SKI-II - a sphingosine kinase 1 inhibitor - exacerbates atherosclerosisin low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet

Atherosclerosis

Volumn 240, Issue 1, 2015, Pages 212-215

  Potì, Francesco ^a   Ceglarek, Uta ^b   Burkhardt, Ralph ^b   Simoni, Manuela ^a   Nofer, Jerzy Roch ^a,c  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^c UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Animal models of atherosclerosis; Hypercholesterolemia; Inflammation; Sphingosine 1 phosphate

Indexed keywords

2 (4 HYDROXYANILINO) 4 (4 CHLOROPHENYL)THIAZOLE; CHOLESTEROL; ENZYME INHIBITOR; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERCELLULAR ADHESION MOLECULE 1; LOW DENSITY LIPOPROTEIN RECEPTOR; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; 4-(4-(4-CHLORO-PHENYL)THIAZOL-2-YLAMINO)PHENOL; BIOLOGICAL MARKER; CHOLESTEROL INTAKE; ICAM1 PROTEIN, MOUSE; LYSOPHOSPHOLIPID; PHOSPHOTRANSFERASE; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE KINASE; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ATHEROSCLEROSIS; ARTICLE; BLOOD CELL COUNT; BODY WEIGHT; CHOLESTEROL DIET; CONTROLLED STUDY; DISEASE EXACERBATION; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; THORACIC AORTA; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; AORTA DISEASE; ATHEROSCLEROSIS; BLOOD; CHEMICALLY INDUCED; CHOLESTEROL INTAKE; COMPLICATION; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HYPERCHOLESTEROLEMIA; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; RISK FACTOR; TIME; WESTERN DIET;

ANIMALS; AORTA, THORACIC; AORTIC DISEASES; ATHEROSCLEROSIS; BIOMARKERS; CHOLESTEROL, DIETARY; CHOLESTEROL, HDL; DIET, WESTERN; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEMALE; HYPERCHOLESTEROLEMIA; INTERCELLULAR ADHESION MOLECULE-1; LYSOPHOSPHOLIPIDS; MICE, KNOCKOUT; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTORS, LDL; RISK FACTORS; SPHINGOSINE; THIAZOLES; TIME FACTORS; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84925047615     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2015.03.020     Document Type: Article

References (25)

