Estimation of the optimum dose of vitamin D for disease prevention in older people: Rationale, design and baseline characteristics of the BEST-D trial

Maturitas

Volumn 80, Issue 4, 2015, Pages 426-431

  Clarke, Robert ^a   Newman, Connie ^b   Tomson, Joseph ^a   Hin, Harold ^c   Kurien, Rijo ^a   Cox, Jolyon ^a   Lay, Michael ^a   Sayer, Jenny ^a   Hill, Michael ^a   Emberson, Jonathan ^a   Armitage, Jane ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Hightown Surgery   (United Kingdom)

Author keywords

25 Hydroxyvitamin D; Parathyroid hormone; Vitamin D supplementation trial

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTITHROMBOCYTIC AGENT; CALCIUM; COLECALCIFEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NON PRESCRIPTION DRUG; PLACEBO; 25-HYDROXYVITAMIN D; BONE DENSITY CONSERVATION AGENT; VITAMIN D;

AGED; ANTIHYPERTENSIVE THERAPY; ARTERIAL STIFFNESS; ARTICLE; BODY MASS; BONE DENSITY; CALCIUM INTAKE; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG MEGADOSE; DRUG SAFETY; ECHOCARDIOGRAPHY; FALLING; FEMALE; FRACTURE; FUNCTIONAL ASSESSMENT; GERIATRIC DISORDER; GRIP STRENGTH; HEART FUNCTION; HEEL; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; OPTIMAL DRUG DOSE; PATIENT ASSESSMENT; PHYSICAL PERFORMANCE; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; SECONDARY ANALYSIS; SYSTOLIC BLOOD PRESSURE; UNITED KINGDOM; UNSPECIFIED SIDE EFFECT; VASCULAR DISEASE; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; WRIST; ANALOGS AND DERIVATIVES; BLOOD; BLOOD PRESSURE; DIETARY SUPPLEMENT; DRUG EFFECTS; FRACTURES, BONE; HAND STRENGTH; HEART; METHODOLOGY; PHYSIOLOGY; PREVENTION AND CONTROL;

ACCIDENTAL FALLS; AGED; BLOOD PRESSURE; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; CHOLECALCIFEROL; DIETARY SUPPLEMENTS; ECHOCARDIOGRAPHY; FEMALE; FRACTURES, BONE; HAND STRENGTH; HEART; HUMANS; MALE; RESEARCH DESIGN; VASCULAR STIFFNESS; VITAMIN D;

EID: 84925265624     PISSN: 03785122     EISSN: 18734111     Source Type: Journal    
DOI: 10.1016/j.maturitas.2015.01.013     Document Type: Article

References (31)

