HDL-Mimetic PLGA Nanoparticle To Target Atherosclerosis Plaque Macrophages

Bioconjugate Chemistry

Volumn 26, Issue 3, 2015, Pages 443-451

  Sanchez Gaytan, Brenda L ^a   Fay, Francois ^a   Lobatto, Mark E ^a,b   Tang, Jun ^a   Ouimet, Mireille ^c   Kim, Yongtae ^d   Van Der Staay, Susanne E M ^a   Van Rijs, Sarian M ^a   Priem, Bram ^a   Zhang, Liangfang ^e   Fisher, Edward A ^c   Moore, Kathryn J ^c   Langer, Robert ^f   Fayad, Zahi A ^a   Mulder, Willem J M ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMIMETICS; DISEASES; NANOPARTICLES; PHOSPHOLIPIDS;

ATHEROSCLEROTIC PLAQUE; CONTROLLED RELEASE PROPERTIES; HIGH DENSITY LIPOPROTEIN; HYBRID POLYMERS; HYDROPHOBIC CORE; MIMETICS; NANOCARRIERS; POLY LACTIC-CO-GLYCOLIC ACID; POLY(LACTIC-CO-GLYCOLIC ACID); TARGETING CAPABILITY;

MACROPHAGES;

APOLIPOPROTEIN; APOLIPOPROTEIN E; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN POLYGLACTIN CONJUGATE; LIPID; NANOCARRIER; NANOPARTICLE; POLYGLACTIN; UNCLASSIFIED DRUG; BIOMIMETIC MATERIAL; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BIOMIMETICS; CHOLESTEROL TRANSPORT; CONJUGATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG HALF LIFE; DRUG UPTAKE; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VIVO STUDY; KNOCKOUT MOUSE; LIGHT SCATTERING; MACROPHAGE; MALE; MICROFLUIDICS; MOUSE; NONHUMAN; TISSUE DISTRIBUTION; ANIMAL; CELL SURVIVAL; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PLAQUE, ATHEROSCLEROTIC; PROCEDURES; TUMOR CELL LINE; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; BIOMIMETIC MATERIALS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG DELIVERY SYSTEMS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LACTIC ACID; LIPOPROTEINS, HDL; MACROPHAGES; MALE; MICE; MICE, KNOCKOUT; NANOPARTICLES; PLAQUE, ATHEROSCLEROTIC; POLYGLYCOLIC ACID;

EID: 84925016275     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc500517k     Document Type: Article

References (36)

