Identification and characterization of PERK activators by phenotypic screening and their effects on NRF2 activatione

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Xie, Wensheng ^a   Pariollaud, Marie ^a   Wixted, William E ^a   Chitnis, Nilesh ^b   Fornwald, James ^a   Truong, Maggie ^a   Pao, Christina ^a   Liu, Yan ^a   Ames, Robert S ^a   Callahan, James ^a   Solari, Roberto ^c   Sanchez, Yolanda ^a   Diehl, Alan ^b   Li, Hu ^a  

^a GLAXOSMITHKLINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [2 [1 (2,4 BIS(TRITRIFLUOROMETHYL)BENZYL) 3 [4 [[TRIFLUOROMETHYL]THIO]PHENYL]UREIDO]ETHYL]PHENOXY] 2 METHYLPROPANOIC; 5 [6 [[3 [2,6 DICHLOROPHENYL] 5 ISOPROPYLISOXAZOL 4 YL]METHOXY]NAPHTHALEN 2 YL] 2 FLUOROBENZOIC ACID; ENZYME ACTIVATOR; ENZYME INHIBITOR; ETHYL 2 [3,5 BIS[TRIFLUOROMETHYL]PHENYL] 3 OXO 2,3 DIHYDRO 1H PYRAZOLE 4 CARBOXYLATE; GREEN FLUORESCENT PROTEIN; GSK 2606414; INITIATION FACTOR 2ALPHA; PHOSPHOTRANSFERASE; PROTEIN KINASE R LIKE ENDOPLASMIC RETICULUM KINASE; PROTEIN KINASE R LIKE ENDOPLASMIC RETICULUM KINASE ACTIVATOR; PROTEIN KINASE R LIKE ENDOPLASMIC RETICULUM KINASE INHIBITOR; THAPSIGARGIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; INITIATION FACTOR 2; MOLECULAR LIBRARY; NFE2L2 PROTEIN, MOUSE; PERK KINASE; PROTEIN KINASE R;

ARTICLE; BLOOD LEVEL; CELL DENSITY; DIAGNOSTIC KIT; EC50; EMBRYO CELL; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; FIBROBLAST; GENE INDUCTION; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; PHENOTYPE; PROTEIN PHOSPHORYLATION; SIGNAL PROCESSING; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; HIGH THROUGHPUT SCREENING; HOMEOSTASIS; METABOLISM; MOLECULAR LIBRARY; MOUSE; PHOSPHORYLATION; PHYSIOLOGY; PROCEDURES; PROTEIN SYNTHESIS; VALIDATION STUDY;

EUKARYOTA;

ANIMALS; CELLS, CULTURED; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; GREEN FLUORESCENT PROTEINS; HIGH-THROUGHPUT SCREENING ASSAYS; HOMEOSTASIS; MICE; NF-E2-RELATED FACTOR 2; PHENOTYPE; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; THAPSIGARGIN;

EID: 84925004646     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0119738     Document Type: Article

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