Trans-conjunctival aqueous humor outflow in glaucomatous patients treated with prostaglandin analogues: an in vivo confocal microscopy study

Graefe's Archive for Clinical and Experimental Ophthalmology

Volumn 252, Issue 9, 2014, Pages 1469-1476

  Mastropasqua, Rodolfo ^a   Fasanella, Vincenzo ^b   Pedrotti, Emilio ^a   Lanzini, Manuela ^b   Di Staso, Silvio ^c   Mastropasqua, Leonardo ^b   Agnifili, Luca ^b  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Benzalkonium chloride; Conjunctival microcysts; Glaucoma; In vivo confocal microscopy; Prostaglandins analogues; Trans conjunctival aqueous humor outflow; Trans scleral aqueous humor outflow

Indexed keywords

ANTIHYPERTENSIVE AGENT; EYE DROPS; LATANOPROST; PRESERVATIVE; PROSTAGLANDIN F; TIMOLOL;

AQUEOUS HUMOR; CELL COUNT; CONFOCAL MICROSCOPY; CONJUNCTIVA; CONTROLLED STUDY; CYST; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; EPITHELIUM CELL; FEMALE; GLAUCOMA; HUMAN; INTRAOCULAR PRESSURE; MALE; METABOLISM; MIDDLE AGED; OCULOPLETHYSMOGRAPHY; PHYSIOLOGY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TOPICAL DRUG ADMINISTRATION; VISUAL ACUITY;

ADMINISTRATION, TOPICAL; ANTIHYPERTENSIVE AGENTS; AQUEOUS HUMOR; CELL COUNT; CONJUNCTIVA; CYSTS; DOUBLE-BLIND METHOD; EPITHELIAL CELLS; FEMALE; GLAUCOMA; HUMANS; INTRAOCULAR PRESSURE; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; OPHTHALMIC SOLUTIONS; PRESERVATIVES, PHARMACEUTICAL; PROSPECTIVE STUDIES; PROSTAGLANDINS F, SYNTHETIC; TIMOLOL; TONOMETRY, OCULAR; VISUAL ACUITY;

EID: 84925224163     PISSN: 0721832X     EISSN: 1435702X     Source Type: Journal    
DOI: 10.1007/s00417-014-2664-9     Document Type: Article

References (35)

