Changes in leptin and peptide YY do not explain the greater-than-predicted decreases in resting energy expenditure after weight loss

Journal of Clinical Endocrinology and Metabolism

Volumn 100, Issue 3, 2015, Pages E443-E452

  McNeil, Jessica ^a   Schwartz, Alexander ^b   Rabasa Lhoret, Rémi ^c,e,f   Lavoie, Jean Marc ^d   Brochu, Martin ^g,h   Doucet, Éric ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d UNIVERSITY OF MONTREAL   (Canada)

^e CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^f CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^g UNIVERSITÉ DE SHERBROOKE   (Canada)

^h UNIVERSITY INSTITUTE OF GERIATRICS OF SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; PEPTIDE YY;

ADULT; ARTICLE; BODY MASS; CALCULATION; CALORIC RESTRICTION; CALORIMETRY; CONTROLLED STUDY; DOUBLY LABELED WATER TECHNIQUE; DUAL ENERGY X RAY ABSORPTIOMETRY; FAT MASS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; OBESITY; PHYSICAL ACTIVITY; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESISTANCE TRAINING; RESTING ENERGY EXPENDITURE; TREATMENT OUTCOME; WEIGHT REDUCTION; BASAL METABOLIC RATE; BLOOD; DIET THERAPY; DOWN REGULATION; ENERGY METABOLISM; LOW CALORY DIET; METABOLISM; MIDDLE AGED; PHYSIOLOGY; REST;

BASAL METABOLISM; CALORIC RESTRICTION; DIET, REDUCING; DOWN-REGULATION; ENERGY METABOLISM; FEMALE; HUMANS; LEPTIN; MIDDLE AGED; OBESITY; OVERWEIGHT; PEPTIDE YY; REST; WEIGHT LOSS;

EID: 84924943238     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2014-2210     Document Type: Article

References (41)

