Management of Diabetes in the Elderly

Medical Clinics of North America

Volumn 99, Issue 2, 2015, Pages 351-377

  Bansal, Nidhi ^a   Dhaliwal, Ruban ^a   Weinstock, Ruth S ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

Diabetes mellitus; Frailty; Geriatric; Hypertension; Hypoglycemia; Insulin

Indexed keywords

DIPEPTIDYL PEPTIDASE IV INHIBITOR; INSULIN DERIVATIVE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; SULFONYLUREA;

BLOOD GLUCOSE MONITORING; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; DIABETES MELLITUS; DIET THERAPY; EYE CARE; FOOT CARE; GLYCEMIC CONTROL; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN INFUSION; INSULIN PUMP; INSULIN TREATMENT; KIDNEY FAILURE; KIDNEY FUNCTION; NON INSULIN DEPENDENT DIABETES MELLITUS; PATIENT SAFETY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; RISK FACTOR; SOCIAL SUPPORT; AGED; COMORBIDITY; DIABETES COMPLICATIONS; PSYCHOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; COMORBIDITY; DIABETES COMPLICATIONS; DIABETES MELLITUS; HUMANS; HYPOGLYCEMIA; QUALITY OF LIFE; RISK FACTORS;

EID: 84924979791     PISSN: 00257125     EISSN: 15579859     Source Type: Journal    
DOI: 10.1016/j.mcna.2014.11.008     Document Type: Review

References (82)

