Therapeutic intervention in Crimean-Congo hemorrhagic fever: Where are we now?

Future Virology

Volumn 10, Issue 3, 2015, Pages 203-206

  Spengler, Jessica R ^a   Bente, Dennis A ^b,c  

^a NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

antiviral; Bunyavirus; Crimean Congo hemorrhagic fever; therapeutics; treatment

Indexed keywords

FAVIPIRAVIR; INTERFERON; RIBAVIRIN;

CRIMEAN CONGO HEMORRHAGIC FEVER; CRIMEAN CONGO HEMORRHAGIC FEVER VIRUS; HUMAN; INCUBATION TIME; INFECTION CONTROL; NONHUMAN; PRIORITY JOURNAL; REVIEW; TICK BITE; VIRUS TRANSMISSION;

ORTHOBUNYAVIRUS;

EID: 84925081908     PISSN: 17460794     EISSN: 17460808     Source Type: Journal    
DOI: 10.2217/fvl.14.115     Document Type: Review

References (15)

1. Bente DA, Forrester NL, Watts DM, McAuley AJ, Whitehouse CA, Bray M. Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity. Antiviral Res. 100, 159-118 (2013
2. Ergonul O. Treatment of Crimean-Congo hemorrhagic fever. Antiviral Res. 78, 125-131 (2008
3. Hoogstraal H. The epidemiology of tick-borne Crimean-Congo hemorrhagic fever in Asia, Europe, and Africa. J. Med. Entomol. 15, 307-417 (1979
4. Bergeron É, Albariño CG, Khristova ML, Nichol ST. Crimean-Congo hemorrhagic fever virus-encoded ovarian tumor protease activity is dispensable for virus RNA polymerase function. J. Virol. 84, 216-226 (2010
5. Bente DA, Alimonti JB, Shieh W., et al. Pathogenesis and immune response of Crimean-Congo hemorrhagic fever virus in a STAT-1 knockout mouse model. J. Virol. 84, 11089-11100 (2010
6. Keshtkar-Jahromi M, Kuhn JH, Christova I, Bradfute SB, Jahrling PB, Bavari S. Crimean-Congo hemorrhagic fever: current and future prospects of vaccines and therapies. Antiviral Res. 90, 85-92 (2011
7. Oestereich L, Rieger T, Neumann M., et al. Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for crimean-congo hemorrhagic Fever. PLoS Negl. Trop. Dis. 8, e2804 (2014
8. Bergeron É, Vincent MJ, Nichol ST, Bergeron E. Crimean-Congo hemorrhagic fever virus glycoprotein processing by the endoprotease SKI-1/S1P is critical for virus infectivity. J. Virol. 81, 13271-13276 (2007
9. Ergonul O, Tuncbilek S, Baykam N, Celikbas A, Dokuzoguz B. Evaluation of serum levels of interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha in patients with Crimean-Congo hemorrhagic fever. J. Infect. Dis. 193, 941-944 (2006
10. Papa A, Bino S, Velo E, Harxhi A, Kota M, Antoniadis A. Cytokine levels in Crimean- Congo hemorrhagic fever. J. Clin. Virol. 36, 272-276 (2006
11. Onguru P, Akgul EO, Akinci E., et al. High serum levels of neopterin in patients with Crimean-Congo hemorrhagic fever and its relation with mortality. J. Infect. 56, 366-370 (2008
12. Saksida A, Duh D, Wraber B., et al. Interacting roles of immune mechanisms and viral load in the pathogenesis of crimean-congo hemorrhagic fever. Clin. Vaccine Immunol. 17, 1086-1093 (2010
13. Andersson I, Karlberg H, Mousavi-jazi M, Marti L, Weber F, Mirazimi A. Crimean- Congo hemorrhagic fever virus delays activation of the innate immune response. J. Med. Virol. 1404, 1397-1404 (2008
14. Bertolotti-Ciarlet A, Smith J, Strecker K., et al. Cellular localization and antigenic characterization of Crimean-Congo hemorrhagic fever virus glycoproteins. J. Virol. 79, 6152-6616 (2005
15. Ergonul O. Crimean-Congo hemorrhagic fever virus: new outbreaks, new discoveries. Curr. Opin. Virol. 2, 215-220 (2012