1. P. Gerdhem, K.A. Ringsberg, K.J. Obrant, and K. Akesson Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women Osteoporos Int 16 11 2005 1425 1431 (2)
2. A.C. Looker, and M.E. Mussolino Serum 25-hydroxyvitamin D and hip fracture risk in older U.S. white adults J Bone Miner Res 23 1 2008 143 150
3. Institute of Medicine Dietary Reference Intakes for Calcium and Vitamin D 2011 Institute of Medicine, The National Academies Press Washington, DC
4. J. Tomson, J. Emberson, and M. Hill Vitamin D and risk of death from vascular and non-vascular causes in the Whitehall study and meta-analyses of 12,000 deaths Eur Heart J 34 18 2012 1365 1374
5. M.C. Chapuy, M.E. Arlot, and F. Duboeuf Vitamin D3 and calcium to prevent hip fractures in the elderly women N Engl J Med 327 23 1992 1637 1642
6. D.P. Trivedi, R. Doll, and K.T. Khaw Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial BMJ 326 7387 2003 469
7. A.M. Grant, A. Avenell, and M.K. Campbell Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (randomised evaluation of calcium or vitamin D, RECORD): a randomised placebo-controlled trial Lancet 365 9471 2005 1621 1628
8. R.D. Jackson, A.Z. LaCroix, and M. Gass Calcium plus vitamin D supplementation and the risk of fractures N Engl J Med 354 7 2006 669 683
9. P. Lips, W.C. Graafmans, M.E. Ooms, P.D. Bezemer, and L.M. Bouter Vitamin D supplementation and fracture incidence in elderly persons. A randomized, placebo-controlled clinical trial Ann Intern Med 124 4 1996 400 406
10. A. Cranney, T. Horsley, and S. O'Donnell Effectiveness and safety of vitamin D in relation to bone health Evid Rep Technol Assess (Full Rep) 158 2007 1 235
11. A. Avenell, W.J. Gillespie, L.D. Gillespie, and D. O'Connell Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis Cochrane Database Syst Rev 2 2009 CD000227
12. H.A. Bischoff-Ferrari, W.C. Willett, and J.B. Wong Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials Arch Intern Med 169 6 2009 551 561
13. H.A. Bischoff-Ferrari, W.C. Willett, and E.J. Orav A pooled analysis of vitamin D dose requirements for fracture prevention N Engl J Med 367 1 2012 40 49
14. DIPART Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe BMJ 340 2010 b5463
15. M.K. Thomas, D.M. Lloyd-Jones, and R.I. Thadhani Hypovitaminosis D in medical inpatients N Engl J Med 338 12 1998 777 783
16. R.P. Heaney Functional indices of vitamin D status and ramifications of vitamin D deficiency Am J Clin Nutr 80 6 Suppl. 2004 1706S-9S
17. A.W. Roddam, R. Neale, P. Appleby, N.E. Allen, S. Tipper, and T.J. Key Association between plasma 25-hydroxyvitamin D levels and fracture risk: the EPIC-Oxford study Am J Epidemiol 166 11 2007 1327 1336
18. R.P. Heaney, K.M. Davies, T.C. Chen, M.F. Holick, and M.J. Barger-Lux Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol Am J Clin Nutr 77 1 2003 204 210
19. V. Hirani, and P. Primatesta Vitamin D concentrations among people aged 65 years and over living in private households and institutions in England: population survey Age Ageing 34 5 2005 485 491
20. H.A. Bischoff-Ferrari, E. Giovannucci, W.C. Willett, T. Dietrich, and B. Dawson-Hughes Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes Am J Clin Nutr 84 1 2006 18 28 (21)
21. C.J. Bates, A. Prentice, and T.J. Cole Micronutrients: highlights and research challenges from the 1994-5 National Diet and Nutrition Survey of people aged 65 years and over Br J Nutr 82 1 1999 7 15 (22)
22. R. Peto, M.C. Pike, and P. Armitage Design and analysis of randomized clinical trials requiring prolonged observation of each patient I. Introduction and design Br J Cancer 34 6 1976 585 612 (23)
23. R. Peto, M.C. Pike, and P. Armitage Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples Br J Cancer 35 1 1977 1 39 (24)
24. J.I. Sheikh, J.A. Yesavage, and J.O. Brooks 3rd Proposed factor structure of the Geriatric Depression Scale Int Psychogeriatr 3 1 1991 23 28
25. H.J. Martin, H.E. Syddall, E.M. Dennison, C. Cooper, and A.A. Sayer Relationship between customary physical activity, muscle strength and physical performance in older men and women: findings from the Hertfordshire Cohort Study Age Ageing 37 5 2008 589 593 (26)
26. C. Vlachopoulos, K. Aznaouridis, and C. Stefanadis Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis J Am Coll Cardiol 55 13 2010 1318 1327 (27)
27. H.C. Roberts, H.J. Denison, and H.J. Martin A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach Age Ageing 40 4 2011 423 429
28. M.F. Holick Vitamin D deficiency N Engl J Med 357 3 2007 266 281
29. J.E. Manson, S.T. Mayne, and S.K. Clinton Vitamin D and prevention of cancer - ready for prime time? N Engl J Med 364 15 2011 1385 1387 (30)
30. K. Kupferschmidt Uncertain verdict as vitamin D goes on trial Science 337 6101 2012 1476 1478
31. R. Chowdhury, S. Kunutsor, and A. Vitezova Vitamin D and cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies BMJ 348 2014 g1903 (30)