1. US Centers for Disease Control and Prevention: National Diabetes Statistics Report, 2014. Available at: . Accessed June 20, 2014. http://www.cdc.gov/diabetes/pubs/statsreport14.htm.
2. Selvin E., Parrinello C.M., Sacks D.B., et al. Trends in prevalence and control of diabetes in the United States, 1988-1994 and 1999-2010. Ann Intern Med 2014, 160(8):517-525.
3. Andreassen L.M., Sandberg S., Kristensen G.B., et al. Nursing home patients with diabetes: prevalence, drug treatment and glycemic control. Diabetes Res Clin Pract 2014, 105(1):102-109.
4. Gregg E.W., Beckles G.L., Williamson D.F., et al. Diabetes and physical disability among older US adults. Diabetes Care 2000, 23(9):1272-1277.
5. Gregg E.W., Li Y., Wang J., et al. Changes in diabetes related complications in the United States, 1990-2010. NEngl J Med 2014, 370(16):1514-1523.
6. Currie C.J., Peters J.R., Tynan A., et al. Survival as a function of HbA1c in people with type 2 diabetes: a retrospective cohort study. Lancet 2010, 375(9713):481-489.
7. Huang E.S., Liu J.Y., Moffet H.H., et al. Glycemic control, complications, and death in older diabetic patients: the diabetes and aging study. Diabetes Care 2011, 34(6):1329-1336.
8. Sanon V.P., Sanon S., Kanakia R., et al. Hypoglycemia from a cardiologist's perspective. Clin Cardiol 2014, Available at:. http://www.ncbi.nlm.nih.gov/pubmed?term=Chilton%20R%5BAuthor%5D%26cauthor=true%26cauthor_uid=24895268, 10.1002/clc.22288.
9. Tseng C.L., Soroka O., Maney M., et al. Asssessing potential glycemic overtreatment in persons at hypoglycemic risk. JAMA Intern Med 2014, 174(2):259-268.
10. Lipska K.J., Ross J.S., Wang Y., et al. National trends in US hospital admissions for hyperglycemia and hypoglycemia among Medicare beneficiaries, 1999 to 2011. JAMA Intern Med 2014, 174(7):1116-1124.
11. Geller A.I., Shehab N., Lovegrove M.C., et al. National estimates of insulin-related hypoglycemia and errors leading to emergency department visits and hospitalizations. JAMA Intern Med 2014, 174(5):678-686.
12. Majumdar S.R., Hemmelgarn B.R., Lin M., et al. Hypoglycemia associated with hospitalization and adverse events in older people: population-based cohort study. Diabetes Care 2013, 36(11):3585-3590.
13. Weinstock R.S., Xing D., Maahs D.M., et al. T1D Exchange Clinic Network. Severe hypoglycemia and diabetic ketoacidosis in adults with type 1 diabetes: results from the T1D Exchange clinic registry. JClin Endocrinol Metab 2013, 98(8):3411-3419.
14. Gold A.E., Macleod K.M., Frier B.M. Frequency of severe hypoglycemia in patients with type 1 diabetes with impaired awareness of hypoglycemia. Diabetes Care 1994, 17(7):697-703.
15. Matyka K., Evans M., Lomas J., et al. Altered hierarchy of protective responses against severe hypoglycemia in normal aging in healthy men. Diabetes Care 1997, 20(2):135-141.
16. Brierley E.J., Broughton D.L., James O.F., et al. Reduced awareness of hypoglycaemia in the elderly despite an intact counter-regulatory response. QJ Med 1995, 88(6):439-445.
17. Bremer J.P., Jauch-Chara K., Hallschmid M., et al. Hypoglycemia unawareness in older compared with middle-aged patients with type 2 diabetes. Diabetes Care 2009, 32(8):1513-1517.
18. Cryer P.E. Hypoglycemia in type 1 diabetes mellitus. Endocrinol Metab Clin North Am 2010, 39(3):641-654.
19. Whitmer R.A., Karter A.J., Yaffe K., et al. Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 2009, 301(15):1565-1572.
20. Feinkohl I., Aung P.P., Keller M., et al. Severe hypoglycemia and cognitive decline in older people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes Care 2014, 37(2):507-515.
21. Nordin C. The case for hypoglycaemia as a proarrhythmic event: basic and clinical evidence. Diabetologia 2010, 53(8):1552-1561.
22. Bonds D.E., Miller M.E., Bergenstal R.M., et al. The association between symptomatic, severe hypoglycaemia and mortality in type 2 diabetes: retrospective epidemiological analysis of the ACCORD study. BMJ 2010, 340:b4909.
23. Zoungas S., Patel A., Chalmers J., et al. Severe hypoglycemia and risks of vascular events and death. NEngl J Med 2010, 363(15):1410-1418. ADVANCE Collaborative Group.
24. Green A.J., Fox K.M., Grandy S. SHIELD Study Group. Self-reported hypoglycemia and impact on quality of life and depression among adults with type 2 diabetes mellitus. Diabetes Res Clin Pract 2012, 96(3):313-318.
25. Trief P., Xing D., Foster N., et al. Depression in adults in the T1D exchange clinic registry. Depression in adults in the T1D exchange clinic registry. Diabetes Care 2014, 37(6):1563-1572.
26. Laiteerapong N., Karter A.J., Liu J.Y., et al. Correlates of quality of life in older adults with diabetes: the Diabetes & Aging Study. Diabetes Care 2011, 34(8):1749-1753.
27. Araki A., Ito H. Diabetes mellitus and geriatric syndromes. Geriatr Gerontol Int 2009, 9(2):105-114.
28. Kirkman M.S., Briscoe V.J., Clark N., et al. Consensus Development Conference on Diabetes and Older Adults. Diabetes in older adults: a consensus report. JAm Geriatr Soc 2012, 60(12):2342-2356.