1. Mitka, M. (2012) New basic care goals seek to rein in global rise in cardiovascular disease JAMA, J. Am. Med. Assoc. 308, 1725-1726
2. Libby, P. (2002) Inflammation in atherosclerosis Nature 420, 868-874
3. Libby, P., Ridker, P. M., and Hansson, G. K. (2011) Progress and challenges in translating the biology of atherosclerosis Nature 473, 317-325
4. Majmudar, M. D., Keliher, E. J., Heidt, T., Leuschner, F., Truelove, J., Sena, B. F., Gorbatov, R., Iwamoto, Y., Dutta, P., Wojtkiewicz, G., Courties, G., Sebas, M., Borodovsky, A., Fitzgerald, K., Nolte, M. W., Dickneite, G., Chen, J. W., Anderson, D. G., Swirski, F. K., Weissleder, R., and Nahrendorf, M. (2013) Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice Circulation 127, 2038-2046
5. Charo, I. F. and Taub, R. (2011) Anti-inflammatory therapeutics for the treatment of atherosclerosis Nat. Rev. Drug Discovery 10, 365-376
6. Barnes, P. J. (2011) Glucocorticosteroids: current and future directions Br. J. Pharmacol. 163, 29-43
7. Lobatto, M. E., Fayad, Z. A., Silvera, S., Vucic, E., Calcagno, C., Mani, V., Dickson, S. D., Nicolay, K., Banciu, M., Schiffelers, R. M., Metselaar, J. M., van Bloois, L., Wu, H.-S., Fallon, J. T., Rudd, J. H., Fuster, V., Fisher, E. A., Storm, G., and Mulder, W. J. M. (2010) Multimodal clinical imaging to longitudinally assess a nanomedical anti-inflammatory treatment in experimental atherosclerosis Mol. Pharmaceutics 7, 2020-2029
8. Lobatto, M. E., Fuster, V., Fayad, Z. A., and Mulder, W. J. M. (2011) Perspectives and opportunities for nanomedicine in the management of atherosclerosis Nat. Rev. Drug Discovery 10, 835-852
9. Cormode, D. P., Jarzyna, P. A., Mulder, W. J. M., and Fayad, Z. A. (2010) Modified natural nanoparticles as contrast agents for medical imaging Adv. Drug. Delivery Rev. 62, 329-338
10. Gordon, S. M., Deng, J., Lu, L. J., and Davidson, W. S. (2010) Proteomic characterization of human plasma high density lipoprotein fractionated by gel filtration chromatography J. Proteome Res. 9, 5239-5249
11. Wang, N., Lan, D., Chen, W., Matsuura, F., and Tall, A. R. (2004) ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins Proc. Natl. Acad. Sci. U.S.A. 101, 9774-9779
12. Duong, M., Collins, H. L., Jin, W., Zanotti, I., Favari, E., and Rothblat, G. H. (2006) Relative contributions of ABCA1 and SR-BI to cholesterol efflux to serum from fibroblasts and macrophages Arterioscler., Thromb., Vasc. Biol. 26, 541-547
13. Fisher, E. A., Feig, J. E., Hewing, B., Hazen, S. L., and Smith, J. D. (2012) High-density lipoprotein function, dysfunction, and reverse cholesterol transport Arterioscler., Thromb., Vasc. Biol. 32, 2813-2820
14. Frias, J. C., Ma, Y., Williams, K. J., Fayad, Z. A., and Fisher, E. A. (2006) Properties of a versatile nanoparticle platform contrast agent to image and characterize atherosclerotic plaques by magnetic resonance imaging Nano Lett. 6, 2220-2224
15. Cormode, D. P., Skajaa, T., van Schooneveld, M. M., Koole, R., Jarzyna, P., Lobatto, M. E., Calcagno, C., Barazza, A., Gordon, R. E., Zanzonico, P., Fisher, E. A., Fayad, Z. A., and Mulder, W. J. M. (2008) Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform Nano Lett. 8, 3715-3723
16. McMahon, K. M., Mutharasan, R. K., Tripathy, S., Veliceasa, D., Bobeica, M., Shumaker, D. K., Luthi, A. J., Helfand, B. T., Ardehali, H., Mirkin, C. A., Volpert, O., and Thaxton, C. S. (2011) Biomimetic high density lipoprotein nanoparticles for nucleic acid delivery Nano Lett. 11, 1208-1214
17. Luthi, A. J., Zhang, H., Kim, D., Giljohann, D. A., Mirkin, C. A., and Thaxton, C. S. (2012) Tailoring of biomimetic high-density lipoprotein nanostructures changes cholesterol binding and efflux ACS Nano 6, 276-285
