Absence of neurocognitive effect of hepatitis C infection in HIV-coinfected people

Neurology

Volumn 84, Issue 3, 2015, Pages 241-250

  Clifford, David B ^a   Vaida, Florin ^b   Kao, Yu Ting ^b   Franklin, Donald R ^b   Letendre, Scott L ^b   Collier, Ann C ^c   Marra, Christina M ^c   Gelman, Benjamin B ^d   McArthur, Justin C ^e   Morgello, Susan ^f   Simpson, David M ^f   Grant, Igor ^b   Heaton, Robert K ^b  

^a WASHINGTON UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

^f MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; VIRUS RNA;

ADULT; ANTIRETROVIRAL THERAPY; ANTIVIRAL THERAPY; ARTICLE; COGNITION; COMORBIDITY; DEMOGRAPHY; FEMALE; GLOBAL DEFICIT SCORE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; PRIORITY JOURNAL; SCORING SYSTEM; TASK PERFORMANCE; UNIVARIATE ANALYSIS; CD4+ T LYMPHOCYTE; CLINICAL TRIAL; COGNITION DISORDERS; COHORT ANALYSIS; COMPLICATION; GENETICS; HEPACIVIRUS; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOLOGY; MIDDLE AGED; MULTICENTER STUDY; NEUROPSYCHOLOGICAL TEST; PATHOGENICITY; PATHOLOGY; SEROLOGY; UNITED STATES; VIRUS LOAD;

ADULT; ANTI-HIV AGENTS; CD4-POSITIVE T-LYMPHOCYTES; COGNITION DISORDERS; COHORT STUDIES; FEMALE; HEPACIVIRUS; HEPATITIS C; HIV; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; SEROLOGIC TESTS; UNITED STATES; VIRAL LOAD;

EID: 84925300030     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000001156     Document Type: Article

References (37)