1. Gandy K.A., Obeid L.M. Regulation of the sphingosine kinase/sphingosine 1-phosphate pathway. Handb. Exp. Pharmacol. 2013, 216:275-303.
2. Maceyka M., Spiegel S. Sphingolipid metabolites in inflammatory disease. Nature 2014, 510:58-67.
3. Blaho V.A., Hla T. An update on the biology of sphingosine 1-phosphate receptors. J.Lipid Res. 2014, 55:1596-1608.
4. Hait N.C., Allegood J., Maceyka M., Strub G.M., Harikumar K.B., Singh S.K., Luo C., Marmorstein R., Kordula T., Milstien S., Spiegel S. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 2009, 325:1254-1257.
5. Alvarez S.E., Harikumar K.B., Hait N.C., Allegood J., Strub G.M., Kim E.Y., Maceyka M., Jiang H., Luo C., Kordula T., Milstien S., Spiegel S. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature 2010, 465:1084-1088.
6. Christoffersen C., Nielsen L.B. Apolipoprotein M: bridging HDL and endothelial function. Curr. Opin. Lipidol. 2013, 24:295-300.
7. Potì F., Simoni M., Nofer J.R. Atheroprotective role of high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P). Cardiovasc. Res. 2014, 103:395-404.
8. Nofer J.-R., Bot M., Brodde M., Taylor P.J., Salm P., Brinkmann V., van Berkel T., Assmann G., Biessen E.A.L. FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 2007, 115:501-508.
9. Keul P., Tölle M., Lucke S., von Wnuck Lipinski K., Heusch G., Schuchardt M., van der Giet M., Levkau B. The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 2007, 27:607-613.
10. Potì F., Gualtieri F., Sacchi S., Weißen-Plenz G., Varga G., Brodde M., Weber C., Simoni M., Nofer J.-R. KRP-203, sphingosine 1-Phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice. Arterioscler. Thromb. Vasc. Biol. 2013, 33:1505-1512.
11. Klingenberg R., Nofer J.-R., Rudling M., Bea F., Blessing E., Preusch M., Grone H.J., Katus H.A., Hansson G.K., Dengler T.J. Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 2007, 27:2392-2399.
12. -) mice. Vasc. Pharmacol. 2012, 57:56-64.
13. Keul P., Lucke S., von Wnuck Lipinski K., Bode C., Gräler M., Heusch G., Levkau B. Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis. Circ. Res. 2011, 108:314-323.
14. Skoura A., Michaud J., Im D.-S., Thangada S., Xiong Y., Smith J.D., Hla T. Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2011, 31:81-85.
15. Poti F., Bot M., Costa S., Bergonzini V., Maines L., Varga G., Freise H., Robenek H., Simoni M., Nofer J.-R. Sphingosine kinase inhibition exerts both pro- and anti-atherogenic effects in low-density lipoprotein receptor-deficient (LDL-R(-/-)) mice. Thromb. Haemost. 2012, 107:552-561.
16. French K.J., Schrecengost R.S., Lee B.D., Zhuang Y., Smith S.N., Eberly J.L., Yun J.K., Smith C.D. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003, 63:5962-5969.
17. Ceglarek U., Dittrich J., Helmschrodt C., Wagner K., Nofer J.R., Thiery J., Becker S. Preanalytical standardization of sphingosine-1-phosphate, sphinganine-1-phosphate and sphingosine analysis in human plasma by liquid chromatography-tandem mass spectrometry. Clin. Chim. Acta 2014, 435:1-6.
18. Ren S., Xin C., Pfeilschifter J., Huwiler A. Anovel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation. Cell. Physiol. Biochem. 2010, 26:97-104.
19. Loveridge C., Tonelli F., Leclercq T., Lim K.G., Long J.S., Berdyshev E., Tate R.J., Natarajan V., Pitson S.M., Pyne N.J., Pyne S. The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells. J.Biol. Chem. 2010, 285:38841-38852.
20. French K.J., Upson J.J., Keller S.N., Zhuang Y., Yun J.K., Smith C.D. Antitumor activity of sphingosine kinase inhibitors. J.Pharmacol. Exp. Ther. 2006, 318:596-603.
21. Jun D.J., Lee J.H., Choi B.H., Koh T.K., Ha D.C., Jeong M.W., Kim K.T. Sphingosine-1-phosphate modulates both lipolysis and leptin production in differentiated rat white adipocytes. Endocrinology 2006, 147:5835-5844.
22. Kleemann R., Verschuren L., van Erk M.J., Nikolsky Y., Cnubben N.H., Verheij E.R., Smilde A.K., Hendriks H.F., Zadelaar S., Smith G.J., Kaznacheev V., Nikolskaya T., Melnikov A., Hurt-Camejo E., van der Greef J., van Ommen B., Kooistra T. Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis. Genome Biol. 2007, 8:R200.
23. Subramanian S., Han C.Y., Chiba T., McMillen T.S., Wang S.A., Haw A., Kirk E.A., O'Brien K.D., Chait A. Dietary cholesterol worsens adipose tissue macrophage accumulation and atherosclerosis in obese LDL receptor-deficient mice. Arterioscler. Thromb. Vasc. Biol. 2008, 28:685-691.
24. Stokes K.Y., Clanton E.C., Clements K.P., Granger D.N. Role of interferon-gamma in hypercholesterolemia-induced leukocyte-endothelial cell adhesion. Circulation 2003, 107:2140-2145.
25. Stokes K.Y., Clanton E.C., Gehrig J.L., Granger D.N. Role of interleukin 12 in hypercholesterolemia-induced inflammation. Am. J. Physiol. Heart Circ. Physiol. 2003, 285:H2623-H2629.