The influence of equol on the hypothalamic-pituitary-thyroid axis and hepatic lipid metabolic parameters in adult male rats

Life Sciences

Volumn 128, Issue , 2015, Pages 1-7

  Loutchanwoot, Panida ^a   Srivilai, Prayook ^a   Jarry, Hubertus ^b  

^a MAHASARAKHAM UNIVERSITY   (Thailand)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Equol; Prostate; Serum lipids; Thyroid hormones; Thyrotropin secretion; Thyrotropin releasing hormone

Indexed keywords

CHOLESTEROL; EQUOL; FLUTAMIDE; HIGH DENSITY LIPOPROTEIN; LIOTHYRONINE; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; PROTIRELIN; THYROID HORMONE; THYROTROPIN; THYROTROPIN BETA SUBUNIT; THYROXINE; TRIACYLGLYCEROL;

ADULT; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG MEGADOSE; GENE EXPRESSION; HYPOPHYSIS FUNCTION; HYPOTHALAMUS FUNCTION; LIOTHYRONINE BLOOD LEVEL; LIPID LIVER LEVEL; LIPID METABOLISM; LIPOPROTEIN BLOOD LEVEL; LIVER WEIGHT; LOW DRUG DOSE; MALE; NONHUMAN; PROSTATE WEIGHT; RADIOIMMUNOASSAY; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID FUNCTION; THYROTROPIN BLOOD LEVEL; THYROTROPIN RELEASE; THYROXINE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; DRUG EFFECTS; EATING; GENETICS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS SYSTEM; LIVER; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; THYROID GLAND;

ANIMALIA; RATTUS;

ANIMALS; CHOLESTEROL; EATING; EQUOL; GENE EXPRESSION; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHALAMUS; LIPID METABOLISM; LIVER; MALE; PITUITARY-ADRENAL SYSTEM; RATS, SPRAGUE-DAWLEY; THYROID GLAND; THYROTROPIN; THYROTROPIN-RELEASING HORMONE; THYROXINE; TRIIODOTHYRONINE;

EID: 84924975873     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2015.02.002     Document Type: Article

References (41)