1. van der Valk R, Webers CA, Schouten JS, Zeegers MP, Hendrikse F, Prins MH (2005) Intraocular pressure–lowering effects of all commonly used glaucoma drugs: a meta-analysis of randomized clinical trials. Ophthalmology 112:1177–1185
2. Toris CB, Zhan G, Camras CB (2004) Increase in outflow facility with unoprostone treatment in ocular hypertensive patients. Arch Ophthalmol 122:1782–1787
3. Toris CB, Zhan G, Fan S, Dickerson JE, Landry TA, Bergamini MV, Camras CB (2007) Effects of travoprost on aqueous humor dynamics in patients with elevated intraocular pressure. J Glaucoma 16:189–195
4. Bahler CK, Howell KG, Hann CR, Fautsch MP, Fautsch MP, Johnson DH (2008) Prostaglandins increase trabecular meshwork outflow facility in cultured human anterior segments. Am J Ophthalmol 145:114–119
5. Toris CB, Zhan GL, Zhao J, Camras CB, Camras CB, Yablonski ME (2001) Potential mechanism for the additivity of pilocarpine and latanoprost. Am J Ophthalmol 131:722–728
6. Mastropasqua L, Agnifili L, Ciancaglini M, Nubile M, Carpineto P, Fasanella V, Figus M, Lazzeri S, Nardi M (2010) In vivo analysis of conjunctiva in gold micro shunt implantation for glaucoma. Br J Ophthalmol 94:1592–1596
7. Toris CB, Gabelt BT, Kaufman PL (2008) Update on the mechanism of action of topical prostaglandins for intraocular pressure reduction. Surv Ophthalmol 53 Suppl 1:S107-120
8. Zhivov A, Stachs O, Kraak R, Stave J, Guthoff RF (2006) In vivo confocal microscopy of the ocular surface. Ocul Surf 4(2):81–93
9. Ciancaglini M, Carpineto P, Agnifili L, Nubile M, Fasanella V, Mastropasqua L (2008) Conjunctival modifications in ocular hypertension and primary open-angle glaucoma: an in vivo confocal microscopy study. Invest Ophthalmol Vis Sci 49(7):3042–3048
10. Ciancaglini M, Carpineto P, Agnifili L, Nubile M, Fasanella V, Mattei PA, Mastropasqua L (2009) Conjunctival characteristics in primary open-angle glaucoma and modifications induced by trabeculectomy with mitomycin C: an in vivo confocal microscopy study. Br J Ophthalmol 93(9):1204–1209
11. Mastropasqua L, Agnifili L, Salvetat ML, Ciancaglini M, Fasanella V, Nubile M, Mastropasqua R, Zeppieri M, Brusini P (2012) In vivo analysis of conjunctiva in canaloplasty for glaucoma. Br J Ophthalmol 96:634–639
12. Agnifili L, Carpineto P, Fasanella V, Mastropasqua R, Zappacosta A, Di Staso S, Costagliola C, Mastropasqua L (2012) Conjunctival findings in hyperbaric and low-tension glaucoma: an in vivo confocal microscopy study. Acta Ophthalmol 90(2):e132–137
13. Labbe’ A, Dupas B, Hamard P, Baudouin C (2005) In vivo confocal microscopy study of blebs after filtering surgery. Ophthalmology 112:1979–1986
14. Mills RP, Budenz DL, Lee PP, Noecker RJ, Walt JG, Siegartel LR, Evans SJ, Doyle JJ (2006) Categorizing the stage of glaucoma from pre-diagnosis to end-stage disease. Am J Ophthalmol 141:24–30
15. Terai N, Schlötzer-Schrehardt U, Lampel J, Böhm AG, Rummelt C, Schmidt E, Pillunat LE (2009) Effect of latanoprost and timolol on the histopathology of the human conjunctiva. Br J Ophthalmol 93(2):219–224
16. Mietz H, Schlötzer-Schrehardt U, Strassfeld C, Krieglstein GK (2001) Effect of latanoprost and timolol on the histopathology of the rabbit conjunctiva. Invest Ophthalmol Vis Sci 42(3):679–687
17. Galin MA, Baras I, McLean JM (1966) The mechanism of external filtration. Am J Ophthalmol 61:63–68
18. Kronfeld PC (1952) The chemical demonstration of transconjunctival passage of aqueous after antiglaucomatous operations. Am J Ophthalmol 35:38–45
19. Candia OA, Alvarez LJ (2008) Fluid transport phenomena in ocular epithelia. Prog Retin Eye Res 27(2):197–212
20. Amar N, Labbè A, Hamard P, Dupas B, Baudouin C (2008) Filtering blebs and aqueous pathway. An immunocytological and in vivo confocal microscopy. Ophthalmology 115:1154–1161
21. Tressler CS, Beatty R, MD, Lemp MA (2011) Preservative use in topical glaucoma medications. Ocul Surf 9:140–158
22. Noecker R, Miller KV (2011) Benzalkonium chloride in glaucoma medications. Ocul Surf 9:159–62
23. Villani E, Baudouin C, Efron N, Hamrah P, Kojima T, Patel SV, Pflugfelder SC, Zhivov A, Dogru M (2014) In vivo confocal microscopy of the ocular surface: from bench to bedside. Curr Eye Res 39(3):213–231
24. McCarey B, Edelhauser H (2007) In vivo corneal epithelial permeability following treatment with prostaglandin analogs [correction of analoges] with or without benzalkonium chloride. J Ocul Pharmacol Ther 23(5):445–451
25. Noecker RJ, Herrygers LA, Anwaruddin R (2004) Corneal and conjunctival changes caused by commonly used glaucoma medications. Cornea 23(5):490–496
26. Okabe K, Kimura H, Okabe J, Kato A, Shimizu H, Ueda T, Shimada S, Ogura Y (2005) Effect of benzalkonium chloride on transscleral drug delivery. Invest Ophthalmol Vis Sci 46:703–708
27. Mastropasqua L, Agnifili L, Mastropasqua R, Fasanella V (2013) Conjunctival modifications induced by medical and surgical therapies in patients with glaucoma. Curr Opin Pharmacol 13(1):56–64
28. Pisella PJ, Debbasch C, Hamard P, Creuzot-Garcher C, Rat P, Brignole F, Baudouin C (2004) Conjunctival proinflammatory and proapoptotic effects of latanoprost and preserved and unpreserved timolol: an ex vivo and in vitro study. Invest Ophthalmol Vis Sci 45:1360–1368
29. Emi K, Pederson JE, Toris CB (1989) Hydrostatic pressure of the suprachoroidal space. Invest Ophthalmol Vis Sci 30:233–238
30. Guthoff RF, Baudouin C, Stave J (2006) Conjunctiva-pathological findings. In: Guthoff RF, Baudouin C, Stave J. Atlas of confocal laser scanning in-vivo microscopy in ophthalmology. Berlin, Germany: Springer:134
31. Wakamatsu TH, Sato EA, Matsumoto Y, Ibrahim OM, Dogru M, Kaido M, Ishida R, Tsubota K (2010) Conjunctival in vivo confocal scanning laser microscopy in patients with Sjögren syndrome. Invest Ophthalmol Vis Sci 51:144–150
32. Efron N, Al-Dossari M, Pritchard N (2010) Confocal microscopy of the bulbar conjunctiva in contact lens wear. Cornea 29:43–52
33. Guenoun JM, Baudouin C, Rat P, Pauly A, Warnet JM, Brignole-Baudouin F (2005) In vitro study of inflammatory potential and toxicity profile of latanoprost, travoprost, and bimatoprost in conjunctiva-derived epithelial cells. Invest Ophthalmol Vis Sci 46(7):2444–2450
34. Pisella PJ, Debbasch C, Hamard P, Creuzot-Garcher C, Rat P, Brignole F, Baudouin C (2004) Conjunctival proinflammatory and proapoptotic effects of latanoprost and preserved and unpreserved timolol: an ex vivo and in vitro study. Invest Ophthalmol Vis Sci 45(5):1360–1368
35. Yu DY, Morgan WH, Sun X, Su EN, Cringle SJ, Yu PK, House P, Guo W, Yu X (2009) The critical role of the conjunctiva in glaucoma filtration surgery. Prog Retin Eye Res 28(5):303–328