Anti-CarP antibodies in two large cohorts of patients with rheumatoid arthritis and their relationship to genetic risk factors, cigarette smoking and other autoantibodies

Annals of the Rheumatic Diseases

Volumn 73, Issue 10, 2014, Pages 1761-1768

  Jiang, Xia ^a   Trouw, Leendert A ^b   Van Wesemael, Tineke J ^b   Shi, Jing ^b   Bengtsson, Camilla ^a   Källberg, Henrik ^a   Malmström, Vivi ^a   Israelsson, Lena ^a   Hreggvidsdottir, Hulda ^a   Verduijn, Willem ^b   Klareskog, Lars ^a   Alfredsson, Lars ^a,c   Huizinga, Tom W J ^b   Toes, Rene E M ^b   Lundberg, Karin ^a   Van Der Woude, Diane ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c STOCKHOLM COUNTY COUNCIL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANKRD1 PROTEIN, HUMAN; AUTOANTIBODY; CYCLIC CITRULLINATED PEPTIDE; CYCLOPEPTIDE; HLA DRB1 ANTIGEN; IMMUNOGLOBULIN G; MUSCLE PROTEIN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; NUCLEAR PROTEIN; PTPN22 PROTEIN, HUMAN; REPRESSOR PROTEIN;

ADOLESCENT; ADULT; AGED; ALLELE; ARTHRITIS, RHEUMATOID; BLOOD; CASE CONTROL STUDY; COHORT ANALYSIS; FEMALE; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; IMMUNOLOGY; MALE; META ANALYSIS; MIDDLE AGED; RISK FACTOR; SMOKING; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ALLELES; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; CASE-CONTROL STUDIES; COHORT STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HLA-DRB1 CHAINS; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; MUSCLE PROTEINS; NUCLEAR PROTEINS; PEPTIDES, CYCLIC; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 22; REPRESSOR PROTEINS; RISK FACTORS; SMOKING; YOUNG ADULT;

EID: 84925231994     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2013-205109     Document Type: Article

References (24)

1. Aletaha D, Neogi T, Silman AJ, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010;62:2569-81.
2. Turesson C, Jacobsson LT, Sturfelt G, et al. Rheumatoid factor and antibodies to cyclic citrullinated peptides are associated with severe extra-articular manifestations in rheumatoid arthritis. Ann Rheum Dis 2007;66:59-64.
3. van der Helm-van Mil AH, Verpoort KN, Breedveld FC, et al. Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis. Arthritis Res Ther 2005;7:R949-58.
4. Nielen MM, van Schaardenburg D, Reesink HW, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum 2004;50:380-6.
5. Rantapaa-Dahlqvist S, de Jong BA, Berglin E, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 2003;48:2741-9.
6. Huizinga TW, Amos CI, van der Helm-van Mil AH, et al. Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum 2005;52:3433-8.
7. Kallberg H, Padyukov L, Plenge RM, et al. Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. Am J Hum Genet 2007;80:867-75.
8. Klareskog L, Stolt P, Lundberg K, et al. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 2006;54:38-46.
9. Shi J, Knevel R, Suwannalai P, et al. Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage. Proc Natl Acad Sci USA 2011;108:17372-7.
10. Shi J, van de Stadt LA, Levarht EW, et al. Anti-carbamylated protein antibodies are present in arthralgia patients and predict the development of rheumatoid arthritis. Arthritis Rheum 2013;65:911-15.
11. Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
12. Bengtsson C, Berglund A, Serra ML, et al. Non-participation in EIRA: a populationbased case-control study of rheumatoid arthritis. Scand J Rheumatol 2010;39:344-6.
13. van Aken J, van Bilsen JH, Allaart CF, et al. The Leiden Early Arthritis Clinic. Clin Exp Rheumatol 2003;21:S100-105.
14. Padyukov L, Silva C, Stolt P, et al. A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis. Arthritis Rheum 2004;50:3085-92.
15. van der Helm-van Mil AH, Huizinga TW, Schreuder GM, et al. An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility. Arthritis Rheum 2005;52:2637-44.
16. Plenge RM, Padyukov L, Remmers EF, et al. Replication of putative candidate-gene associations with rheumatoid arthritis in >4, 000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Am J Hum Genet 2005;77:1044-60.
17. Feitsma AL, Toes RE, Begovich AB, et al. Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients. Rheumatology (Oxford) 2007;46:1092-5.
18. Stolt P, Bengtsson C, Nordmark B, et al. Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based case-control study, using incident cases. Ann Rheum Dis 2003;62:835-41.
19. Willemze A, van der Woude D, Ghidey W, et al. The interaction between HLA shared epitope alleles and smoking and its contribution to autoimmunity against several citrullinated antigens. Arthritis Rheum 2011;63:1823-32.
20. Lundberg K, Bengtsson C, Kharlamova N, et al. Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile. Ann Rheum Dis 2013;72:652-8.
21. Trouw LA, Mahler M. Closing the serological gap: promising novel biomarkers for the early diagnosis of rheumatoid arthritis. Autoimmun Rev 2012;12:318-22.
22. Hissink Muller PC, Anink J, Shi J, et al. Anticarbamylated protein (anti-CarP) antibodies are present in sera of juvenile idiopathic arthritis (JIA) patients. Ann Rheum Dis 2013;72:2053-5.
23. Shi J, Willemze A, Janssen GM, et al. Recognition of citrullinated and carbamylated proteins by human antibodies: specificity, cross-reactivity and the 'AMC-Senshu' method. Ann Rheum Dis 2013;72:148-50.
24. Trouw LA, Huizinga TW, Toes RE. Autoimmunity in rheumatoid arthritis: different antigens-common principles. Ann Rheum Dis 2013;72(Suppl 2):ii132-6.