Heart palpitation relief with Melissa officinalis leaf extract: Double blind, randomized, placebo controlled trial of efficacy and safety

Journal of Ethnopharmacology

Volumn 164, Issue , 2015, Pages 378-384

  Alijaniha, Fatemeh ^a   Naseri, Mohsen ^b   Afsharypuor, Suleiman ^c   Fallahi, Faramarz ^b   Noorbala, Ahmadali ^d   Mosaddegh, Mahmood ^e   Faghihzadeh, Soghrat ^f   Sadrai, Sima ^g  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHED UNIVERSITY   (Iran)

^c ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f ZANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^g TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Aqueous extract; Lemon balm; Melissa officinalis; Palpitations; Traditional Iranian Medicine (TIM)

Indexed keywords

MELISSA OFFICINALIS EXTRACT; PLACEBO; PLANT EXTRACT;

ADULT; ANXIETY; ARTICLE; BLOOD PRESSURE; COMPARATIVE STUDY; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FREEZE DRYING; GENERAL HEALTH QUESTIONNAIRE; HEART PALPITATION; HEART RATE; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MALE; MELISSA OFFICINALIS; PLACEBO EFFECT; PLANT LEAF; RANDOMIZED CONTROLLED TRIAL; SELF REPORT; SOCIAL DISABILITY; SOMATIZATION; UNSPECIFIED SIDE EFFECT; VISUAL ANALOG SCALE; ARRHYTHMIAS, CARDIAC; MIDDLE AGED; PHYTOTHERAPY; TREATMENT OUTCOME;

CITRUS LIMON; MELISSA OFFICINALIS;

ADULT; ARRHYTHMIAS, CARDIAC; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MELISSA; MIDDLE AGED; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; TREATMENT OUTCOME;

EID: 84924874276     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2015.02.007     Document Type: Article

References (50)

