Discovery of novel S1P2 antagonists. Part 1: Discovery of 1,3-bis(aryloxy)benzene derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 7, 2015, Pages 1479-1482

  Kusumi, Kensuke ^a   Shinozaki, Koji ^a   Kanaji, Toshiya ^a   Kurata, Haruto ^a   Naganawa, Atsushi ^a   Otsuki, Kazuhiro ^a   Matsushita, Takeshi ^a   Sekiguchi, Tetsuya ^a   Kakuuchi, Akito ^a   Seko, Takuya ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Antagonist; G protein coupled receptors; Sphingosine 1 phosphate receptor 2

Indexed keywords

1,3 BIS(ARYLOXY)BENZENE DERIVATIVE; BENZENE DERIVATIVE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG; S1PR2 PROTEIN, HUMAN;

ARTICLE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; HUMAN; SYNTHESIS;

BENZENE DERIVATIVES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, LYSOSPHINGOLIPID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84925220211     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.02.029     Document Type: Article

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