Effects of mesenchymal stem/stromal cells on cultures of corneal epithelial progenitor cells with ethanol injury

Investigative Ophthalmology and Visual Science

Volumn 55, Issue 11, 2014, Pages 7628-7635

  Oh, Joo Youn ^a   Ko, Jung Hwa ^a   Kim, Mee Kum ^a   Wee, Won Ryang ^a  

^a Seoul National University Hospital   (South Korea)

Author keywords

Apoptosis; Corneal epithelial cells; Mesenchymal stem stromal cells; Proliferation; Survival

Indexed keywords

ALCOHOL; BREAST CANCER RESISTANCE PROTEIN; GAMMA INTERFERON; HYPOCALCIN; LACTATE DEHYDROGENASE; PROTEIN P63; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL TISSUE; APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CHEMICAL INJURY; CORNEA EPITHELIUM; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MESENCHYMAL STEM CELL; MESENCHYMAL STROMA CELL; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; RABBIT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; WOUND HEALING; ANIMAL; BURNS, CHEMICAL; CELL CULTURE; CHEMICALLY INDUCED; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; EYE BURNS; MESENCHYMAL STEM CELL TRANSPLANTATION; PATHOLOGY; PROCEDURES; TISSUE REGENERATION; TOXICITY;

ANIMALS; APOPTOSIS; BURNS, CHEMICAL; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EPITHELIUM, CORNEAL; ETHANOL; EYE BURNS; GUIDED TISSUE REGENERATION; HUMANS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; RABBITS;

EID: 84924870515     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.14-15424     Document Type: Article

References (23)

1. Prockop DJ, Oh JY. Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation. Mol Ther. 2012;20:14–20.
2. Prockop DJ, Oh JY. Medical therapies with adult stem/ progenitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations. J Cell Biochem. 2012;113:1460–1469.
3. Munoz JR, Stoutenger BR, Robinson AP, Spees JL, Prockop DJ. Human stem/progenitor cells from bone marrow promote neurogenesis of endogenous neural stem cells in the hippocampus of mice. Proc Natl Acad Sci U S A. 2005;102: 18171–18176.
4. Lee RH, Oh JY, Choi H, Bazhanov N. Therapeutic factors secreted by mesenchymal stromal cells and tissue repair. J Cell Biochem. 2011;112:3073–3078.
5. Ranganath SH, Levy O, Inamdar MS, Karp JM. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell. 2012;10:244–258.
6. Roddy GW, Oh JY, Lee RH, et al. Action at a distance: systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraft-ment and primarily by secretion of TNF-a stimulated gene/ protein 6. Stem Cells. 2011;29:1572–1579.
7. Oh JY, Kim MK, Shin MS, et al. The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury. Stem Cells. 2008;26:1047–1055.
8. Oh JY, Roddy GW, Choi H, et al. Anti-inflammatory protein TSG-6 reduces inflammatory damage to the cornea following chemical and mechanical injury. Proc Natl Acad Sci U S A. 2010;107:16875–16880.
9. Block GJ, Ohkouchi S, Fung F, et al. Multipotent stromal cells are activated to reduce apoptosis in part by upregulation and secretion of stanniocalcin-1. Stem Cells. 2009;27:670–681.
10. Ohkouchi S, Block GJ, Katsha AM, et al. Mesenchymal stromal cells protect cancer cells from ROS-induced apoptosis and enhance the Warburg effect by secreting STC1. Mol Ther. 2012;20:417–423.
11. Yeung BH, Law AY, Wong CK. Evolution and roles of stanniocalcin. Mol Cell Endocrinol. 2012;349:272–280.
12. Roddy GW, Rosa RH Jr, Oh JY, et al. Stanniocalcin-1 rescued photoreceptor degeneration in two rat models of inherited retinal degeneration. Mol Ther. 2012;20:788–797.
13. Kim SJ, Ko JH, Yun JH, et al. Stanniocalcin-1 protects retinal ganglion cells by inhibiting apoptosis and oxidative damage. PLoS One. 2013;8:e63749.
14. Crop MJ, Baan CC, Korevaar SS, et al. Inflammatory conditions affect gene expression and function of human adipose tissue-derived mesenchymal stem cells. Clin Exp Immunol. 2010; 162:474–486.
15. Hemeda H, Jakob M, Ludwig AK, Giebel B, Lang S, Brandau S. Interferon-gamma and tumor necrosis factor-alpha differentially affect cytokine expression and migration properties of mesenchymal stem cells. Stem Cells Dev. 2010;19:693–706.
16. Oh JY, Yu JM, Ko JH. Analysis of ethanol effects on corneal epithelium. Invest Ophthalmol Vis Sci. 2013;54:3852–3856.
17. Brana C, Benham C, Sundstrom L. A method for characterising cell death in vitro by combining propidium iodide staining with immunohistochemistry. Brain Res Brain Res Protoc. 2002;10:109–114.
18. Schlötzer-Schrehardt U, Kruse FE. Identification and characterization of limbal stem cells. Exp Eye Res. 2005;81:247–264.
19. Westberg JA, Serlachius M, Lankila P, et al. Hypoxic preconditioning induces neuroprotective stanniocalcin-1 in brain via IL-6 signaling. Stroke. 2007;38:1025–1030.
20. Zhang K, Lindsberg PJ, Tatlisumak T, et al. A molecular guard of neurons during cerebral ischemia. Proc Natl Acad Sci U S A. 2000;97:3637–3642.
21. Wang Y, Huang L, Abdelrahim M, et al. Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2. J Leukoc Biol. 2009;86: 981–988.
22. Oh JY, Ko JH, Lee HJ, et al. Mesenchymal stem/stromal cells inhibit the NLRP3 inflammasome by decreasing mitochondrial reactive oxygen species. Stem Cells. 2014;32:1553–1563.
23. Sheikh-Hamad D. Mammalian stanniocalcin-1 activates mito-chondrial antioxidant pathways: new paradigms for regulation of macrophages and endothelium. Am J Physiol Renal Physiol. 2010;298:F248–F254.