Growth factors mediated differentiation of mesenchymal stem cells to cardiac polymicrotissue using hanging drop and bioreactor

Cell Biology International

Volumn 39, Issue 4, 2015, Pages 502-507

  Konstantinou, Dimitrios ^a,b   Lei, Ming ^c   Xia, Zhidao ^b   Kanamarlapudi, Venkateswarlu ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b SWANSEA UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cell differentiation

Indexed keywords

GROWTH FACTOR; SPHINGOSINE 1 PHOSPHATE; SURAMIN; LYSOPHOSPHOLIPID; SIGNAL PEPTIDE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ARTICLE; BIOREACTOR; CARDIAC POLYMICROTISSUE; CARDIOVASCULAR PROCEDURE; CELL ASSAY; CELL DIFFERENTIATION; CONTROLLED STUDY; HANGING DROP TECHNIQUE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMAGING AND DISPLAY; IMMUNOCYTOCHEMISTRY; MESENCHYMAL STEM CELL; MOLECULAR DYNAMICS; PROTEIN DETERMINATION; PROTEIN FUNCTION; THREE DIMENSIONAL IMAGING; TISSUE CHARACTERIZATION; TISSUE SPECIFICITY; TISSUES; TWO DIMENSIONAL IMAGING; ANALOGS AND DERIVATIVES; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STROMA CELL; UMBILICAL CORD;

BIOREACTORS; CELL DIFFERENTIATION; CELLS, CULTURED; HUMANS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYSOPHOSPHOLIPIDS; MESENCHYMAL STROMAL CELLS; MYOCYTES, CARDIAC; SPHINGOSINE; SURAMIN; UMBILICAL CORD;

EID: 84925326222     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10409     Document Type: Article

References (20)

1. Anzalone R, Lo Iacono M, Corrao S, Magno F, Loria T, Cappello F, Zummo G, Farina F, La Rocca G ( 2010) New emerging potentials for human Wharton's jelly mesenchymal stem cells: immunological features and hepatocyte-like differentiative capacity. Stem Cell Dev 19: 423-38.
2. Augello A, De Bari C ( 2010) The regulation of differentiation in mesenchymal stem cells. Hum Gene Ther 21: 1226-38.
3. Avery K, Avery S, Shepherd J, Heath PR, Moore H ( 2008) Sphingosine-1-phosphate mediates transcriptional regulation of key targets associated with survival, proliferation, and pluripotency in human embryonic stem cells. Stem Cells Dev 17: 1195-20.
4. Cho HJ, Staikopoulos V, Ivanusic JJ, Jennings EA ( 2009) Hyperpolarization-activated cyclic-nucleotide gated 4 (HCN4) protein is expressed in a subset of rat dorsal root and trigeminal ganglion neurons. Cell Tissue Res 338: 171-7.
5. Fabiato A ( 1983) Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am J Physiol 245: C1-14.
6. Jeong JO, Han JW, Kim JM, Cho HJ, Park C, Lee N, Kim DW, Yoon YS ( 2011) Malignant tumor formation after transplantation of short-term cultured bone marrow mesenchymal stem cells in experimental myocardial infarction and diabetic neuropathy. Circ Res 108: 1340-7.
7. Karabekian Z, Posnack NG, Sarvazyan N ( 2011) Immunological barriers to stem-cell based cardiac repair. Stem Cell Rev 7: 315-2.
8. Kelm JM, Ehler E, Perriard JM, Fussenegger M ( 2005) Design and characterization of cardiomyocyte-derived microtissue. ESACT Proceeding 2: 213-9.
9. Kloen P, Jennings CL, Gebhardt MC, Springfield DS, Mankin HJ ( 1994) Suramin inhibits growth and transforming growth factor-beta 1 (TGF-beta 1) binding in osteosarcoma cell lines. Eur J Cancer 30A: 678-82.
10. Mazhari R, Hare JM ( 2012) Translational findings from cardiovascular stem cell research. Trends Cardiovasc Med 22: 1-6.
11. Mensah GA, Brown DW ( 2007) An overview of cardiovascular disease burden in the United States. Health Aff (Millwood) 26: 38-4.
12. Overington JP, Al-Lazikani B, Hopkins AL ( 2006) How many drug targets are there. Nat Rev Drug Discov 5: 993-6.
13. Price MM, Kapitonov D, Allegood J, Milstien S, Oskeritzian CA, Spiegel S ( 2009) Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors. FASEB J 23: 3506-15.
14. Rao TP, Kuhl M ( 2010) An updated overview on Wnt signaling pathways: a prelude for more. Circ Res 106: 1798-806.
15. Wiese C, Nikolova T, Zahanich I, Sulzbacher S, Fuchs J, Yamanaka S, Graf E, Ravens U, Boheler KR, Wobus AM ( 2011) Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin. Int J Cardiol 147: 95-111.
16. Williams AR, Hare JM ( 2011) Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease. Circ Res 109: 923-40.
17. Wolner I, Kassack MU, Ullmann H, Karel A, Hohenegger M ( 2005) Use-dependent inhibition of the skeletal muscle ryanodine receptor by the suramin analogue NF676. Br J Pharmacol 146: 525-33.
18. Yamanaka S ( 2012) Induced pluripotent stem cells: past, present, and future. Cell Stem Cell 10: 678-84.
19. Zanghi JA, Renner WA, Bailey JE, Fussenegger M ( 2000) The growth factor inhibitor suramin reduces apoptosis and cell aggregation in protein-free CHO cell batch cultures. Biotechnol Prog 16: 319-25.
20. Zhao Z, Chen Z, Zhao X, Pan F, Cai M, Wang T, Zhang H, Lu JR, Lei M ( 2011) Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions. J Biomed Sci; 18.