1. P. Andrews, A. Freyberger, E. Hartmann, R. Eiben, I. Loof, U. Schmidt, M. Temerowski, and M. Becka Feasibility and potential gains of enhancing the subacute rat study protocol (OECD test guideline no. 407) by additional parameters selected to determine endocrine modulation. A pre-validation study to determine endocrine-mediated effects of the antiandrogenic drug flutamide Arch. Toxicol. 75 2001 65 73
2. P. Arias, H. Jarry, S. Leonhardt, J.A. Moguilevsky, and W. Wuttke Estradiol modulates the LH release response to N-methyl-d-aspartate in adult female rats: studies on hypothalamic luteinizing hormone-releasing hormone and neurotransmitter release Neuroendocrinology 57 1993 710 715
3. A. Baur, K. Bauer, H. Jarry, and J. Kohrle Effects of proinflammatory cytokines on anterior pituitary 5′-deiodinase type I and type II J. Endocrinol. 167 2000 505 515
4. S.J. Bhathena, and M.T. Velasquez Beneficial role of dietary phytoestrogens in obesity and diabetes Am. J. Clin. Nutr. 76 2002 1191 1201
5. T.F. Bovee, W.G. Schoonen, A.R. Hamers, M.J. Bento, and A.A. Peijnenburg Screening of synthetic and plant-derived compounds for (anti)estrogenic and (anti)androgenic activities Anal. Bioanal. Chem. 390 2008 1111 1119
6. E. Bowey, H. Adlercreutz, and I. Rowland Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats Food Chem. Toxicol. 41 2003 631 636
7. D.R. Doerge, and H.C. Chang Inactivation of thyroid peroxidase by soy isoflavones, in vitro and in vivo. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 1-2 2002 269 279
8. L. Fernández-Pérez, R. Santana-Farré, M. de Mirecki-Garrido, I. García, B. Guerra, C. Mateo-Díaz, D. Iglesias-Gato, J.C. Díaz-Chico, A. Flores-Morales, and M. Díaz Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver. PLoS One 9 2014 e96305
9. I. Hamann, D. Seidlova-Wuttke, W. Wuttke, and J. Köhrle Effects of isoflavonoids and other plant-derived compounds on the hypothalamus-pituitary-thyroid hormone axis Maturitas 55S 2006 S14 S25
10. T.E. Hedlund, W.U. Johannes, and G.J. Miller Soy isoflavonoid equol modulates the growth of benign and malignant prostatic epithelial cells in vitro Prostate 54 2003 68 78
11. W.M. Hunter, and F.C. Greenwood Preparation of iodine-131 labelled human growth hormone of high specific activity Nature 194 1962 495 496
12. V.C. Jordan, S. Mittal, B. Gosden, R. Koch, and M.E. Lieberman Structure-activity relationships of estrogens Environ. Health Perspect. 61 1985 97 110
13. H. Klammer, C. Schlecht, W. Wuttke, C. Schmutzler, I. Gotthardt, J. Köhrle, and H. Jarry Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary-thyroid function in rats. Toxicology 238 2007 192 199
14. S.N. Kolle, S. Melching-Kollmuss, G. Krennrich, R. Landsiedel, and B. van Ravenzwaay Assessment of combinations of antiandrogenic compounds vinclozolin and flutamide in a yeast based reporter assay Regul. Toxicol. Pharmacol. 60 2011 373 380
15. K.J. Koller, R.S. Wolff, M.K. Warden, and R.T. Zoeller Thyroid hormones regulate levels of thyrotropin-releasing-hormone mRNA in the paraventricular nucleus. Proc. Natl. Acad. Sci. U. S. A. 84 1987 7329 7333
16. T. Kunimatsu, T. Yamada, K. Miyata, S. Yabushita, T. Seki, Y. Okuno, and M. Matsuo Evaluation for reliability and feasibility of the draft protocol for the enhanced rat 28-day subacute study (OECD guideline 407) using androgen antagonist flutamide Toxicology 200 2004 77 89
17. F. Labrie Mechanism of action and pure antiandrogenic properties of flutamide Cancer 72 1993 3816 3827
18. A. Lateef, A.Q. Khan, M. Tahir, R. Khan, M.U. Rehman, F. Ali, O.O. Hamiza, and S. Sultana Androgen deprivation by flutamide modulates uPAR, MMP-9 expressions, lipid profile, and oxidative stress: amelioration by daidzein Mol. Cell. Biochem. 374 2013 49 59
19. P. Loutchanwoot, P. Srivilai, and H. Jarry Effects of the natural endocrine disruptor equol on the pituitary function in adult male rats. Toxicology 304 2013 69 75
20. P. Loutchanwoot, P. Srivilai, and H. Jarry Lack of an anti-androgenic neuroendocrine and sexual behavioral action of equol in the adult male rat Horm. Behav. 65 2014 22 31
