Protective effects of the aqueous extract of Crocus sativus against ethylene glycol induced nephrolithiasis in rats

EXCLI Journal

Volumn 14, Issue , 2015, Pages 411-422

  Amin, Bahareh ^a   Moghri Feriz, Hanieh ^b   Timcheh Hariri, Alireza ^c   Tayyebi Meybodi, Naser ^d   Hosseinzadeh, Hossein ^e  

^a SABZEVAR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Calcium oxalate; Crocus sativus; Ethylene glycol; Hyperoxaluria; Kidney stone; Nephrolithiasis; Oxidative stress; Renal calculus; Saffron

Indexed keywords

CALCIUM OXALATE; CITRATE POTASSIUM; CITRIC ACID; CROCUS SATIVUS EXTRACT; ETHYLENE GLYCOL; HYDROCHLOROTHIAZIDE; MAGNESIUM; MALONALDEHYDE; PHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM OXALATE STONE; CONTROLLED STUDY; DRUG DOSE COMPARISON; HYPEROXALURIA; LIPID PEROXIDATION; MAGNESIUM URINE LEVEL; MALE; NONHUMAN; PHOSPHATE URINE LEVEL; PROTEINURIA; RAT; URINE VOLUME;

CROCUS SATIVUS; RATTUS; RATTUS NORVEGICUS;

EID: 84924902502     PISSN: None     EISSN: 16112156     Source Type: Journal    
DOI: 10.17179/excli2014-510     Document Type: Article

References (35)

