Bufalin is a steroid receptor coactivator inhibitor - Letter

Cancer Research

Volumn 75, Issue 6, 2015, Pages 1156-

  Calderón Montaño, José Manuel ^a   Burgos Morón, Estefanía ^a   Orta, Manuel Luis ^a   García Domínguez, Irene ^a   Maldonado Navas, Dolores ^a   López Lázaro, Miguel ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BUFALIN; STEROID RECEPTOR COACTIVATOR 1; STEROID RECEPTOR COACTIVATOR 3; BUFADIENOLIDE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BREAST CANCER; BREAST CANCER CELL LINE; CANCER GROWTH; CANCER INHIBITION; CANCER THERAPY; CELL SPECIFICITY; CONCENTRATION RESPONSE; DRUG CYTOTOXICITY; DRUG SELECTIVITY; DRUG SENSITIVITY; HUMAN; LETTER; MCF 7 CELL LINE; MDA MB 231 CELL LINE; NONHUMAN; PRIORITY JOURNAL; SPECIES DIFFERENCE; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS;

ANIMALS; BUFANOLIDES; HUMANS; NUCLEAR RECEPTOR COACTIVATOR 1; NUCLEAR RECEPTOR COACTIVATOR 3;

EID: 84924967077     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-0398     Document Type: Letter

References (6)

1. Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, Wang J, et al. Bufalin is a potent small molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Cancer Res 2014;74:1506-17.
2. Clifford RJ, Kaplan JH. Human breast tumor cells are more resistant to cardiac glycoside toxicity than non-tumorigenic breast cells. PLoS One 2013;8:e84306.
3. Yan S, Qu X, Xu C, Zhu Z, Zhang L, Xu L, et al. Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells. J Cancer Res Clin Oncol 2012;138:1279-89.
4. Lopez-Lazaro M. Digoxin, HIF-1, and cancer. Proc Natl Acad Sci U S A 2009;106:E26.
5. Calderón-Montaño JM, Burgos-Morón E, López-Lázaro M. The in vivo antitumor activity of cardiac glycosides in mice xenografted with human cancer cells is probably an experimental artifact. Oncogene 2014;33:2947-48.
6. Gupta RS, Chopra A, Stetsko DK. Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis). J Cell Physiol 1986;127:197-206.