1. Hunter GR, Byrne NM, Sirikul B, et al. Resistance training conserves fat-free mass and resting energy expenditure following weight loss. Obesity (Silver Spring). 2008;16:1045-1051.
2. Jakicic JM, Clark K, Coleman E, et al. American College of Sports Medicine position stand. Appropriate intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc. 2001;33:2145-2156.
3. Keys A, Brozek J, Henschel A. The Biology of Human Starvation. St Paul: North Central Publishing; 1950.
4. Schwartz A, Doucet E. Relative changes in resting energy expenditure during weight loss: a systematic review. Obes Rev. 2010;11:531-547.
5. Dulloo AG, Jacquet J. Adaptive reduction in basal metabolic rate in response to food deprivation in humans: a role for feedback signals from fat stores. Am J Clin Nutr. 1998;68:599-606.
6. Ravussin E, Lillioja S, Anderson TE, Christin L, Bogardus C. Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. J Clin Invest. 1986;78:1568-1578.
7. Weyer C, Walford RL, Harper IT, et al. Energy metabolism after 2 y of energy restriction: the biosphere 2 experiment. Am J Clin Nutr. 2000;72:946-953.
8. Doucet E, Imbeault P, St Pierre S, et al. Greater than predicted decrease in energy expenditure during exercise after body weight loss in obese men. Clin Sci (Lond). 2003;105:89-95.
9. Doucet E, St Pierre S, Almeras N, Despres JP, Bouchard C, Tremblay A. Evidence for the existence of adaptive thermogenesis during weight loss. Br J Nutr. 2001;85:715-723.
10. Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med. 1995;332:621-628.
11. Miller DS, Parsonage S. Resistance to slimming: adaptation or illusion? Lancet. 1975;1:773-775.
12. Johannsen DL, Knuth ND, Huizenga R, Rood JC, Ravussin E, Hall KD. Metabolic slowing with massive weight loss despite preservation of fat-free mass. J Clin Endocrinol Metab. 2012;97:2489-2496.
13. Camps SG, Verhoef SP, Westerterp KR. Weight loss, weight maintenance, and adaptive thermogenesis. Am J Clin Nutr. 2013;97:990-994.
14. Knuth ND, Johannsen DL, Tamboli RA, et al. Metabolic adaptation following massive weight loss is related to the degree of energy imbalance and changes in circulating leptin. Obesity. (Silver Spring) 2014;XXX.
15. Astrup A, Gotzsche PC, van de Werken K, et al. Meta-analysis of resting metabolic rate in formerly obese subjects. Am J Clin Nutr. 1999;69:1117-1122.
16. Rosenbaum M, Hirsch J, Gallagher DA, Leibel RL. Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr. 2008;88:906-912.
17. Rosenbaum M, Hirsch J, Murphy E, Leibel RL. Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid function. Am J Clin Nutr. 2000;71:1421-1432.
18. Doucet E, St Pierre S, Almeras N, Mauriege P, Richard D, Tremblay A. Changes in energy expenditure and substrate oxidation resulting from weight loss in obese men and women: is there an important contribution of leptin? J Clin Endocrinol Metab. 2000;85:1550-1556.
19. Verdich C, Toubro S, Buemann B, et al. Leptin levels are associated with fat oxidation and dietary-induced weight loss in obesity. Obes Res. 2001;9:452-461.
20. Rosenbaum M, Murphy EM, Heymsfield SB, Matthews DE, Leibel RL. Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab. 2002;87:2391-2394.
21. Sloth B, Holst JJ, Flint A, Gregersen NT, Astrup A. Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects. Am J Physiol Endocrinol Metab. 2007;292:E1062-E1068.
22. Doucet E, Laviolette M, Imbeault P, Strychar I, Rabasa-Lhoret R, Prud'homme D. Total peptide YY is a correlate of postprandial energy expenditure but not of appetite or energy intake in healthy women. Metabolism. 2008;57:1458-1464.
23. Hill BR, De Souza MJ, Williams NI. Characterization of the diurnal rhythm of peptide YY and its association with energy balance parameters in normal-weight premenopausal women. Am J Physiol Endocrinol Metab. 2011;301:E409-E415.
24. Guo Y, Ma L, Enriori PJ, et al. Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans. Obesity (Silver Spring). 2006;14:1562-1570.
25. Brochu M, Malita MF, Messier V, et al. Resistance training does not contribute to improving the metabolic profile after a 6-month weight loss program in overweight and obese postmenopausal women. J Clin Endocrinol Metab. 2009;94:3226-3233.
26. Tremblay A, Pelletier C, Doucet E, Imbeault P. Thermogenesis and weight loss in obese individuals: a primary association with organochlorine pollution. Int J Obes Relat Metab Disord. 2004;28:936-939.
27. St Onge M, Rabasa-Lhoret R, Strychar I, Faraj M, Doucet E, Lavoie JM. Impact of energy restriction with or without resistance training on energy metabolism in overweight and obese postmenopausal women: a Montreal Ottawa New Emerging Team group study. Menopause. 2013;20:194-201.
28. Karelis AD, Tousignant B, Nantel J, et al. Association of insulin sensitivity and muscle strength in overweight and obese sedentary postmenopausal women. Appl Physiol Nutr Metab. 2007;32:297-301.
29. St Onge M, Mignault D, Allison DB, Rabasa-Lhoret R. Evaluation of a portable device to measure daily energy expenditure in free-living adults. Am J Clin Nutr. 2007;85:742-749.
30. Rosenbaum M, Nicolson M, Hirsch J, Murphy E, Chu F, Leibel RL. Effects of weight change on plasma leptin concentrations and energy expenditure. J Clin Endocrinol Metab. 1997;82:3647-3654.
31. Labayen I, Ortega FB, Ruiz JR, Lasa A, Simon E, Margareto J. Role of baseline leptin and ghrelin levels on body weight and fat mass changes after an energy-restricted diet intervention in obese women: effects on energy metabolism. J Clin Endocrinol Metab. 2011;96:E996-E1000.
32. Shih LY, Liou TH, Chao JC, et al. Leptin, superoxide dismutase, and weight loss: initial leptin predicts weight loss. Obesity (Silver Spring). 2006;14:2184-2192.
33. Dulloo AG, Jacquet J. An adipose-specific control of thermogenesis in body weight regulation. Int J Obes Relat Metab Disord. 25(suppl 2001);5:S22-S29.
34. Menozzi R, Bondi M, Baldini A, Venneri MG, Velardo A, Del Rio G. Resting metabolic rate, fat-free mass and catecholamine excretion during weight loss in female obese patients. Br J Nutr. 2000;84:515-520.
35. Astrup A, Buemann B, Christensen NJ, et al. The effect of ephedrine/caffeine mixture on energy expenditure and body composition in obese women. Metabolism. 1992;41:686-688.
36. Elias M. Organ and tissue contribution to metabolic rate. In: Kinney JM, Tucker HN, eds. Energy Metabolism: Tissue Determinants and Cellular Corollaries. New York: Raven Press; 1991:61-80.
37. Bosy-Westphal A, Kossel E, Goele K, et al. Contribution of individual organ mass loss to weight loss-associated decline in resting energy expenditure. Am J Clin Nutr. 2009;90:993-1001.
38. Prentice AM. Starvation in humans: evolutionary background and contemporary implications. Mech Ageing Dev. 2005;126:976-981.
39. Hwa JJ, Witten MB, Williams P, et al. Activation of the NPY Y5 receptor regulates both feeding and energy expenditure. Am J Physiol. 1999;277:R1428-R1434.
40. Keire DA, Bowers CW, Solomon TE, Reeve JR Jr. Structure and receptor binding of PYY analogs. Peptides. 2002;23:305-321.
41. Melby C, Scholl C, Edwards G, Bullough R. Effect of acute resistance exercise on postexercise energy expenditure and resting metabolic rate. J Appl Physiol (1985). 1993;75:1847-1853.