1. Abdullaev F. Biological effects of saffron. BioFactors. 1993;4:83-6.
2. Abe K, Saito H. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytother Res. 2000;14:149-52.
3. Alavizadeh SH, Hosseinzadeh H. Bioactivity assessment and toxicity of crocin: a comprehensive review. Food Chem Toxicol. 2014;64:65-80.
4. Butterweck V, Khan SR. Herbal medicines in the management of urolithiasis: alternative or complementary? Planta Med. 2009;75:1095-103.
5. Fan J, Michael AG, Chandhoke PS. Impact of ammonium chloride administration on a rat ethylene glycol urolithiaisis model. Scanning Microsc. 1999;13:299-306.
6. Gandhi M, Aggarwal M, Puri S, Singla SK. Prophylactic effect of coconut water (Cocos nucifera L.) on ethylene glycol induced nephrocalcinosis in male wistar rat. Int Braz J Urol. 2013;39:108-17.
7. Hosseinzadeh H, Nassiri-Asl M. Avicenna's (Ibn Sina) the canon of medicine and saffron (Crocus sativus): a review. Phytother Res. 2013;27:475-83.
8. Hosseinzadeh H, Sadeghnia HR. Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. J Pharm Pharm Sci. 2005;8:394-9.
9. Hosseinzadeh H, Shariaty V. Anti-nociceptive effect of safranal, a constituent of Crocus sativus (saffron), in mice. Pharmacologyonline. 2007;2:498–503.
10. Hosseinzadeh H, Younesi HM. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol. 2002;2: 7-12.
11. Hosseinzadeh H, Ziaei T. Effects of Crocus sativus stigma extract and its constituents, crocin and safranal, on intact memory and scopolamine-induced learning deficits in rats performing the Morris water maze task. J Med Plants. 2006;5:40-50.
12. Hosseinzadeh H, Karimi G, Niapoor M. Antidepressant effect of Crocus sativus L. stigma extracts and their constituents, crocin and safranal, in mice. ISHS. 2003:435–45.
13. Hosseinzadeh H, Sadeghnia HR, Rahimi A. Effect of safranal on extracellular hippocampal levels of glutamate and aspartate during kainic acid treatment in anesthetized rats. Planta Med. 2008;74:1441-5.
14. Hosseinzadeh H, Shamsaie F, Mehri S. Antioxidant activity of aqueous and ethanolic extracts of Crocus sativus L. stigma and its bioactive constituents, crocin and safranal. Pharmacogn Mag. 2009;5:419-21.
15. Hosseinzadeh H, Khooei AR, Khashayarmanesh Z, Motamed-Shariaty V. Antiurolithiatic activity of Pinus Eldarica Medw. fruits aqueous extract in rats. Urol J. 2010;7:232-7.
16. Jnaneshwari S, Hemshekhar M, Santhosh MS, Sunitha K, Thushara R, Thirunavukkarasu C, et al. Crocin, a dietary colorant mitigates cyclophosphamide- induced organ toxicity by modulating antioxidant status and inflammatory cytokines. J Pharm Pharmacol. 2013;65:604-14.
17. Khan S. Animal models of kidney stone formation: an analysis. World J Urol. 1997;15:236-43.
18. Lipschitz WL, Hadidian Z, Kerpcsar A. Bioassay of diuretics. J Pharmacol Exp Ther. 1943;79:97-110.
19. Mehri S, Abnous K, Mousavi SH, Shariaty VM, Hosseinzadeh H. Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol Neurobiol. 2012;32:227-35.
20. Moe OW. Kidney stones: pathophysiology and medical management. The Lancet. 2006;367:333-44.
21. Moraga AR, Rambla JL, Ahrazem O, Granell A, Gómez-Gómez L. Metabolite and target transcript analyses during Crocus sativus stigma development. Phytochemistry. 2009;70:1009-16.
22. Mousavi SZ, Bathaie SZ. Historical uses of saffron: identifying potential new avenues for modern research. Avicenna. J Phytomed. 2011;1:57-66.
23. Nam KN, Park YM, Jung HJ, Lee JY, Min BD, Park SU, et al. Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells. Eur J Pharmacol. 2010;648:110-6.
24. Rajaei Z, Hadjzadeh MA, Nemati H, Hosseini M, Ahmadi M, Shafiee S. Antihyperglycemic and antioxidant activity of crocin in streptozotocin-induced diabetic rats. J Med Food. 2013;16:206-10.
25. Revuelta MP, Cantabrana B, Hidalgo A. Depolarization- dependent effect of flavonoids in rat uterine smooth muscle contraction elicited by CaCl2. Gen Pharmacol. 1997;29:847-57.
26. Rezaee R, Hosseinzadeh H. Safranal: from an aromatic natural product to a rewarding pharmacological agent. Iran J Basic Med Sci. 2013;16:12-26.
27. Selvam R, Bijikurien T. Methionine feeding prevents kidney stone deposition by restoration of free radical mediated changes in experimental rat urolithiasis. J Nutr Biochem. 1991;2:644-51.
28. Sheng L, Qian Z, Shi Y, Ji H. Crocetin improves the insulin resistance induced by high-fat diet in rats. Br. J Pharmacol. 2008;154:1016-24.
29. Shirfule AL, Racharla V, Qadri SS, Khandare AL. Exploring antiurolithic effects of gokshuradi polyherbal ayurvedic formulation in ethylene-glycolinduced urolithic rats. Evid Based Complement Alternat Med 2013;2013:763720.
30. Thamilselvan S, Khan SR, Menon M. Oxalate and calcium oxalate mediated free radical toxicity in renal epithelial cells: effect of antioxidants. Urol Res. 2003; 31:3-9.
31. Thushara RM, Hemshekhar M, Santhosh MS, Jnaneshwari S, Nayaka SC, Naveen S, et al. Crocin, a dietary additive protects platelets from oxidative stress-induced apoptosis and inhibits platelet aggregation. Mol Cell Biochem. 2013;373:73-83.
32. Uchiyama M, Mihara M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem. 1978;86:271-8.
33. Vahidi H, Kamalinejad M, Sedaghati N. Antimicrobial properties of Croccus sativus L. Iran J Pharm Res. 2010;1:33-5.
34. Yoshino F, Yoshida A, Umigai N, Kubo K, Lee MC. Crocetin reduces the oxidative stress induced reactive oxygen species in the stroke-prone spontaneously hypertensive rats (SHRSPs) brain. J Clin Biochem Nutr. 2011;49:182-7.
35. Zuckerman JM, Assimos DG. Hypocitraturia: pathophysiology and medical management. Rev Urol. 2009;11:134-44.