1. Lauer GM, Walker BD. Hepatitis C virus infection. N Engl J Med 2001;345:41-52.
2. Armstrong GL, Wasley A, Simard EP, McQuillan GM, Kuhnert WL, Alter MJ. Ann Intern Med 2006;144: 705-714.
3. Heaton RK, Franklin DR, Ellis RJ, et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J NeuroVirol 2011;17:3-16.
4. McArthur JC, Steiner J, Sacktor N, Nath A. Human immunodeficiency virus-associated neurocognitive disorders mind the gap. Ann Neurol 2010;67:699-714.
5. Spudich S. HIV and neurocognitive dysfunction. Curr HIV/AIDS Rep 2013;10:235-243.
6. Caudai C,Maimone D, Almi P, et al. The potential role of hepatitis C virus in the pathogenesis of the neurological syndrome in chronic hepatitis C. Gut 1997;41: 411-412.
7. Forton DM, Allsop JM, Cox IJ, et al. A review of cognitive impairment and cerebral metabolite abnormalities in patients with hepatitis C infection. AIDS 2005;19: S53-S63.
8. Forton DM, Thomas HC, Murphy CA, et al. Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease. Hepatology 2002;35:433-439.
9. Forton DM, Allsop JM, Main J, Foster GR, Thomas HC, Taylor-Robinson SD. Evidence for a cerebral effect of the hepatitis C virus. Lancet 2001;358:38-39.
10. Ryan EL, Morgello S, Isaacs K, Naseer M, Gerits P; Manhattan HIVBB. Neuropsychiatric impact of hepatitis C on advanced HIV. Neurology 2004;62:957-962.
11. Clifford DB, Evans SR, Yang Y, Gulick RM. The neuropsychological and neurologic impact of HCV co-infection in HIV-infected subjects. AIDS 2005;19:S64-S71.
12. Clifford DB, Yang Y, Evans S. Review: neurologic consequences of hepatitis C and human immunodeficiency virus coinfection. J NeuroVirol 2005;11:67-71.
13. Morgello S, Estanislao L, Ryan E, et al. Effects of hepatic function and hepatitis C virus on the nervous system assessment of advanced-stage HIV-infected individuals. AIDS 2005;19(suppl 3):S116-S122.
14. Letendre SL, Cherner M, Ellis RJ, et al. The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: biological correlates of disease. AIDS 2005;19(suppl 3):S72-S78.
15. Hinkin CH, Castellon SA, Levine AJ, Barclay TR, Singer EJ. Neurocognition in individuals co-infected with HIV and hepatitis C. J Addict Dis 2008;27:11-17.
16. Thiyagarajan A, Garvey LJ, Pflugrad H, et al. Cerebral function tests reveal differences in HIV-infected subjects with and without chronic HCV co-infection. Clin Microbiol Infect 2010;16:1579-1584.
17. Vivithanaporn P, Nelles K, DeBlock L, Newman SC, Gill MJ, Power C. Hepatitis C virus co-infection increases neurocognitive impairment severity and risk of death in treated HIV/AIDS. J Neurol Sci 2012;312:45-51.
18. Hilsabeck RC, Castellon SA, Hinkin CH. Neuropsychological aspects of coinfection with HIV and hepatitis C virus. Clin Infect Dis 2005;41:S38-S44.
19. Perry W, Carlson MD, Barakat F, et al. Neuropsychological test performance in patients co-infected with hepatitis C virus and HIV. AIDS 2005;19:S79-S84.
20. Liang TJ, Ghany MG. Current and future therapies for hepatitis C virus infection. N Engl J Med 2013;368: 1907-1917.
21. Heaton RK, Clifford DB, Franklin DR Jr, et al. HIVassociated neurocognitive disorders persist in the era of potent antiretroviral therapy. CHARTER study. Neurology 2010;75:2087-2096.
22. Fishman SL, Murray JM, Eng FJ, Walewski JL, Morgello S, Branch AD. Molecular and bioinformatic evidence of hepatitis C virus evolution in brain. J Infect Dis 2008;197:597-607.
23. Carey CL, Woods SP, Gonzalez R, et al. Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection. J Clin Exp Neuropsychol 2004;26:307-319.
24. Woods SP, Rippeth JD, Frol AB, et al. Interrater reliability of clinical ratings and neurocognitive diagnoses in HIV. J Clin Exp Neuropsychol 2004;26:759-778.
25. Antinori A, Arendt G, Becker JT, et al. Updated research nosology for HIV-associated neurocognitive disorders. Neurology 2007;69:1789-1799.
26. Blackstone K, Moore DJ, Franklin DR, et al. Defining neurocognitive impairment in HIV: deficit scores versus clinical ratings. Clin Neuropsychol 2012;26:894-908.
27. Beck AT, Steer RA, Brown GK. Beck Depression Inventory, second edition manual. San Antonio: The Psychological Corporation; 1996.
28. Wilkinson J, Radkowski M, Laskus T. Hepatitis C virus neuroinvasion: identification of infected cells. J Virol 2009;83:1312-1319.
29. Letendre S, Paulino AD, Rockenstein E, et al. Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIV. J Infect Dis 2007;196:361-370.
30. Weissenborn K, Krause J, Bokemeyer M, et al. Hepatitis C virus infection affects the brain: evidence from psychometric studies and magnetic resonance spectroscopy. J Hepatol 2004;41:845-851.
31. Richardson JL, Nowicki M, Danley K, et al. Neuropsychological functioning in a cohort of HIV-and hepatitis C virus-infected women. AIDS 2005;19:1659-1667.
32. Cherner M, Letendre S, Heaton RK, et al. Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine. Neurology 2005;64:1343-1347.
33. Clifford D, Smurzynski M, Park LS, et al. Neurological effects of active hepatitis C virus replication in HIVinfected subjects enrolled into ACTG 5001 who are virologically suppressed on HAART. Paper presented at 4th International AIDS Society meeting, Melbourne, Australia, 2007.
34. Soogoor M, Lynn HS, Donfield SM, et al. Hepatitis C virus infection and neurocognitive function. Neurology 2006;67:1482-1485.
35. Thein HH, Maruff P, Krahn M, et al. Cognitive function, mood and health-related quality of life in hepatitis C virus (HCV)-monoinfected and HIV/HCV-coinfected individuals commencing HCV treatment. HIV Med 2007;8: 192-202.
36. Byrnes V, Miller A, Lowry D, et al. Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition. J Hepatol 2012;56:549-556.
37. Jernigan TL, Archibald SL, Fennema-Notestine C, et al. Clinical factors related to brain structure in HIV: the CHARTER study. J Neurovirol 2011;17:248-257.