29. Rydén L., Grant P.J., Anker S.D., et al. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the Task Force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur Heart J 2013, 34(39):3035-3087.
30. International Diabetes Federation Global Guideline for Managing Older People with Type 2 Diabetes. 2013. Available at: . Accessed June 12, 2014. http://www.idf.org/guidelines/managing-older-people-type-2-diabetes.
31. Sinclair A., Morley J.E., Rodriguez-Manas L., et al. Diabetes mellitus in older people: position statement on behalf of the International Association of Gerontology and Geriatrics (IAGG), the European Diabetes Working Party for Older People (EDWPOP), and the International Task Force of Experts in Diabetes. JAm Med Dir Assoc 2012, 13(6):497-502.
32. The Department of Veterans Affairs and the Department of Defense Clinical Practice Guidelines. Management of diabetes in primary care. 2010. Available at: . Accessed July 1, 2014. http://www.healthquality.va.gov/guidelines/CD/diabetes/DM2010_FUL-v4e.pdf.
33. The Department of Veterans Affairs and the Department of Defense Clinical Practice Guidelines. Management of hypertension in primary care. 2005. Available at: . Accessed July 1, 2014. http://www.healthquality.va.gov/guidelines/CD/htn/htn04_pdf1.pdf.
34. The Department of Veterans Affairs and the Department of Defense Clinical Practice Guidelines. Management of dyslipidemia. 2006. Available at: . Accessed July 1, 2014. http://www.healthquality.va.gov/guidelines/CD/lipids/lip05_950_final2.pdf.
35. James P.A., Oparil S., Carter B.L., et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014, 13(5):507-520.
36. Mancia G., Fagard R., Narkiewicz K., et al. 2013 ESH/ESC guidelines for the management of arterial hypertension. Blood Press 2014, 23(1):3-16.
37. Stone N.J., Robinson J., Lichtenstein A.H., et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014, 129(25Suppl 2):S1-S45.
38. Solano M.P., Goldberg R.B. Management of dyslipidemia in diabetes. Cardiol Rev 2006, 14(3):125-135.
39. Petersen L.K., Christensen K., Kragstrup J. Lipid-lowering treatment to the end? Areview of observational studies and RCTs on cholesterol and mortality in 80+-year-olds. Age Ageing 2010, 39(6):674-680.
40. American Geriatrics Society 2012 Beers Criteria Update Expert Panel American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults. JAm Geriatr Soc 2012, 60(4):616-631.
41. Munshi M.N., Segal A.R., Suhl E., et al. Assessment of barriers to improve diabetes management in older adults. Diabetes Care 2013, 36(3):543-549.
42. Aids for insulin users 2014. Diabetes Forecast. Available at: . Accessed July 06, 2014. http://www.diabetesforecast.org/2014/Jan/aids-for-insulin-users-2014.html.
43. Dhaliwal R., Weinstock R.S. Management of type 1 diabetes in older adults. Diabetes Spectr 2014, 27(1):9-20.
44. Ober S.K., Watts S., Lawrence R.H. Insulin use in elderly diabetic patients. Clin Interv Aging 2006, 1(2):107-113.
45. Ligthelm R.J., Kaiser M., Vora J., et al. Insulin use in elderly adults: risk of hypoglycemia and strategies for care. JAm Geriatr Soc 2012, 60(8):1564-1570.
46. Rosenstock J. Management of type 2 diabetes mellitus in the elderly. Drugs Aging 2001, 18(1):31-44.
47. Hendra T.J. Starting insulin therapy in elderly patients. JR Soc Med 2002, 95(9):453-455.
48. Drugs for type 2 diabetes. Treat Guidel Med Lett 2014, 12(139):17-24. Available at:. http://www.medicalletter.org.
49. Matejko B., Cyganek K., Katra B., et al. Insulin pump therapy is equally effective and safe in elderly and young type 1 diabetes patients. Rev Diabet Stud 2011, 8(2):254-258.
50. Bergenstal R.M., Klonoff D.C., Garg S.K., ASPIRE In-Home Study Group, et al. Threshold-based insulin pump interruption for reduction of hypoglycemia. NEngl J Med 2013, 369(3):224-232.
51. Lipska K.J., Bailey C.J., Inzucchi S.E. Use of metformin in the setting of mild-to moderate renal insufficiency. Diabetes Care 2011, 34(6):1431-1437.
52. Riddle M.C. More reasons to say goodbye to glyburide. JClin Endocrinol Metab 2010, 95(11):4867-4870.
53. Round E.M., Engel S.S., Golm G.T., et al. Safety and tolerability of sitagliptin in elderly patients with type 2 diabetes: a pooled analysis of 25 clinical studies. Drugs Aging 2014, 31(3):203-214.
54. Wu S., Hopper I., Skip M., et al. Dipeptidyl peptidase-4 inhibitors and cardiovascular outcomes: meta-analysis of randomized clinical trials with 55,141 participants. Cardiovasc Ther 2014, 32(4):147-158. 10.1111/1755-5922.12075.
55. Plosker G.L., Figgitt D.P. Repaglinide: a pharmacoeconomic review of its use in type 2 diabetes mellitus. Pharmacoeconomics 2004, 22(6):389-411.
56. van de Laar F.A., Lucassen P.L., Akkermans R.P., et al. Alpha-glucosidase inhibitors for patients with type 2 diabetes: results from a Cochrane systematic review and meta-analysis. Diabetes Care 2005, 28(1):154-163.
57. Miller E.M. Individualizing care with injectable glucose-lowering agents. JFam Pract 2013, 62(12 Suppl CME):S12-S19.
