Metabolic and adipose tissue signatures in adults with Prader-Willi syndrome: A model of extreme adiposity

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 3, 2015, Pages 850-859

  Lacroix, Delphine ^a,b   Moutel, Sandrine ^c,d   Coupaye, Muriel ^c,d   Huvenne, Hélène ^a,b   Faucher, Pauline ^c,d   Pelloux, Véronique ^a,b   Rouault, Christine ^a,b   Bastard, Jean Philippe ^c   Cagnard, Nicolas ^e   Dubern, Béatrice ^a,b,c   Clément, Karine ^a,b,c,d   Poitou, Christine ^a,b,c,d  

^a INSERM   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; GHRELIN; INSULIN; TRANSCRIPTOME;

ADIPOCYTE; ADULT; ANGIOGENESIS; ARTICLE; BODY FAT DISTRIBUTION; CD3E GENE; CD68 GENE; CELL SIZE; CHEMOKINE LIGAND 5 GENE; COLLAGEN TYPE 4 ALPHA GENE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FAT MASS; FEMALE; GENE; GENE EXPRESSION; HOMEOSTASIS MODEL ASSESSMENT INSULIN RESISTANCE; HORMONE BLOOD LEVEL; HUMAN; IL 1BETA GENE; INFLAMMATION; LYSYL OXIDASE GENE; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; OBESITY; PRADER WILLI SYNDROME; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTOMICS; ADOLESCENT; CASE CONTROL STUDY; COMPLICATION; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; MICROARRAY ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; SUBCUTANEOUS FAT; YOUNG ADULT;

ADIPOSITY; ADOLESCENT; ADULT; BODY FAT DISTRIBUTION; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MALE; MICROARRAY ANALYSIS; OBESITY; PRADER-WILLI SYNDROME; SUBCUTANEOUS FAT; TRANSCRIPTOME; YOUNG ADULT;

EID: 84924955692     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-3127     Document Type: Article

References (43)

