Efficacy and safety of umbilical cord milking at birth: A systematic review and meta-analysis

JAMA Pediatrics

Volumn 169, Issue 1, 2015, Pages 18-25

  Al Wassia, Heidi ^a   Shah, Prakesh S ^b,c  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; INOTROPIC AGENT; PLASMA SUBSTITUTE;

APGAR SCORE; ARTERIAL PH; ARTICLE; BIRTH; BRAIN HEMORRHAGE; CHILD SAFETY; CLINICAL EFFECTIVENESS; CLINICAL TRIAL (TOPIC); GESTATIONAL AGE; HEMOGLOBIN BLOOD LEVEL; HOSPITALIZATION; HUMAN; HYPOTENSION; META ANALYSIS; NEWBORN CARE; NEWBORN MORTALITY; OUTCOME ASSESSMENT; OXYGEN CONSUMPTION; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTEMATIC REVIEW; UMBILICAL CORD; UMBILICAL CORD MILKING; FEMALE; INFANT; INFANT MORTALITY; INFANT, PREMATURE, DISEASES; NEWBORN; PHYSIOLOGY; PLACENTA CIRCULATION; PREGNANCY; TREATMENT OUTCOME;

FEMALE; GESTATIONAL AGE; HEMOGLOBINS; HUMANS; INFANT; INFANT MORTALITY; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; PLACENTAL CIRCULATION; PREGNANCY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME; UMBILICAL CORD;

EID: 84925023971     PISSN: 21686203     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapediatrics.2014.1906     Document Type: Article

References (37)