58. Ferrannini E., Solini A. SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects. Nat Rev Endocrinol 2012, 8(8):495-502.
59. Sharma V., Aggarwal S., Sharma A. Diabetes in elderly. JEndocrinol Metab 2011, 1(1):9-13.
60. Odegard P.S., Setter S.M., Neumiller J.J. Considerations for the pharmacological treatment of diabetes in older adults. Diabetes Spectr 2007, 20(4):239-247.
61. Lostia S., Lunetta M., Lunetta M., et al. Safety, efficacy, acceptability of a pre-filled insulin pen in diabetic patients over 60 years old. Diabetes Res Clin Pract 1995, 28(3):173-177.
62. Sullivan D.H., Bopp M.M., Roberson P.K. Protein-energy undernutrition and life-threatening complications among the hospitalized elderly. JGen Intern Med 2002, 17(12):923-932.
63. Wells J.L., Dumbrell A.C. Nutrition and aging: assessment and treatment of compromised nutritional status in frail elderly patients. Clin Interv Aging 2006, 1(1):67-79.
64. Chiang J.L., Kirkman M.S., Laffel L.M., on behalf of the Type 1 Diabetes Sourcebook Authors, et al. Type 1 diabetes through the life span: a position statement of the American Diabetes Association. Diabetes Care 2014, 37(7):2034-2054.
65. Pastors J.G., Warshaw H., Daly A., et al. The evidence for the effectiveness of medical nutrition therapy in diabetes management. Diabetes Care 2002, 25(3):608-613.
66. Franz M.J., Boucher J.L., Evert A.B. Evidence-based diabetes nutrition therapy recommendations are effective: the key is individualization. Diabetes Metab Syndr Obes 2014, 7:65-72.
67. Villareal D.T., Apovian C.M., Kushner R.F., American Society for Nutrition; NAASO, The Obesity Society, et al. Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Am J Clin Nutr 2005, 82(5):923-934.
68. Suhl E., Bonsignore P. Diabetes self-management education for older adults: general principles and practical application. Diabetes Spectr 2006, 19(4):234-240.
69. Scott R., O'Brien R., Fulcher G., et al. Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study Investigators. Effects of fenofibrate treatment on cardiovascular disease risk in 9,795 individuals with type 2 diabetes and various components of the metabolic syndrome The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study. Diabetes Care 2009, 32(3):493-498.
70. Mann J.F., Schmieder R.E., McQueen M., et al. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet 2008, 372(9638):547-553.
71. Mainous A.G., Tanner R.J., Shorr R.I., et al. Use of aspirin for primary and secondary cardiovascular disease prevention in the United States, 2011-2012. JAm Heart Assoc 2014, 3(4). pii:e000989.
72. Smith S.A., Poland G.A., American Diabetes Association Influenza and pneumococcal immunization in diabetes. Diabetes Care 2004, 27(1):S111-S113.
73. Centers for Disease Control and Prevention: Diabetes and Adult Vaccinations. 2014. Available at: . Accessed July 26, 2014. http://www.cdc.gov/vaccines/hcp/patient-ed/adults/downloads/f-diabetes-vaccines.pdf.
74. Housden L., Wong S.T., Dawes M. Effectiveness of group medical visits for improving diabetes care: a systematic review and meta-analysis. CMAJ 2013, 185(13):E635-E644.
75. Suksomboon N., Poolsup N., Nge Y.L. Impact of phone call intervention on glycemic control in diabetes patients: a systematic review and meta-analysis of randomized, controlled trials. PLoS One 2014, 9(2):e89207.
76. Health Quality Ontario Home telemonitoring for type 2 diabetes: an evidence-based analysis. Ont Health Technol Assess Ser 2009, 9(24):1-38.
77. Shea S., Weinstock R.S., Teresi J.A., et al. Arandomized trial comparing telemedicine case management with usual care in older, ethnically diverse, medically underserved patients with diabetes mellitus: 5 year results of the IDEATel study. JAm Med Inform Assoc 2009, 16(4):446-456. IDEATel Consortium.
78. Shea S., Kothari D., Teresi J.A., et al. Social impact analysis of the effects of a telemedicine intervention to improve diabetes outcomes in an ethnically diverse, medically underserved population: findings from the IDEATel Study. Am J Public Health 2013, 103(10):1888-1894.
79. Weinstock R.S., Teresi J.A., Goland R., et al. Glycemic control and health disparities in older ethnically diverse underserved adults with diabetes: five-year results from the Informatics for Diabetes Education and Telemedicine (IDEATel) study. Diabetes Care 2011, 34(2):274-279. IDEATel Consortium.
80. Weinstock R.S., Brooks G., Palmas W., et al. Lessened decline in physical activity and impairment of older adults with diabetes with telemedicine and pedometer use: results from the IDEATel study. Age Ageing 2011, 40(1):98-105.
81. Luchsinger J.A., Palmas W., Teresi J.A., et al. Improved diabetes control in the elderly delays global cognitive decline. JNutr Health Aging 2011, 15(6):445-449.
82. Dy P., Morin P.C., Weinstock R.S. Use of telemedicine to improve glycemic management in a skilled nursing facility: a pilot study. Telemed J E Health 2013, 19(8):643-645.