1. Goldstone AP, Holland AJ, Hauffa BP, Hokken-Koelega AC, Tauber M, speakers contributors at the Second Expert Meeting of the Comprehensive Care of Patients with PWS. Recommendations for the diagnosis and management of Prader-Willi syndrome. J Clin Endocrinol Metab. 2008;93(11):4183-4197.
2. Miller JL, Lynn CH, Driscoll DC, et al. Nutritional phases in Prader-Willi syndrome. Am J Med Genet A. 2011;155A(5):1040-1049.
3. Schuster DP, Osei K, Zipf WB. Characterization of alterations in glucose and insulin metabolism in Prader-Willi subjects. Metabolism. 1996;45(12):1514-1520.
4. Talebizadeh Z, Butler MG. Insulin resistance and obesity-related factors in Prader-Willi syndrome: comparison with obese subjects. Clin Genet. 2005;67(3):230-239.
5. Faienza MF, Ventura A, Lauciello R, et al. Analysis of endothelial protein C receptor gene and metabolic profile in Prader-Willi syndrome and obese subjects. Obesity (Silver Spring Md). 2012;20(9):1866-1870.
6. Haqq AM, Muehlbauer MJ, Newgard CB, Grambow S, Freemark M. The metabolic phenotype of Prader-Willi syndrome (PWS) in childhood: heightened insulin sensitivity relative to body mass index. J Clin Endocrinol Metab. 2011;96(1):E225-E232.
7. Grugni G, Crinò A, Bedogni G, et al. Metabolic syndrome in adult patients with Prader-Willi syndrome. Nutr Metab Cardiovasc Dis NMCD. 2013;23(11):1134-1140.
8. Reus L, Zwarts M, van Vlimmeren LA, Willemsen MA, Otten BJ, Nijhuis-van der Sanden MWG. Motor problems in Prader-Willi syndrome: a systematic review on body composition and neuromuscular functioning. Neurosci Biobehav Rev. 2011;35(3):956-969.
9. Eiholzer U, Blum WF, Molinari L. Body fat determined by skinfold measurements is elevated despite underweight in infants with Prader-Labhart-Willi syndrome. J Pediatr. 1999;134(2):222-225.
10. Theodoro MF, Talebizadeh Z, Butler MG. Body composition and fatness patterns in Prader-Willi syndrome: comparison with simple obesity. Obesity (Silver Spring Md). 2006;14(10):1685-1690.
11. Sode-Carlsen R, Farholt S, Rabben KF, et al. Body composition, endocrine and metabolic profiles in adults with Prader-Willi syndrome. Growth Horm IGF Res. 2010;20(3):179-184.
12. Lloret-Linares C, Faucher P, Coupaye M, et al. Comparison of body composition, basal metabolic rate and metabolic outcomes of adults with Prader Willi syndrome or lesional hypothalamic disease, with primary obesity. Int J Obes 2013;37(9):1198-1203.
13. Goldstone AP, Thomas EL, Brynes AE, et al. Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi syndrome female adults: evidence for novel influences on body fat distribution. J Clin Endocrinol Metab. 2001;86(9):4330-4338.
14. Goldstone AP, Brynes AE, Thomas EL, et al. Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome. Am J Clin Nutr. 2002;75(3):468-475.
15. Kennedy L, Bittel DC, Kibiryeva N, Kalra SP, Torto R, Butler MG. Circulating adiponectin levels, body composition and obesity-related variables in Prader-Willi syndrome: comparison with obese subjects. Int J Obes 2005. 2006;30(2):382-387.
16. Patel P, Abate N. Role of subcutaneous adipose tissue in the pathogenesis of insulin resistance. J Obes. 2013;2013:489187.
17. Chmelar J, Chung K-J, Chavakis T. The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance. Thromb Haemost. 2013;109(3):399-406.
18. Cadoudal T, Buléon M, Sengenès C, et al.Impairment of adipose tissue in Prader-Willi syndrome rescued by growth hormone treatment. Int J Obes. 2014;38(9):1234-1240.
19. Coupaye M, Lorenzini F, Lloret-Linares C, et al. Growth hormone therapy for children and adolescents with Prader-Willi syndrome is associated with improved body composition and metabolic status in adulthood. J Clin Endocrinol Metab. 2013;98(2):E328-E335.
20. Dalmas E, Kahn J-F, Giral P, et al. Intima-media thickness in severe obesity: links with BMI and metabolic status but not with systemic or adipose tissue inflammation. Diabetes Care. 2013;36(11):3793-3802.
21. Ciangura C, Bouillot J-L, Lloret-Linares C, et al. Dynamics of change in total and regional body composition after gastric bypass in obese patients. Obesity (Silver Spring Md). 2010;18(4):760-765.
22. Ferreira I, Snijder MB, Twisk JWR, et al. Central fat mass versus peripheral fat and lean mass: opposite (adverse versus favorable) associations with arterial stiffness? The Amsterdam Growth and Health Longitudinal Study. J Clin Endocrinol Metab. 2004;89(6):2632-2639.
23. Dalmas E, Rouault C, Abdennour M, et al. Variations in circulating inflammatory factors are related to changes in calorie and carbohydrate intakes early in the course of surgery-induced weight reduction. Am J Clin Nutr. 2011;94(2):450-458.
24. Cotillard A, Poitou C, Torcivia A, et al.Adipocyte size threshold matters: link with risk of type 2 diabetes and improved insulinresistance after gastric bypass. J Clin Endocrinol Metab. 2014:jc20141074.
25. Spalding KL, Arner E, Westermark PO, et al. Dynamics of fat cell turnover in humans. Nature. 2008;453(7196):783-787.
26. Henegar C, Tordjman J, Achard V, et al Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol. 2008;9(1):R14.
27. Garg A. Regional adiposity and insulin resistance. J Clin Endocrinol Metab. 2004;89(9):4206-4210.
28. Vidal-Puig A. Adipose tissue expandability, lipotoxicity and the metabolic syndrome. Endocrinol Nutr Órgano Soc Esp Endocrinol Nutr. 2013;60(suppl 1):39-43.
29. Virtue S, Vidal-Puig A. Adipose tissue expandability, lipotoxicity and the metabolic syndrome - an allostatic perspective. Biochim Biophys Acta. 2010;1801(3):338-349.
30. Crowe S, Wu LE, Economou C, et al. Pigment epithelium-derived factor contributes to insulin resistance in obesity. Cell Metab. 2009;10(1):40-47.
31. Sabater M, Moreno-Navarrete JM, Ortega FJ, et al. Circulating pigment epithelium-derived factor levels are associated with insulin resistance and decrease after weight loss. J Clin Endocrinol Metab. 2010;95(10):4720-4728.
32. Gattu AK, Birkenfeld AL, Jornayvaz F, et al. Insulin resistance is associated with elevated serum pigment epithelium-derived factor (PEDF) levels in morbidly obese patients. Acta Diabetol. 2012;49(suppl 1):S161-S169.
33. Kyrgios I, Galli-Tsinopoulou A, Stylianou C, Papakonstantinou E, Arvanitidou M, Haidich A-B. Elevated circulating levels of the serum acute-phase protein YKL-40 (chitinase 3-like protein 1) are a marker of obesity and insulin resistance in prepubertal children. Metabolism. 2012;61(4):562-568.
34. Cangemi C, Skov V, Poulsen MK, et al. Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2 diabetes. Clin Chem. 2011;57(11):1556-1565.
35. Laugesen E, Høyem P, Christiansen JS, et al. Plasma levels of the arterial wall protein fibulin-1 are associated with carotid-femoral pulse wave velocity: a cross-sectional study. Cardiovasc Diabetol. 2013;12(1):107.
36. Scholze A, Bladbjerg E-M, Sidelmann JJ, et al. Plasma concentrations of extracellular matrix protein fibulin-1 are related to cardiovascular risk markers in chronic kidney disease and diabetes. Cardiovasc Diabetol. 2013;12:6.
37. Pierleoni C, Verdenelli F, Castellucci M, Cinti S. Fibronectins and basal lamina molecules expression in human subcutaneous white adipose tissue. Eur J Histochem EJH. 1998;42(3):183-188.
38. Choi JW, Herr DR, Noguchi K, et al. LPA receptors: subtypes and biological actions. Annu Rev Pharmacol Toxicol. 2010;50:157-186.
39. Rancoule C, Viaud M, Gres S, et al. Pro-fibrotic activity of lysophosphatidic acid in adipose tissue: in vivo and in vitro evidence. Biochim Biophys Acta. 2014;1841(1):88-96.
40. Divoux A, Tordjman J, Lacasa D, et al. Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss. Diabetes. 2010;59(11):2817-2825.
41. Sun K, Tordjman J, Clément K, Scherer PE. Fibrosis and adipose tissue dysfunction. Cell Metab. 2013;18(4):470-477.
42. Bush JR, Wevrick R. Loss of the Prader-Willi obesity syndrome protein necdin promotes adipogenesis. Gene. 2012;497(1):45-51.
43. Fujiwara K, Hasegawa K, Ohkumo T, Miyoshi H, Tseng Y-H, Yoshikawa K. Necdin controls proliferation of white adipocyte progenitor cells. PloS One. 2012;7(1):e30948.