1. McCausland AM, Holmes F, Schumann WR. Management of cord and placental blood and its effect upon the newborn. Calif Med. 1949;71(3): 190-196.
2. DeMarsh Q, Alt H, Windle W, Hills D. The effect of depriving the infant of its placental blood on the blood picture during the first week of life. JAMA. 1941;116(23):2568-2573.
3. Wilson E, Windle W, Alt H. Deprivation of placental blood as a cause of iron deficiency in infants. AJDC. 1941;62(2):320-327.
4. Rabe H, Diaz-Rossello JL, Duley L, Dowswell T. Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes. Cochrane Database Syst Rev. 2012;8:CD003248.
5. McDonald SJ, Middleton P, Dowswell T, Morris PS. Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes. Cochrane Database Syst Rev. 2013;7:CD004074.
6. Siddall RS, Richardson RP. Milking or stripping the umbilical cord: effect on vaginally delivered babies. Obstet Gynecol. 1953;1(2):230-233.
7. Walsh SZ. Early clamping versus stripping of cord: comparative study of electrocardiogram in neonatal period. Br Heart J. 1969;31(1):122-126.
8. Lanzkowsky P. Effects of early and late clamping of umbilical cord on infant's haemoglobin level. BMJ. 1960;2(5215):1777-1782.
9. Usher R, Shephard M, Lind J. The blood volume of the newborn infant and placental transfusion. Acta Paediatr. 1963;52:497-512.
10. Colozzi AE. Clamping of the umbilical cord: its effect on the placental transfusion. N Engl J Med. 1954;250(15):629-632.
11. Hosono S, Mugishima H, Fujita H, et al. Umbilical cord milking reduces the need for red cell transfusions and improves neonatal adaptation in infants born at less than 29 weeks' gestation: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2008;93(1):F14-F19.
12. March MI, Hacker MR, Parson AW, Modest AM, de Veciana M. The effects of umbilical cord milking in extremely preterm infants: a randomized controlled trial. J Perinatol. 2013;33(10):763-767.
13. Upadhyay A, Gothwal S, Parihar R, et al. Effect of umbilical cord milking in term and near term infants: randomized control trial. AmJ Obstet Gynecol. 2013;208(2):120.e1-120.e6. doi:10.1016/j.ajog.2012.10.884.
14. Rabe H, Jewison A, Alvarez RF, et al; Brighton Perinatal Study Group. Milking compared with delayed cord clamping to increase placental transfusion in preterm neonates: a randomized controlled trial. Obstet Gynecol. 2011;117(2, pt 1): 205-211.
15. Katheria AC, Leone TA, Woelkers D, Garey DM, Rich W, Finer NN. The effects of umbilical cord milking on hemodynamics and neonatal outcomes in premature neonates. J Pediatr. 2014;164(5): 1045-1050.e1. doi:10.1016/j.jpeds.2014.01.024.
16. Alan S, Arsan S, Okulu E, et al. Effects of umbilical cord milking on the need for packed red blood cell transfusions and early neonatal hemodynamic adaptation in preterm infants born ≤1500 g: a prospective, randomized, controlled trial [published online March 13, 2014]. J Pediatr Hematol Oncol.
17. Erickson-Owens DA, Mercer JS, Oh W. Umbilical cord milking in term infants delivered by cesarean section: a randomized controlled trial. J Perinatol. 2012;32(8):580-584.
18. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009;62(10):e1-e34.
19. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1500 gm. J Pediatr. 1978;92 (4):529-534.
20. Shennan AT, Dunn MS, Ohlsson A, Lennox K, Hoskins EM. Abnormal pulmonary outcomes in premature infants: prediction from oxygen requirement in the neonatal period. Pediatrics. 1988;82(4):527-532.
21. Bell MJ, Ternberg JL, Feigin RD, et al. Neonatal necrotizing enterocolitis: therapeutic decisions based upon clinical staging. Ann Surg. 1978;187(1):1-7.
22. Higgins J, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration; 2011. http://handbook.cochrane.org/. Accessed January 12, 2014.
23. Egger M, Smith GD, Altman DG. Systematic Reviews in Health Care: Meta-Analysis in Context. 2nd ed. London, England: BMJ Publishing; 2001:87-108.
24. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency inmeta-analyses. BMJ. 2003;327(7414):557-560.
25. Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med ResMethodol. 2005;5:13. doi:10.1186/1471-2288-5-13.
26. Milking the umbilical cord vs immediate clamping in pre-term infants <33 weeks. NLM identifier NCT01819532. http://clinicaltrials.gov/ct2/show/NCT01819532. Accessed May 5, 2014.
27. Milking the umbilical cord for extreme preterm infants. NLM identifier NCT01666847. http://clinicaltrials.gov/ct2/show/NCT01666847. Accessed May 5, 2014.
28. The effect of cord milking on hemodynamic status of preterm infants. NLM identifier: NCT01487187. http://clinicaltrials.gov/ct2/show/NCT01487187. Accessed May 5, 2014.
29. Gupta R, Ramji S. Effect of delayed cord clamping on iron stores in infants born to anemic mothers: a randomized controlled trial. Indian Pediatr. 2002;39(2):130-135.
30. Chaparro CM, Neufeld LM, Tena Alavez G, Eguia-Líz Cedillo R, Dewey KG. Effect of timing of umbilical cord clamping on iron status in Mexican infants: a randomised controlled trial. Lancet. 2006;367(9527):1997-2004.
31. Lozoff B, Jimenez E, Hagen J, Mollen E,Wolf AW. Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics. 2000;105(4):e51.
32. Takami T, Suganami Y, Sunohara D, et al. Umbilical cord milking stabilizes cerebral oxygenation and perfusion in infants born before 29weeks of gestation. J Pediatr. 2012;161(4):742-747.
33. Kluckow M, Evans N. Low superior vena cava flow and intraventricular haemorrhage in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2000;82(3):F188-F194.
34. Chang YS, Ahn SY, Yoo HS, et al. Mesenchymal stem cells for bronchopulmonary dysplasia: phase 1 dose-escalation clinical trial. J Pediatr. 2014;164(5): 966-972.e6. doi:10.1016/j.jpeds.2013.12.011.
35. Pierro M, Ionescu L, Montemurro T, et al. Short-term, long-term and paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and repair in experimental bronchopulmonary dysplasia. Thorax. 2013;68(5):475-484.
36. Carroll J. Human cord blood for the hypoxic-ischemic neonate. Pediatr Res. 2012;71(4, pt 2):459-463.
37. Committee on Obstetric Practice, American College of Obstetricians and Gynecologists. Committee opinion No. 543: timing of umbilical cord clamping after birth. Obstet Gynecol. 2012;120(6):1522-1526.