitoza CQ, Wang PM, Damião MJ, Bertocchi AP, Pacheco-Silva A, Câmara NO. The role of toll-like receptor 4 in cisplatin-induced renal injury. Transplant Proc, 2007, 39(2):409–411.
31. [31] Zhang B, Ramesh G, Uematsu S, Akira S, Reeves WB. TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity. J Am Soc Nephrol, 2008, 19(5):923–932.
32. [32] Lepenies J, Eardley KS, Kienitz T, Hewison M, Ihl T, Stewart PM, Cockwell P, Quinkler M. Renal TLR4 mRNA expression correlates with inflammatory marker MCP-1 and profibrotic molecule TGF-β1 in patients with chronic kidney disease. Nephron Clin Pract, 2011, 119(2):c97–c104.
33. [33] Stribos EG, van Werkhoven MB, Poppelaars F, van Goor H, Olinga P, van Son WJ, Damman J, Seelen MA. Renal expression of Toll-like receptor 2 and 4: dynamics in human allograft injury and comparison to rodents. Mol Immunol, 2015, 64(1):82–89.