1. A.V. Abbott Diagnostic approach to palpitations American Family Physician 71 2005 743 750
2. M. Abu-Asab, H. Amri, and M.S. Micozzi Avicenna's Medicine: A New Translation of the 11th-Century Canon with Practical Applications for Integrative Health Care 1st ed. 2013 Healing Arts Press Toronto, Canada
3. M. Aghilikhorasani Makhzan-al-Advia 2009 Institute of Medical History, Islamic and Complementary Medicine, Iran University of Medical Sciences Tehran
4. S. Akhondzadeh, M. Noroozian, M. Mohammadi, S. Ohadinia, A. Jamshidi, and M. Khani Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial Journal of Neurology, Neurosurgery & Psychiatry 74 2003 863 866
5. A. Al-Heravi Kita¯b al-Abnyia an Haqa¯iq al-Adwiya (in Persian) 1st ed. 1992 Tehran University Tehran
6. A. Alves, L. Vidal, R. Kuster, C. Lage, and A. Leitão Genotoxic and Mutagenic Effects of Melissa officinalis (Erva Cidreira) Extracts The Open Toxicology Journal 3 2009 58 69
7. E. Aparecida Gelfuso, D. Santos Rosa, A. Lúcia Fachin, M. Renata Mortari, A. Olimpio Siqueira Cunha, and R. Oliveira Beleboni Anxiety: A Systematic Review of Neurobiology, Traditional Pharmaceuticals and Novel Alternatives from Medicinal Plants CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders) 13 2014 150 165
8. M. Asghari, M. Naseri, Z. Sabet, A. Davati, M. Kamalinejad, M.R. Jalali-Nadoushan, A. Shaali, S. Doost, and M. Alamshekan Efficacy and safety of Ziabites (an Iranian traditional medicine compound) on glycemic control in type 2 diabetic patients Journal of Medicinal Plants Research 7 2013 1624 1627
9. H. Avicenna (IbnSina) Ghanoon dar Teb (Canon) 2005 Soroush Press Tehran
10. R. Awad, A. Muhammad, T. Durst, V.L. Trudeau, and J.T. Arnason Bioassaya-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity Phytotherapy Research 23 2009 1075 1081
11. S. Bolkent, R. Yanardag, O. Karabulut-Bulan, and B. Yesilyaprak Protective role of Melissa officinalis L. extract on liver of hyperlipidemic rats: a morphological and biochemical study Journal of Ethnopharmacology 99 2005 391 398
12. T. Brendler, J. Gruenwald, B. Kligler, D. Keifer, T.R. Abrams, J. Woods, H. Boon, C.D. Kirkwood, E. Basch, and H.J. Lafferty Lemon Balm (Melissa officinalis L.): an evidence-based systematic review by the natural standard research collaboration Journal of Herbal Pharmacotherapy 5 2005 71 114
13. British Herbal Pharmacopoeia British Herbal Pharmacopoeia 1983 Megaron Press Ltd. Bournemouth
14. British Pharmacopea British Pharmacopea 2009 The Stationery Office London
15. P. Brugada, E. Andries, S. Gürsoy, and J. Brugada Investigation of palpitations The Lancet 341 1993 1254 1258
16. J. Cases, A. Ibarra, N. Feuillere, M. Roller, and S.G. Sukkar Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances Mediterranean Journal of Nutrition and Metabolism 4 2011 211 218
17. T. Ershadifar, B. Minaiee, M. Gharooni, M.M. Isfahani, A. Nikbakht Nasrabadi, E. Nazem, A.A. Gousheguir, and D. Kazemi Saleh Heart palpitation from traditional and modern medicine perspectives Iranian Red Crescent Medical Journal 16 2014 e14301
18. P. Faridi, H. Seradj, S. Mohammadi-Samani, M. Vossoughi, A. Mohagheghzadeh, and J. Roozbeh Randomized and double-blinded clinical trial of the safety and calcium kidney stone dissolving efficacy of Lapis judaicus Journal of Ethnopharmacology 156 2014 82 87
19. P. Faridi, and M.M. Zarshenas Ibn Sina's book on drugs for cardiovascular diseases International Journal of Cardiology 145 2010 223
20. R. Gazola, D. Machado, C. Ruggiero, G. Singi, and M. Macedo Alexandre Lippia alba, Melissa officinalis and Cymbopogon citratus: effects of the aqueous extracts on the isolated hearts of rats Pharmacological Research 50 2004 477 480
21. F. Ghaffari, F. Alijaniha, and F. Fallahi Single remedies for Khafaghan in Iranian traditional medicine Journal of Islamic and Iranian Traditional Medicine 4 2013 1 11
22. D. Goldberg Screening for psychiatric disorders P. Williams, G. Wilkinson, The scope of epidemiological psychiatry 1989 Routledge London
23. D.P. Goldberg The detection of psychiatric illness by questionnaire: A technique for the identification and assessment of non-psychotic psychiatric illness 1972 Oxford University Press London
24. E. Jonsbu, T. Dammen, G. Morken, A. Lied, H. Vik-Mo, and E.W. Martinsen Cardiac and psychiatric diagnoses among patients referred for chest pain and palpitations Scandinavian Cardiovascular Journal 43 2009 256 259