21. T.D. Lund, D.J. Munson, M.E. Haldy, K.D. Setchell, E.D. Lephart, and R.J. Handa Equol is a novel anti-androgen that inhibits prostate growth and hormone feedback Biol. Reprod. 70 2004 1188 1195
22. T.D. Lund, C. Blake, L. Bu, A.N. Hamaker, and E.D. Lephart Equol an isoflavonoid: potential for improved prostate health, in vitro and in vivo evidence. Reprod. Biol. Endocrinol. 9 2011 4 9
23. F. Mannaa, H.H. Ahmed, S.F. Estefan, H.A. Sharaf, and E.F. Eskander Saccharomyces cerevisiae intervention for relieving flutamide-induced hepatotoxicity in male rats Pharmazie 60 2005 689 695
24. M.S. Morton, O. Arisaka, N. Miyake, L.D. Morgan, and B.A. Evans Phytoestrogen concentrations in serum from Japanese men and women over forty years of age J. Nutr. 132 2002 3168 3171
25. R.S. Muthyala, Y.H. Ju, S. Sheng, L.D. Williams, D.R. Doerge, B.S. Katzenellenbogen, W.G. Helferich, and J.A. Katzenellenbogen Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta Bioorg. Med. Chem. 12 2004 1559 1567
26. R. Neri Pharmacology and pharmacokinetics of flutamide Urology 34 1989 46 56
27. J.C. O'Connor, J.C. Cook, T.W. Slone, G.T. Makovec, S.R. Frame, and L.G. Davis An ongoing validation of a Tier I screening battery for detecting endocrine-active compounds (EACs) Toxicol. Sci. 46 1998 45 60
28. J.C. O'Connor, S.R. Frame, and G.S. Ladics Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens Toxicol. Sci. 69 2002 92 108
29. T. Ohtomo, M. Uehara, J.L. Peñalvo, H. Adlercreutz, S. Katsumata, K. Suzuki, K. Takeda, R. Masuyama, and Y. Ishimi Comparative activities of daidzein metabolites, equol and O-desmethylangolensin, on bone mineral density and lipid metabolism in ovariectomized mice and in osteoclast cell cultures Eur. J. Nutr. 47 2008 273 279
30. L.J. Pellegrino, A.S. Pellegrino, and A.J. Cushman A Stereotaxic Atlas of the Rat Brain 1979 Plenum Press New York
31. D. Rachoń, T. Vortherms, D. Seidlová-Wuttke, and W. Wuttke Effects of dietary equol on body weight gain, intra-abdominal fat accumulation, plasma lipids, and glucose tolerance in ovariectomized Sprague-Dawley rats. Menopause 14 2007 925 932
32. D. Rachoń, T. Vortherms, D. Seidlová-Wuttke, A. Menche, and W. Wuttke Uterotropic effects of dietary equol administration in ovariectomized Sprague-Dawley rats. Climacteric 10 2007 416 426
33. P. Roy, H. Salminen, P. Koskimies, J. Simola, A. Smeds, P. Saukko, and I.T. Huhtaniemi Screening of some anti-androgenic endocrine disruptors using a recombinant cell-based in vitro bioassay J. Steroid Biochem. Mol. Biol. 88 2004 157 166
34. N. Sathyamoorthy, and T.T. Wang Differential effects of dietary phyto-oestrogens daidzein and equol on human breast cancer MCF-7 cells Eur. J. Cancer 33 1997 2384 2389
35. T.P. Segerson, J. Kauer, H.C. Wolfe, H. Mobtaker, P. Wu, I.M. Jackson, and R.M. Lechan Thyroid hormone regulates TRH biosynthesis in the paraventricular nucleus of the rat hypothalamus Science 238 1987 78 80
36. K.D. Setchell, S.P. Borriello, P. Hulme, D.N. Kirk, and M. Axelson Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease Am. J. Clin. Nutr. 40 1984 569 578
37. F.A. Simmen, C.P. Mercado, A.M. Zavacki, S.A. Huang, A.D. Greenway, P. Kang, M.T. Bowman, and R.L. Prior Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male rat J. Nutr. Biochem. 21 2010 1106 1113
38. B. Sosić-Jurjević, B. Filipović, V. Milosević, N. Nestorović, N. Negić, and M. Sekulić Effects of ovariectomy and chronic estradiol administration on pituitary-thyroid axis in adult rats Life Sci. 79 2006 890 897
39. Y. Takahashi, T.O. Odbayar, and T. Ide A comparative analysis of genistein and daidzein in affecting lipid metabolism in rat liver J. Clin. Biochem. Nutr. 44 2009 223 230
40. J.F. Wang, Y.X. Guo, J.Z. Niu, J. Liu, L.Q. Wang, and P.H. Li Effects of Radix Puerariae flavones on liver lipid metabolism in ovariectomized rats World J. Gastroenterol. 10 2004 1967 1970
41. F. Wang, Y. Tan, C. Wang, X. Zhang, Y. Zhao, X. Song, B. Zhang, Q. Guan, J. Xu, and J. Zhang Thyroid-stimulating hormone levels within the reference range are associated with serum lipid profiles independent of thyroid hormones J. Clin. Endocrinol. Metab. 97 2012 2724 2731