18. Skajaa, T., Cormode, D. P., Falk, E., Mulder, W. J. M., Fisher, E. A., and Fayad, Z. A. (2010) High-density lipoprotein-based contrast agents for multimodal imaging of atherosclerosis Arterioscler., Thromb., Vasc. Biol. 30, 169-176
19. Tang, J., Duivenvoorden, R., Izquierdo-Garcia, D., Cormode, D. P., Stroes, E. S., Lobatto, M. E., Kuan, E. L., Randolph, G. L., Fuster, V., Fisher, E. A., and Mulder, W. J. M. (2011) A statin-loaded nanotherapy increases anti-inflammatory effects of statin on atherosclerosis Circulation A9601
20. Makadia, H. K. and Siegel, S. J. (2011) Poly lactic- co -glycolic acid (PLGA) as biodegradable controlled drug delivery carrier Polymers 3, 1377-1397
21. Cheng, J., Teply, B. A., Sherifi, I., Sung, J., Luther, G., Gu, F. X., Levy-Nissenbaum, E., Radovic-Moreno, A. F., Langer, R., and Farokhzad, O. C. (2007) Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery Biomaterials 28, 869-876
22. Dhar, S., Gu, F. X., Langer, R., Farokhzad, O. C., and Lippard, S. J. (2008) Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles Proc. Natl. Acad. Sci. U.S.A. 105, 17356-17361
23. Kamaly, N., Xiao, Z., Valencia, P. M., Radovic-Moreno, A. F., and Farokhzad, O. C. (2012) Targeted polymeric therapeutic nanoparticles: design, development and clinical translation Chem. Soc. Rev. 41, 2971-3010
24. Kim, Y., Lee Chung, B., Ma, M., Mulder, W. J. M., Fayad, Z. A., Farokhzad, O. C., and Langer, R. (2012) Mass production and size control of lipid polymer hybrid nanoparticles through controlled microvortices Nano Lett. 12, 3587-3591
25. Kim, Y., Fay, F., Cormode, D. P., Sanchez-Gaytan, B. L., Tang, J., Hennessy, E. J., Ma, M., Moore, K., Farokhzad, O. C., Fisher, E. A., Mulder, W. J. M., Langer, R., and Fayad, Z. A. (2013) Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics ACS Nano 7, 9975-9983
26. Farokhzad, O. C. and Langer, R. (2006) Nanomedicine: developing smarter therapeutic and diagnostic modalities Adv. Drug. Delivery Rev. 58, 1456-1459
27. Frias, J. C., Williams, K. J., Fisher, E. A., and Fayad, Z. A. (2004) Recombinant HDL-like nanoparticles: a specific contrast agent for MRI of atherosclerotic plaques J. Am. Chem. Soc. 126, 16316-16317
28. Lund-Katz, S., Liu, L., Thuahnai, S. T., and Philips, M. C. (2003) High density lipiprotein structure Front. Biosci. 8, d1044-1054
29. Shih, A. Y., Sligar, S. G., and Schulten, K. (2009) Maturation of high-density lipoproteins J. R. Soc., Interface 6, 863-871
30. Jonas, A. (1986) Reconstitution of high-density lipoproteins Methods Enzymol. 128, 553-582
31. Duivenvoorden, R. l., Tang, J., Cormode, D. P., Mieszawska, A. J., Izquierdo-Garcia, D., Ozcan, C., Otten, M. J., Zaidi, N., Lobatto, M. E., van Rijs, S. M., Priem, B., Kuan, E. L., Martel, C., Hewing, B., Sager, H., Nahrendorf, M., Randolph, G. J., Stroes, E. S. G., Fuster, V., Fisher, E. A., Fayad, Z. A., and Mulder, W. J. M. (2014) A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation Nat. Commun. 5, 3065
32. Hu, C.-M. J., Zhang, L., Aryal, S., Cheung, C., Fang, R. H., and Zhang, L. (2011) Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform Proc. Natl. Acad. Sci. U.S.A. 108, 10980-10985
33. Lee, M. J.-E., Veiseh, O., Bhattarai, N., Sun, C., Hansen, S. J., Ditzler, S., Knoblaugh, S., Lee, D., Ellenbogen, R., Zhang, M., and Olson, J. M. (2010) Rapid pharmacokinetic and biodistribution studies using cholorotoxin-conjugated iron oxide nanoparticles: a novel non-radioactive method PLoS One 5, e9536
34. Swirski, F. K. and Nahrendorf, M. (2013) Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure Science 339, 161-166
35. Rouser, G., Fleischer, S., and Yamamoto, A. (1970) Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots Lipids 5, 494-496
36. Markwell, M. A. K., Haas, S. M., Bieber, L. L., and Tolbert, N. E. (1978) A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples Anal. Biochem. 87, 206-210