The English (H6R) familial Alzheimer's disease mutation facilitates zinc-induced dimerization of the amyloid-β metal-binding domain

Metallomics

Volumn 7, Issue 3, 2015, Pages 422-425

  Kozin, S A ^a   Kulikova, A A ^a   Istrate, A N ^a   Tsvetkov, P O ^a   Zhokhov, S S ^b   Mezentsev, Y V ^c   Kechko, O I ^a   Ivanov, A S ^c   Polshakov, V I ^d   Makarov, A A ^a  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

^c INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

^d LOMONOSOV MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEINS; NEURODEGENERATIVE DISEASES;

ALZHEIMER'S DISEASE; METAL BINDING DOMAIN; ZINC IONS;

ZINC;

AMYLOID BETA PROTEIN; ARGININE; BINDING PROTEIN; DIMER; HISTIDINE; METAL BINDING PROTEIN; UNCLASSIFIED DRUG; ZINC; ZINC ION; PROTEIN BINDING;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHELATION; CONTROLLED STUDY; DIMERIZATION; FAMILIAL DISEASE; GENE MUTATION; ISOTHERMAL TITRATION CALORIMETRY; METAL BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; STOICHIOMETRY; SURFACE PLASMON RESONANCE; CALORIMETRY; CHEMISTRY; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; UNITED KINGDOM;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; CALORIMETRY; ENGLAND; HUMANS; MUTATION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTON MAGNETIC RESONANCE SPECTROSCOPY; SURFACE PLASMON RESONANCE; ZINC;

EID: 84925013128     PISSN: 17565901     EISSN: 1756591X     Source Type: Journal    
DOI: 10.1039/c4mt00259h     Document Type: Article

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