25. E. Jonsbu, T. Dammen, G. Morken, and E.W. Martinsen Patients with noncardiac chest pain and benign palpitations referred for cardiac outpatient investigation: a 6-month follow-up General Hospital Psychiatry 32 2010 406 412
26. E. Jonsbu, T. Dammen, G. Morken, T. Moum, and E.W. Martinsen Short-term cognitive behavioral therapy for non-cardiac chest pain and benign palpitations: a randomized controlled trial Journal of Psychosomatic Research 70 2011 117 123
27. D.O. Kennedy, W. Little, and A.B. Scholey Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (lemon balm) Psychosomatic Medicine 66 2004 607 613
28. D.O. Kennedy, and A.B. Scholey The psychopharmacology of European herbs with cognition-enhancing properties Current Pharmaceutical Design 12 2006 4613 4623
29. R.Y. Khamis, and M. Dancy Palpitations Medicine 37 2009 100 105
30. E. Koksal, E. Bursal, E. Dikici, F. Tozoglu, and I. Gulcin Antioxidant activity of Melissa officinalis leaves Journal of Medicinal Plants Research 5 2011 217 222
31. N.-S. Lok, and C.-P. Lau Prevalence of palpitations, cardiac arrhythmias and their associated risk factors in ambulant elderly International Journal of Cardiology 54 1996 231 236
32. R. Mayou Chest pain, palpitation and panic Journal of Psychosomatic Research 44 1998 53 70
33. R. Mayou, D. Sprigings, J. Birkhead, and J. Price Characteristics of patients presenting to a cardiac clinic with palpitation QJM: An International Journal of Medicine 96 2003 115 123
34. R. Mokaberinejad, N. Zafarghandi, S. Bioos, F.H. Dabaghian, M. Naseri, M. Kamalinejad, G. Amin, A. Ghobadi, M. Tansaz, A. Akhbari, and M. Hamiditabar Mentha longifolia syrup in secondary amenorrhea: a double-blind, placebo-controlled, randomized trials DARU Journal of Pharmaceutical Sciences 20 2012 97
35. S.A. Mozaffarpur, M. Naseri, M.R. Esmaeilidooki, M. Kamalinejad, and A. Bijani The effect of cassia fistula emulsion on pediatric functional constipation in comparison with mineral oil: a randomized, clinical trial DARU Journal of Pharmaceutical Sciences 20 2012 83
36. M. Mu'min Tonekaboni Tohfeh al-Momenin 1st ed. 2007 Moasese Nashreshahr Publication Tehran
37. S. Müller, and S. Klement A combination of valerian and lemon balm is effective in the treatment of restlessness and dyssomnia in children Phytomedicine 13 2006 383 387
38. M. Musavi Daruhayi galbi: A Persian Translation of al-adwiat al-qalbiyya of ibn-I sina 1st ed. 2004 Society for Appreciation of Cultural Works and Dignitaries, Institue of Islamic Studies Tehran-Mcgill Universities Tehran
39. A. Noorbala, S.B. Yazdi, M. Yasamy, and K. Mohammad Mental health survey of the adult population in Iran The British Journal of Psychiatry 184 2004 70 73
40. A.A. Noorbala, S.A. Bagheri Yazdi, M. Asadi Lari, V. Mahdavi, and M. Reza Mental health status of individuals fifteen years and older in Tehran-Iran (2009) Iranian Journal of Psychiatry and Clinical Psychology 16 2011 479 483
41. J.R. Price Medically unexplained physical symptoms Medicine 36 2008 449 451
42. M.Z. Razes (Razi) Alhavi fi-al-tibb 2002 Dar Ehia Al Tourah Al-Arabi Beirut
43. H. Rezaeizadeh, M. Alizadeh, M. Naseri, and M.S. Ardakani The traditional Iranian medicine point of view on health and disease Iranian Journal of Public Health 38 2009 169 172
44. N.N. Soodi, H. Hajimehdipoor, S. Choopani, and E. Sahraei, M. Memory-improving activity of Melissa officinalis extract in naïve and scopolamine-treated rats Research in Pharmaceutical Sciences 9 2013 107 114
45. B.E. Weber, and W.N. Kapoor Evaluation and outcomes of patients with palpitation American Journal of Medicine 100 1996 138 148
46. M.E. Wewers, and N.K. Lowe A critical review of visual analogue scales in the measurement of clinical phenomena Research in Nursing & Health 13 1990 227 236
47. A. Zarei, S. Changizi Ashtiani, S. Taheri, and F. Rasekh Comparison between effects of different doses of Melissa officinalis and atorvastatin on the activity of liver enzymes in hypercholesterolemia rats Avicenna Journal of Phytomedicine 4 2014 15 23
48. A. Zargaran, A. Mehdizadeh, M.M. Zarshenas, and A. Mohagheghzadeh Avicenna (980-1037 AD) Journal of Neurology 259 2012 389 390
49. A. Zargaran, M.M. Zarshenas, A. Karimi, H. Yarmohammadi, and A. Borhani-Haghighi Management of stroke as described by Ibn Sina (Avicenna) in the Canon of Medicine International Journal of Cardiology 169 2013 233 237
50. P. Zimetbaum, and M.E. Josephson Evaluation of patients with palpitations New England Journal of Medicine 338 1998 1369 1373