Reduced functional connectivity during controlled semantic integration in schizophrenia: A multivariate approach

Human Brain Mapping

Volumn 36, Issue 8, 2015, Pages 2948-2964

  Woodward, Todd S ^a,b   Tipper, Christine M ^a,b   Leung, Alexander L ^a,b   Lavigne, Katie M ^a,b   Sanford, Nicole ^a,b   Metzak, Paul D ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b PROVINCIAL HEALTH SERVICES AUTHORITY   (Canada)

Author keywords

constrained principal component analysis; functional connectivity; functional magnetic resonance imaging; schizophrenia; semantic association; semantic distance; semantic integration

Indexed keywords

ADULT; ARTICLE; ASSOCIATION; BRAIN FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; HUMAN; HYPERACTIVITY; HYPOACTIVITY; MALE; NUCLEAR MAGNETIC RESONANCE SCANNER; PRIORITY JOURNAL; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SEMANTIC INTEGRATION; SENSORIMOTOR INTEGRATION; TASK PERFORMANCE; BRAIN; BRAIN MAPPING; LANGUAGE TEST; MULTIVARIATE ANALYSIS; NERVE TRACT; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PATTERN RECOGNITION; PHYSIOLOGY; PROCEDURES; PSYCHOSIS; REACTION TIME; READING; SEMANTICS; SIGNAL PROCESSING;

ADULT; BRAIN; BRAIN MAPPING; FEMALE; HUMANS; LANGUAGE TESTS; MAGNETIC RESONANCE IMAGING; MALE; MULTIVARIATE ANALYSIS; NEURAL PATHWAYS; NEUROPSYCHOLOGICAL TESTS; PATTERN RECOGNITION, VISUAL; PSYCHOTIC DISORDERS; REACTION TIME; READING; SCHIZOPHRENIA; SEMANTICS; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 84925008227     PISSN: 10659471     EISSN: 10970193     Source Type: Journal    
DOI: 10.1002/hbm.22820     Document Type: Article

References (56)

