TNFα gene G-308A polymorphism and the risk of ischemic stroke

Neurologia i Neurochirurgia Polska

Volumn 48, Issue 6, 2014, Pages 387-390

  Wawrzynek, Alicja ^a   Dobiała, Jacek ^c   Wender, Mieczysław ^b   Kozubski, Wojciech ^a   Michałowska Wender, Grażyna ^a,b  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^b MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^c Neuropsych Hospital   (Poland)

Author keywords

Ischemic stroke; Polymorphism; TNF

Indexed keywords

GENOMIC DNA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DNA EXTRACTION; FEMALE; GENE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR ALPHA GENE; CAUCASIAN; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; POLAND; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICS AND NUMERICAL DATA; STROKE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BRAIN ISCHEMIA; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLAND; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; STROKE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84925285345     PISSN: 00283843     EISSN: 18974260     Source Type: Journal    
DOI: 10.1016/j.pjnns.2014.09.007     Document Type: Article

References (15)

1. Um JY, An NH, Kim HM. TNF-alpha and TNF-beta gene polymorphisms in cerebral infarction. J Mol Neurosci 2003;21:167–71.
2. Lee BC, Ahn SY, Doo HK, Yim SV, Lee HJ, Jin SY, et al. Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-a genes, but not the interleukin-1b gene. Neurosci Lett 2004;357:33–6.
3. Trifunovic Cvetkovic J, Wiklund PG, Ahmed E, Weinehall L, Hallmans G, Lefvert AK. Polymorphisms of IL-1β, IL-1Rα, and TNF-α genes: a nested case–control study of their association with risk for stroke. J Stroke Cerebrovasc Dis 2005;14:29–35.
4. Lalouschek W, Schillinger M, Hsieh K, Endler G, Greisenegger S, Marculescu R, et al. Polymorphisms of the inflammatory system and risk of ischemic cerebrovascular events. Clin Chem Lab Med 2006;44:918–23.
5. Harcom P, Laki J, Kiszel P, Széplaki Z, Szolnoki Z, Kovács M, et al. Decreased frequency of the TNF2 allele of TNF-alpha- 308 promoter polymorphism is associated with lacunar infarction. Cytokine 2006;21:100–5.
6. Tong Y, Geng Y, Xu J, Wang Z, Zhang Y, Lin L, et al. The role of functional polymorphisms of the TNF-alpha gene promoter in the risk of ischemic stroke in Chinese Han and Uyghur populations: two case–control studies. Clin Chim Acta 2010;411:1291–5.
7. Kim OJ, Lee JH, Choi JK, Oh SH, Hong SH, Oh D, et al. Association between tumor necrosis factor-alpha (-308G®A and -238G®A) polymorphisms and homocysteine levels in patients with ischemic strokes and silent brain infarctions. Cerebrovasc Dis 2010;30: 483–90.
8. Pereira TV, Rudnicki M, Franco RF, Pereira AC, Krieger JE. Effect of the G-308A polymorphism of the tumor necrosis factor alpha gene on the risk of ischemic heart disease and ischemic stroke: a meta-analysis. Am Heart J 2007;153:821–30.
9. Cui G, Wang H, Li R, Zhang L, Li Z, Wang Y, et al. Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promotor, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke. J Neuroinflammation 2012;10:235.
10. Goldstein L, Jones M, Matchar D, Edwards LJ, Hoff J, Chilukuri V, et al. Improving the reliability of stroke subgroup classification using the trial of ORG 10172 in acute stroke treatment (TOAST) criteria. Stroke 2001;32:1091–7.
11. Rubattu S, Speranza R, Ferrari M, Evangelista A, Beccia M, Stanzione R, et al. A role of TNF-alpha gene variant on juvenile ischemic stroke: a case–control study. Eur J Neurol 2005;12:989–93.
12. Kamel H, Iadecola C. Brain–immune interactions and ischemic stroke. Neurol Rev 2012;69:576–81.
13. Tuttolomondo A, Di Raimondo D, Pecoraro R, Arnao V, Pinto A, Licata G. Inflammation in ischemic stroke subtypes. Curr Pharm Des 2012;18:4289–310.
14. Karahan ZC, Deda G, Sipahi T, Elhan AH, Akar N. TNF-α-308 G/A and IL-6-174 G/C polymorphisms in the Turkish pediatric stroke patients. Thromb Res 2005;115:393–8.
15. Gupta V, Gupta A, Jafar T, Gupta V, Agrawal S, Srivastava N, et al. Association of TNF-α promoter gene G-308A polymorphism with metabolic syndrome, insulin resistance, serum TNF-α and leptin levels in Indian adult women. Cytokine 2012;57:32–6.