1. American Psychiatric Association (2000): Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Washington: American Psychiatric Association.
2. Badre D, Poldrack RA, Pare-Blagoev EJ, Insler RZ, Wagner AD (2005): Dissociable controlled retrieval and generalized selection mechanisms in ventrolateral prefrontal cortex. Neuron 47:907–918.
3. Beck AT, Rector NA, Stolar N, Grant P (2009): Schizophrenia: Cognitive Theory, Research, and Therapy. New York: Guilford.
4. Belin P, Zatorre RJ, Lafaille P, Ahad P, Pike B (2000): Voice-selective areas in human auditory cortex. Nature 403:309–312.
5. Bleuler E (1911): Dementia praecox: Or, the Group of Schizophrenias. Zinkin J, translator. New York: International Universities Press.
6. Buckner RL, Krienen FM, Castellanos A, Diaz JC, Yeo BT (2011): The organization of the human cerebellum estimated by intrinsic functional connectivity. J Neurophysiol 106:2322–2345.
7. Bunge SA, Wendelken C, Badre D, Wagner AD (2005): Analogical reasoning and prefrontal cortex: Evidence for separable retrieval and integration mechanisms. Cereb Cortex 15:239–249.
8. Callicott JH, Mattay VS, Verchinski BA, Marenco S, Egan MF, Weinberger DR (2003): Complexity of prefrontal cortical dysfunction in schizophrenia: More than up or down. Am J Psychiatry 160:2209–2215.
9. Choi EY, Yeo BT, Buckner RL (2012): The organization of the human striatum estimated by intrinsic functional connectivity. J Neurophysiol 108:2242–2263.
10. Dale AM (1999): Optimal experimental design for event-related fMRI. Hum Brain Mapp 8:109–114.
11. Duncan J, Owen AM (2000): Common regions of the human frontal lobe recruited by diverse cognitive demands. Trends Neurosci 23:475–483.
12. Durda K, Buchanan L (2006): WordMine2 Available Online at http://web2.uwindsor.ca/wordmine. Last accessed April 29, 2015.
13. Fedorenko E, Duncan J, Kanwisher N (2013): Broad domain generality in focal regions of frontal and parietal cortex. Proc Natl Acad Sci USA 110:16616–16621.
14. Fletcher P, McKenna PJ, Friston KJ, Frith CD, Dolan RJ (1999): Abnormal cingulate modulation of fronto-temporal connectivity in schizophrenia. Neuroimage 9:337–342.
15. Frith CD, Friston KJ, Herold S, Silbersweig P, Fletcher C, Cahill RJ, Dolan R, Frackowiak SJ, Liddle PF (1995): Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. Br J Psychiatry 167:343–349.
16. Gold BT, Balota DA, Jones SJ, Powell DK, Smith CD, Andersen AH (2006): Dissociation of automatic and strategic Lexical-semantics: Functional magnetic resonance imaging evidence for differing roles of multiple frontotemporal regions. J Neurosci 26:6523–6532.
17. Hacker CD, Laumann TO, Szrama NP, Baldassarre A, Snyder AZ, Leuthardt EC, Corbetta M (2013): Resting state network estimation in individual subjects. NeuroImage 82:616–633.
18. Hagoort P (2013): MUC (memory, unification, control) and beyond. Front Psychol 4:416
19. Heinrichs W, Zakzanis KK (1998): Neurocognitive deficit in schizophrenia: A quantitative review of the evidence. Neuropsychology 12:426–445.
20. Henson R, Rugg MD, Friston K (2001): The choice of basis functions in event-related fMRI. NeuroImage 13:149s
21. Hunter MA, Takane Y (2002): Constrained principal component analysis: Various applications. J Educ Behav Stat 27:105–145.
22. Jamadar SD, Pearlson GD, O'Neil KM, Assaf M (2013): Semantic association fMRI impairments represent a potential schizophrenia biomarker. Schizophr Res 145:20–26.
23. Karlsgodt KH, Sanz J, van Erp TGM, Bearden CE, Nuechterlein KH, Cannon TD (2009): Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia. Schizophr Res 108:143–150.
24. Keefe RS, Bilder RM, Davis SM, Harvey PD, Palmer BW, Gold JM, Meltzer HY, Green MF, Capuano G, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO, Davis CE, Hsiao JK, Lieberman JA, CATIE Investigators, Neurocognitive Working Group (2007): Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia. Arch Gen Psychiatry 64:633–647.
25. Kiang M, Kutas M, Light GA, Braff DL (2008): An event-related brain potential study of direct and indirect semantic priming in schizophrenia. Am J Psychiatry 165:74–81.
26. Kiss GR, Armstrong C, Milroy R, Piper J (1973): An associative thesaurus of English and its computer analysis. In: Aitkin AJ, Bailey RW, Hamilton-Smith N, editors. The Computer and Literary Studies. Edinburgh: University Press. pp 153–165.
27. Kubicki M, McCarley RW, Nestor PG, Huh T, Kikinis R, Shenton ME, Wible CG (2003): An fMRI study of semantic processing in men with schizophrenia. NeuroImage 20:1923–1933.
28. Kuperberg GR (2007): Neural mechanisms of language comprehension: Challenges to syntax. Brain Res 1146:23–49.
29. Kuperberg GR, Deckersbach T, Holt DJ, Goff D, West WC (2007): Increased temporal and prefrontal activity in response to semantic associations in schizophrenia. Arch Gen Psychiatry 64:138–151.
30. Kuperberg GR, West WC, Lakshmanan BM, Goff D (2008): Functional magnetic resonance imaging reveals neuroanatomical dissociations during semantic integration in schizophrenia. Biol Psychiatry 64:407–418.
31. Lau EF, Phillips C, Poeppel D (2008): A cortical network for semantics: (De)Constructing the n400. Nat Rev Neurosci 9:920−933.
32. Lavigne KM, Metzak PD, Woodward TS (2015a): Functional brain networks underlying detection and integration of disconfirmatory evidence. NeuroImage 112:138–151.
33. Lavigne KM, Rapin LA, Metzak PM, Whitman JC, Jung K, Dohen M, Loevenbruck H, Woodward TS (2015b): Left-dominant temporal-frontal hypercoupling in schizophrenia patients with hallucinations during speech perception. Schizophr Bull 41:259–267.
34. Li X, Branch CA, DeLisi LE (2009): Language pathway abnormalities in schizophrenia: A review of fMRI and other imaging studies. Curr Opin Psychiatry 22:131–139.
35. Li X, Branch C, Nierenberg J, DeLisi L (2010): Disturbed functional connectivity of cortical activation during semantic discrimination in patients with schizophrenia and subjects at genetic High-risk. Brain Imaging Behav 4:109–120.
36. Liddle PF, Ngan ETN, Duffield G, Kho K, Warren AJ (2002): Signs and symptoms of psychotic illness: A rating scale. Br J Psychiatry 180:45–50.
37. Metzak PD, Riley JD, Wang L, Whitman JC, Ngan ETC, Woodward TS (2012): Decreased efficiency of task-positive and task-negative networks during working memory in schizophrenia. Schizophr Bull 38:803–813.
38. Moritz S, Woodward TS, Küppers D, Lausen A, Schickel M (2003): Increased automatic spreading of activation in thought-disordered schizophrenic patients. Schizophr Res 59:181–186.
39. Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL (2001): A default mode of brain function. Proc Natl Acad Sci USA 98:676–682.
40. Rapin L, Loevenbruck H, Dohen M, Metzak PD, Whitman JC, Woodward TS (2012): Hyperintensity of functional networks involving voice-selective cortical regions during silent thought in schizophrenia. Psychiatry Res: Neuroimaging 202:110–117.
41. Serences JT (2004): A comparison of methods for characterizing the event-related BOLD timeseries in rapid fMRI. NeuroImage 21:1690–1700.
42. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998): The Mini-international neuropsychiatric interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59:22–33.
43. Spitzer M (1997): A cognitive neuroscience view of schizophrenic thought disorder. Schizophr Bull 23:29–50.
44. Stephan KE, Friston KJ, Frith CD (2009): Dysconnection in schizophrenia: From abnormal synaptic plasticity to failures of self-monitoring. Schizophr Bull 35:509–527.
45. Takane Y, Shibayama T (1991): Principal component analysis with external information on both subjects and variables. Psychometrika 56:97–120.
46. Thompson-Schill SL, D'Esposito M, Aguirre GK, Farah MJ (1997): Role of left inferior prefrontal cortex in retrieval of semantic knowledge: A reevaluation. Proc Natl Acad Sci USA 94:14792–14797.
47. Thompson-Schill SL, D'Esposito M, Kan IP (1999): Effects of repetition and competition on activity in left prefrontal cortex during word generation. Neuron 23:513–522.
48. Van Petten C, Luka BJ (2006): Neural localization of semantic context effects in electromagnetic and hemodynamic studies. Brain Lang 97:279–293.
49. Vistoli D, Passerieux C, Houze B, Hardy-Baylé M, Brunet-Gouet E (2011): Neural basis of semantic priming in schizophrenia during a lexical decision task: A magneto-encephalography study. Schizophr Res 130:114–122.
50. Wagner AD, Davachi L (2001): Cognitive neuroscience: Forgetting of things past. Curr Biol 11:R964–R967.
51. Wagner AD, Paré-Blagoev EJ, Clark J, Poldrack RA (2001): Recovering meaning: Left prefrontal cortex guides controlled semantic retrieval. Neuron 31:329–338.
52. Weinstein S, Werker JF, Vouloumanos A, Woodward TS, Ngan ET (2006): Do you hear what I hear? Neural correlates of thought disorder during listening to speech in schizophrenia. Schizophr Res 86:130–137.
53. Whitman JC, Metzak PD, Lavigne K, Woodward TS (2013): Functional connectivity in a frontoparietal network involving the dorsal anterior cingulate cortex underlies decisions to accept a hypothesis. Neuropsychologia 51:1132–1141.
54. Woodward TS, Feredoes E, Metzak PD, Takane Y, Manoach DS (2013): Epoch-specific functional networks involved in working memory. NeuroImage 65:529–539.
55. Yeo BT, Krienen FM, Sepulcre J, Sabuncu MR, Lashkari D, Hollinshead M, Roffman JL, Smoller JW, Zollei L, Polimeni JR, Fischl B, Liu H, Buckner RL (2011): The organization of the human cerebral cortex estimated by intrinsic functional connectivity. J Neurophysiol 106:1125–1165.
56. Zatorre RJ, Evans AC, Meyer E, Gjedde A (1992): Lateralization of phonetic and pitch discrimination in speech processing. Science 256:846–849.